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MOLECULAR　MECHANICAL　AND　QUANTUM　CHEMICAL　CALCULATION　ON　ACyLATION　REACTIVITy　FOR　1－（NITRO　SUBSTITUTed　ANILINO）－4－SUBSTITUTed－2，6－PIPERAZINedIONES

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Chinese Chemical Letters 1995年第8期6卷 691-694页

作者： Jiang, HL Li, Q Chen, KX Tang, y Shen, X Ji, Ry Xie, yy Chinese Acad Sci Shanghai Inst Mat Med Shanghai 200031 Peoples R China

Molecular mechanical and quantum chemical methods were used to calculate the conformational and electronic structures of the template molecules of (nitro substituted an ill no)-4 - sub st nut ed -2, 6 -piperazinediones, With the calculation results we explained the acylation reactivity of title compounds satisfactorily.

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中长期使用他达拉非治疗勃起功能障碍患者的疗效及安全性研究

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中华男科学杂志 2009年第3期15卷 285-285页

作者： J Sex med 杨念钦王国民不详上海复旦大学附属中山医院泌尿外科 200032

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济南市学龄儿童头发中铜铅镉的正常值

山东医科大学学报 1987年第3期 56-60页

作者：韩国安张延岭姜会敏山东医科大学分析化学教研室山东医科大学卫生化学教研室山东医科大学生物医学工程教研室

为探讨微量元素与儿童某些疾病的关系,需确定本地区童发中微量元素正常值范围。检测了415名儿童发样,结果:据根对数正态分布,童发铜含量均值为13.52μg/g,发铅、发镉用百分位数法求正常值95%上限,Pb:男9.679μg/g,女14.878μg/g,Cd:男0.... 详细信息

为探讨微量元素与儿童某些疾病的关系,需确定本地区童发中微量元素正常值范围。检测了415名儿童发样,结果:据根对数正态分布,童发铜含量均值为13.52μg/g,发铅、发镉用百分位数法求正常值95%上限,Pb:男9.679μg/g,女14.878μg/g,Cd:男0.382μg/g,女0.18μg/g。Cu-Pb,Cu-Cd,Pb-Cd含量均高度正相关。

关键词：微量元素铜铅镉毛发儿童

gp210-C端肽链抗体滴度作为监测原发性胆汁性肝硬化的一个临床指标

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 52-53页

作者： Nakamura M. Shimizu- yoshida y. Takii y. 王铮 Department of Hepatology Natl. Hosp. Org. Nagasaki Med. Ctr. Nagasaki Univ. Grad. Sch. Biomed. S. Kubara 2- 1001- 1 Omura Nagasaki 856- 8562 Japan

Background/Aims: The presence of antibodies to the 210- kDa glycoprotein of the nuclear pore complex (gp210) is highly indicative of primary biliary cirrhos is (PBC). However, the significance of anti- gp210 antibody titers for monitori ng PBC remains unresolved. Methods: We used an ELISA with a gp210 C- terminal p eptide as an antigen to assess serum antibody titers in 71 patients with PBC. Re sults: Patients were classified into three groups: Group A in whom anti- gp210 titers were sustained at a high level, Group B in whom anti- gp210 status chang ed from positive to negative under ursodeoxycholic acid (UDCA) therapy, Group C in whom anti- gp210 antibodies were negative at the time of diagnosis. The rate of progression to end- stage hepatic failure was significantly higher in group A (60% ) as compared to groups B (0% ) and C (4.2% ). The sustained antibody response to gp210 was closely associated with the severity of interface hepatit is. The significance of anti- gp210 antibody was confirmed by National Hospital Organization Study Group for Liver Disease in Japan. Conclusions: The serial qu antitation of serum anti- gp210- C- terminal peptide antibodies is useful for monitoring the effect of UDCA and for the early identification of patients at h igh risk for end- stage hepatic failure.

关键词： gp210-C端抗体滴度熊去氧胆酸血清抗体肝衰竭核孔复合物 UDCA 肝病研究抗体反应

中位神经运动传导速度与髓磷脂蛋白零基因突变相一致

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 40-41页

作者： Lee y.-C. Soong B.-W. 赵睿

Background: Myelin protein zero gene (MPZ) mutations may account for a small p roportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutatio ns may be associated with different clinical and electrophysiological phenotypes .Objectives: To expand our understanding of the characteristics of nerve conduct ion velocity (NCV) in patients with different MPZ mutations, the authors collect ed and analysed the NCVvalues from patients with MPZ mutations. Materials and Me thods:The NCVs of fourteen patients from six families carrying MPZ mutations of Val58Asp, Ser63Phe, Thr65Ile,Arg98Cys,Arg98His, and Ser233fs were collected retr ospectively. Five of them had received nerve conduction studies (NCS) twice. The mutations were verified by polymerase chain reaction (PCR)-amplifications and nucleotide sequencing. Scatterplot analyses of media n motor NCV (MNCV) versus specific MPZ mutation were performed. Results: The med ian MNCV varied widely,with a mean of 16.3 m/s (SD=7.7 m/s) and a range of 5.1- 32.9 m/s. median MNCVs of patients with particular MPZ mutations were similar. M oreover, median MNCV did not change significantly over time. Conclusions: There was concordance between median MNCV and specific MPZ ***, median M NCV is not an ideal measure with which to distinguish CMT1B patients with MPZ mu tations from CMT1A patients with PMP22 mutations.

关键词：运动传导速度基因突变髓磷脂核苷酸序列肌肉萎缩电生理学散点图时间变化

无症状性患者成功进行冠状动脉血管成形术后连续6年定量血管造影术随访研究

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 39-40页

作者： Takeda y. Kobayashi T. Awata N. 张明娟 Department of Cardiology Osaka Med. Ctr. Cancer C. 1-3-3 Na kamichi Higashinariku Osaka City Osaka 537-8511 Japan Dr.

Objective: To evaluate long term(six years) lumen changes after balloon angiop lasty by using quantitative coronary angiography. Methods: Complete serial quant itative coronary angiography(before and after angioplasty and at six months, thr ee years, and six years) was performed in 100 patients with successful angioplas ty and without subsequent repeated revascularisation. In all, 198 dilated segmen ts were compared with 395 non dilated segments thatwere obtained from non targ et arteries of study patients. Results: From six months to three years after ang ioplasty, minimum lumen diameter (MLD) increased significantly by 0.13(0.28)(mea n(SD))mm in dilated segments and decreased significantly by 0.04 (0.27) mm in no n dilated segments. From three years to six years, MLD remained stable in dilat ed segments but decreased further (by 0.04 (0.28)mm) in non dilated segments. C onsequently, the MLD between six months and six years was larger in dilated segm ents than in non dilated segments (0.12 (0.32) v -0.08(0.34); p years correlated positively with the percentage diameter stenosis (DS) at six months in each group (dilated segments r=0.47, ped segments r=0.49, pysis showed tha t the only independent predictor of MLD over six years for each group was the DS at six months. Conclusions: Lesion regression occurs within the first three yea rs after angioplasty and reaches a plateau thereafter. Moreover, the stenosis se verity at six months predicts the magnitude of late regression after angioplasty .

关键词：管成形术血管造影术冠状动脉血无症状性随访研究管腔直径狭窄程度损伤性扩张段血管重建术

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急性心肌梗死的心律失常56例的临床分析

上海第一医学院学报 1965年第1期 1-5页

作者：叶湘裕戴瑞鸿曹凤岗陶寿淇上海第一医学院附属第一医院上海第一医学院附属中山医院

近年来国内心肌梗死病例有增多趋势急性心肌梗死伴发心律失常又颇常见,一般学者意见心律失常的发生可使预后恶化,死亡率增高,并认为有些心律失常与一定的梗死部位有关。国内有关急性心肌梗死伴发心律失常的文献报告沿不多见,我们收集上... 详细信息

近年来国内心肌梗死病例有增多趋势急性心肌梗死伴发心律失常又颇常见,一般学者意见心律失常的发生可使预后恶化,死亡率增高,并认为有些心律失常与一定的梗死部位有关。国内有关急性心肌梗死伴发心律失常的文献报告沿不多见,我们收集上海第一医学院附属第一医院与中山医院1951至1964年初的急性心肌梗死住院病例166例中伴发心律失常者56例,并将有关其发生率,心律失常类型和预后等加以分析讨论,以供参考。

关键词：心律失常发生率梗死部位心肌梗死完全性房室传导阻滞过早搏动心室率

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子宫内膜息肉的潜在恶变性

世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 21-22页

作者： Ben-Arie A. Goldchmit C. Laviv y. A. Ben-Arie 张剑萍 Dept. of Obstetrics an d Gynecology Kaplan Med. Ctr.(Affil. Hadassah M. Jerusalem) P.O. Box 1 76100 RehovotIsrael

Objectives: To determine the pre-malignant and malignant potential o f endomet rial polyps and to assess whether different clinical parameters are associated w ith malignancy in the polyps. Study design: Four hundred and thirty consecutive cases of hysteroscopic diagnosis of endometrial polyp were retriev ed. The medical records, preoperative vaginal sonography results and histopathol ogy findings were reviewed. Statistical analysis was performed. Results: Hystero scopy truly identi-fied endometrial polyps in 95.7%of the cases. In 11.4%case s, hyperplasia without atypia was found in the endometrial polyp. In 3.3 and 3.0 %of women pre-malignant or malignant conditions were found in the polyp. Older age, menopause status and polyps larger than 1.5 cm were associated with signif icant pre-malignant or malignant changes, although the positive predictive valu e for malignancy was low. All the malignant polyps were diagnosed only in postme nopausal women. The presence of postmenopausal or irregular vaginal bleeding, wa s not a predictor of malignancy in the polyp. Conclusions: Postmenopausal women with endometrial polyps are at increased risk of malignancy in the polyp. Those patients, whether symptomatic or not should be evaluated by hysteroscopic resect ion of the polyps. Asymptomatic premenopausal patients with polyps smaller than 1.5 cm can be observed.

关键词：宫内膜息肉癌前病变病理学结果子宫内膜息肉患者非典型增生前阴道息肉恶变宫腔镜检查息肉直径

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 59-60页

作者： Nomura I. Abe J. Noma S. D. y. M. Leung 王经纬 Natl. Jewish med. and R es. Center Department of Pediatrics 1400 Jackson Street Denver CO 80206 United StatesDr.

Kawasaki disease (KD) is an acute inflammatory disorder of children frequently associated with the development of coronary artery abnormalities. Although a gr eat deal is known about inflammatory and immune responses in acute KD, the mecha nisms linking the immune response to vascular changes are not known. To gain fur ther insight into this process, we performed a microarray gene expression analys is on RNA isolated from the peripheral blood mononuclear cells of four patients with KD during both their acute and convalescent phases. Fortyseven genes of 712 9 genes examined showed an increased expression in three or all four patients in the acute compared with the convalescent phase of KD. Fourteen of these genes w ere significantly (p ed, including several inflammatory resp onse genes (e. g. S-100 A9 protein) and also anti-inflammatory genes (e. g. TS G-6). Of greatest interest, the adrenomedullin (ADM) gene, known to be associat ed with coronary artery vasodilation, was up-regulated in the acute phase of KD (p = 0.024). Up-regulation of ADM in the acute phase of KD was confirmed in p eripheral blood mononuclear cells of 11 additional KD patients by reverse transc riptase-PCR (p ed blood monocytes but not lymphocytes were demo nstrated by real-time PCR to have increased ADM mRNA (p = 0.01). Plasma ADM pr otein level in 32 additional KD patients was also confirmed to be higher in acut e KD compared with convalescent KD (p y results, other molecules known to be associated with coronary dilation, including nitric oxide, prostacyclin, acetylcholine, bradykinin, substance P, an d serotonin, were not elevated in acute KD. Our current study suggests that ADMe xpressing monocytes that infiltrate the coronary vascular wall may be the cause of coronary dilation in the acute phase of KD.

关键词：川崎病肾上腺髓质激素基因表达冠状动脉扩张急性期前列腺环素冠状动脉血管炎症反应免疫反应缓激肽