检索结果-南通市图书馆

Efficacy of small-volume simethicone given at least 30 min before gastroscopy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 572-578页

作者： Mingjun Song Andrew Boon Eu Kwek Ngai moh Law Jeannie Peng Lan Ong Jessica Yi-Lyn Tan Prem harichander Thurairajah Daphne Shih Wen Ang Tiing Leong Ang Department of Gastroenterology and hepatology Changi General Hospital

AIMTo evaluate the efficacy of 5 mL simethicone solution in decreasing gastric foam if given at least 30 min before gastroscopy. METhODSThis was a randomized, placebo controlled, endoscopist blinded study performed at Changi General hospital. Patients were at least 21 years old, had no prior surgical resection of the upper gastrointestinal tract, and scheduled for elective diagnostic gastroscopies. The primary outcome was the total mucosal visibility score (TMVS) which was evaluated using McNally score. The sample size was calculated to be 24 per group (SD 2.4, 80% power, P t test). RESULTSFifty-four patients were randomised to receive either simethicone [1 mL liquid simethicone (100 mg) in 5 mL of water] or placebo (5 mL of water) at least 30 min before their gastroscopy. Six accredited consultants conducted the gastroscopy, and the interobserver agreement of scoring TMVS was good with a Kappa statistic of 0.73. The simethicone group had significantly better mean TMVS compared to placebo (5.78 ± SD 1.65 vs 8.89 ± SD 1.97, P CONCLUSIONWith a premedication time of at least 30 min, 5 mL simethicone can significantly decrease gastric foam, decrease the volume of additional flushes, and shorten gastroscopy time.

关键词： Simethicone Premedication Gastroscopy Gastric foam

Tissue inhibitor of metalloproteinase-1 protects MCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2010年第5期30卷 720-720页

作者： Wang,T Lv,Jh Zhang,XF Li,CJ han,X Sun,YJ Nanjing med Univ,Key Lab human Funct Genom Jiangsu Prov,Nanjing 210029,Peoples R China Nanjing med Univ,Dept Cell Biol & med Genet,Nanjing 210029,Peoples R China Nanjing Univ,Sch med,Nanjing 210008,Peoples R China Nanjing med Univ,Ctr Canc,Nanjing 210029,Peoples R China

Paclitaxel(PTX) is a very effective drug in treating *** disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis,leading to cell death by ***,the effectiveness of PTX in cancer chemotherapy is hampered by drug resistance in some *** inhibitor of metalloproteinase-1(TIMP-1) is well known to be capable of inhibiting *** tumor tissue TIMP-1 levels have been significantly associated with a poor response to *** hypothesized that TIMP-1 could reduce the sensitivity of breast cancer cells to PTX by inhibiting *** test this hypothesis,we first examined the effects of TIMP-1 on the apoptosis induced by PTX and investigated the effects of TIMP-1 on the expression and stability of cyclin B1 that critically regulates the metaphase to anaphase transition during mitosis in MCF-7 breast cancer *** data demonstrate that TIMP-1 could significantly decrease the sensitivity of MCF-7 cells to PTX-induced apoptosis,attenuate mitotic blockage in G(2) /M,and enhance the degradation of cyclin *** further investigate whether the inhibitory effect of TIMP-1 on PTX-induced apoptosis is mediated by lowering levels of cyclin B1,a cyclin B1-expression plasmid was transfected into clone overexpressing *** levels of PTX-induced apoptosis were then *** data showed that the TIMP-1-based decrease in PTX-induced apoptosis was reversed by cyclin *** data indicate that TIMP-1 can protect breast cancer cells from PTX-induced apoptosis by decreasing the stability of cyclin B1.

关键词：肺癌癌细胞临床化疗

在线全文

学校读者我要写书评

暂无评论

双极奇椭圆函数

南京大学学报(自然科学版) 1956年第4期 1-11页

作者：莫绍揆

ξ1 二级奇椭函数由Liouville定理,可知最低级的椭圆函数(常数除外)为二级椭圆函数,又知一切椭圆函数均可由任一椭圆函数(在特例,由任一二级椭圆函数)及其导数有理地表示,因此二级椭圆函数可以看作最基本的椭圆函数。二级椭圆函数只有... 详细信息

ξ1 二级奇椭函数由Liouville定理,可知最低级的椭圆函数(常数除外)为二级椭圆函数,又知一切椭圆函数均可由任一椭圆函数(在特例,由任一二级椭圆函数)及其导数有理地表示,因此二级椭圆函数可以看作最基本的椭圆函数。二级椭圆函数只有两个可能,或者具有一个极点(二重极点),可名日单极椭

关键词：椭圆函数双极函数系

Abrupt decrease of c-myc expression by antisense transcripts induces terminal differentiation and apoptosis in human promyelocytic leukemia hL-60 cells

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cell Research 1996年第2期6卷 189-199页

作者： hAO XIU JUAN PEI hSIEN TANG XIU SEN LI FEI ZI JIANG YONG ZhI XI NING MAO DE LIN DU MIN WU (Institute of Basic medical Sciences, Beijing 100850)(National Laboratory of Molecular Oncology, In stitute of Cancer Research Beijing, Chinese Academy of med Institute of Basic medical Sciences Beijing 100850 National Laboratory of Molecular Oncology Institute of Cancer Research Beijing Chinese Academy of Medical Sciences Beijing 100021

This study was designed using c-myc antisense transcripts to evaluate how alteration of c-myc expression in human myeloid leukemic hL-60 cells could influence the myelomonocytic differentiation and induction of apoptosis. The recombinant plasmid pDACx expressing antisense transcripts to c-myc fragment containing a part of intron 1 and 137 nt exon 2 was constructed. pDACx was transfected into hL-60 cell line by lipofectin *** stainings including NBT reduction, peroxidase and α -NAE as well as detection of CD13 and CD33 antigens by flow cytometric analysis indicated occurrence of myelomonocytic differentiation in cells expressing antisense transcripts to c-myc. DNA degradation measured by DNA gel electrophoresis and typical morphological changes observed under electron microscope proved the switchon of apoptosis in terminally differentiating hL-60 cells.

关键词： c-myc oncogene antisense transcripts differentiation apoptosis

Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

南京医科大学学报(自然科学版) 2009年第7期 991-991页

作者： huang, S. M. Zhang, A. h. Ding, G. X. Chen, R. h. Nanjing med Univ, Nanjing Childrens hosp, Dept Nephrol, Nanjing, Peoples R China. Nanjing med Univ, Inst Pediat, Nanjing, Peoples R China.

huang S, Zhang A, Ding G, Chen R. Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation. Am J Physiol Renal Physiol 296: F1323-F1333, 2009. First published April 1, 2009; doi: 10.1152 / ajprenal. 90428.2008. -Aldosterone (Aldo) stimulates glomerular mesangial cell (MC) proliferation, in part, through an ERK1 / 2-dependent pathway. In this study, we examined whether Aldo activation of ERK1 / 2 in MC is mediated through redox-dependent EGF receptor (EGFR) transactivation, as well as the involvement of other signaling mechanisms in Aldo-induced MC proliferation. Aldo increased human MC proliferation, as determined by [h-3]thymidine incorporation and cell counts. This increase in proliferation was blocked by inhibition of the mineralocorticoid receptor (MR). Continuing our observations downstream in the signaling pathway, we examined the ability of Aldo to activate both the Ras / MAPK and the PI3K signaling pathways. Aldo increased Ki-RasA and Ki-RasA:GTP levels, and sequentially phosphorylated c-Raf, MAPK kinase (MEK1 / 2), and ERK1 / 2. Ki-RasA small interfering RNA (siRNA), the c-Raf inhibitor GW5074, and the MEK1 / 2 inhibitor PD98059 reduced Aldo-induced cell proliferation by similar to 65%. Aldo also increased phosphorylation of PI3K, Akt, the mammalian target of rapamycin (mTOR), and the 70-kDa ribosomal S6 kinase (p70S6K1). Inhibition of the PI3K pathways by the selective PI3K inhibitor LY 294002, an Akt inhibitor, or the mTOR inhibitor rapamycin reduced cell proliferation by 51% . Combining LY 294002 and PD98059 completely blocked Aldo-induced MC proliferation. Next, we confirmed that Aldo exerts its effect on MAPK and PI3K activation, as well as on cell proliferation, by activating the EGFR. Pretreatment with the EGFR antagonist AG1478 inhibited MC proliferation, as well as the activation of Ras / MAPK and PI3K / Akt, suggesting that Ras / MAPK and PI3K / Akt activation occur downstream of EGFR activation. Finally, we exa

关键词： reactive oxygen species PI3K hypertensive-rats phosphatidylinositol 3-kinase stimulates proliferation mesenchymal transition epithelial-cells nadph oxidase s6 kinase activation ras cascade

艾芜《南行记》中殖民社会下的缅甸人物形象分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

品位·经典 2019年第4期 16-19页

作者：柳忆甜北京语言大学

艾芜《南行记》中的人物形象研究一直是学界关注的问题,其中关于缅甸的人物形象也是值得研究者去挖掘的重要领域。本文中运用形象学的研究方法分析缅甸殖民时期殖民社会视角下不同的缅甸人物形象与其价值观念,其中包含殖民社会下的叛变... 详细信息

艾芜《南行记》中的人物形象研究一直是学界关注的问题,其中关于缅甸的人物形象也是值得研究者去挖掘的重要领域。本文中运用形象学的研究方法分析缅甸殖民时期殖民社会视角下不同的缅甸人物形象与其价值观念,其中包含殖民社会下的叛变者、牺牲者以及反抗者等多种人物形象。

关键词：殖民社会叛变者牺牲者反抗者

Correlation between the structural, morphological, optical, and electrical properties of In_2O_3 thin films obtained by an ultrasonic spray CVD process

在线全文

学校读者我要写书评

暂无评论

Journal of Semiconductors 2015年第8期36卷 9-14页

作者： A.Bouhdjer A.Attaf h.Saidi h.Bendjedidi Y.Benkhetta I.Bouhaf Laboratory of Semiconductors Materials University of Med Kheider

Indium oxide （In2O3） thin films are successfully times by an ultrasonic spray technique using Indium chloride deposited on glass substrate at different deposition as the precursor solution; the physical properties of these films are characterized by XRD, SEM, and UV-visible. XRD analysis showed that the films are polycrys- talline in nature having a cubic crystal structure and symmetry space group Ia3 with a preferred grain orientation along the （222） plane when the deposition time changes from 4 to 10 min, but when the deposition time equals 13 min we found that the majority of grains preferred the （400） plane. The surface morphology of the In2O3 thin films revealed that the shape of grains changes with the change of the preferential growth orientation. The trans- mittance improvement of In2O3 films was closely related to the good crystalline quality of the films. The optical gap energy is found to increase from 3.46 to 3.79 eV with the increasing of deposition time from 4 to 13 min. The film thickness was varied between 395 and 725 nm. The film grown at 13 min is found to exhibit low resistivity （10-2 Ω.cm）, and relatively high transmittance （- 93%）.

关键词： indium oxide deposition time ultrasonic spray optical and electrical properties

Study of T-lymphocyte subsets,nitric oxide,hexosamine and helicobacter pylori infection in patients with chronic gastric diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2000年第4期6卷 601-604页

作者： Zhang h Jiang SL Yao XX hebei med Univ Hosp 2 Dept Gastroenterol Shijiazhuang 050000 Hebei Province Peoples R China

Chronic gastritis ( CG ) and peptic ulcer ( PU ) are frequently-occurring diseases. It is now well recognized that helicobacter pylori (hp) is a major factor that leads to CG and PU[1-8] In order to study the relationship among T lymphocyte subsets, NO, hexosamine and hp infection in patients with chronic gastric diseases, the levelsof blood T lymphocyte subsets, plasma NO and hexosamine in gastric mucosa were measured respectively in 30 patients with CG and 32 patients of PU + CG.

关键词： stomach disease Tlymphocyte nitric oxide helicobacter pylori hexosamine helicobacter infections gastric mucosa

Structures of Isodoternifolin A and B

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1996年第9期7卷 816-817页

作者： Wang, ZM Feng, h Liang, XT ChINESE ACAD TRADIT ChINESE med INST CHINESE MAT MEDBEIJING 100700PEOPLES R CHINA ChINESE ACAD med SCI INST MAT MEDBEIJING 100050PEOPLES R CHINA

Two new diterpenoids, named isodoternifolins A(1) and B(2), together with seven known compounds were isolated from the ethanol extract of dried stems and leaves of Isodon ternifolius (D. Don) Kudo. The structures of 1 and 2 were determined as 7 beta-hydroxy-6 beta,11 alpha,15 beta-triacetoxy-7 alpha, 20-epoxy-entkaur-16-ene and 6 beta,7 beta,15 beta-trihydroxy-11 alpha-acetoxy-7 alpha,20-epoxy-entkaur-16-ene by chemical and spectral evidence respectively.

关键词： CONSTITUENTS DITERPENOIDS