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Effect of perioperative fluid therapy on early phase prognosis after liver transplanta.ion

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 367-372页

作者： Jiang, Guo-Qing Peng, min-Hao Yang, Ding-Hua Guangxi med Univ Affiliated Hosp 1 Dept Hepatobiliary Surg Nanning 530021 Peoples R China Peoples Hosp Subei Dept Hepatobiliary Surg Yangzhou 225001 Peoples R China

BACKGROUND: Although liver transplanta.ion (LT) has made rapid progress, early pulmonary complications still occur. More attention should be paid to fluid therapy that may be an importa.t factor leading to these complications. It is necessary to investigate the correlation between intraoperative and postoperative fluid therapy and early pulmonary complications after LT, then attempt to provide a reasonable fluid therapy in the perioperative period. METHODS: Sixty-two patients who had undergone Ff were enrolled and analyzed retrospectively. Based on early phase prognosis after LT, the 62 patients were divided into a non-pulmonary complication group and a pulmonary complication group. Twenty perioperative variables were analyzed in both groups to screen out several factors causing early pulmonary complications, then the parameters reflecting postoperative recovery were analyzed. RESULTS: The pulmonary complication group had 29 patients (46.77%), 3 (4.84%) of whom died during the perioperative period. Using monofactorial analysis for each variable, the two groups differed in the following variables: preoperative lung function, volume of intraoperative transfusion, volume of intraoperative bleeding, and volume of intraoperative net fluid retention and fluid balance (= 2 of the first 3 days after operation. Analysis of the relationship between multivariate factors and pulmonary complications after LT by logistic multivariate regression analysis showed that preoperative lung function, volume of intraoperative bleeding, and fluid balance (=-2 of the first 3 days after operation were influential factors. CONCLUSIONS: It is importa.t to mainta.n fluid balance during the perioperative period of LT. If the hemodynamics are sta.le, appropriate negative fluid balance in the first 3 days after operation apparently decreases the incidence of early pulmonary complications after LT. These measures are associated with better postoperative recovery.

关键词： liver transplanta.ion perioperative period fluid therapy fluid balance

A new diterpenoid from Euphorbia helioscopia

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Chinese Chemical Letters 2010年第1期21卷 73-75页

作者： Geng, Di Shi, Yao min, Zhi Da Liang, Jing Yu China Pharmaceut Univ Dept Nat Med Chem Nanjing 210009 Peoples R China

A new jatrophane-type diterpenoid,7β,14β,15β-triacetoxy-3β-benzoyloxy-9-oxojatropha-5E,11E-diene,named euphornin N was isolated from Euphorbia helioscopia *** structure and relative stereochemistry of the new comp... 详细信息

关键词： 7β 14β 15β-Triacetoxy-3β-benzoyloxy-9-oxojatropha-5E 11E-diene Euphornin N Euphorbia helioscopia

Heavy Meta. Ions Removal by Nano-sized Spherical Polymer Brushes

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Chinese Journal of Polymer Science 2014年第4期32卷 432-438页

作者： Qing-chuan Chen 王杰 Kai-min Chen Rui Zhang Li Li Xu-hong Guo Sta.e Key Laboratory of Chemical Engineering East China University of Science and Technology med-X Research Institute Shanghai Jiao Tong University

Nano-sized spherical polymer brushes （SPBs） consisting of both a polystyrene （PS） core and a brush shell of poly（acrylic acid）（PAA）, poly（N-acrylcysteamine）（PSH）, or poly（N-acrylcysteamine-co-acrylic acid）（P（SH-co-AA））, were prepared by photo-emulsion polymerization. The core-shell structure was observed by dynamic light scattering and transmission electron microscopy. Due to the strengthened Donnan effect, the PAA brush can adsorb heavy meta. ions. Effects of the conta.t time, thickness of PAA brush and pH value on the adsorption results were investigated. Due to the coordination between the mercapto groups and heavy meta. ions as well as the electrosta.ic interactions, SPBs with mercapto groups are capable to remove heavy meta. ions selectively from aqueous solutions. The order of adsorption capacity of the heavy meta. ions by SPBs with mercapto groups is： Hg2＋ ≈ Au3＋〉 Pb2＋〉 CH2＋〉 Ni2＋. The adsorbed heavy meta. ions can be eluted from SPB by aqueous HCI solution, and the SPBs can be recovered. After three regenerations the recovered SPBs still mainta.n their adsorption capacity.

关键词： Nano-sized spherical polymer brushes Photo-emulsion polymerization Heavy meta. ions.

Multiple chronic non-specific ulcer of small intestine characterized by anemia and hypoalbuminemia

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World Journal of Gastroenterology 2010年第6期16卷 782-784页

作者： Chen, Yan Ma, Wang-Qian Chen, Jia-min Cai, Jian-Ting Zhejiang Univ Dept Gastroenterol Affiliated Hosp 2 Coll Med Hangzhou 310009 Zhejiang Peoples R China

A female patient with anemia and hypoalbuminemia was admitted to our hospita. due to an over 20-year history of recurrent dizziness,fatigue and ankle *** was diagnosed as multiple chronic nonspecific ulcer of the smal... 详细信息

关键词： Small intestinal ulcer Hypoalbuminemia Anemia Gastrointestinal bleeding Capsule endoscopy

Prevalence of post-traumatic stress disorder after earthquakes among the elderly in China: A meta.analysis

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World Journal of Emergency medicine 2021年第2期12卷 137-142页

作者： Yong Liang Hong Zeng Yu-geng Liu Ai-min Xu Wen-hong Liu Emergency medicine Clinical Research Center Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100043China

BACKGROUND: The study aims to investigate the occurrence of post-traumatic stress disorder(PTSD) after earthquakes among the elderly. METHODS: Data.from cross-sectional studies focusing on the prevalence of PTSD after earthquakes among the elderly were collected from Pub med, EMBASE, Cochrane Library, and China National Knowledge Infrastructure in December 2019. The search terms included post-traumatic stress disorder, earthquake, and elderly. This study used Review Manager 5.0 to evaluate the impact of the results. In addition, forest plots, sensitivity analysis, and bias analysis were carried out on the included articles. The combined estimate of the risk ratio and the sta.dard deviation of the 95% confidence interval(95% CI) were measurements of the size of the ***: There were 4,834 patients included from 10 eligible studies. The sample sizes of PTSD group and non-PTSD group were 1,277 and 3,557, respectively. The meta.analysis showed that the overall occurrence of PTSD after earthquakes among the elderly was 0.25;the occurrence in females was higher than that in males, and the occurrence in the same province indicated little difference(Wenchuan city 0.25 and Ya'an city 0.24).CONCLUSIONS: After earthquakes, the occurrence of PTSD is higher among the elderly than among other age groups, and higher among the females than among the males, while there is little difference among different areas within the same province. This indicated that prioritized specific psychological interventions should be provided to the aged and the females.

关键词： Post-traumatic stress disorder The elderly Earthquake

基于机器学习的饮食质量指数及其对血压水平及高血压的预测研究

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右江民族医学院学报 2024年第3期46卷 295-300,306页

作者：刘炎张玲李琦杨灿杜亚楠袁敏安徽医科大学卫生管理学院卫生健康数据科学系安徽合肥230032

目的基于机器学习弹性网变量选择方法提出一种数据自适应的饮食质量指数,并探讨其与血压及高血压患病风险的关联。方法数据来源于美国营养调查协会(NHANES)2011~2018年4个周期的1143个亚裔样本数据,其中男性占59.06%,平均年龄为(43.12±... 详细信息

目的基于机器学习弹性网变量选择方法提出一种数据自适应的饮食质量指数,并探讨其与血压及高血压患病风险的关联。方法数据来源于美国营养调查协会(NHANES)2011~2018年4个周期的1143个亚裔样本数据,其中男性占59.06%,平均年龄为(43.12±15.10)岁;其它变量包括人口统计学变量、29种食物摄入成分以及舒张压和收缩压测量值。在控制相关混杂因素的前提下,利用弹性网变量选择方法筛选出重要食物摄入成分,并以食物成分对应的回归系数为权重计算加权平均值作为数据自适应饮食质量指数(ddDQS)。进一步分析新指数与高血压风险的关联,并与健康饮食指数(HEI-2015)、替代健康饮食指数(AHEI)、得舒饮食指数(DASH)以及地中海饮食指数(med)4种常用的饮食指数进行比较。结果高血压患病率为26.15%,患高血压个体的平均年龄[(52.94±14.77)岁]显著高于没有患高血压的个体[(39.64±13.62)岁]。ddDQS包含5个重要的膳食成分(精制谷物、油、酒精、添加糖以及马铃薯),与收缩压(SBP)(β=-2.08,95%CI=-3.24~-0.92,Pmed与DBP、SBP以及HTN的关联。结论与常用饮食指数相比,ddDQS对高血压有更好的预测。ddDQS越高越有益于血压及高血压风险的降低。针对亚裔人群的饮食指数的构建可指导未来研究进行高血压预防与控制。

关键词：高血压饮食质量指数弹性网变量选择机器学习

中国2012—2022年羊群中蓝舌病毒流行的Meta.析

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畜牧兽医学报 2024年第2期55卷 706-717页

作者：高辉方敏姜玲玲马耀玉刘强张刚牛小霞王璞李勇张思浓宁夏大学生命科学学院银川750021 宁夏大学西部特色生物资源保护与利用教育部重点实验室银川750021 夏河县麻当镇畜牧兽医工作站夏河747100

旨在系统评价和分析我国2012—2022年羊群中蓝舌病毒(bluetongue virus,BTV)感染状况,为我国羊群BTV防控提供理论依据。通过检索2012—2022年中国知网(CNKI)、万方、维普、Pubmed和ScienceDirect 5个数据库中对中国羊群BTV流行情况研究... 详细信息

旨在系统评价和分析我国2012—2022年羊群中蓝舌病毒(bluetongue virus,BTV)感染状况,为我国羊群BTV防控提供理论依据。通过检索2012—2022年中国知网(CNKI)、万方、维普、Pubmed和ScienceDirect 5个数据库中对中国羊群BTV流行情况研究的文献并进行Meta.析。检索并筛选后共纳入Meta.析的有28篇文献,涉及样本总数为38226头羊,其中9109头羊为BTV阳性。分析显示,我国羊群中BTV的整体流行率为23.8%(95%CI:23.4,24.3),其中绵羊流行率为29.4%(95%CI:14.7,44.1),山羊流行率为25.1%(95%CI:18.6,31.7)。我国各省/市间比较发现,重庆市流行率最高,为34.6%(95%CI:32.0,37.1),其次为云南省和内蒙古自治区。亚组分析发现,我国5大区域BTV流行率存在显著地区差异(P=0.011),中国东部、南部、西部、北部及中部地区流行率分别为6.1%(95%CI:4.3,7.9)、33.8%(95%CI:29.5,38.1)、21.7%(95%CI:17.1,26.2)、21.0%(95%CI:8.3,33.6)及26.6%(95%CI:24.3,28.8)。同时,检测方式和气候类型也是我国羊群中BTV流行的风险因子(P<0.05)。上述分析结果提示,我国羊群中BTV流行率较高并且分布广泛,有必要持续对我国BTV的感染状况进行监测并采取适当的预防措施。

关键词：蓝舌病毒蓝舌病羊流行率 Meta.析

沙利度胺联合CAG方案治疗老年急性髓系白血病患者有效性与安全性的Meta.析

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中国药房 2024年第9期35卷 1139-1144页

作者：李晓靖胡琦陆嘉惠刘敏邓剑青江雯雯鲍计章上海中医药大学附属市中医医院血液病科上海200040

目的系统评价沙利度胺联合阿克拉霉素、粒细胞集落刺激因子与阿糖胞苷(CAG)方案治疗老年急性髓系白血病(AML)患者的疗效与安全性。方法检索中国知网、万方数据、维普网、Sino med、Pubmed、Embase、the Cochrane Library、Web of Scien... 详细信息

目的系统评价沙利度胺联合阿克拉霉素、粒细胞集落刺激因子与阿糖胞苷(CAG)方案治疗老年急性髓系白血病(AML)患者的疗效与安全性。方法检索中国知网、万方数据、维普网、Sino med、Pubmed、Embase、the Cochrane Library、Web of Science,检索时限为数据库建库至2023年8月27日。收集沙利度胺联合CAG方案(试验组)对比CAG方案(对照组)治疗老年AML患者的临床随机对照试验,对纳入的研究采用RevMan 5.3软件进行Meta.析。结果最终纳入7项临床随机对照试验,共计601例患者,其中试验组307例、对照组294例。Meta.析结果显示,试验组在提升总有效率[Z=4.75,P<0.00001,OR=2.80,95%CI(1.83,4.28)]、完全缓解率[Z=2.82,P=0.005,OR=1.61,95%CI(1.16,2.25)],改善血小板计数[Z=2.70,P=0.007,MD=64.02,95%CI(17.53,110.51)]、血管内皮生长因子水平[Z=13.63,P<0.00001,MD=-65.17,95%CI(-74.54,-55.80)]、血管内皮生长因子受体水平[Z=12.03,P<0.00001,MD=-499.01,95%CI(-580.31,-417.71)]、碱性成纤维细胞生长因子水平[Z=4.17,P<0.0001,MD=-0.23,95%CI(-0.35,-0.12)]等方面均显著优于对照组,不良反应发生率[Z=0.99,P=0.32,OR=0.52,95%CI(0.14,1.89)]以及恶心呕吐[Z=1.06,P=0.29,OR=0.66,95%CI(0.30,1.43)]、便秘或腹泻[Z=0.92,P=0.36,OR=0.65,95%CI(0.26,1.63)]、嗜睡[Z=1.38,P=0.17,OR=0.57,95%CI(0.26,1.27)]、骨髓抑制[Z=0.88,P=0.38,OR=0.68,95%CI(0.28,1.62)]的发生率与对照组比较,差异均无统计学意义。结论沙利度胺联合CAG方案治疗老年AML患者能显著增加疗效,且安全性较好。

关键词：沙利度胺阿克拉霉素粒细胞集落刺激因子阿糖胞苷急性髓系白血病老年患者 Meta.析

p38 MAPK is a Component of the Signal Transduction Pathway Triggering Cold Stress Response in the med Cryptic Species of Bemisia ta.aci

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Journal of Integrative Agriculture 2012年第2期11卷 303-311页

作者： LI Fang-fang XIA Jun LI Jun-min LIU Shu-sheng WANG Xiao-wei Key Laboratory of Agricultural Entomology Ministry of Agriculture/Institute of Insect SciencesZhejiang UniversityHangzhou 310029P.R.China

Cold stress responses help insects to survive under low temperatures that would be lethal *** phenomenon might contribute to the invasion of some Bemisia ta.aci cryptic species from subtropical areas to temperate ***,the molecular mechanisms regulating cold stress responses in whitefly are yet ***-activated protein kinases（MAPKs）which including p38,ERK,and JNK,are well known for their roles in regulating meta.olic responses to cold stress in many *** this study,we explored the possible roles of the MAPKs in response to low temperature stresses in the mediterranean cryptic species（the Q-biotype）of the *** species ***,we cloned the p38 and ERK genes from the whitefly cDNA ***,we analyzed the activation of MAPKs during cold stress in the mediterranean cryptic species by *** cold stress,the level of phospho-p38 increased but no significant change was observed in the phosphorylation of ERK and JNK,thus suggesting that the p38 might be responsible for the defense response to low temperature ***,we demonstrated that：i）3 min chilling at 0°C was sufficient for the activation of p38 MAPK pathway in this whitefly;and ii）the amount of phosphorylated p38 increased significantly in the first 20 min of chilling,reversed by 60 min,and then returned to the original level by 120 *** together,our results suggest that the p38 pathway is importa.t during response to low temperature stress in the mediterranean cryptic species of the *** species complex.

关键词： Bemisia ta.aci cold stress MAPK p38 phosphorylation signal transduction