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Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial

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Chinese Medical Journal 2024年第3期137卷 312-319页

作者： Xingshan Zhao Yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao Liping ma Liping Qi Xiaoyan Yan Haibo Wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian Ding Qiang Guo Wanjun dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu Shubin Qiao Department of Cardiology Beijing Jishuitan HospitalCapital Medical UniversityThe Fourth Clinical Medical College of Peking UniversityBeijing 100035China Peking University Clinical Research Institute Peking University First HospitalBeijing 100191China Department of Cardiology The First Hospital of Lanzhou UniversityLanzhouGansu 730013China Department of Cardiology The First Affiliated Hospital of Liaoning Medical UniversityJinzhouLiaoning 110002China Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Huaihe Hospital of Henan UniversityKaifengHenan 450001China Department of Cardiology Bayannur HospitalBayannurInner Mongolia 015208China Department of Cardiology Puyang People’s HospitalPuyangHenan 457099China Department of Cardiology Xingtai Third HospitalXingtaiHebei 054099China Department of Cardiology Lintao County People’s HospitalDingxiGansu 730599China Department of Cardiology Dancheng County People’s HospitalZhoukouHenan 477150China Department of Cardiology The First People’s Hospital of LingbaoSanmenxiaHenan 472500China Department of Cardiology Shanyin County People’s HospitalShuozhouShanxi 036999China Department of Cardiology Uxin Banner People’s HospitalOrdosInner Mongolia 017399China Department of Cardiology Lingqiu County People’s HospitalDatongShanxi 034499China Department of Cardiology Huaibin County People’s HospitalXinyangHenan 464411China Department of Cardiology Tianzhu County People’s HospitalWuweiGansu 733200China Guangzhou Recomgen Biotech Co. LtdGuangzhouGuangdong 510530China

Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tpa)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)*** study was designed as a pivotal postmarketing trial to compare its efficacy and safety with rrecombinant human tissue-type plasminogen activator alteplase(rt-pa)in Chinese patients with ***:In this multicenter,randomized,open-label,non-inferiority trial,patients with acute STEMI were randomly assigned(1:1)to receive an intravenous bolus of 16 mg rhTNK-tpa or an intravenous bolus of 8 mg rt-pa followed by an infusion of 42 mg in 90 *** primary endpoint was recanalization defined by thrombolysis in myocardial infarction(TIMI)flow grade 2 or *** secondary endpoint was clinically justified *** endpoints included 30-day major adverse cardiovascular and cerebrovascular events(maCCEs)and safety ***:From July 2016 to September 2019,767 eligible patients were randomly assigned to receive rhTNK-tpa(n=384)or rt-pa(n=383).Among them,369 patients had coronary angiography data on TIMI flow,and 711 patients had data on clinically justified *** used a–15%difference as the non-inferiority efficacy *** comparison to rt-pa,both the proportion of patients with TIMI grade 2 or 3 flow(78.3%[148/189]vs.81.7%[147/180];differences:–3.4%;95%confidence interval[CI]:–11.5%,4.8%)and clinically justified recanalization(85.4%[305/357]vs.85.9%[304/354];difference:–0.5%;95%CI:–5.6%,4.7%)in the rhTNK-tpa group were *** occurrence of 30-day maCCEs(10.2%[39/384]vs.11.0%[42/383];hazard ratio:0.96;95%CI:0.61,1.50)did not differ significantly between *** safety outcomes significantly differed between ***:rhTNK-tpa was non-inferior to rt-pa in the effect of improving recanalization of the infarct-related artery,a validated surrogate of clinical outcomes,among Chinese patients with acute ***

关键词： Thrombolytic therapy rhTNK-tpa Randomized controlled trial ST elevation myocardial infarction

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电力变压器安装与保护调试要点分析

科技资讯 2024年第8期22卷 89-91页

作者：马丽昌吉职业技术学院新疆昌吉831100

主要分析了电力变压器安装技术要点,阐述了变压器本体安装方式,并逐一介绍了过流保护、差动保护、瓦斯保护三类保护装置的安装方法,还分析了盘圈、高压套管等变压器附近安装的具体方式。在安装好变压器后,介绍了调试前期准备工作,并对... 详细信息

主要分析了电力变压器安装技术要点,阐述了变压器本体安装方式,并逐一介绍了过流保护、差动保护、瓦斯保护三类保护装置的安装方法,还分析了盘圈、高压套管等变压器附近安装的具体方式。在安装好变压器后,介绍了调试前期准备工作,并对无负荷、半负荷、满负荷3种状态下变压器调试技术要点展开了探讨,旨在为电力系统安装调试变压器提供参考。

关键词：电力系统变压器安装技术保护调试

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大尺度跨境流域径流预测的迁移学习框架--敏感性分析及在数据稀缺流域的适用性

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Journal of Geographical Sciences 2024年第5期34卷 963-984页

作者：马凯申朝鹏许紫月何大明 Institute of International Rivers and Eco-security Yunnan UniversityKunming 650091China Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Yunnan UniversityKunming 650091China Civil and Environmental Engineering Pennsylvania State UniversityUniversity ParkPAUnited States

The imbalance in global streamflow gauge distribution and regional data scarcity,especially in large transboundary basins,challenge regional water resource *** utilizing these limited data to construct reliable models is of crucial practical *** study employs a transfer learning(TL)framework to simulate daily streamflow in the Dulong-lrrawaddy River Basin(DIRB),a less-studied transboundary basin shared by Myanmar,China,and *** results show that TL significantly improves streamflow predictions:the optimal TL model achieves an average Nash-Sutcliffe efficiency of 0.872,showing a marked improvement in the Hkamti *** data scarcity,TL achieves a mean NSE of 0.817,surpassing the 0.655 of the process-based model MIKE ***,our study reveals the importance of source model selection in TL,as different parts of the flow are affected by the diversity and similarity of data in the source *** learning models,particularly TL,exhibit complex sensitivities to meteorological inputs,more accurately capturing non-linear relationships among multiple variables than the process-based *** gradients(IG)analysis furtherillustrates TL's ability to capture spatial het-erogeneity in upstream and downstream sub-basins and its adeptness in characterizing different flow *** study underscores the potential of TL in enhancing the understanding of hydrological processes in large-scale catchments and highlights its value for water resource management in transboundary basins under data scarcity.

关键词： transfer learning streamflow prediction deep learning model sensitivity data scarcity international river

Efficacy of Pudilan Xiaoyan Oral Liquid in the treatment of pneumonia induced by drug-resistant Pseudomonas aeruginosa

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Infectious Diseases Research 2024年第3期5卷 22-29页

作者： Jing ma Yan-Yan Bao Xiao-Rui Wang Kuok Kuantai Leong-man Chon Xiao-Lan Cui Ju-Ying Zhong Yu-Jing Shi Institute of Chinese materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Conde S.Januário Hospital(CHCSJ) pharmacy departmentMacao 999078China Lin Fong Charities Traditional Chinese Medicine Treatment Centre Macao 999078China Experimental Research Center China Academy of Chinese Medical SciencesBeijing 100700China

Background:Pudilan Xiaoyan Oral Liquid(PDL)is a Chinese patent medicine with notable pharmacological properties,including anti-inflammatory and antibacterial ***-resistant Pseudomonas aeruginosa infection is a common and refractory bacterial infection in clinical *** to its high drug resistance,it brings great challenges to *** study aimed to assess the therapeutic efficacy of PDL in a murine model of pneumonia induced by drug-resistant Pseudomonas ***:Three different doses of PDL(11 mL/kg/d,5.5 mL/kg/d,2.75 mL/kg/d)were used to observe lung tissue pathology and inflammatory cytokine levels in pneumonia mouse models induced by multidrug-resistant Pseudomonas aeruginosa(MDR-pa).Additionally,the protective efficacy of PDL against mortality in infected mice was evaluated using a death model caused by *** sub-MIC concentration of levofloxacin was used to induce drug-resistant mice pneumonia model to evaluate the role of PDL in reversing drug *** data are expressed as mean±standard *** significance was determined by one-way analysis of variance followed by Tukey’s multiple-comparisons ***:Treatment effect of PDL on MDR-pa pneumonia:the medium and small doses of PDL can significantly reduce the lung index of multi-drug resistant bacteria infected pneumonia model mice(P<0.05),the lung index inhibition rates for these groups were 55.09%and 58.43%,and improve the degree of lung tissue lesions of mice;The expression of serum cytokines keratinocyte chemoattractant,tumor necrosis factor-αand monocyte chemoattractant protein-1 could be decreased in the three dosage groups of PDL(P<0.01).PDL treatment not only lowered the mortality but also extended the survival duration in mice infected with *** was found after sub-MIC concentration of levofloxacin induced resistance of Pseudomonas aeruginosa to pneumonia in *** with the model group,the lung index of mice in high

关键词： pudilan Pseudomonas aeruginosa drug resistance mice model

声学超材料和亥姆霍兹共振结构的自供能传感器

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机械科学与技术 2024年第1期43卷 110-116页

作者：马珂婧陈虎越张文明上海交通大学机械与动力工程学院上海200240 上海交通大学密西根联合学院上海200240

随着物联网的发展,自供能声学传感器得到了广泛关注。然而,压电传感器的灵敏度等关键指标难以进一步提升。声学超材料能以传统材料无法实现的方式操控声波,为新型声学传感器的设计提供了新思路。本文设计了一种声学超材料和亥姆霍兹谐... 详细信息

随着物联网的发展,自供能声学传感器得到了广泛关注。然而,压电传感器的灵敏度等关键指标难以进一步提升。声学超材料能以传统材料无法实现的方式操控声波,为新型声学传感器的设计提供了新思路。本文设计了一种声学超材料和亥姆霍兹谐振结构的自供能声学传感器,并验证了具有缺陷的声学超材料能够聚焦声能;此外,亥姆霍兹谐振器能将聚焦在声学超材料缺陷处的能量进一步放大,传输比超过40 mV/pa,能满足小型传感器的自供能需求。实验结果表明:与仅有局部缺陷的声学超材料传感器相比,基于亥姆霍兹谐振器的声学超材料传感器具有更高的灵敏度和信噪比。

关键词：声学超材料亥姆霍兹谐振器声学传感器

阿司匹林与氯吡格雷联合疏血通治疗对急性脑梗死患者血液流变学指标、神经功能及安全性的影响

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反射疗法与康复医学 2024年第9期5卷 156-159页

作者：马启荣兰陵县人民医院脑血管病科山东临沂276000

目的探讨阿司匹林与氯吡格雷联合疏血通治疗对急性脑梗死(ACI)患者的影响。方法选择2021年2月—2023年10月兰陵县人民医院收治的82例ACI患者为研究对象,按照随机数字表法将其分为对照组和观察组,各41例。对照组予以阿司匹林与氯吡格雷治... 详细信息

目的探讨阿司匹林与氯吡格雷联合疏血通治疗对急性脑梗死(ACI)患者的影响。方法选择2021年2月—2023年10月兰陵县人民医院收治的82例ACI患者为研究对象,按照随机数字表法将其分为对照组和观察组,各41例。对照组予以阿司匹林与氯吡格雷治疗,观察组在对照组基础上加用疏血通治疗。比较两组的血液流变学指标、神经功能、生活质量及不良反应。结果治疗14 d后,观察组全血低切黏度为(9.57±0.74)m pa·s、血浆黏度为(1.58±0.11)mpa·s、纤维蛋白原为(3.01±0.03)g/L、全血高切黏度为(4.93±0.77)mpa·s、美国国立卫生研究院卒中量表为(7.22±1.08)分,均低于对照组的(10.87±0.82)mpa·s、(1.71±0.14)mpa·s、(4.52±0.07)g/L、(6.15±0.81)mpa·s、(9.84±2.76)分,组间差异有统计学意义(P0.05)。结论将阿司匹林与氯吡格雷联合疏血通治疗ACI患者的效果明显,可减轻患者的神经损伤程度,改善机体内血液流变学指标,提高患者生活质量,且不会增加不良反应,安全性高。

关键词：急性脑梗死疏血通氯吡格雷阿司匹林神经功能血液流变学安全性

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血缘关系影响下闽台同名村空间布局特征研究

地理研究 2024年第7期43卷 1790-1808页

作者：赵亚琛张兵华黄婧婧马冬青山东大学土建与水利学院济南250100 福州大学建筑与城乡规划学院福州350108 山东大学城乡人居环境研究中心济南250100 古建筑保护福建省高校工程研究中心福州350108 合肥工业大学建筑与艺术学院合肥230002 徽州古村落数字化保护与传承创意安徽省重点实验室合肥230002

选取中国闽台缘博物馆《闽台同名村》中收录的138对村落为研究对象,应用地理信息系统空间分析、空间组构分析、比较研究以及文献资料佐证等技术与方法,梳理闽台同名村的形成背景,分析其空间布局特征;从整体聚落空间、房族组团空间、建... 详细信息

选取中国闽台缘博物馆《闽台同名村》中收录的138对村落为研究对象,应用地理信息系统空间分析、空间组构分析、比较研究以及文献资料佐证等技术与方法,梳理闽台同名村的形成背景,分析其空间布局特征;从整体聚落空间、房族组团空间、建筑空间三个层面验证分析在血缘关系影响下,两岸闽台同名村在聚居空间布局上的相关性。分析得出:(1)在选址择居上,闽台同名村在台湾省的分布上呈现与祖籍地相似的地缘特征。(2)在聚落空间格局上,以血缘关系为基础呈现同族聚居特征。(3)在组团空间布局上,体现一脉相承的乡土伦理秩序。(4)在建筑空间布局上,表现出继承祖籍地同房分序的特征。通过研究闽台同名村的迁徙分布以及不同尺度空间布局的相关性,体现了在历史变迁和社会发展的空间演变中台湾省人民对祖籍地深厚的认同和眷恋,对强化两岸同胞同根同源的原乡认同、文化认同具有重要意义。

关键词：闽台同名村血缘空间特征历史溯源分布格局

高速铁路长大隧道音爆现象及斜井辅助泄压缓解效果研究

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中国铁道科学 2024年第3期45卷 87-96页

作者：韩嘉强马伟斌程爱君王辰高龙杨旭张桐中国铁道科学研究院集团有限公司铁道建筑研究所北京100081

随着高速铁路隧道运营速度不断增大,隧道空气动力学问题日益凸显。为此,首先调研整理国内外典型高速铁路隧道音爆案例,并在国内某隧道开展一系列实车测试试验,分析200,250和300 km·h^(-1)3个典型速度条件下隧道内初始压缩波压力梯度与... 详细信息

随着高速铁路隧道运营速度不断增大,隧道空气动力学问题日益凸显。为此,首先调研整理国内外典型高速铁路隧道音爆案例,并在国内某隧道开展一系列实车测试试验,分析200,250和300 km·h^(-1)3个典型速度条件下隧道内初始压缩波压力梯度与洞口微气压波峰值变化规律,并对比不同斜井启闭条件下的辅助泄压缓解效果。结果表明:音爆现象主要发生在长度大于5.0 km隧道;当列车速度低于300 km·h^(-1)时,测试隧道内初始压缩波压力梯度峰值与隧道洞口微气压波峰值相对较小,此时压缩波未发生激化,测试隧道洞口未监测到音爆;当列车速度达到300 km·h^(-1)及以上时,压缩波发生激化,初始压缩波压力梯度峰值与洞口微气压波峰值分别超过90 kpa·s^(-1),150 pa,此时在测试隧道洞口监测到明显音爆现象;相同速度条件下,不同动车组通过测试隧道时隧道内初始压缩波压力梯度峰值与洞口微气压波峰值存在一定差异,CRH380系列动车组测试数据低于CR400系列动车组;开启斜井能够缓解压力梯度及微气压波峰值,但开启压力梯度峰值达到最大值位置之前的斜井缓解效果更好,而同时开启隧道进口、出口处2个斜井对于压力梯度峰值缓解率最大可达到27.5%。

关键词：高速铁路隧道音爆实车测试压力梯度微气压波缓解效果

PEI/SA/Cu三元体系改性荷正电纳滤膜及其脱盐性能

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膜科学与技术 2024年第4期44卷 8-16页

作者：马晓华梁晓康许振良华东理工大学化工学院化学工程研究所膜科学与工程研发中心上海200237

通过将海藻酸钠(SA)与聚乙烯亚胺(PEI)共混作为二次界面聚合反应的水相溶液,SA与PEI强相互作用使SA嵌入到聚酰胺层中,从而提高膜的致密性.随后通过Cu^(2+)与SA结合提高膜表面荷正电性,提高膜对多价阳离子的截留性能.对比研究了SA和Cu^(... 详细信息

通过将海藻酸钠(SA)与聚乙烯亚胺(PEI)共混作为二次界面聚合反应的水相溶液,SA与PEI强相互作用使SA嵌入到聚酰胺层中,从而提高膜的致密性.随后通过Cu^(2+)与SA结合提高膜表面荷正电性,提高膜对多价阳离子的截留性能.对比研究了SA和Cu^(2+)浓度对复合膜物化性质、表面形貌及分离性能的影响.结果表明,荷正电纳滤膜的最佳制备条件为:SA质量分数为0.01%,Cu^(2+)浓度为25 mmol/L,所对应的PS/Cu-3复合膜亲水性提高.与Control-PEI膜相比,其通量提高了257%,为(40.0±0.8)L/(m^(2)·h),对MgCl2的截留率从92.0%提升至97.1%,且具有良好的耐压性和稳定性.

关键词： PEI/SA/Cu三元体系改性荷正电纳滤膜脱盐性能

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