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重症肺心病的联合扩血管治疗

皖南医学院学报 1999年第1期18卷 21-22页

作者：周红勤胡婵汪顺清宋菊桂陈九平湖南省邵阳市第一人民医院心肺血管内科 422001

　１１０例伴有呼衰和心衰的慢性肺心病（ＣＰＨＤ）者随机分为观察组（６０例）和对照组（５０例），对照组采用常规治疗，观察组在常规治疗的基础上加用苄胺唑啉（ＰＨＬ）、多巴胺（ＤＡ）及卡托普利（ＣＰ） ... 详细信息

　１１０例伴有呼衰和心衰的慢性肺心病（ＣＰＨＤ）者随机分为观察组（６０例）和对照组（５０例），对照组采用常规治疗，观察组在常规治疗的基础上加用苄胺唑啉（ＰＨＬ）、多巴胺（ＤＡ）及卡托普利（ＣＰ）。通过对两组病人的临床和动脉血气的监测发现：扩血管治疗既可显著提高常规治疗的疗效（Ｐ＜００５），还可通过促进心肺功能的改善，显著升高ＰａＯ２，降低ＰａＣＯ２（Ｐ均＜００５）；未见明显不良反应。

关键词：肺心病呼吸衰竭心力衰竭扩血管治疗 CPHD

超声诊断慢性乙型肝炎与肝活检的病理诊断的对比研究

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实用医技杂志 2008年第32期15卷 4557-4559页

作者：刘建琴耿爱文张剑秋韩立彬泰州市人民医院江苏泰州225300

目的:探讨慢性乙型肝炎(CHB)的超声诊断与病情评估的准确性,为CHB的正确治疗提供依据。方法:对超声引导下80例慢性乙型肝炎患者肝活检的病理结果与超声诊断进行对比分析。结果:80例肝活检结果,超声引导下16G切割针取材成功100%,超声诊... 详细信息

目的:探讨慢性乙型肝炎(CHB)的超声诊断与病情评估的准确性,为CHB的正确治疗提供依据。方法:对超声引导下80例慢性乙型肝炎患者肝活检的病理结果与超声诊断进行对比分析。结果:80例肝活检结果,超声引导下16G切割针取材成功100%,超声诊断轻度慢性乙型肝炎、早期肝硬化、肝硬化与病理诊断无差异性(P>0.05),而中度慢性乙型肝炎B超诊断结果与病理诊断有差异性(χ2=5.481,P<0.05)。结论:超声在诊断轻度慢性乙型肝炎、早期肝硬化、肝硬化中有很好的诊断价值,而对中度慢性乙型肝炎诊断符合率较低。

关键词：超声引导肝炎乙型肝活检

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骨盆骨折伴后尿道断裂的早期处理

实用全科医学 2006年第2期4卷 169-170页

作者：冷国雄吴涛章久武王宝鑫安徽省黄山市第一人民医院泌尿外科 245000

目的探讨骨盆骨折伴后尿道断裂伤早期安全、有效的治疗方法。方法回顾性总结28例骨盆骨折伴后尿道断裂患者采用简化的尿道会师加牵引术,术后适时辅以尿道扩张的临床治疗效果。结果本组随访24例中21例能正常排尿,治愈率为87.5%;阳萎(ed)... 详细信息

目的探讨骨盆骨折伴后尿道断裂伤早期安全、有效的治疗方法。方法回顾性总结28例骨盆骨折伴后尿道断裂患者采用简化的尿道会师加牵引术,术后适时辅以尿道扩张的临床治疗效果。结果本组随访24例中21例能正常排尿,治愈率为87.5%;阳萎(ed)3例。结论在骨盆骨折合并后尿道损伤中,应用尿道会师加牵引术,拔管后及时尿道扩张的方法简单、安全,能有效地恢复尿道功能的排尿连续性,是早期处理后尿道断裂伤的首选方法。

关键词：尿道损伤骨盆骨折尿道会师术

应用聚乙二醇沉淀比浊法检测水貂血清中循环免疫复合物的研究

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特产研究 1994年第2期16卷 1-4页

作者：籍玉林曲维江赵元楷肖家美郑君鲁月英中国农业科学院特产研究所

该项研究确立了聚乙二醇（ＰＥＧ）沉淀比浊法，是检测水貂血清中循环免疫复合物（ＣＩＣ）的理想方法。该方法的最适条件是：ＰＥＧ浓度为５％；缓冲液浓度为０．１Ｍ，ｐＨ８．４；作用温度为４℃，作用时间为１ｈ；室温２０℃放置时... 详细信息

该项研究确立了聚乙二醇（ＰＥＧ）沉淀比浊法，是检测水貂血清中循环免疫复合物（ＣＩＣ）的理想方法。该方法的最适条件是：ＰＥＧ浓度为５％；缓冲液浓度为０．１Ｍ，ｐＨ８．４；作用温度为４℃，作用时间为１ｈ；室温２０℃放置时间为３０分钟。用该方法检测临床上健康、经阿留申病（ＡＤ）对流免疫电泳（ＣＩＥＰ）确认为阴性的水貂血清２００份、阿留申病阳性水貂血清６００份，其结果（ＯＤ值，Ｘ±ＳＤ）为：健康水貂０．０３４±０．０２３，阿留申病水貂０．２４１±０．１５２。经统计学处理，健康水貂与阿留申病貂的血清ＯＤ值之间，差异极显著（Ｐ＜０．０１），说明水貂ＡＤ的发病与ＣＩＣ密切相关。ＰＥＧ沉淀比浊法具有快速、简便、不需要特殊设备和重复性好等特点。

关键词：免疫复合物水貂阿留申病血清

循环酪氨酸酶和MART-1mRNA不能独立预测AJCCI-II期黑色素瘤患者的复发或存活

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 15-15页

作者： schmidt H. sorensen B.s. sjoegren P. 朱国兴 Department of Oncology Aarhus University Hospital Norrebrogade 44 8000 Aarhus C Denmark Dr.

The detection of melanoma cells in peripheral blood has been proposed to select patients with a high risk of relapse. In this study, tyrosinase and melanoma antigen recognized by T cells 1 (MART-1) mRNA expression was evaluated in serial samples obtained before definitive surgery and during follow-up in patients with American Joint Committee on Cancer stage I-II melanoma. serial samples (n = 2,262) were collected from 236 patients from 1997 to 2002. Analyses of the RNA samples were performed with a calibrated reverse transcriptase-PCR assay. Gender, age, primary tumor site, ulceration, thickness, Clark level, and histological subtype were analyzed together with tyrosinase and MART-1 mRNA treated as updated covariates in a Cox proportional-hazard model. After a median follow-up time of 66 months, 42 out of 236 patients (18%) had relapsed. The following variables were significantly associated with relapse free survival in the univariate analyses: tyrosinase, MART-1, gender, ulceration, thickness, Clark level, and histological subtype. Entering these covariates into a multivariate Cox analysis resulted in thickness as the single independent prognostic factor (P s MART-1 (P = 0.07) approached significance at the 5%significance level. The serial measurements of tyrosinase and MART-1 mRNA in peripheral blood of stage I-II melanoma patients cannot be demonstrated to have independent prognostic impact on relapse free survival.

关键词：黑色素瘤细胞 MART-1 酪氨酸酶 mRNA 预测因素无复发患者 AJCC 存活 Ⅱ期

足月臀先露妊娠行剖宫产术及阴道分娩后2年婴儿结局分析:足月臀先露国际随机试验

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 16-16页

作者： Whyte H. Hannah M.E. saigal s. 朱晓明

The purpose of this study was to determine whether planned cesarean delivery for the singleton fetus in breech presen-tation at term reduces the risk of dea th or neurodevelop-mental delay at 2years of *** sele cted centers in the Term Breech Trial,children were screened for abnormali-ties at≥2years of age with the Ages and stages Ques-tionnaire,followed by a neurodevelopmental assessment if the Ages and stages Questionnaire sc ore was abnormal.A total of 923of 1159children(79.6%)from 85centers were followed to 2years of *** risk of death or neu-rodevelopmental delay was no different for the planned ce-sarean than for the planned vaginal birth groups(14chil-dren3.1%vs 13children2.8%;relative risk,1.09;95%CI,0.52-2.30;P =.85;risk diffe rence,+0.3%;95%CI,-1.9%,+2.4%).Planned cesarean delivery is not associated with a red uction in risk of death or neurodevelopmental delay in childr en at 2years of age.

关键词：臀先露剖宫产术阴道分娩随机试验单胎妊娠神经发育筛检试验中心无显著性差异险度

比较患者自己与医生指导下采集的样本中特异性人乳头瘤病毒

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世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 26-26页

作者： Baldwin s. santos C. Mendez BrownE. F. Garcia 侯巍 University of Arizona Health Sciences Center 1501 N Campbell Avenue Tucson AZ 85724-5078 United States

Objective(s). To compare the type-specific human papillomavirus (HPV) recover y from physician and patient-collected samples. Methods. Three hundred thirty- four (334) women attending colposcopy clinics in three countries were enrolled i n this cross-sectional study. Cervicovaginal samples were collected by patients and physicians and processed with polymerase chain reaction and reverse line bl ot genotyping. McNemar’s Chi-squared tests and Kappa statistics were utilized to determine statistical associations between physician-versus patient-collect ed samples. Results. Oncogenic HPV infection was identified in 23.2%of patient -collected specimens compared to 34.9%of physician-collected specimens. Physi cian sampling detected significantly more infections with type 16 and 52 than di d self-sampling and significantly more oncogenic HPV infection overall. For non -oncogenic HPV detection, there was no statistical difference between physician -and patientcollected samples. Conclusion(s). Patient sampling for HPV using a single vaginal brush does not identify all oncogenic HPV subtypes.

关键词：人乳头瘤病毒特异性基因型检测采集样致癌性横断面调查无显著性差异

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小儿Meckel憩室的腹腔镜治疗

世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 46-46页

作者： shalaby R.Y. soliman s.M. FawyM. samaha A. 宁亮 Dar Al-shifa Hospital PO Box 3390 Safat 13034 Kuwait

Background: Rectal bleeding, recurrent abdominal pain, nausea, and vomiting i n children could present a diagnostic as well as therapeutic challenge. Meckel s diverticulum (MD) is one of the causes. The objective of the current study wa s to evaluate the feasibility and outcome of laparoscopic management of MD. Meth ods: The clinical data of 33 children admitted with rectal bleeding and/or recur rent abdominal pain with no identifiable cause were reviewed over a period of 8 years. There were 23 boys and 10 girls with a mean age of 5.12 ± 2 years (rang e, 3- 12 years). In 21 cases, MD was an incidental finding on laparoscopic appe ndectomy and symptomatic in 12 cases. Patients with rectal bleeding were subject ed to upper gastrointestinal endoscopy; colonoscopy, and technetium Tc 99m- lab eled pertechnetate scan (Ms). All patients were subjected to routine laboratory investigations and diagnostic laparoscopy. Results: Of the 1200 appendectomies, incidental MD was found in 21 (1.9% ) patients and symptomatic in 12 cases. Upp er gastrointestinal endoscopy and colonoscopy did not show a bleeding source in 7 patients presented with bleeding per rectum. Four cases showed a positive Ms u ptake. Of these, 3 were found on laparoscopy to have an MD. Three cases showed a negative scan. Of these, 2 had an MD. In 5 cases with recurrent abdominal pain , nausea, vomiting, and abdominal distention, diagnostic laparoscopy revealed Meckel’s diverticulitis in 3 cases and intussusception secondary to MD in 1 ca se. Laparoscopic Meckel’s diverticulectomy and laparoscopic- assisted Meckel ’s diverticulectomy was done for 18 and 12 cases, respectively. Ectopic gastri c mucosa was present in 13 cases (44% ). Conclusions: Laparoscopy is safe, cost - effective, and efficient for the diagnosis and definitive treatment of MD. Co mpared with conventional laparotomy, it has the advantage of precise operative d iagnosis, less traumatic access, fewer intraoperative and postoperative complica tion

关键词：腔镜治疗 Meckel憩室复发性腹痛直肠出血异位胃黏膜阑尾切除术结肠镜检查术后并发症内窥镜检查常规化验检查

关于何时对腰穿后头痛进行硬膜外血贴疗法的一项基于79例患者队列的理论研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 8-8页

作者： Vilming s.T. Kloster R. sandvik L. 高宗恩 Department of Neurology Ullevaal Hospital University of Oslo 0407 Oslo Norway

The aim of the present study was to decide on which day in the course of post lumbar puncture headache (PPH) an epidural blood patch (EBP) should be performed to minimize suffering. A cohort of 79 patients (64 female, 15 male) was followe d prospectively for 14 days and the consequences of performing an EBP on differe nt days were studied. If no EBP was performed, the patients would accumulate 141 days with PPH5 (bedridden most of the day), 216 days with PPH4- 5 (bedridden m ore than half the day), and 293 days with PPH3- 5 (bedridden half the day or mo re). If these patients were patched on day 2, 3 or 4 after an initial observatio n of the PPH grade on day 1, the expected suffering was substantially reduced, a nd the more the earlier in the course the EBP was performed. If the strategy was to treat only patients with PPH5 with an expected 90% success rate, the reduc tion compared with no treatment was 50% if treated on day 2, 37% if treated on day 3, and 29% if treated on day 4. The corresponding figures for treating patients with PPH4- 5 was a 51, 44 and 29% reduction, and for PPH3- 5 the re duction was 62, 49 and 35% , respectively. Irrespective of strategy, the expect ed reduction of suffering in the cohort was greatest when the EBP was performed early in the course of PPH. It is suggested that the decision to perform an EBP should be made at an early stage and offered to patients who have to lie in bed for more than half a day despite conservative treatment.

关键词：腰穿后头痛理论研究程中