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Breast Cancers in Young Woman under 40 Years in Sub-Saharan Africa: Experience of the Gynecology Department of the University and Hospital Center of Treichville (Abidjan—Cote d’Ivoire)

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Journal of Cancer Therapy 2017年第8期8卷 714-725页

作者： Jean Marc Dia moctar touré Ignace Yao Eric Bohoussou Corneil Saki Mouhideen Oyelade Gérard Okon Simplice Anongba Gynecology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire Cancerology Department of the University and Hospital Center of Treichville (CHUT) Abidjan C&ocirc te d’Ivoire

Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conducted over 10 years on the management of breast cancer in 105 patients under 40 years in the Gynecology Service of the University and Hospital Center of Treichville. Results: The incidence of breast cancer in women under 40 years was 8.4%, and the majority of patients were over 35 years old (64.8%) and had a low socioeconomic level (61.7%). Some patients had classic risk factors for breast cancer: menarche before 12 years (48.6%), nulliparity (20%), family history of breast cancer (1.9%). The discovery of a breast abnormality was made by patients in 97.1% of the cases. Cancers were either isolated (92.4%) or associated with pregnancy (5.7%) or bilateral (1.9%). The majority of cancers were infiltrating ductal carcinomas (86.7%), of SBR II grade (69%). Patients generally benefited from a mastectomy with axillary dissection, framed by chemotherapy. The global survival at 10 years was 5%. Conclusion: This study allowed us to confirm that breast cancers in younger women were a reality in our country and posed us enormous difficulties in their management.

关键词： Breast Cancer Young Women Diagnosis Treatment

Profile of Patients with Breast Cancer Brain Metastasis in Abidjan

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Advances in Breast Cancer Research 2018年第2期7卷 201-210页

作者： Kouame Konan Yvon Kouassi moctar touré Evrard Narcisse Seka Oumou Kimso Mudasiru Akanji Oseni Bitti Adde Odo Arsène Gaetan Kagambega Innocent Adoubi Oncology Department of the Treichville University Hospital Department of Medicine and Medical Specialties Felix Houphou-et-Boigny University Abidjan Cote d'Ivoire

Patients with breast cancer will develop brain metastases in 15% - 25% of cases. Objective: To identify the profile of patients with breast cancer brain metastasis. Method: Retrospective study over 4 years in the oncology department of Treichville Hospital. All patients with breast carcinoma who had a brain metastasis during their cancer management were included. Results: 41 cases of breast carcinoma brain metastasis were collected. Patients were older than 40 years in 78% of cases. Family history of breast cancer was found in 7% of patients. More than 80% of patients had consulted with T3 and T4 tumor masses, with 100% of cases of node involvement. The brain was the second site of metastasis. The tumors were Triple negative in 48%, Her2 positive in 36% and luminal in 16%. Brain metastases were of late onset in the majority of cases (68%). They were clinically characterized by headaches (100%), most often included in an intracranial hypertension syndrome (52%). They were multiple (60%). Therapeutically, no surgery was performed on the metastases. Three patients received whole brain radiation therapy. All patients received systemic therapy. In terms of response, 30 cases of progression were observed after treatment and 2 cases of complete response were obtained. Survival from onset of brain metastasis was of 75% at 3 months and 2% at 12 months. Patients with longer survival rates were over 40 years old with triple negative breast cancer. Conclusion: Brain metastasis from breast cancer most often occurs in a particular clinical and pathological context in our countries.

关键词： Breast Cancer Brain Metastasis Abidjan

Non-Small Cell Lung Cancer:Therapeutic and Evolutionary Aspects in Cote d’Ivoire

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Advances in Lung Cancer 2018年第1期7卷 1-8页

作者： tourémoctar Kouassi KouaméKonan Yvon Séka Evrard Narcisse TraoréKadjatou TraoréAsmaho Danielle Odo Bitti Addé Oumou Kimso Kagambega Arsène Gaetan Adoubi Innocent Oncology Department of the Treichville University Hospital AbidjanCote d’Ivoire

Non-small cell lung cancer (NSCLC) is a heterogeneous group of malignancies including squamous cell carcinoma, adenocarcinoma, bronchioloalveolar carcinoma and large cell carcinoma. They are known to be of poor prognosis, despite a better understanding of bronchial oncogenesis. This descriptive retrospective study carried out over three years (January 2013 to December 31st, 2016) at the Oncology Department of the Treichville University Hospital in Abidjan was aimed to assess the efficacy of new treatments for NSCLC in Cote d’Ivoire and to specify their benefit in terms of quality of life, comfort and overall survival. This 77 patients study, found that NSCLC, the most frequent of which is squamous cell carcinoma, occurs in relatively young subjects, smokers (91%) diagnosed at a locally advanced or metastatic stage (89%). Cisplatin base multi-drug chemotherapy was mostly used (71%). Combined all treatments, there was a significant clinical gain. However, no complete response was observed. Hematological and digestive toxicities were seen in more than 30% of cases. Overall survival was of 9 months on average. This study is an advocate to optimize primary prevention policies for a cancer with poor prognosis despite the development of new treatments such as target therapies.

关键词： Non-Small Cell Lung Cancer Treatment Evolution

Benefit of Targeted Therapies in Metastatic Colon Cancer in the Ivorian Context

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Journal of Cancer Therapy 2017年第8期8卷 785-792页

作者： touré moctar Kouassi Kouamé K. Yvon Séka E. Narcisse Traoré Kady Kimso Oumou Niang D. Rokhaya Odo B. Adde Oseni Jelili Adoubi Innocent Department of Oncology University Hospital of Treichville Abidjan Cote d’Ivoire

In our daily practice, the use of targeted therapies (Bevacizumab and rarely Cetuximab) in metastatic colic cancers is recent. Very few patients benefit from these therapies because of their high cost. In a cohort of 68 patients who received these therapies, a retrospective and prospective study was conducted over three years period (1 January 2013 to 31 December 2015) to evaluate their benefit in terms of quality of life, tolerance and overall survival. These targeted therapies provided a significant clinical and biological gain with acceptable toxicities (most often resolving spontaneously). Moreover, they have allowed a significant improvement in overall survival in first line metastatic treatment. The limiting factor remains their extremely high cost and therefore inaccessibility to the majority of our patients.

关键词： Cancer-Colon-Metastasis-Targeted Therapy

Physico-Chemical Features of the Kpassa Reservoir, Northern Benin, with Emphasis on Its Trophic State: A Preliminary Study

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Journal of Environmental Protection 2016年第13期7卷 2067-2080页

作者： Ousmane touré Boukari Daouda Mama Youssouf Abou moctar Limam Bawa Laboratory of Applied Hydrology Department of Hydrology and Integrated Management of Water Resources National Institute of Water University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Ecology and Aquatic Ecosystem Management Department of Zoology Faculty of Sciences and Technics University of Abomey-Calavi Abomey-Calavi Benin Laboratory of Water Chemistry Department of Chemistry Faculty of Sciences University of Lomé Lomé Togo

This work presents recent data on the physico-chemical properties and the trophic status of Kpassa reservoir at eighteen locations from August 2014 to February 2015. Seventeen physico-chemical parameters were measured and data obtained were statistically analyzed. The descriptive statistics showed their variations (minima-maxima) as follows: pH (4.65 - 7.30), temperature (25.1°C - 29.9°C), dissolved oxygen (1 - 5.79 mg/L), oxydability (0.32 - 10.88 mg O2/L), electrical conductivity (55 - 77 μS/cm𕒵), TDS (76 - 94 mg/L), turbidity (15.70 - 274.40 NTU), transparency (0.24 - 1.55 m), suspended matter (3 - 92 mg/L), total phosphorus (0.25 - 1.90 mg/L), orthophosphate (0.08 - 0.61 mg/L), nitrate (undetected 5.50 mg/L), nitrite (undetected 0.79 mg/L), ammonia (undetected 0.36 mg/L), chlorophyll a (7.20 - 2334.6 μg/L), silica (4.34 - 15.67 mg/L) and N/P ratio (0.08 - 42.62). These parameters were mainly influenced by agricultural activities and climatic conditions. The restriction or the removal of the use of chemical fertilizers in agricultural activities in Kpassa reservoir basin was recommended. The highest values of Pearson and Spearman correlations were observed across TDS and conductivity (0.967;0.951), turbidity and oxydability (0.924;0.665), turbidity and chlorophyll a (0.884;0.663), turbidity and suspended matter (0.982;0.793), suspended matter and transparency (𕒴.781;𕒴.819), suspended matter and nitrate (𕒴.813;𕒴.839), suspended matter and oxydability (0.919;0.602) and suspended matter and chlorophyll a (0.879;0.656). Carlson’s trophic state index (TSI) values varied between 36 and 66 showing that Kpassa reservoir was eutrophic in August and mesotrophic to oligotrophic during the other months of the sampling period. ANOVA and Kruskal-Wallis test indicated that there were no significant differences between sampling stations.

关键词： Physico-Chemical Features Trophic State Kpassa Reservoir Okpara River Benin

SnO2-reduced graphene oxide nanoribbons as anodes for lithium ion batteries with enhanced cycling stability

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Nano Research 2014年第9期7卷 1319-1326页

作者： Lei Li Anton Kovalchuk James M. tour Department of Chemistry Rice University 6 I00 Main Street Houston Texas 77005 USA Richard E. Smalley Institute for Nanoscale Science and Technology Rice University 6100 Main Street Houston Texas 77005 USA Department of Materials Science and NanoEngineering Rice University 6100 Main Street Houston Texas 77005 USA

A nanocomposite material of SnO2-reduced graphene oxide nanoribbons has been developed. In this composite, the reduced graphene oxide nanoribbons are uniformly coated by nanosized SnO2 that formed a thin layer of SnO2 on the surface. When used as anodes in lithium ion batteries, the composite shows outstanding electrochemical performance with the high reversible discharge capacity of 1,027 mAh/g at 0.1 A/g after 165 cycles and 640 mAh/g at 3.0 A/g after 160 cycles with current rates varying from 0.1 to 3.0 A/g and no capacity decay after 600 cycles compared to the second cycle at a current density of 1.0 A/g. The high reversible capacity, good rate performance and excellent cycling stability of the composite are due to the synergistic combination of electrically conductive reduced graphene oxide nanoribbons and SnO2, The method developed here is practical for the large-scale development of anode materials for lithium ion batteries.

关键词： lithium ion battery tin oxide graphene oxide nanoribbons energy storage

Confirmatory analysis of the 13‐MD and ranking of its meta‐dimensions and items

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Health Care Science

Health Care Science 2024年第4期3卷 249-263页

作者： Moustapha touré Thomas G.Poder École de gestion Universitéde SherbrookeSherbrookeQuebecCanada Centre de recherche de l'IUSMM CIUSSS de l'Est de l'île de MontréalMontrealQuebecCanada École de santépublique Universitéde MontréalMontrealQuebecCanada

Background:The 13‐MD is a new generic instrument developed to measure general health‐related quality of life(GHRQoL).This instrument considers all aspects of health(i.e.,physical,mental,and social)in a balanced way.A previous study led to minor changes in the original version of the 13‐*** objective of this study was to confirm the validity of the modified 13‐***:Validity was assessed with recent data from the general population of Quebec,*** meta‐dimensions and items composing the 13‐MD were also subjected to a ranking procedure,which allowed to determine the most important aspects for ***:A total of 1337 French‐speaking participants were recruited with 1099 completing the 13‐MD for validation purposes and 1084 completing the ranking *** 13‐MD showed very satisfactory results and confirmed to be a valid *** ranking of the meta‐dimensions revealed that“Well‐being”received the most points,followed by“Sleep and energy”and“Body functioning.”Conclusion:These results will be very useful in the continuous improvement of the 13‐MD,ultimately leading to the valuation stage(i.e.,development of a value set).

关键词： cost‐utility analysis health‐related quality of life generic instrument

Oncosexology in côte d’Ivoire:Attitudes and Practices of Physicians Involved in the Management of Breast and Prostate Cancer

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Psycho-Oncologie 2024年第4期18卷 359-365页

作者： KouaméKonan Yvon Kouassi Bitti Adde Odo Yenahaban Lazare toure Ouowene Prisca Marina Sougue Petiori Gningayou Laurenceépouse Kamara touré N’Guessan Manlan Prosper Mebiala Fleur Audrey Sessegnon Marie Sandrine Koffi Akissi Marie Barbara Yvonne Nogbou Sherif Traore Asmaho Akissi Danielle Andree Traore-Kouassi moctar toure Department of Medicine and Medical Specialties UFR Medical SciencesFélix Houphouët Boigny UniversityYamoussoukro01 BP V166 Abidjan 01Côte d’Ivoire Service De Cancerologie Du Chu De Treichville Treichville01 BP V03 Abidjan 01Côte d’Ivoire

Objective:To evaluate the attitudes and practices of oncosexology in the management of breast and prostate cancer in Côte d’***:A cross-sectional,multicenter,descriptive and analytical survey carried out over 02 months from 1 November to 31 December 2022,among doctors involved in the management of breast and prostate cancer in Côte d’***:78 physicians on 114 participated in the study,with a participation rate of 79.5%.Only one doctor discussed the sexual risks associated with cancer with all his patients and 7.7%of doctors said they never broached questions of sexuality with their *** approach to sexuality was strongly associated with occupation(p=0.002).A request for oncosexological care was initiated by the patient and the partner respectively in 3.8%and 25.6%of *** 5.1%of physicians claimed to have received training in *** 92.3%of cases,doctors would like to have training on this ***:On the questions relating to sexuality,Physicians are not addressing sexuality with their patients diagnosed with breast or prostate *** lack of training in this area appears to be the main reason for this lack of communication and onco-sexological care.

关键词： Oncosexology oncosexuality breast prostate

Soluble Graphene Through Edge-Selective Functionalization

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Nano Research 2010年第2期3卷 117-125页

作者： Zhengzong Sun Shin-ichiro Kohama Zengxing Zhang Jay RLomeda James M.tour Department of Chemistry and Mechanical Engineering and Materials Science and the Smalley Institute for Nanoscale Science and Technology Rice UniversityMS 2226100 Main StreetHoustonTexas 77005USA

Thermally expanded graphite was functionalized with 4-bromophenyl addends using the in situ diazonium formation procedure,and after mild sonication treatment in N,N’-dimethylformamide,thin graphene layers were exfoliated from the bulk *** chemically-assisted exfoliated graphene(CEG)sheets had higher solubility than pristine graphene without any stabilizer *** than 70%of these soluble flakes had less than 5 *** filtered transmission electron microscopy(EFTEM)elemental mapping provided evidence of the edge-selective diazonium functionalization with graphene.A majority of the Br signals came from the edges of the CEG indicating that the basal planes were not highly *** CEG was also characterized by X-ray photoelectron spectroscopy,atomic force microscopy,Raman spectroscopy,and transmission electron microscopy.

关键词： Edge-selective functionalization graphene energy filtered transmission electron microscopy(EFTEM) chemically-assisted exfoliation