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Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices

Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1072-1076页

作者： Mojtaba Shahnazi Abbas Azadmehr moazzam dosti jondabeh Reza Hajiaghaee Reza Norian Hamidreza Aghaei Mehrzad Saraei Mahmood Alipour Department of Parasitology Qazvin University of Medical SciencesQazvinIran Cellular&Molecular Research Institute Qazvin University of Medical SciencesQazvinIran Department of Immunology Qazvin University of Medical SciencesQazvinIran Department of Immunology Babol University of Medical SciencesBabolIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran Department of Microbiology Faculty of Veterinary MedicineUrmia UniversityUrmiaIran Department of Social Medicine Qazvin University of Medical SciencesQazvinIran

ObjectiveTo evaluate the possible involvement of programmed cell death strategy in hydatid cyst protoscolices following treatment with Myrtus communis (M. communis) as an herbal *** were aseptically collected from sheep liver hydatid cysts. Evaluating the effect of M. communis extract on programmed cell death and increased activity of caspases 3, 8, and 9 in hydatid cyst protoscolices was conducted by treating the protoscolices with different concentration (5, 50, and 100 mg/mL) of M. communis extract at 37 °C and 5% CO2 for 4 h by using the Bradford test and ELISA commercial *** extract of M. communis at all concentrations led to initiation of programmed cell death in protoscolices and this effect, was only significant at 50 and 100 mg/mL concentrations, compared to the negative control (P < 0.05). Also, the activity of caspases 3, 8, and 9 in hydatid cyst protoscolices, was shown that the extract at all 3 concentrations could only increase the activity of caspases 3 and 9. Moreover, a significant increase in the activity of caspase 3 was only observed at concentrations 50 and 100 mg/mL by 37.00% and 66.19% while a significant increase in the activity of caspase 9 at the same concentrations was observed by 20.89% and 63.67%, respectively (P < 0.05).ConclusionsThe extract of M. communis at different concentrations could increase the activity of caspases 3 and 9 and caused programmed cell death in hydatid cyst protoscolices however, this effect was significant at high concentrations of the extract.

关键词： Echinococcus granulosus Protoscolex Myrtus communis Programmed cell death Caspase

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