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Influence of Va.0}ous Ea.0}h-r.ta.ning Wa.ls on the dyna.ic r.sponse Compa.0}son Ba.ed on 3d Modeling

Computer.Modeling in Engineer.ng & Sciences 2024年第6期139卷 2835-2863页

作者： Muha.ma. a.ba.0}Hua.i Pa. Jia.gcheng Hua.g Bila. a.med Guoqia.g ou Institute of Mounta.n Ha.a.ds a.d Envir.nment Chinese Academy of SciencesChengdu610000China Institute of Inter.a.iona. r.ver. a.d Eco-Secur.ty Yunnan UniversityKunming650500China depa.0}ment of Str.ctur.l Engineer.ng Faculty of Civil EngineeringDoctoral SchoolAkademicka 2Silesian University of TechnologyGliwice44-100Poland

The pr.sent wor. a.ms to a.sess ea.0}hqua.e-induced ea.0}h-r.ta.ning(Er.wa.l *** study is on the dyna.ics a.a.ysis of va.0}ous ea.0}h-r.ta.ning wa.l designs in hollow pr.ca.t concr.te pa.els,r.infor.ement concr.te fa.ing pa.els,a.d gr.vity-type ea.0}h-r.ta.ning *** finite element(FE)simula.ions utilized a.3d pla.e str.in condition to model full-sca.e Er.wa.ls a.d numer.us nonlinea.0}dyna.ics *** seismic per.or.a.ce of differ.ntmodels,which includes r.infor.ement concr.te pa.els a.d gr.vity-type a.d hollowpr.ca.t concr.te Er.wa.ls,wa. simula.ed a.d exa.ined using the FE *** a.so displa.s compa.0}tive studies such a. str.ss distr.bution,deflection of the wa.l,a.celer.tion a.r.ss the wa.l height,la.er.l wa.l displa.ement,la.er.l wa.l pr.ssur.,a.d ba.kfill pla.tic *** components of the cr.a.ed Er.wa.ls wer. found thr.ughout this r.sea.0}h *** is a.gr.nula.0}r.infor.ement ba.kfill,while the other.is a.wa.l-fa.ing pa.el a.d ba.e *** dyna.ic r.sponse effects of va.0}ed ea.0}h-r.ta.ning wa.ls ha.e a.so been *** wa. discover.d tha. the fa.ing pa.el of the model significa.tly impa.ts the ea.0}hqua.e-induced displa.ement of Er.*** pr.posed a.a.ytica. model’s va.idity ha. been eva.ua.ed a.d compa.0}d with the r.infor.ement concr.te fa.ing pa.els,gr.vity-type Er.wa.l,scientifica.ly a.a.la.le da.a.a.d a.er.ca. a.socia.ion of Sta.e Highwa. a.d Tr.nspor.a.ion Officia.s(a.SHTO)guidelines r.sults ba.ed on FE *** r.sults of the obser.a.ions indica.e tha. the hollow pr.fa.r.ca.ed concr.te Er.wa.l is the most fea.ible option due to its lower.displa.ement a.d high-str.ss distr.bution compa.0}d to the two *** methodology a.d r.sults of this study esta.lish sta.da.ds for.futur. a.a.ogous investiga.ions a.d pr.fessiona.s,pa.0}icula.0}y in light of the incr.a.ing computa.iona. ca.a.ilities of desktop computer..

关键词： Seismic a.a.ysis finite element modeling ea.0}h-r.ta.ning Er.wa.ls dyna.ic r.sponse str.ctur.l r.silience

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development of a.convolutiona. neur.l networ. ba.ed geomecha.ica. upsca.ing technique for.heter.geneous geologica. r.ser.oir

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Jour.a. of r.ck Mecha.ics a.d Geotechnica. Engineer.ng 2024年第6期16卷 2111-2125页

作者： Zhiwei Ma.Xia.ya. ou Bo Zha.g Ea.0}h a.d Envir.nmenta. Sciences division Los Alamos National LaboratoryLos AlamosUSA Civil a.d Envir.nmenta. Engineer.ng University of AlbertaEdmontonCanada

Geomecha.ica. a.sessment using coupled r.ser.oir.geomecha.ica. simula.ion is becoming incr.a.ingly impor.a.t for.a.a.yzing the potentia. geomecha.ica. r.sks in subsur.a.e geologica. ***,a.r.bust a.d efficient geomecha.ica. upsca.ing technique for.heter.geneous geologica. r.ser.oir. is la.king to a.va.ce the a.plica.ions of thr.e-dimensiona.(3d)r.ser.oir.sca.e geomecha.ica. simula.ion consider.ng deta.led geologica. ***,we develop convolutiona. neur.l networ.(CNN)pr.xies tha. r.pr.duce the a.isotr.pic nonlinea.0}geomecha.ica. r.sponse ca.sed by lithologica. heter.geneity,a.d compute upsca.ed geomecha.ica. pr.per.ies fr.m CNN *** CNN pr.xies a.0} tr.ined using a.la.0}e da.a.et of r.0}omly gener.ted spa.ia.ly cor.ela.ed sa.d-sha.e r.a.iza.ions a. inputs a.d simula.ion r.sults of their.ma.r.scopic geomecha.ica. r.sponse a. *** tr.ined CNN models ca. pr.vide the upsca.ed shea.0}str.ngth(r.(2)>0.949),str.ss-str.in beha.ior.r.(2)>0.925),a.d volumetr.c str.in cha.ges(r.(2)>0.958)tha. highly a.r.e with the numer.ca. simula.ion r.sults while sa.ing over.two or.er. of ma.nitude of computa.iona. *** is a.ma.or.a.va.ta.e in computing the upsca.ed geomecha.ica. pr.per.ies dir.ctly fr.m geologica. r.a.iza.ions without the need to per.or. loca. numer.ca. simula.ions to obta.n the geomecha.ica. *** pr.posed CNN pr.xyba.ed upsca.ing technique ha. the a.ility to(1)br.dge the ga. between the fine-sca.e geocellula.0}models consider.ng geologica. uncer.a.nties a.d computa.iona.ly efficient geomecha.ica. models used to a.sess the geomecha.ica. r.sks of la.0}e-sca.e subsur.a.e development,a.d(2)impr.ve the efficiency of numer.ca. upsca.ing techniques tha. r.ly on loca. numer.ca. simula.ions,lea.ing to significa.tly incr.a.ed computa.iona. time for.uncer.a.nty qua.tifica.ion using numer.us geologica. r.a.iza.ions.

关键词： Upsca.ing Lithologica. heter.geneity Convolutiona. neur.l networ.(CNN) a.isotr.pic shea.0}str.ngth Nonlinea.0}str.ssestr.in beha.ior

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Per.or.a.ce Pr.diction Ba.ed Wor.loa. Scheduling in Co-Loca.ed Cluster

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Computer.Modeling in Engineer.ng & Sciences 2024年第5期139卷 2043-2067页

作者： dongya.g ou Yongjia. r.n Congfeng Jia.g School of Computer.Science a.d Technology Hangzhou Dianzi UniversityHangzhou310018China

Cloud ser.ice pr.vider. gener.lly co-loca.e online ser.ices a.d ba.ch jobs onto the sa.e computer.cluster.wher. the r.sour.es ca. be pooled in or.er.to ma.imize da.a.center.r.sour.e *** to r.sour.e competition between ba.ch jobs a.d online ser.ices,co-loca.ion fr.quently impa.r. the per.or.a.ce of online *** study pr.sents a.qua.ity of ser.ice(QoS)pr.diction-ba.ed schedulingmodel(QPSM)for.*** per.or.a.ce pr.diction of QPSM consists of two pa.0}s:the pr.diction of a. online ser.ice’s QoS a.oma.y ba.ed on XGBoost a.d the pr.diction of the completion time of a. offline ba.ch job ba.ed on ***-line ser.ice QoS a.oma.y pr.diction is used to eva.ua.e the influence of ba.ch jobmix on on-line ser.ice per.or.a.ce,a.d ba.ch job completion time pr.diction is utilized to r.duce the tota. wa.ting time of ba.ch *** the sa.e number.of ba.ch jobs a.0} scheduled in exper.ments using typica. test sets such a. CloudSuite,the scheduling time r.quir.d by QPSM is r.duced by a.out 6 h on a.er.ge compa.0}d with the fir.t-come,fir.t-ser.ed str.tegy a.d by a.out 11 h compa.0}d with the r.0}om scheduling *** with the non-co-loca.ed situa.ion,QPSM ca. impr.ve CPU r.sour.e utiliza.ion by 12.15% a.d memor. r.sour.e utiliza.ion by 5.7% on *** show tha. the QPSM scheduling str.tegy pr.posed in this study ca. effectively gua.0}ntee the qua.ity of online ser.ices a.d fur.her.impr.ve cluster.r.sour.e utiliza.ion.

关键词： Co-loca.ed cluster wor.loa. scheduling online ser.ice ba.ch jobs da.a.center

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Cr.wdsour.ing r.K:a.new GNSS positioning fr.mewor. for.building spa.ia. high-r.solution a.mospher.c ma.s ba.ed on ma.sive vehicle GNSS da.a

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Sa.ellite Na.iga.ion 2024年第1期5卷 91-108页

作者： Hongjin Xu Xingyu Chen Jikun ou Yunbin Yua. Sta.e Key La.or.tor. of Geodesy a.d Ea.0}h’s dyna.ics Innovation Academy for Precision Measurement Science and Technology(APM)Chinese Academy of Sciences(CAS)Wuhan430071China College of Ea.0}h a.d Pla.eta.0} Sciences University of Chinese Academy of SciencesBeijingChina

High-qua.ity spa.ia. a.mospher.c dela. cor.ection infor.a.ion is essentia. for.a.hieving fa.t integer.a.biguity r.solution(a.0}in pr.cise ***,tr.ditiona. r.a.-time pr.cise positioning fr.mewor.s(i.e.,Nr.K a.d PPP-r.K)depend on spa.ia. low-r.solution a.mospher.c dela. cor.ection thr.ugh the expensive a.d spa.0}ely distr.buted COr. *** r.sults in limited public *** the ma.s pr.duction of a.tonomous dr.ving vehicles,mor. cost-effective a.d widespr.a. da.a.sour.es ca. be explor.d to cr.a.e spa.ia. high-r.solution a.mospher.c *** this study,we pr.pose a.new GNSS positioning fr.mewor. tha. r.lies on dua. ba.e sta.ions,ma.sive vehicle GNSS da.a.a.d cr.wdsour.ed a.mospher.c dela. cor.ection ma.s(Ca.).The ma. is ea.ily pr.duced a.d upda.ed by vehicles equipped with GNSS r.ceiver. in a.cr.wd-sour.ed ***,the ma. consists of between-sta.ion single-differ.nced ionospher.c a.d tr.pospher.c *** intr.duce the whole fr.mewor. of Ca. initia.iza.ion for.individua. vehicles,on-cloud Ca. ma.ntena.ce,a.d Ca.-a.gmented user.end *** ma. da.a.a.0} collected a.d pr.pr.cessed in ***,the cr.wdsour.ed da.a.a.0} uploa.ed to a.cloud *** ma.sive da.a.fr.m multiple vehicles a.0} mer.ed in the cloud to upda.e the Ca. in ***,the Ca. will a.gment the user.positioning *** fr.mewor. for.s a.beneficia. cycle wher. the Ca.’s spa.ia. r.solution a.d the user.positioning per.or.a.ce mutua.ly impr.ve ea.h *** va.ida.e the per.or.a.ce of the pr.posed fr.mewor. in r.a.-wor.d exper.ments a.d the a.plied potency a. differ.nt spa.ia. *** highlight tha. this fr.mewor. is a.r.lia.le a.d pr.ctica. positioning solution tha. meets the r.quir.ments of ubiquitous high-pr.cision positioning.

关键词： New GNSS positioning fr.mewor. Spa.ia. high-r.solution a.mospher.c dela. cor.ection Cr.wdsour.ed a.mospher.c dela. cor.ection ma.s Cr.wdsour.ed ionospher. Cr.wdsour.ed tr.pospher. Ubiquitous

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Numer.ca. a.a.ysis of geosynthetic-r.infor.ed emba.kment per.or.a.ce under.moving loa.s

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Jour.a. of r.ck Mecha.ics a.d Geotechnica. Engineer.ng 2024年第2期16卷 682-696页

作者： Xua.ming ding Jinqia. Zha. Qia.g ou Jia.fei Liu College of Civil Engineer.ng Chongqing UniversityChongqing400045China Key La.or.tor. of New Technology for.Constr.ction of Cities in Mounta.n a.0}a Chongqing UniversityChongqing400045China China.United Engineer.ng Cor.or.tion Limited Hangzhou310052China

The per.or.a.ce of geosynthetic-r.infor.ed emba.kments under.tr.ffic moving loa.s is a.wa.s a.hotspot in the geotechnica. engineer.ng field.a.thr.e-dimensiona.(3d)model of a.geosynthetic-r.infor.ed emba.kment without dr.ina.e consolida.ion wa. esta.lished using the finite element softwa.0} *** this model,the tr.ffic loa.s wer. simula.ed by two moving loa.s of r.cta.gula.0}pa.ter.,a.d their.a.plitude,r.nge,a.d moving speed wer. r.a.ized by a.For.r.n *** emba.kment fill wa. simula.ed by a. equiva.ent linea.0}viscoela.tic model,which ca. r.flect its *** geogr.d wa. simula.ed by the tr.ss element,a.d the geocell wa. simula.ed by the membr.ne *** elements wer. utilized to wea.en the bounda.0} effect ca.sed by the model geometr. a. the *** of the esta.lished numer.ca. model wa. conducted by compa.0}ng the pr.dicted defor.a.ions in the cr.ss-section of the geosynthetic-r.infor.ed emba.kment with those fr.m the existing *** this ba.is,the dyna.ic str.ss a.d str.in distr.bution in the pa.ement str.ctur. la.er.of the geosynthetic-r.infor.ed emba.kment under.a.moving loa. wa. a.so ***,a.pa.0}metr.c study wa. conducted to exa.ine the influences of the differ.nt types of r.infor.ement,over.oa.,a.d the moving loa. velocity on the geosynthetic-r.infor.ed emba.kment.

关键词： Geosynthetic-r.infor.ed la.er Numer.ca. model Moving loa. Emba.kment defor.a.ion Str.ss

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Ultr.thin two-dimensiona. medium-entr.py oxide a. a.highly efficient a.d sta.le electr.ca.a.yst for.oxygen evolution r.a.tion

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Na.o r.sea.0}h 2024年第4期17卷 2555-2562页

作者： Gua.gyua. Ya. Tia.lu Wa.g Biwei Zha. Wenjing Ga. Tong Wu Liming ou School of Mecha.ica. Electronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

medium-entr.py oxides(MEOs)with br.a. compositiona. tuna.ility a.d entr.py-dr.ven str.ctur.l sta.ility,a.1} r.ceiving booming a.tention a. a.pr.mising ca.dida.e for.oxygen evolution r.a.tion(OEr.***,ultr.thin two-dimensiona.(2d)na.ostr.ctur. offer. extr.mely la.1}e specific sur.a.e a.1}a.a.d is ther.for. consider.d to be a. idea. ca.a.yst ***,it r.ma.ns a.gr.nt cha.lenge to synthesize ultr.thin 2d MEOs due to distinct nuclea.ion a.d gr.wth kinetics of constituent multimeta.lic elements in 2d a.isotr.pic *** this wor.,a. ultr.thin 2d MEO(MnFeCoNi)O wa. successfully synthesized by a.fa.ile a.d low-temper.tur. ionic la.er.epita.y *** fr.m multi-meta. syner.istic effects within ultr.thin 2d na.ostr.ctur.,this 2d MEO(MnFeCoNi)O r.vea.ed excellent OEr.electr.ca.a.ytic per.or.a.ce with a.quite low over.otentia. of 117 mV a. 10 ma.cm^(-2) a.d a. impr.ssive sta.ility for.120 h continuous oper.tion with only 6.9%***,the extr.mely high ma.s a.tivity(5584.3 a.g^(-1))wa. thr.e or.er. of ma.nitude higher.tha. benchma.1} r.O_(2)(3.4 a.g^(-1))a. the sa.e over.otentia. of 117 *** wor. opens up a.new a.enue for.developing highly efficient a.d sta.le electr.ca.a.ysts by cr.a.ing 2d na.ostr.ctur.d MEOs.

关键词： medium-entr.py oxide two-dimensiona. na.oma.er.a.s ionic la.er.epita.y oxygen evolution r.a.tion electr.ca.a.ysis

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a.Video Ca.tioning Method by Sema.tic Topic-Guided Gener.tion

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Computer., Ma.er.a.s & Continua 2024年第1期78卷 1071-1093页

作者： ou Ye Xinli Wei Zhenhua.Yu Ya. Fu Ying Ya.g College of Computer.Science a.d Technology Xi’an University of Science and TechnologyXi’an710054China

In the video ca.tioning methods ba.ed on a. encoder.decoder.limited visua. fea.ur.s a.0} extr.cted by a. encoder.a.d a.na.ur.l sentence of the video content is gener.ted using a.***,this kind ofmethod is dependent on a.single video input sour.e a.d few visua. la.els,a.d ther. is a.pr.blem with sema.tic a.ignment between video contents a.d gener.ted na.ur.l sentences,which a.0} not suita.le for.a.cur.tely compr.hending a.d descr.bing the video *** a.dr.ss this issue,this pa.er.pr.poses a.video ca.tioning method by sema.tic topic-guided ***,a.3d convolutiona. neur.l networ. is utilized to extr.ct the spa.iotempor.l fea.ur.s of videos dur.ng the ***,the sema.tic topics of video da.a.a.0} extr.cted using the visua. la.els r.tr.eved fr.m simila.0}video *** the decoding,a.decoder.is constr.cted by combining a.novel Enha.ce-TopK sa.pling a.gor.thm with a.Gener.tive Pr.-tr.ined Tr.nsfor.er.2 deep neur.l networ.,which decr.a.es the influence of“devia.ion”in the sema.tic ma.ping pr.cess between videos a.d texts by jointly decoding a.ba.eline a.d sema.tic topics of video *** this pr.cess,the designed Enha.ce-TopK sa.pling a.gor.thm ca. a.levia.e a.long-ta.l pr.blem by dyna.ica.ly a.justing the pr.ba.ility distr.bution of the pr.dicted ***,the exper.ments a.0} conducted on two publicly used Micr.soft r.sea.0}h Video descr.ption a.dMicr.soft r.sea.0}h-Video to Text *** exper.menta. r.sults demonstr.te tha. the pr.posed method outper.or.s sever.l sta.e-of-a.0} ***,the per.or.a.ce indica.or. Bilingua. Eva.ua.ion Under.tudy,Metr.c for.Eva.ua.ion of Tr.nsla.ion with Explicit Or.er.ng,r.ca.l Or.ented Under.tudy for.Gisting Eva.ua.ion-longest common subsequence,a.d Consensus-ba.ed Ima.e descr.ption Eva.ua.ion of the pr.posed method a.0} impr.ved by 1.2%,0.1%,0.3%,a.d 2.4% on the Micr.soft r.sea.0}h Video descr.ption da.a.et,a.d 0.1%,1.0%,0.1%,a.d 2.8% on the Micr.soft r.sea.0}h-Video to Text da.a.et

关键词： Video ca.tioning encoder.decoder sema.tic topic jointly decoding Enha.ce-TopK sa.pling

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Hea. dissipa.ion of ca.0}on shell in Zr.-SiC/Ta. coa.ing to impr.ve pr.tective a.ility a.a.nst ultr.high temper.tur. a.la.ion

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Jour.a. of a.va.ced Cer.mics 2024年第7期13卷 1080-1091页

作者： Yuyu Zha.g Xuemeng Zha.g Hongka.g ou Bozhe Wa.g Jia.Sun Qia.ga.g Fu Science a.d Technology on Ther.ostr.ctur.l Composite Ma.er.a.s La.or.tor. Shaanxi Key Laboratory of Fiber Reinforced Light-Weight CompositesNorthwestern Polytechnical UniversityXi’an 710072China System design Institute of Hubei a.r.spa.e Technology a.a.emy Wuhan 430040China

To efficiently decr.a.e a.la.ion hea. a.cumula.ion a.d impr.ve the a.ility of Zr.-SiC/Ta. coa.ings to pr.tect ca.0}on/ca.0}on(C/C)composites,a.ther.a.ly conductive na.onetwor. with a.cer.mic@ca.0}on cor.-shell str.ctur. wa. designed a.d ***-der.ved SiC/Ta. with a.gr.phene ca.0}on shell wa. synthesized a.d intr.duced into a.Zr. coa.ing by super.onic a.mospher.c pla.ma.spr.ying(Sa.S).Gr.phene shell pa.hs incr.a.ed the hea. tr.nsfer.ca.a.ility by lower.ng the sur.a.e temper.tur. to a.pr.xima.ely 200℃dur.ng oxya.etylene *** hea. dissipa.ion of the gr.phene shell in the Zr.-SiC/Ta.@C coa.ing r.duced the vola.iliza.ion of low-melting-point pha.es a.d dela.ed the sinter.ng of Zr._(2) ***,the gr.phene shell in Zr.-SiC/Ta.@C coa.ing decr.a.ed the ma.s a.d linea.0}a.la.ion r.tes by 91.4%a.d 93.7%compa.0}d to Zr.-SiC/Ta. coa.ing,*** wor. pr.vided a.constr.ctive idea.for.impr.ving the a.la.ion r.sista.ce of the coa.ings by incor.or.ting ca.0}on na.oma.er.a.s a. a.function of hea. dissipa.ion.

关键词： ca.0}on/ca.0}on(C/C)composites ca.0}on na.oma.er.a.s cor.-shell str.ctur. polymer.der.ved cer.mic(PdC) a.la.ion r.sista.ce

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Tr.nsfor.er.a.ded deep double dueling Spa.ia.-Tempor.l Q-Networ. for.Spa.ia. Cr.wdsour.ing a.a.ysis

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Computer.Modeling in Engineer.ng & Sciences 2024年第4期139卷 893-909页

作者： Yu Li Mingxia. Li dongya.g ou Junjie Guo Fa.gyua. Pa. depa.0}ment of Computing Hangzhou Dianzi UniversityHangzhou310018China

With the r.pid development ofmobile Inter.et,spa.ia. cr.wdsour.ing ha. becomemor. a.dmor. *** cr.wdsour.ing consists of ma.y differ.nt types of a.plica.ions,such a. spa.ia. cr.wd-sensing *** ter.s of spa.ia. cr.wd-sensing,it collects a.d a.a.yzes tr.ffic sensing da.a.fr.m clients like vehicles a.d tr.ffic lights to constr.ct intelligent tr.ffic pr.diction *** collecting sensing da.a.spa.ia. cr.wdsour.ing a.so includes spa.ia. deliver. ser.ices like didi a.d *** ta.k a.signment a.d wor.er.selection domina.e the ser.ice qua.ity for.spa.ia. cr.wdsour.ing *** r.sea.0}h conducted ta.k a.signments via.tr.ditiona. ma.ching a.pr.a.hes or.using simple networ. ***,a.va.ced mining methods a.0} la.king to explor. the r.la.ionship between wor.er.,ta.k publisher.,a.d the spa.io-tempor.l a.tr.butes in ***,in this pa.er.we pr.pose a.deep double dueling Spa.ia.-tempor.l Q Networ.(d3SQN)to a.a.tively lea.0} the spa.ia.tempor.l r.la.ionship between ta.k,ta.k publisher.,a.d wor.er. in a.dyna.ic envir.nment to a.hieve optima. ***,d3SQNis r.vised thr.ugh r.infor.ement lea.0}ing by a.ding a.spa.ia.-tempor.l tr.nsfor.er.tha. ca. estima.e the expected sta.e va.ues a.d a.tion a.va.ta.es so a. to impr.ve the a.cur.cy of ta.k *** exper.ments a.0} conducted over.r.a. da.a.collected fr.mdidi a.d ELM,a.d the simula.ion r.sults ver.fy the effectiveness of our.pr.posed models.

关键词： Histor.ca. beha.ior.a.a.ysis spa.ia. cr.wdsour.ing deep double dueling Q-networ.s

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On implica.ions of soma.osta.in in dia.etic r.tinopa.hy

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Neur.l r.gener.tion r.sea.0}h 2024年第9期19卷 1984-1990页

作者： Ya.hong Fa.g Qionghua.Wa.g Youjia. Li Li Zeng Jia. Liu Kepeng ou depa.0}ment of Ophtha.mology Chongqing University Jiangjin HospitalChongqingChina College of Pha.0}a.y National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsIATTIChongqing University of Arts and SciencesChongqingChina Sha.dong Pr.vincia. Hospita. Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong ProvinceChina a.a.emic Unit of Ophtha.mology Bristol Medical SchoolUniversity of BristolBristolUK

Soma.osta.in,a.na.ur.lly pr.duced neur.pr.tective peptide,depr.sses excita.or. neur.tr.nsmission a.d exer.s a.ti-pr.lifer.tive a.d a.ti-infla.ma.or. effects on the *** this r.view,we summa.0}ze the pr.gr.ss of soma.osta.in tr.a.ment of dia.etic r.tinopa.hy thr.ugh a.a.ysis of r.leva.t studies published fr.m Febr.a.0} 2019 to Febr.a.0} 2023 extr.cted fr.m the Pubmed a.d Google Schola.0}*** neur.pr.tection,which occur. a. a.consequence of declined expr.ssion or.dysr.gula.ion of r.tina. soma.osta.in in the ver. ea.0}y sta.es of dia.etic r.tinopa.hy,tr.gger. r.tina. neur.va.cula.0}unit impa.r.ent a.d micr.va.cula.0}*** r.pla.ement is a.pr.mising tr.a.ment for.r.tina. neur.degener.tion in dia.etic *** pr.-clinica. a.d clinica. tr.a.s of soma.osta.in a.a.og tr.a.ment for.ea.0}y dia.etic r.tinopa.hy ha.e been *** one such tr.a.(EUr.CONdOr.,topica. a.ministr.tion of soma.osta.in wa. found to exer. neur.pr.tective effects in pa.ients with pr.-existing r.tina. neur.dysfunction,but ha. no impa.t on the onset of dia.etic ***,we concluded tha. soma.osta.in r.stor.tion ma. be especia.ly beneficia. for.the gr.wing popula.ion of pa.ients with ea.0}y-sta.e *** or.er.to a.hieve ea.0}y pr.vention of dia.etic r.tinopa.hy initia.ion,a.d ther.by sa.va.e visua. function befor. the a.pea.0}nce of moder.te non-pr.lifer.tive dia.etic r.tinopa.hy,sever.l issues need to be *** include the needs to:a.upda.e a.d sta.da.dize the r.tina. scr.ening scheme to incor.or.te the detection of ea.0}y neur.degener.tion,b)identify pa.ient subgr.ups who would benefit fr.m soma.osta.in a.a.og supplementa.ion,c)elucida.e the inter.ctions of soma.osta.in,pa.0}icula.0}y exogenously-deliver.d soma.osta.in a.a.ogs,with other.r.tina. peptides in the context of hyper.lycemia.a.d d)design sa.e,fea.ible,low cost,a.d effective a.ministr.tion r.utes.

关键词： dia.etes r.tinopa.hy excitotoxicity gr.wth hor.one insulin like gr.wth fa.tor ir.sin neur.degener.tion neur.infla.ma.ion neur.pr.tection neur.va.cula.0}unit octr.otide oxida.ive str.ss soma.osta.in

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