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THE STRUCTURE OF ASTERBATANOSIDE J FROM ASTER BATANGENSIS

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Chinese Chemical Letters 1995年第3期6卷 221-224页

作者： Shao, Y Zhou, BN Lin, LZ Cordell, ga Acad Sinica Shanghai Inst Mat Med Shanghai 200031 Peoples R China Univ Illinois Coll Pharm Dept Med Chem & Pharmacognosy Program Collaborat Res Pharmaceut Sci Chicago IL USA

A new medicagenic acid saponin named asterbatanoside J was isolated from the roots of Aster batangensis. On the basis of chemical and spectral studies especially 2D NMR including COSY, HETCOR, HOHAHA, ROESY and HMBC techniques, its structure has been established as 3-O-beta -D-glucopyranosyl-(1 -->6)-beta -D-glucopyranosyl-2 beta ,3 beta -dihydroxy-olean-12-en-23 alpha ,28-dioic acid-28-O-alpha -L-arabinopyranosyl-(1 -->3)-alpha -L-rhamnopyranosyl-(1 -->2)-beta -D-fucopyranoside.

关键词： ct^

TWONEW　TRITERPENOID　SAPONINS，ASTERBATANOSIDE　H　AND　I，FROM　ASTER　BATANGENSIS

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Chinese Chemical Letters 1995年第2期6卷 105-108页

作者： Shao, Y Zhou, BN Lin, LZ Cordell, ga Acad Sinica Shanghai Inst Mat Med Shanghai 200031 Peoples R China Univ Illinois Coll Pharm Dept Med Chem & Pharmacognosy Programm Collaborat Res Pharmaceut Sci Chicago IL USA

Two new triterpenoid saponins named asterbatanoside H and I have been isolated from the roots of Aster batsngensis and their structures elucidated as 3-O-β-D-glucopyranosyl-(1→3) β-D-glucopyranosyl-bayogenin-28-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosy-(1→6) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-23-O-acetyl-bayogenin-28-O-β-D-glucopyranosyl-(1→6) β-D-glucopyranoside, respectively, by means of spectral and chemical data.

关键词： ASTERBATANOSIDE TRITERPENOID TWONEW FROM SAPONINS AND BATANGENSIS

Intelligent back analysis of geotechnical parameters for time-dependent rock mass surrounding mine openings using grey Verhulst model

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Journal of Central South University 2021年第10期28卷 3099-3116页

作者： Un Chol HAN Chung Song CHOE Kun ui HONG Hyon Il HAN School of Science and Engineering Kim Chaek University of TechnologyPyongyang 999093Democratic People's Republic of Korea Faculty of Mining Engineering Kim Chaek University of TechnologyPyongyang 999093Democratic People's Republic of Korea

In this paper,we present a new method of intelligent back analysis(IBA)using grey Verhulst model(GVM)to identify geotechnical parameters of rock mass surrounding tunnel,and validate it via a test for a main openings of−600 m level in Coal Mine“6.13”,Democratic People's Republic of *** displacement components used for back analysis are the crown settlement and sidewalls convergence monitored at the end of the openings excavation,and the final closures predicted by *** non-linear relation between displacements and back analysis parameters was obtained by artificial neural network(ANN)and Burger-creep viscoplastic(CVISC)model of ***,the optimal parameters were determined for rock mass surrounding tunnel by genetic algorithm(ga)with both groups of measured displacements at the end of the final excavation and closures predicted by *** maximum absolute error(MAE)and standard deviation(Std)between calculated displacements by numerical simulation with back analysis parameters and in situ ones were less than 6 and 2 mm,***,it was found that the proposed method could be successfully applied to determining design parameters and stability for tunnels and underground cavities,as well as mine openings and stopes.

关键词： intelligent back analysis(IBA) grey Verhulst model(GVM) closure prediction mine openings burgercreep viscoplastic(CVISC)model

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Biomedical and Environmental Sciences 1996年第4期9卷 380-385页

作者： G. UMA DEVI K. INDIRA G. R. V. BABU AND C. S. CHETTY (Dopartment of Zoology, S. V University, Tirupati-517 502 India Department of medicine, Univ. med Center, Jackson, MS 39216, USA, Department of Biology, Savannah State University, Savannah,ga 31404 Department of Zoology S. V. University Tirupati India.

Induced-acetaldehyde toxic effects on gluatathione [GSH] metabolism and sulfhydryl (SH) groups in liver and in brain of female albino rats with reference to age was *** total -SH groups were decreased whereas the specific activities of glutathione-S-transferase [GST] and glutathione peroxidase [GP0] were increased in acetaldehyde treated rats. However, the specific activity levels of glutathione reductase [GR] and Γ-glutamylcysteine synthetase [Γ-GCS] were decreased. In general, acetaldehyde indueed changes in the specific activities of the enzymes that increase with increasing age

关键词： SH Age-related Metabolic Effects of Acetaldehyde on Rats With Reference to Detoxification Enzymes and Sulfhydryl Groups

Effect of Acetaldehyde on Oxidoreductases in Tissues of Rats at Different Ages

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Biomedical and Environmental Sciences 1996年第4期9卷 430-436页

作者： G. UMA DEVI K. INDIRA G. R. V. BABU AND C. S. CHETTY (Department of Zoology, S. V University, Tirupati-517 502 India Department of medicine, Univ. med Center, Jackson, MS-39216,USA Department of Biology, Savannah State University,Savannah ga-31404, Department of Zoology S. V. University Tirupati India.

The toxicity of acetaldehyde and age related changes on oxidoreductases in the liver,brain, kidney, and musele of female albino rats (Wistar strain) were studied. The specific activities of lactate [LDH], isocitrate [ICDH (NAD/NADP)], succinate [SDH], malate [MDH], glutamate [GDH] and glucose-6-Phosphate [G-6-PDH] dehydrogenases were signifieantly inereased as a function of age. However, acetaldehyde treatment significantly inhibited oxidoreductases in the tissues of 21, 90 and 180 day old rats. Liver enzymes of young (21 days) rats exhibited greater sensitivity to acetaldehyde toxicity. Similar inhibition of oxidoreductases in brain and kidney of adult (180 days) rats treated with acetaldehyde was observed. LDH and GDH as compared to other enzymes studied showed higher susceptibility to acetaldehyde toxicity. The differential sensitivity of tissues and inhibition of oxidoreductases by acetaldehyde as a function of age could be attributed to hypoxic conditions, energy crisis, and mitochondrial structural changes. The results suggest that acetaldehyde affects oxidation of glucose via HMP shuni pathway, glycolytic pathway and Krebs cycle resulting in the impairment of carbohydrate metabolism

关键词： Effect of Acetaldehyde on Oxidoreductases in Tissues of Rats at Different Ages

阴离子功能化生物柴油离子液体抗氧化剂[X][C_6H_5COO]的制备

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燃料化学学报 2019年第1期47卷 66-73页

作者：隋猛李法社吴学华王霜李明冶金节能减排教育部工程研究中心云南昆明650093 昆明理工大学冶金与能源工程学院云南昆明650093 昆明理工大学理学院云南昆明650093 中国科学院广州能源研究所广东广州510000

设计合成了两种阴离子功能化离子液体抗氧化剂([MI][C_6H_5COO]、[Ch][C_6H_5COO]),采用核磁共振氢谱、傅里叶红外光谱对其结构进行了表征,并研究了两种离子液体抗氧化剂对小桐子生物柴油抗氧化性、铜片腐蚀性和油溶性能的影响。结果表... 详细信息

设计合成了两种阴离子功能化离子液体抗氧化剂([MI][C_6H_5COO]、[Ch][C_6H_5COO]),采用核磁共振氢谱、傅里叶红外光谱对其结构进行了表征,并研究了两种离子液体抗氧化剂对小桐子生物柴油抗氧化性、铜片腐蚀性和油溶性能的影响。结果表明,离子液体抗氧化剂可有效提高生物柴油氧化稳定性,在添加量为0.3‰时,[MI][C_6H_5COO]的小桐子生物柴油诱导期提高了238%,超过了中国国家标准(6 h),[Ch][C_6H_5COO]的小桐子生物柴油诱导期提高了141%,未达到中国国家标准。进一步研究了两种离子液体抗氧化剂的油溶性,油溶性能从大到小的顺序为[MI][C_6H_5COO]>[Ch][C_6H_5COO]>ga(合成离子液体抗氧化剂的原料)。实验表明,合成的两种离子液体抗氧化剂中含有亲油阳离子的[M I][C_6H_5COO]综合性能明显优于含有亲水阳离子的[Ch][C_6H_5COO]。

关键词：离子液体生物柴油抗氧化剂油溶性氧化稳定性

Single Nucleotide Polymorphism rs10919543 in FCGR2A/ FCGR3A Region Confers Susceptibility to Takayasu Arteritis in Chinese Population

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Chinese medical Journal 2016年第7期129卷 854-859页

作者： Fang Qin Hu Wang Lei Song Xi-Li Lu Li-Rui Yang Er-Peng Liang Wei Wang Yu-Bao Zou Jin Bian Hai-Ying Wu Xian-Liang Zhou Ru-Tai Hui H ui--Min Zhang Xiong-Jing Jiang Hypertension Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background： Takayasu arteritis （TA） is a rare inflammatory arteriopathy of unknown etiology. The aim of this study was to investigate the genetic susceptibility to TA in a Chinese population. Methods： Four single nucleotide polymorphisms （SNPs） those locate in the IL12B region （rs56167332）, the MLX region （rs665268）, the FCGR2A/FCGR3A locus （rsi0919543）, and the HLA-B/M1CA locus （rs12524487）, associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. A Chi-square test was used to test for genotype/allele frequencies variants. Results： Among the four SNPs, rs 10919543 was found to be significantly associated with TA in the studied population. The GG genotype of rs 10919543 at the FCGR2A/FCGR3A locus is a high risk factor （odds ratio [OR] = 6.532, 95% confidence interval [C1] = 2.402 - 17.763, P 〈 0.001 ） for TA. Among TA patients, the level of eosinophil granulocytes （Eos） in the peripheral blood was observed to be higher in the GG group of rs 10919543 （n = 23, Eos = 0. I 1 [0.08, 0.17] x 109/L） than the ga ＋ AA group （n = 100, Eos = 0.08 [0.05, 0.13] 10/L, P = 0.028）. No correlation between the genotypes of the other three SNPs and TA patients was observed. Conclusions： Our findings revealed unique genetic pattern in Chinese TA patients that may be partly responsible for the higher risk of TA in this population. FCGR2A/FCGR3A-related immune disorder might contribute to the etiology of TA.

关键词： FCGR2A, FCGR3A Single Nucleotide Polymorphisms Takayasu Arteritis

IL-6基因多态性与COPD发病风险关系的Meta分析

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中国循证医学杂志 2014年第9期14卷 1131-1134页

作者：魏江涛候明勇何斌邓磊廖玍成都大学附属医院麻醉科成都610081 四川大学华西口腔医院口腔疾病研究国家重点实验室成都610041

目的系统评价白细胞介素6(IL-6)基因-174G/C多态性与慢性阻塞性肺疾病(COPD)发病风险的相关性。方法计算机检索Pubmed、EMbase、CNKI、WanFang Data、CBM和VIP数据库有关IL-6基因-174G/C多态性与COPD发病风险的病例-对照研究,检索时限... 详细信息

目的系统评价白细胞介素6(IL-6)基因-174G/C多态性与慢性阻塞性肺疾病(COPD)发病风险的相关性。方法计算机检索Pubmed、EMbase、CNKI、WanFang Data、CBM和VIP数据库有关IL-6基因-174G/C多态性与COPD发病风险的病例-对照研究,检索时限均为从建库至2013年6月。由2位研究者按纳入与排除标准独立筛选文献、提取资料后,采用RevMan 5.2软件进行Meta分析。结果最终纳入5个研究,共计487例COPD患者和786例对照。Meta分析结果显示IL-6基因-174G/C多态性和COPD发病风险无相关性:GC+CC ***:OR=1.01,95%CI(0.76,1.34),P=0.95;CC ***+GG:OR=1.04,95%CI(0.70,1.54),P=0.85;CC ***:OR=1.05,95%CI(0.69,1.61),P=0.81;GC ***:OR=1.00,95%CI(0.74,1.35),P=0.99;C vs.G:OR=1.02,95%CI(0.83,1.24),P=0.88。结论 IL-6基因-174G/C多态性可能不是COPD发病风险的危险因素。

关键词：慢性阻塞性肺疾病 IL-6 多态性 Meta分析病例一对照研究

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蜂斗菜总内酯对动物高原缺氧保护作用的研究

药学实践杂志 2017年第2期35卷 116-120,125页

作者：王业晴谢曜宇张慧吴弘郭美丽第二军医大学药学院生药学教研室上海200433 海军医学研究所航空医学研究室上海200433 第二军医大学附属长海医院心内科上海200433

目的探讨蜂斗菜总内酯对动物高原缺氧的保护作用。方法通过建立小鼠急性密闭缺氧模型、小鼠急性减压缺氧模型以及大鼠减压缺氧模型,观察蜂斗菜总内酯对实验动物存活时间及死亡率的影响,并检测动物血糖、不同脏器中糖原、三磷酸腺苷(aden... 详细信息

目的探讨蜂斗菜总内酯对动物高原缺氧的保护作用。方法通过建立小鼠急性密闭缺氧模型、小鼠急性减压缺氧模型以及大鼠减压缺氧模型,观察蜂斗菜总内酯对实验动物存活时间及死亡率的影响,并检测动物血糖、不同脏器中糖原、三磷酸腺苷(adenosine triphosphate,ATP)、乳酸(lactic acid,LD)、乳酸脱氢酶(lactic dehydrogenase,LDH)的含量。结果蜂斗菜总内酯能够明显延长小鼠急性密闭缺氧的存活时间,提高存活时间增加率;能显著降低小鼠急性减压缺氧的死亡率;对于减压缺氧大鼠,能显著降低血糖含量,显著增加肝脏、骨骼肌、心肌中的糖原含量以及脑、肝脏、骨骼肌、心肌中的ATP含量,并能显著降低血浆、骨骼肌和心肌中的LD含量,降低心肌中的LDH含量。结论蜂斗菜总内酯对小鼠急性密闭缺氧、小鼠急性减压缺氧和大鼠减压缺氧均具有明显的保护作用,其抗高原缺氧作用与其降低血糖含量,提高脏器中糖原含量、ATP含量,降低脏器中LD及LDH含量有关。

关键词：蜂斗菜蜂斗菜总内酯高原抗缺氧减压缺氧