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Protein tyrosine phosphata.es:emerging role in cancer therapy resista.ce

Cancer Communications 2024年第6期44卷 637-653页

作者： min Zhao Wen Shuai Zehao Su Ping Xu Aoxue Wang Qiu Sun Guan Wang Innovation Center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceDepartment of BiotherapyCancer Center and State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalWest China School of NursingSichuan UniversityChengduSichuanP.R.China West China Biomedical Big Data.Center Med-X Center for InformaticsSichuan UniversityChengduSichuanP.R.China Emergency Department Zigong Fourth People’s HospitalChengduSichuanP.R.China

Background:Tyrosine phosphorylation of intracellular proteins is a posttranslational modification that plays a regulatory role in signal transduction during cellular *** of signal transduction proteins caused by protein tyrosine phosphata.es(PTPs)contributed their role as a convergent node to mediate cross-ta.k between signaling *** the context of cancer,PTP-mediated pathways have been identified as signaling hubs that enabled cancer cells to mitigate stress induced by clinical *** is achieved by the promotion of constitutive activation of growth-stimulatory signaling pathways or modulation of the immune-suppressive tumor *** evidences suggested that anticancer drugs will release their greatest therapeutic potency when combined with PTP inhibitors,reversing drug resista.ce that was responsible for clinical failures during cancer *** covered:This review aimed to elaborate recent insights that supported the involvement of PTP-mediated pathways in the development of resista.ce to ta.geted therapy and immune-checkpoint *** opinion:This review proposed the notion of PTP inhibition in anticancer combination therapy as a potential strategy in clinic to achieve long-term tumor *** clinical trials are currently underway to assess the safety and efficacy of combination therapy in advanced-sta.e tumors.

关键词： cancer treatment combination therapy drug resista.ce protein tyrosine phosphata.e

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Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta.Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： Yani Xu Lan Yang min Li Haozhou Shu Na Jia Yunzhen Gao Rongying Shi Xiaojia Yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-ta.geting and Drug Delivery System of the Education ministry West China School of PharmacySichuan UniversityChengdu 610041China med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resista.t to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data.demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate fromminimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

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Bibliometric and visual analysis of post-stroke hemiplegia in the past 20 years

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Clinical Research Communications 2024年第3期7卷 29-37页

作者： Jie Li Xue-min Yin Yong-Fang Yang Xin-Ju Li Acupuncture department Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China. School of Acupuncture Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China. College of Traditional Chinese medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China.

Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 ***:Articles about post-stroke hemiplegia from January 2005 to December 2024 were analyzed in the Web of Science *** software was used to conduct co-cita.ion analysis of the articles about post-stroke hemiplegia as well as cooperative network analyses of authors,countries,and institutions,as well as keyword co-occurrence,clustering,emergence,and time line *** results were displayed in a visual ***:A tota. of 2625 papers were obta.ned,and there were more publications *** and the United Sta.es had the most number of articles,while Chae,John was the author with the most number of *** med University and Ohio Sta.e University had the most articles among their *** keywords"stroke"and"rehabilita.ion"were used the *** key word analysis indicates that the present study focus is on exercise rehabilita.ion measures and post-stroke ***:Using CiteSpace software to analyze the literature on post-stroke hemiplegia,it is discovered that the use of new technologies in the field of mechanical thrombectomy and the effectiveness of rehabilita.ion techniques like mirror treatment are the key areas of study *** study has positive significance for finding safer and more effective treatments for post-stroke hemiplegia.

关键词： CiteSpace stroke hemiplegia visual analysis

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Chinese herbal medicine Ginkgo biloba *** for ischemic stroke:An overview of systematic reviews and meta.analyses

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Journal of Integrative medicine 2024年第2期22卷 163-179页

作者： Tian-tian Meng Ya-ping You min Li Jian-bo Guo Xin-bin Song Jing-yi Ding Xiao-long Xie An-qi Li Shang-jin Li Xiang-jun Yin Peng Wang Zhe Wang Bao-liang Wang Qing-yong He Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100032China Department of Rehabilita.ion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100071China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chinese medicine the University of Hong KongHong KongChina Graduate School Henan University of Chinese MedicineZhengzhou 450008Henan ProvinceChina Department of Acupuncture and Moxibustion Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesZhengzhou 450008Henan ProvinceChina School of Integrated Traditional Chinese and Western medicine Southwest Medical UniversityHangzhou 310053Zhejiang ProvinceChina School of Basic medical Sciences Zhejiang Chinese Medical UniversityHangzhu 310053Zhejang ProvinceChina Department of Neurology the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Ginkgo biloba ***(GBLPs)are a class of Chinese herbal medicine used in the adjuvant treatment of ischemic stroke(IS).Recently,several systematic reviews(SRs)and meta.analyses(MAs)of GBLPs for IS have been ***:This overview aims to assess the quality of related SRs and *** strategy:Pub med,Embase,Cochrane Library,Web of Science,Chinese Biological medicine,China National Knowledge Infrastructure,Wanfang,and Chinese Science and Technology Journals data.ases were searched from their inception to December 31,*** criteria:SRs and MAs of randomized controlled trials(RCTs)that explored the efficacy of GBLPs for patients with IS were *** extraction and analysis:Two independent reviewers extracted data.and assessed the methodological quality,risk of bias(ROB),reporting quality,and credibility of evidence of the included SRs and MAs using A Measurement Tool to Assess Systematic Reviews 2(AMSta. 2),Risk of Bias in Systematic Reviews(ROBIS),the Preferred Reporting Items for Systematic Reviews and Meta.analyses(PRISMA),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),***,descriptive analysis and data.synthesis were ***:Twenty-nine SRs/MAs involving 119 outcomes were included in this *** overall methodological quality of all SRs/MAs was critically low based on AMSta. 2,and 28 had a high ROB based on the *** to the PRISMA sta.ement,the reporting items of the included SRs/MAs are relatively *** results based on GRADE showed that of the 119 outcomes,8 were rated as moderate quality,24 as low quality,and 87 as very low *** on the data.synthesis,GBLPs used in conjunction with conventional treatment were superior to conventional treatment alone for decreasing neurological function ***:GBLPs can be considered a beneficial supplementa. therapy for ***,because of the low quality of the existing eviden

关键词： sta.ement synthesis alone

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社交媒体平台如何向互联网公开募捐平台引流——基于平台技术可供性的研究视角

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吉林大学社会科学学报 2024年第2期64卷 205-219,240页

作者：陈旭清杨敏李健中央民族大学管理学院北京100081 北京航空航天大学公共管理学院北京100191

通过社交媒体平台向互联网公开募捐平台引流是目前慈善组织网络募捐最主要的途径,更是所有互联网公开募捐平台中运营最成功的模式。社交媒体平台引流离不开平台技术功能的支持。以技术接受模型(ta.)作为理论分析框架,探究社交媒体平台... 详细信息

通过社交媒体平台向互联网公开募捐平台引流是目前慈善组织网络募捐最主要的途径,更是所有互联网公开募捐平台中运营最成功的模式。社交媒体平台引流离不开平台技术功能的支持。以技术接受模型(ta.)作为理论分析框架,探究社交媒体平台的技术可供性对公众互联网捐赠意愿产生的影响,深入分析平台技术可供性如何通过激发不同类型的动机从而有效影响公众捐赠意愿。研究发现:技术可供性在提高公众互联网捐赠意愿方面具有显著作用,其中动机在这一过程中起到了关键的中介作用。同时,不同维度的动机变量在中介作用上存在差异,其中个体内在动机发挥了最大的中介效应。研究有助于理解社交媒体平台向互联网公开募捐平台的引流机理,对促进互联网慈善发展具有重要意义。

关键词：技术可供性数字化公益技术接受模型平台引流社交媒体

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现代微生物学研究生课程教学改革与实践——专题教学与seminar教学模式相结合

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微生物学杂志 2024年第1期44卷 123-128页

作者：刘琼蔚晓敏黄孝天南昌大学基础医学院江西南昌330000

现代微生物学是面向基础医学专业硕士研究生开设的一门专业基础课程,旨在培养学生的基本科研素养和科研创造力,而传统的讲授型授课方式已无法满足新时代医学研究生教育要求。因此,本文通过专题教学与seminar教学模式(“讨论课”教学模式... 详细信息

现代微生物学是面向基础医学专业硕士研究生开设的一门专业基础课程,旨在培养学生的基本科研素养和科研创造力,而传统的讲授型授课方式已无法满足新时代医学研究生教育要求。因此,本文通过专题教学与seminar教学模式(“讨论课”教学模式)相结合,设置六大专题板块辅以学生seminar汇报讨论,应用于现代微生物学研究生课程教学,探讨该教学实践的应用效果,全面提升医学研究生的知识理论水平,培养具有创新思维和具备基本科研素质的高层次医学人才,也为医学类专业其他研究生课程的教学改革提供有益参考。

关键词：现代微生物学研究生课程专题教学 seminar教学(“讨论课”教学) 教学实践

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Re-evaluating the role of pelvic radiation in the age of modern precision medicine and systemic therapy

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World Journal of Clinical Oncology 2024年第1期15卷 1-4页

作者： ta.-Wei Ke Yu-min Liao Sheng-Chi Chang Che-Hung Lin William Tzu-Liang Chen Ji-An Liang Chun-Ru Chien Department of Colorecta. Surgery China Medical University HospitalTaichung 40402Taiwan School of Chinese medicine College of Chinese MedicineChina Medical UniversityTaichung 40402Taiwan Division of Hematology and Oncology Department of Internal MedicineChina Medical University HospitalTaichung 40402Taiwan Department of Colorecta. Surgery China Medical University Hsinchu HospitalHsinchu 30272Taiwan School of medicine College of MedicineChina Medical UniversityTaichung 40402Taiwan Department of Radiation Oncology China Medical University HospitalTaichung 40402Taiwan

The efficacy of pelvic radiation in the management of locally advanced sta.e recta. cancer has come under scrutiny in the context of modern precision medicine and systemic therapy as evidenced by recent clinical trials such as FOWARC(J Clin Oncol 2019;37:3223-3233),NCT04165772(N Engl J med 2022;386:2363-2376),and PROSPECT(N Engl J med 2023;389:322-334).In this review,we comprehensively assess these pivota. trials and offer additional insights into the evolving role of pelvic radiation in contemporary oncology.

关键词： Radiotherapy Locally advanced sta.e recta. cancer Precision medicine Systemic therapy Clinical trial

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大鼠脑出血后内源性神经干细胞迁移和微环境中免疫细胞表型变化规律的关系

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四川大学学报（医学版） 2024年第3期55卷 635-640页

作者：林容旭樊朝凤崔文耀冷静思贺民王焱超四川大学华西医院神经外科成都610041 四川大学“医学+材料”中心成都610044

目的研究脑出血(intracerebral hemorrhage, ICH)后内源性神经干细胞(endogenous neural stem cells,eNSCs)及再生微环境的变化规律,观察eNSCs迁移与微环境免疫细胞极化状态变化规律之间的关系,为临床神经修复研究提供研究基础。方法 ... 详细信息

目的研究脑出血(intracerebral hemorrhage, ICH)后内源性神经干细胞(endogenous neural stem cells,eNSCs)及再生微环境的变化规律,观察eNSCs迁移与微环境免疫细胞极化状态变化规律之间的关系,为临床神经修复研究提供研究基础。方法采用胶原酶注射法造模,在体质量为280~300 g的成年雌性Sprague-Dawley大鼠脑组织注射Ⅶ型胶原酶(2 U)诱导脑出血,为模拟急性期(1周内)、亚急性期(1~3周)及慢性期(>3周)脑出血的时间点,在注射后第3天(3-day post injection, 3 DPI)、10 DPI、20 DPI、30 DPI取脑组织评价造模效果。采用DCX抗体对脑组织切片进行免疫荧光染色,观察不同时间脑组织中eNSCs迁移变化规律;采用CD206抗体、CD86抗体对脑组织切片进行免疫荧光染色,分别观察脑组织促炎型(M1型)免疫细胞和抑炎型(M2型)免疫细胞在脑出血后再生微环境变化规律。结果在SD大鼠脑组织内注射Ⅶ型胶原酶可成功诱导大鼠自发性脑出血,血肿体积自3 DPI开始逐渐增加,到10 DPI时血肿体积达到最大。此后血肿逐渐吸收,在30 DPI时全部吸收。对脑组织eNSCs变化规律分析显示,在3 DPI时有少量eNSCs被激活但很快便减少,在10 DPI时eNSCs逐渐开始增多,到20 DPI时有大量eNSCs迁移至脑出血部位,而在30 DPI时eNSCs又明显减少(P0.01)。对脑组织免疫微环境分析显示,促炎型(M1型)免疫细胞在10、20 DPI时明显增加(P0.01),在30 DPI时减少。抑炎型(M2型)免疫细胞在3 DPI时开始逐渐增加,到20 DPI时明显减少(P0.05),而在30 DPI时又出现增加。结论大鼠脑出血后,向脑出血部位迁移的eNSCs先增多后减少,免疫微环境表现出先抑炎、再促炎、最后抑炎的变化规律。炎症对eNSCs迁移可能有刺激作用,但是过强的炎症激活对eNSCs的分化及进一步激活有抑制作用。脑出血后修复及脑保护早期(10 d内)及亚急性期(20 d内)可能是最佳的干预时机。

关键词：脑出血微环境内源性干细胞脑组织修复动物模型

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Effect of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy:a Meta.analysis

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Journal of Traditional Chinese medicine 2015年第1期35卷 15-20页

作者： Sun Qin Yang Gangyi Zhang min Zhang min Chen Shu Chen Pin Department of Gerontology Sichuan Provincial People's Hospital Chengdu 610072 China Department of Endocrinology The Second Affiliated Hospital Chongqing Medical University Chongqing400010 China

OBJECTIVE: To assess the efficacy of Huangshukuihua(Flos Abelmoschi Manihot) on diabetic nephropathy(DN).METHODS: Articles were retrieved from Pub med,EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Chinese Biomedical Literature Data.ase, and China National Knowledge Infrastructure Data.ase, Chinese Evidence-Based medicine Data.ase, and Wanfang Data.ase. Two reviewers independently reviewed the article. Only randomized controlled trials were included and 27 were identified involving 2239 patients(1143 in the treatment group and 1096 in the control group).RESULTS: Huangshukuihua(Flos Abelmoschi Manihot) had a significant effect on renal function by improving blood urea nitrogen and serum creatinine,reducing urine protein(24-h urine protein, and urinary albumin excretion rate), and improving serum albumin level, compared with the control ***: Our findings suggest that, although the bioactive ingredients and mechanism underlying renal protection are unknown, the role of Huangshukuihua(Flos Abelmoschi Manihot) in the treatment of DN deserves further investigation.

关键词： Diabetic nephropathy Renal insuffi-ciency Flos Abelmoschi Manihot Meta.analysis

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Chance and challenge of associating liver partition and porta. vein ligation for sta.ed hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2019年第3期18卷 214-222页

作者： Fei Xiang Ze-min Hu Department of General Surgery Jiangning Hospital of Nanjing Medical University Nanjing 211100 China Department of General Surgery Zhongshan People’s Hospital Zhongshan 528403 China

Background: The associating liver partition and porta. vein ligation for sta.ed hepatectomy(ALPPS) was first performed in 2007. The critical patient selection, timing to perform the second sta.e operation, and minimally invasive technique are three key factors for patient outcomes. The aim of this review is to summarize published data.on these three aspects. Data.sources: Studies were identified by searching Pub med for articles published from January 2007 to October 2018, using the keywords “associating liver partition and porta. vein ligation for sta.ed hepatectomy” or “ALPPS” or “in situ split”. Studies on colorecta. liver meta.ta.is(CRLM), perihilar cholangiocarcinoma(PHC), and hepatocellular carcinoma(HCC) indicated for ALPPS, cutoff values to determine the timing of sta.e 2, as well as modifications of ALPPS were included. Results: The morta.ity of ALPPS for CRLM is declining, for PHC is high. In patients with HCC, essential hypertrophy makes the ALPPS safer. However, the degrees of fibrosis affect the hypertrophy. The future liver remnant volume is still the gold sta.dard to sta.t the second sta.e. Hepatobiliary scintigraphy plays an importa.t role in quantita.ively assessing liver function, whereas cutoff values need to be further calibrated. Less-invasive ALPPS modifications have increased and led to a decreased morta.ity. Conclusions: ALLPS improved the CRLM outcomes;ALPPS is feasible in patients with PHC after failure of porta. vein embolization;ALPPS may be an option for HCC patients with major vascular invasion and thrombosis. The simplified and less-invasive ALPPS is the trend.

关键词： Hepatectomy Liver regeneration Porta. vein Colorecta. liver meta.ta.is Hepatocellular carcinoma Perihilar cholangiocarcinoma

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