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Cell Research 1996年第2期6卷 189-199页

作者： HAO XIU JUAN PEI HSIEN ta.G XIU SEN LI FEI ZI JIANG YONG ZHI XI NING MAO DE LIN DU min WU (Institute of Basic medical Sciences, Beijing 100850)(National Laboratory of Molecular Oncology, In stitute of Cancer Research Beijing, Chinese Academy of med Institute of Basic medical Sciences Beijing 100850 National Laboratory of Molecular Oncology Institute of Cancer Research Beijing Chinese Academy of Medical Sciences Beijing 100021

This study was designed using c-myc antisense transcripts to evaluate how alteration of c-myc expression in human myeloid leukemic HL-60 cells could influence the myelomonocytic differentiation and induction of apoptosis. The recombinant plasmid pDACx expressing antisense transcripts to c-myc fragment conta.ning a part of intron 1 and 137 nt exon 2 was constructed. pDACx was transfected into HL-60 cell line by lipofectin *** sta.nings including NBT reduction, peroxidase and α -NAE as well as detection of CD13 and CD33 antigens by flow cytometric analysis indicated occurrence of myelomonocytic differentiation in cells expressing antisense transcripts to c-myc. DNA degradation measured by DNA gel electrophoresis and typical morphological changes observed under electron microscope proved the switchon of apoptosis in terminally differentiating HL-60 cells.

关键词： c-myc oncogene antisense transcripts differentiation apoptosis

Effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus in Chinese patients： A Meta.analysis

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Journal of Traditional Chinese medicine 2018年第2期38卷 167-174页

作者： Yang Hongchang Wu Xueping Wang min Physical Education Department Hohai University Nanjing 210098 China Shanghai Key Lab of Human Performance Shanghai University of Sport Shanghai 200438 China School of Physical Education and Coaching Shanghai University of Sport Shanghai 200438 China Scientific Research Department Academy of Science Shanghai University of Sport Shanghai 200438 China School of Kinesiology Shanghai University of Sport Shanghai 200438 China Physical Education Department Shanghai Unversity of Finance and Economics Shanghai 200433 China

OBJECTIVE: To systematically evaluate the effect of conventional medical treatment plus Qigong exercise on type 2 diabetes mellitus(T2 DM) in Chinese ***: A literature search was conducted in Pub med, medline, Embase, China National Knowledge Infrastructure Data.ase, Wanfang and China Science and Technology Journal Data.ase until on January 2017. In this Meta.analysis, enrolled were the studies, including experimenta. group(with conventional medical treatment plus Qigong therapy) and control group(with conventional medicaltreatment plus diet control or other exercises).Then, the sta.dardized mean differences(SMDs) of fasting blood-glucose(FBG), 2-hplasmaglucose(2 h PG), hemoglobin Alc(Hb Alc), triglyceride(TG),tota. cholesterol(TC), high-density lipoprotein(HDL) and low density lipoprotein(LDL), as well as their 95% confidence interval(CIs) were calculated to evaluate the effect of Qigong on patients with T2 DM by Rev Man 5.2 and Sta.a 11.0 ***: Tota.ly 834 cases of T2 DM from 11 studies were included in this review. The pooled SMDs with its 95% CIs of FBG, 2 h PG, Hb Alc, TG,TC, HDL and LDL were-0.70(-0.93,-0.47),-0.66(-1.11,-0.21),-0.73(-0.96,-0.50),-1.05(-1.67,-0.43),-0.42(-1.12, 0.28), 0.69(0.19, 1.19), and-0.26(-0.69, 0.18), *** pooled data.showed significantly difference between Qigong and the levels of FBG, 2 h PG, Hb A1 c,TG, and HDL in patients with T2 DM(P medical treatment, Qigong exercise might have significant effect on T2 DM in Chinese patients.

关键词： Qigong Diabetes mellitus type 2 Blood glucose Meta.analysis Asian continenta. an-cestry group

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuota. Wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outsta.ding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Tota. synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine

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Chinese Chemical Letters 2010年第2期21卷 155-158页

作者： Yuan, Lei Wang, Jin Hui Sun, Tie min Shenyang Pharmaceut Univ Sch Pharmaceut Engn Shenyang 110016 Peoples R China Shenyang Pharmaceut Univ Sch Traditt Chinese Mat Med Shenyang 110016 Peoples R China

All stereoisomers of asperphenamate 1a and patriscabratine 2a were achieved with a high yield,and tota. synthesis of 2a is firstly described *** absolute configuration of patriscabratine was determined as(S,S).The compounds 1a-d and 2a-d have been tested by MTT assay in T47D,MDA-MB231,HL60,Hela and SGC-7901 cell lines in *** them,the(R,S) stereoisomer shows the strongest anticancer effects,while the(S,R) shows the weakest one.

关键词： N N -substituted phenylalanine-phenylalaninol ester Asperphenamate Patriscabratine Tota. synthesis Anticancer activity

基于自适应中值预测和霍夫曼编码的密文域可逆信息隐藏算法

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科学技术与工程 2024年第27期24卷 11752-11762页

作者：蒋宗宝张敏情董炜娜孔咏骏万洪莉网络与信息安全武警部队重点实验室西安710086 武警工程大学密码工程学院西安710086

为提高密文域可逆信息隐藏的嵌入容量,提出了一种基于自适应中值预测(adaptive median edge detection,Amed)和霍夫曼编码的密文域可逆信息隐藏算法。所提算法首先对载体图像进行块级扩展。然后,预测阶段引入自适应参数提出中值预测(med... 详细信息

为提高密文域可逆信息隐藏的嵌入容量,提出了一种基于自适应中值预测(adaptive median edge detection,Amed)和霍夫曼编码的密文域可逆信息隐藏算法。所提算法首先对载体图像进行块级扩展。然后,预测阶段引入自适应参数提出中值预测(median edge detection,med)优化方案,参数会随着图像纹理特征而变化,进而提高像素预测准确度。最后,对像素高有效位信息(most significant bit,MSB)进行标记,采用霍夫曼编码对标记结果进行压缩,从而腾出空间进行秘密信息的嵌入。实验结果表明,本文算法可以在保证可逆恢复的基础上实现秘密信息的正确提取。同时,与现有算法相比,嵌入容量有所提高,平均嵌入率高达2.6320 bpp。

关键词：自适应中值预测霍夫曼编码密文域可逆信息隐藏高嵌入容量

24-Hour Urinary Sodium Excretion Association with Cardiovascular Events:A Systematic Review and Dose-Response Meta.Analysis

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Biomedical and Environmenta. Sciences 2022年第10期35卷 921-930页

作者： ZHAO Dan LI Hua min LI Chao Xiu ZHOU Bo Department of Clinical Epidemiology and Evidence-Based medicine The First Hospital of China Medical UniversityShenyang 110000LiaoningChina School of Public Health China Medical UniversityShenyang 110000LiaoningChina

Objective The relationship between sodium inta.e and cardiovascular(CV)events remains ***,we carried out a systematic review and dose-response meta.analysis for evaluating the potential impact of 24-hour sodium excretion on CV ***,24-hour sodium excretion was used to replace daily sodium diet *** We searched ISI Web of Science,Embase,Pub med,and the Cochrane *** study included cohort studies reporting hazard ratio(HR).The random-effects model was used for summarizing the tota. relative risks(RRs)between the included *** addition,the generalized least-squares regression was employed to fit the study *** A tota. of 9 studies involving 645,006 participants were included in this study.A significant non-linear relationship was observed between sodium excretion and CV events(P^(non-linearity)ta.e was associated with an increased risk of CV events up to 4%.Further studies are required to validate our conclusions further.

关键词： Cardiovascular events Meta.analysis 24-h urinary sodium excretion Dose-response Sodium inta.e

平衡生物反馈训练对脑卒中足内翻患者足底压力和平衡功能的影响

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生物医学工程与临床 2024年第2期28卷 245-250页

作者：陈炜王玲张学敏季润天津理工大学天津市先进机电系统设计与智能控制重点实验室机电工程国家级实验教学示范中心天津300384 国家康复辅具研究中心附属康复医院民政部康复辅具技术与系统重点实验室北京市老年功能障碍康复辅助技术重点实验室北京100176

目的探讨平衡生物反馈训练对脑卒中足内翻患者的足底压力和平衡功能的作用。方法选择60例脑卒中足内翻患者,其中男性35例,女性25例;年龄50~58岁,平均年龄54.79岁;病程79~92 d,平均病程87.76 d;偏瘫左侧33例,右侧27例;脑梗死31例,脑出血2... 详细信息

目的探讨平衡生物反馈训练对脑卒中足内翻患者的足底压力和平衡功能的作用。方法选择60例脑卒中足内翻患者,其中男性35例,女性25例;年龄50~58岁,平均年龄54.79岁;病程79~92 d,平均病程87.76 d;偏瘫左侧33例,右侧27例;脑梗死31例,脑出血29例。随机选择30例作为对照组,另外30例为试验组。对照组和试验组都进行综合训练,试验组在此基础上进行平衡生物反馈训练。两组连续训练8周,每周5 d,每天2次,每次共60 min。选用美国Tekscan公司的Footscan三维动态足底压力步态分析系统。在治疗前和治疗后8周,对患者的足底压力和平衡运动学参数进行对比。结果在足底压力方面,治疗前,两组患者内外侧压力和接触面积差异无统计学意义(P>0.05);治疗后,两组患者内侧压力增大(P0.05);治疗后两组患者的X、Y轴上的轨迹长度、均方差、最大动摇径、总轨迹、偏移长度和包络面积均显著降低(P<0.05),速度、单位面积轨迹长度均显著升高(P<0.05),试验组平衡运动学参数改善更为显著(P<0.05)。结论平衡生物反馈训练可显著提高脑卒中足内翻患者的足底压力和平衡功能。

关键词：脑卒中平衡生物反馈训练足底压力平衡功能

医生职业倦怠现状及危险因素研究:基于系统性综述

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职业卫生与应急救援 2024年第3期42卷 385-391页

作者：陈海梅张敏沙悦汤宇婷中国医学科学院北京协和医院全科医学科(普通内科) 北京100730 中国医学科学院北京协和医学院群医学及公共卫生学院环境与职业健康系北京100005

目的了解医生职业倦怠患病率、危险因素及预防缓解策略。方法使用与职业倦怠相关的检索词在Pub med、中国知网、万方、维普中文科技期刊数据库进行文献检索,筛选2013年11月—2023年11月的系统性综述研究为研究资料,对这些文献再次进行... 详细信息

目的了解医生职业倦怠患病率、危险因素及预防缓解策略。方法使用与职业倦怠相关的检索词在Pub med、中国知网、万方、维普中文科技期刊数据库进行文献检索,筛选2013年11月—2023年11月的系统性综述研究为研究资料,对这些文献再次进行系统性综述,分析、总结医生职业倦怠患病率及其危险因素,提出相应的预防缓解策略。结果共检索到90篇文献,最终有33篇文献纳入研究。有28篇文献报道了研究人群职业倦怠和/或不同维度的患病率,总体职业倦怠患病率估计范围为0~95.2%。12篇文献所报道的情绪衰竭、人格解体、个人成就感降低患病率估计范围分别为0~86.2%、0~91.0%、0~87.1%。医生职业倦怠危险因素包括个体因素、工作组织、患者安全与医疗质量、团队合作与领导支持、与医患关系相关的因素、培训因素。结论医生职业倦怠普遍存在,全球医生职业倦怠程度很高。应当倡导采取系统性的职业健康防护措施,将针对个人的干预和组织层面上的干预相结合,为医生提供更好的职业健康环境,预防和控制职业倦怠。

关键词：职业倦怠医生患病率危险因素系统性综述

Specific molecular markers in hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2007年第3期6卷 241-247页

作者： Yao, Deng-Fu Dong, Zhi-Zhen Yao, min Nantong Univ Affiliated Hosp Res Ctr Clin Mol Biol Nantong 226001 Peoples R China Nantong Univ Affiliated Hosp Dept Diagnost Nantong 226001 Peoples R China Nantong Univ Affiliated Hosp Dept Lab Med Nantong 226001 Peoples R China

BACKGROUND: The carcinogenesis of hepatocellular carcinoma (HCC) is a multi-factorial, multistep and complex process. Its prognosis is poor, and early diagnosis and monitoring meta.ta.is of HCC is of the utmost importa.ce. Circulating diagnostic and prognostic biomarkers could be used in proper postoperative treatment of patients at an early sta.e of HCC development. This review summarizes recent studies of the specific biomarkers in diagnosis and monitoring meta.ta.is or postoperative recurrence of HCC. DAta.SOURCES: An English-language literature search was conducted using medLINE (June 1998 to Spetember 2006) on researches of some valuable specific biomarkers in diagnosis and monitoring meta.ta.is or postoperative recurrence of HCC. RESULTS: Hepatoma tissues can synthesize various tumor-related proteins, polypeptides, and isoenzymes, such as alpha-fetoprotein (AFP), hepatoma-specific gamma-gluta.yl transpeptidase (HS-GGT), etc, and then secrete into blood. The valuable early diagnostic and prognostic biomarkers could predict the development an meta.ta.es of HCC. Recent researches have confirmed that circulating hepatoma-specific AFP subfraction, transforming growth factor (TGF)-beta.1, HS-GGT, and free insulin-like growth factor (IGF)-II may be more specific markers than tota. AFP level for early diagnosis for HCC. The circulating genetic markers such as AFP-mRNA, TGF-beta.1-mRNA, IGF-II-mRNA, etc from peripheral blood mononuclear cells of HCC patients have been most extensively used in monitoring dista. meta.ta.is or postoperative recurrence of HCC. CONCLUSIONS: Hepatoma tissues synthesize and secrete valuable molecular markers into blood. The analyses of circulating hepatoma-specific biomarkers are useful to early diagnosis of HCC or monitoring meta.ta.is or postoperative recurrence of HCC.

关键词： carcinoma hepatocellular molecular marker early diagnosis meta.ta.is of tumor postoperative recurrence

Stem cell transplanta.ion for spinal cord injury： a meta.analysis of treatment effectiveness and safety

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Neural Regeneration Research 2017年第5期12卷 815-825页

作者： Xiao Fan Jin-zhao Wang Xiao-min Lin Li Zhang Fujian University of Traditional Chinese medicine Fuzhou Fujian Province China Xiamen medical College Xiamen Fujian Province China

OBJECTIVE： The aim of this study was to evaluate the effectiveness and safety of stem cell transplanta.ion for spinal cord injury（SCI）.DAta.SOURCES： PubM ed, EMBASE, Cochrane, China National Knowledge Infrastructure, China Science and Technology Journal, Wanfang, and Sino med data.ases were systematically searched by computer to select clinical randomized controlled trials using stem cell transplanta.ion to treat SCI, published between each data.ase initiation and July 2016. DAta.SELECTION： Randomized controlled trials comparing stem cell transplanta.ion with rehabilita.ion treatment for patients with SCI. Inclusion criteria：（1） Patients with SCI diagnosed according to the American Spinal Injury Association（ASIA） International sta.dards for neurological classification of SCI;（2） patients with SCI who received only stem cell transplanta.ion therapy or stem cell transplanta.ion combined with rehabilita.ion therapy;（3） one or more of the following outcomes reported： outcomes concerning neurological function including sensory function and locomotor function, activities of daily living, urination functions, and severity of SCI or adverse effects. Studies comprising patients with complications, without full-text, and preclinical animal models were excluded. Quality of the included studies was evaluated using the Cochrane risk of bias assessment tool and Rev Man V5.3 software, provided by the Cochrane Collaboration, was used to perform sta.istical analysis. OUTCOME MEASURES： ASIA motor score, ASIA light touch score, ASIA pinprick score, ASIA impairment scale grading improvement rate, activities of daily living score, residual urine volume, and adverse ***： Ten studies comprising 377 patients were included in the analysis and the overall risk of bias was relatively low level. Four studies did not deta.l how random sequences were generated, two studies did not clearly sta.e the blinding outcome assessment, two studies lacked blinding outcome assessment, one study

关键词： nerve regeneration spinal cord injury stem cells cell transplanta.ion bone marrow mesenchymalstem cells umbilical cord blood stem cells neural stem cells human embryonic stem cells paraplegia meta.analysis neural regeneration