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Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

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Journal of Renewable Materials 2024年第1期12卷 29-43页

作者： Thean Heng Tan Najihah Mohd Hashim Wageeh Abdulhadi Yehya Dabdawb mochamad zakki fahmi Hwei Voon Lee Nanotechnology&Catalysis Research Center(NANOCAT) Universiti MalayaKuala Lumpur50603Malaysia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversiti MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of Science and TechnologyUniversitas AirlanggaCampus CMulyorejoSurabaya60115Indonesia

The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose(NCC)as a potential drug delivery system for targeting folate receptor-positive cancer *** FA-functionalized NCCs were synthesized through a series of chemical reactions,resulting in nanoparticles with favorable properties for biomedical *** microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor ***,these nanoparticles possessed a negative surface charge,enhancing their stability and repelling potential *** binding specificity of FA-functionalized NCCs to folate receptor-positive cancer cells was demonstrated through various *** free folic acid inhibition assay showed approximately 30%decrease in the binding of functionalized NCCs in the presence of just 5 mM free FA,confirming their selectivity for folate receptor-positive *** microscopy further validated this specificity,as only cancer cells displayed significant binding of functionalized ***,biocompatibility tests revealed that both NCCs and FA-functionalized NCCs had minimal effects on red blood cells,and they did not induce erythrocyte ***,cell viability assays demonstrated functionalized NCCs have selective cytotoxicity against colorectal cancer cells HT-29 and SW-620(68%–88%cell viability)while sparing noncancerous colon cells CCD-18Co(81%–97%cell viability).In summary,FA-functionalized NCCs exhibit promising characteristics for targeted drug delivery in cancer *** biocompatibility,stability,and selective cytotoxicity make them an attractive option for delivering therapeutic agents to folate receptor-positive cancer cells,potentially improving the effectiveness of cancer treatments while minimizing harm to healthy tissues.

关键词： Agricultural wastes sustainable nanocarrier blood biocompatibility folic acid receptor drug delivery system nanomedicine

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