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Fi.e Years Follow-Up of Adjustable Conti.ence Therapy (ACT) i. the Treatment of Recurrent Female SUi

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Open Journal of Urology 2013年第2期3卷 132-137页

作者： Ni.ll T. Galloway Sheri. R. Abosei. Pejvak Sassani.Ethan i. Franke Steven d. Nash Joel N. Slutsky Mai.Le Tu Peter J. Pommervi.le Nei. H. Baum Suzette E. Sutherland Can-med Cli.i.al Research i.c. Victoria BC Canada CHUS Flai.mont Quebec City Canada Emory Uni.ersi.y School of medi.i.e Atlanta USA Kai.er Permanente medi.al Center Los Angeles USA Kansas Ci.y Urology Care Leawood USA Metro Urology Centers for Continence Care and Female Urology Minneapolis/St Paul USA Nei. Baum Urology New Orleans USA Urologi.al Surgeons Kankakee USA

Purpose/Objecti.e: The pri.ary objecti.e of thi. FdA study i. to evaluate the safety and effi.acy of the ACT devi.e (Adjustable Conti.ence Therapy) i. the treatment of female recurrent Stress Uri.ary i.conti.ence (SUi.. The secondary objecti.e i. to evaluate the di.fi.ulty of placement and aspects of devi.e adjustabi.i.y. Materi.ls and Methods: The Adjustable Conti.ence Therapy (ACT) system (Uromedi.a, i.c., Plymouth, MN) consi.ts of two si.i.one balloons provi.i.g urethral coapti.n and bladder neck support. Each balloon i. attached to a ti.ani.m port buri.d i. the labi. allowi.g for post-operati.e adjustment of volume. Females wi.h recurrent SUi.wi.h or wi.hout urethral hypermobi.i.y were evaluated at baseli.e and follow-up peri.ds of 6 weeks, 3, 6, 9, 12 months and annually thereafter i.cludi.g uri.alysi., a 3-day voi.i.g di.ry, provocati.e pad wei.ht test, di.ect vi.ual stress test, Stamey score and vali.ated questi.nnai.es to assess severi.y of i.conti.ence, voi.i.g dysfuncti.n, sexual functi.n and quali.y of li.e. Results: duri.g a 5 years peri.d (2002-2007), 162 pati.nts were i.planted (mean age 67.6, range 31 - 94 years). Of these 162 pati.nts 142, 90, 80, 56 and 31 pati.nts completed the 1, 2, 3, 4 and 5 years follow-up respecti.ely. One hundred and thi.ty fi.e (83%) had fai.ed at least one surgery for i.conti.ence and 44% had fai.ed 2 or more procedures pri.r to ACT i.plantati.n. di.fi.ulty of ACT placement was rated mi.d i. 62%, moderate i. 30% and severe i. 9%. i.provement i. Stamey score of >1 grade was achi.ved i. 75% (107/142) at 1 year, 76% (68/90) at 2 years, 86% (62/78) at 3 years, 93% (50/54) at 4 years and 83% (25/30) at 5 years. dry rate (provocati.e pad wei.ht 2 gms) was 51%, 62% , 76%, 76% and 76% at 1 through 5 years, and >50% i.provement was achi.ved i. 83%, 86%, 86%, 90% and 93%,respecti.ely. i.oL i.proved from 37 at baseli.e to 71, 71, 75, 77 and 74 duri.g the study, and opti.al conti.ence was achi.ved wi.h a mean of 4 adjustments, and mean

关键词： Female Uri.ary i.conti.ence i.plant Balloon Adjustments Safety Stamey Score

i.olati.n & i.enti.i.ati.n of i.nperi.li.e from Fri.i.lari. tai.ai.nsi. var. ni.gxi.ens: A Preli.i.ary Report

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宁夏医科大学学报 1988年第4期 112-112页

作者： Hu Chenghao (dept. of Chem., Ni.gxi. med. Coll.)Hua Sumi.g, Chen Yaozu (Faculty of Chem., Lanzhou Uni..)

Fri.i.lari. tai.alensi. P. Y. Li.vat. ni.gxi.ens(宁夏贝母), a member of fami.y Li.i.ceae, a new speci.s recently di.covered, i. di.tri.uted over the MontLi.pan di.tri.t & MontLuo di.tri.t of Ni.gxi.. i.s subterranean bulb has been used as a medi.i.al herb i. folk practi.e beari.g functi.ns of anti.yreti.s, respi.ati.n promoti.n, anti.ussi.e agents,and expectorants, and recently used as a substi.ute for Chuanbei.u(川贝母, F. ci.rhosa d. don) i. composi.e prescri.ti.ns of

关键词： Plants, medi.i.nal/i.ol Ni.gxi.s Pharm acognosy Alkaloi.s/anal Spectrophotometry, i.frared Nuclear magneti. resonance/di.g use Spectrum analysi., mass

杜塞酰胺/噻吗心胺联合用药与拉坦前列腺素对原发性开角型青光眼患者眼压和波动性眼部血流影响的比较研究

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 15-16页

作者： Janulevi.i.n■i. Harri. A. Kagemann L. 程燕 Eye Cli.n. of Kaunas Uni.. of med. Eiveniu 2 Kaunas 3000 Lithuania Dr.

Purpose: To evaluate the effects of dorzolami.e/ti.olol fi.ed combi.ati.n (d/T ) compared to latanoprost on i.traocular pressure (i.P) and pulsati.e ocular blo od flow (POBF) i. pri.ary open-angle glaucoma (POAG) pati.nts. Methods: Thi.ty pati.nts wi.h POAG were randomi.ed i. an open-label, crossover study. i.traocul ar pressure reducti.n was achi.ved by 4 weeks medi.al therapy wi.h d/T twi.e dai.ly or latanoprost 0.005%dosed once i. the eveni.g. duri.g a 4-week run-i. and a 4-week wash-out peri.d between study arms, pati.nts ceased use of all other glaucoma medi.ati.ns and used ti.olol maleate 0.5%twi.e dai.y. Pri.ary effi.ac y vari.bles were i.P and POBF. Results: There was no di.ference i. baseli.e i.P and POBF parameters between the two study arms. Both d/T and latanoprost stati.t i.ally si.ni.i.antly reduced i.P by 4.6 mmHg(P d 3.75 mmHg (P d i.creased POBF by 2.048 μl/second (P=0.003 0) and 2.147 μl/second ( P=0.000 9), respecti.ely. Repeated measures ANOVA detected si.ni.i.ant changes i.n POBF wi.h treatment (P=0.036 1). dorzolami.e/ti.olol fi.ed combi.ati.n stati.t i.ally si.ni.i.antly i.creased pulse volume by 0.767μl (P=0.008 7), whi.e latan oprost therapy had no si.ni.i.ant effect (P=0.240 7). Conclusi.ns: Both drugs ha d si.i.ar effects i. terms of i.P reducti.n. dorzolami.e/ti.olol si.ni.i.antly i.ncreased pulse volume whi.e latanoprost had no effect. Further studi.s are neces sary to establi.h whether the enhancement of choroi.al blood flow can prevent gl aucoma progressi.n.

关键词：拉坦前列腺素联合用药波动性抗青光眼药物疗效评价指标药物治疗横断面研究方差分析重复测量

Cli.i.al Si.ni.i.ance of Fetal Cerebral and Umbi.i.al Arte-ri.l Blood Flow Veloci.y Wave Forms Exami.ati.n.

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Chi.ese medi.al Journal 1995年第7期 56-56页

作者： Yang Yuyi.g et al. The Affi.i.ted Hospi.al, Shandong med Uni. Ji.an 250012,

Color doppler was used to exami.e the blood flow veloci.y wave forms of fetal mi.dle cerebral artery (MCA) and umbi.i.al artery (UA) i. normal pregnancy (58 cases) pregnancy i.duced hypertensi.n (Pi.) wi.h fetal growth retardati.n (i.GR) (54 cases) and wi.hout i.GR (34 cases). The peak-systoli. / di.stole rati. (S/d), pulse i.dex (Pi. and resi.tance i.dex (Ri. values of MCA and UA were calcu-

关键词： MCA Flow i.GR Cli.i.al Si.ni.i.ance of Fetal Cerebral and Umbi.i.al Arte-ri.l Blood Flow Veloci.y Wave Forms Exami.ati.n Wave

单纯气道损伤或格拉斯哥昏迷评分<8分的小儿创伤患者:患者到达医院后,外科主治医师能否及时到达是否会造成不同结果

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世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 41-42页

作者： Lui.F. Gormley P. Sorrells Jr. d. L. F. i. Luks 宁亮 di.i.i.n of Pedi.tri. Surgery Brown Med. Sch. Hasbro Children’s H. Providence RI 02905 United States

Opti.al trauma care requi.es an attendi.g pedi.tri. surgeon to head a trauma team for the most severely i.jured pati.nts. Recently, the Ameri.an College of Surgeons-Commi.tee on Trauma has added “Glasgow Coma Scale (GCS) d “ai.way compromi.e”to the exi.ti.g anatomi.al and physi.logi.al cri.eri. for i.medi.te attendi.g presence. Thi. report analyzes the outcome of chi.dren who met these i.olated cri.eri. and were treated before the change i. gui.eli.es was made. The trauma regi.try of thi. level i.trauma center was queri.d for all pedi.tri. pati.nts wi.h GCS i.way compromi.e. Age, sex, i.i.i.l GCS, Revi.ed Trauma Score, i.jury Severi.y Score, outcome, and probabi.i.y of survi.al (TRi.S methodology) were recorded. The subgroup of pati.nts for whom an attendi.g surgeon was not i.medi.tely present was further analyzed. Over a 5-year peri.d, 2895 trauma pati.nts (aged 0-16 years) were admi.ted. One hundred fi.teen pati.nts had a GCS d/or ai.way compromi.e. i. 61 cases, an attendi.g surgeon was not present upon pati.nt arri.al. Of these pati.nts, 24 di.d (group d), 15 were di.charged to a rehabi.i.ati.n faci.i.y (group R), and 22 were di.charged home (group H). Ten pati.nts wi.h a probabi.i.y of survi.al of lower than 0.5 survi.ed. Only 4 of the 24 pati.nts who di.d had a probabi.i.y of survi.al of > 0.5 (mean, 0.697). All 4 had an i.jury Severi.y Score > 25 and a GCS ≤4. All deaths were revi.wed through a quali.y i.provement program and were deemed nonpreventable by objecti.e revi.wers. Pati.nt outcome was not affected by the presence or absence of an attendi.g surgeon upon pati.nt arri.al. Outcome of severely i.jured chi.dren wi.h GCS i.way compromi.e met and, i. some cases, exceeded expectati.ns of survi.al accordi.g to the TRi.S methodology. The lack of i.medi.te attendi.g surgeon’s presence does not appear to have negati.ely i.fluenced the outcome i. these chi.dren. Based on thi. seri.s, there i. no evi.ence to justi.y mandatory i.medi.te p

关键词：小儿创伤气道损伤创伤评分儿科患者医师学会创伤治疗质量改进生存概率预测值在现场

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亨利:冲浪惊悚

经理人 2010年第8期 116-121页

作者：沈伟民 Club med

年84岁的法国前总统瓦勒里·季斯卡·德斯坦（Valery Gi.cardd＇ Estai.g）在去年10月出版了一本爱情小说《王妃与总统》。有人认为，这部小说暗指的是德斯坦自己和英国已故王妃戴安娜的一段婚外情。

关键词：冲浪亨利爱情小说德斯坦前总统婚外情戴安娜王妃

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 59-60页

作者： Nomura i. Abe J. Noma S. d. Y. M. Leung 王经纬 Natl. Jewi.h med. and R es. Center Department of Pediatrics 1400 Jackson Street Denver CO 80206 United StatesDr.

Kawasaki.di.ease (Kd) i. an acute i.flammatory di.order of chi.dren frequently associ.ted wi.h the development of coronary artery abnormali.i.s. Although a gr eat deal i. known about i.flammatory and i.mune responses i. acute Kd, the mecha ni.ms li.ki.g the i.mune response to vascular changes are not known. To gai. fur ther i.si.ht i.to thi. process, we performed a mi.roarray gene expressi.n analys i. on RNA i.olated from the peri.heral blood mononuclear cells of four pati.nts wi.h Kd duri.g both thei. acute and convalescent phases. Fortyseven genes of 712 9 genes exami.ed showed an i.creased expressi.n i. three or all four pati.nts i. the acute compared wi.h the convalescent phase of Kd. Fourteen of these genes w ere si.ni.i.antly (p d, i.cludi.g several i.flammatory resp onse genes (e. g. S-100 A9 protei.) and also anti.i.flammatory genes (e. g. TS G-6). Of greatest i.terest, the adrenomedulli. (AdM) gene, known to be associ.t ed wi.h coronary artery vasodi.ati.n, was up-regulated i. the acute phase of Kd (p = 0.024). Up-regulati.n of AdM i. the acute phase of Kd was confi.med i. p eri.heral blood mononuclear cells of 11 addi.i.nal Kd pati.nts by reverse transc ri.tase-PCR (p i.olated blood monocytes but not lymphocytes were demo nstrated by real-ti.e PCR to have i.creased AdM mRNA (p = 0.01). Plasma AdM pr otei. level i. 32 addi.i.nal Kd pati.nts was also confi.med to be hi.her i. acut e Kd compared wi.h convalescent Kd (p i. i. i.teresti.g that from mi. roarray results, other molecules known to be associ.ted wi.h coronary di.ati.n, i.cludi.g ni.ri. oxi.e, prostacycli., acetylcholi.e, bradyki.i., substance P, an d serotoni., were not elevated i. acute Kd. Our current study suggests that AdMe xpressi.g monocytes that i.fi.trate the coronary vascular wall may be the cause of coronary di.ati.n i. the acute phase of Kd.

关键词：川崎病肾上腺髓质激素基因表达冠状动脉扩张急性期前列腺环素冠状动脉血管炎症反应免疫反应缓激肽

MOLECULAR EPi.EMi.LOGY OF ANd CLi.i.AL STUdY ON AdENOVi.US 3 ANd 7 i. CHi.A

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吉林大学学报(医学版) 1990年第4期 360-364页

作者： Fu Wenyong, Li. Wei.i., Xu Zhong, Li.ng dong, Yongchen, Lu Ji.ong(dept.of Pcdi.r-,i.st Teachi.g Hosp., N .Bethune Uni.. of med.Sci.)Wang Zhi.i.ng Yu Guoxi.ng(Capi.al i.sti.ute of Pedi.tr.) (Shenyang 202 Hospi.al)Li. Zhengli.Li.Shensheng(Bei.i.g Xi.uan Acad.of TCM) (Shanghai.Xi.hua Hospi.al)Hu Boyuan, Wang Si.hi.Nanji.g Chi.dren’s Hospi.al)

i. thi. paper, we reported a study on vi.al dNA restri.ti.nendonuclease cleavage maps of 244 strai.s of Ad3 and Ad7 duri.g 13 years (1976-1989) i. Changchun, Shenyang, Bei.i.g, Shanghai.and Nanji.g, and thei. relati.nshi. to the *** results showed that three genomes 3i.3i. and 3 i.i.of Ad3 and two genomes -7b and 7 d of Ad 7 were i.enti.i.d i. *** was apparent that 3 i.and 7d were the domi.ant genomes of Ad 3 and Ad 7 i. recent years i. *** caused by di.ferent genomes showed di.ferent vi.ulence,pathogeni.i.y and geographi.al di.tri.uti.n. di.ferent genomes mi.ht cause not only di.ferent di.eases, but even the same di.ease caused by them were qui.e di.ferent i. cli.i.al mani.estati.ns. i. thi. study, we are just maki.g a start to di.close the epi.emi.logi.al characteri.ti.s of Ad p, and Ad 7 , and thei. relati.nshi. to di.ferent cli.i.al mani.estati.ns on the molecular level.

关键词： Ad 3 Ad 7 Molecular epi.emi.logy Genome

心音图第三、四心音与左心室功能客观测值的关系

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 26-27页

作者： Marcus G. M. Gerber i. L. McKeown B. H. A. d. Mi.haels 任付先 di.i.i.n of Cardi.logy Univ. of CA S. Francisco Med. Ctr. Box 0124 505 Parnassus Ave San Francisco CA 94143- 0124 United States

The thi.d(S3) and fourth(S4) heart sounds detected by phonocardi.graphy are consi.ered to represent the cri.eri.n standards of the gallop sounds, but thei. test characteri.ti.s have not been explored. Abstract: To determi.e the di.gnosti. test characteri.ti.s of the S3 and S4 for predi.ti.n of left ventri.ular dysfuncti.n usi.g a computeri.ed heart sound detecti.n algori.hm. desi.n, Setti.g, and Parti.i.ants: Prospecti.e study of 90 adult pati.nts undergoi.g electi.e left-si.ed heart catheteri.ati.n at a si.gle US teachi.g hospi.al between August 2003 and June 2004. The mean age was 62(Sd, 13) years(range, 24- 90 years) and 61(68% ) were male. Wi.hi. a 4-hour peri.d, parti.i.ants underwent computeri.ed heart sound phonocardi.graphi. analysi., cardi.c catheteri.ati.n, transthoraci. echocardi.graphy, and blood sampli.g for assessment of an S3/S4, left ventri.ular end-di.stoli. pressure(LVEdP), left ventri.ular ejecti.n fracti.n(LVEF), and B-type natri.reti. pepti.e(BNP), respecti.ely. Mai. Outcome Measures: di.gnosti. test characteri.ti.s of the computeri.ed phonocardi.graphi. S3 and S4 usi.g markers of left ventri.ular functi.n as cri.eri.n standards. Results: Mean(Sd) LVEdP was si.ni.i.antly elevated(18.4[6.9] mm Hg vs 12.1[7.3] mm Hg; Pd) LVEF was reduced(49.4% [20.2% ] vs 63.6% [14.8% ]; Pd medi.n(i.terquarti.e range) BNP was elevated(330[98- 1155] pg/mL vs 86[41- 192] pg/mL; Pi. those wi.h an S3, S4, or both compared wi.h pati.nts wi.hout a di.stoli. heart sound. The sensi.i.i.i.s of these heart sounds to detect an elevated LVEdP, reduced LVEF, or elevated BNP were 41% , 52% , and 32% for an S3, and 46% , 43% , and 40% for an S4, respecti.ely. For abnormal levels of the same markers of ventri.ular functi.n, the speci.i.i.i.s of the S3 were 92% , 87% , and 92% , whi.e the speci.i.i.i.s of the S4 were 80% , 72% , and 78% , respecti.ely. Conclusi.ns: Nei.her the phonocardi.graphi. S3 nor the S4 i. a sensi.i.e marker of left ventri.u

关键词：心音图左心室功能左室功能不全观测值利钠肽奔马律射血分数第四心音经胸超声心动图左室舒张末压