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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan mo Le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK department of orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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direct Photolithography of Wo_(x)Nanoparticles for High‑Resolution Non‑Emissive displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu Xiang Yu‑mo Zhang Laboratory of optoelectronic Information Technology and devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑optoelectronic Materials and devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(Wox)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for Wox nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widtholution for reported inorganic electrochromic materials).Additionally,the resulting device exhibited impressive electrochromic perfo.mance,such as fast response(oloration efficiency(119.5 cm^(2) C^(−1)),good optical modulation(55.9%),and durability(>3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&d)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic direct photolithography Wox nanoparticles In situ photo-induced ligand exchange High-resolution displays

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： man Han deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BdNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Periodical oscillations of Supercurrent Fluctuation in Mesoscopic Josephson Junctions in Quantized Electromagnetic Fields

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Chinese Physics Letters 1996年第5期13卷 359-361页

作者： KUANG Le-man WANG Yi-wen GE mo-lin Theoretical Physics division Nankai Instilute of MathematicsTianjin 300071 department of Physics Hu'nan Normal UriiversityChangsha 410081

Supercurrent fluctuation of a mesoscopic Josephson jutiction(MJJ)in the presence of a de static voltage and a time-varying quantized electromagnetic field(QEMF)is *** is shown thm the fluctuation of supercurrent in the MJJ exhibits periodical oscillations with a periodicity shich depends upon the rate of the classical static external voltage and the frequency of the QEMF.

关键词： Josephson Electromagnetic Periodical

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Synthesis and blue light-emitting properties of 4,4'-bis(diphenylamino)-quinque(p-phenyl)s

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Chinese Chemical Letters 2007年第7期18卷 823-826页

作者： Zhong Hui Li mo Jun Xiong man Shing Wong department of Chemistry Sichuan College of Education Chengdu 610041 China West China School of Pharmacy Sichuan University Chengdu 610041 China department of Chemistry Hong Kong Baptist University Hong Kong China

An excellent organic blue light-emitting diode based on 4,4＇-bis（diphenylamino）-quinque（p-phenylene）s （oPP（5）-NPh） with a maximum luminance of up to 5000 cd/m^2 and a luminanous efficiency of 1.3 cd/A was reported. This diode was made by using a wide band-gap hole-blocking layer, F-TBB instead of PBd in the oLEd devices. We attribute the good perfo.mance to the one trade-off involved in the use of F-TBB to obtain higher luminance is the increased turn-on voltages and slightly decreased device efficiencies.

关键词： 4,4'-Bis(diphenylamino)-quinque(p-phenylene)s Synthesis organic light-emitting diode (oLEd) optical properties

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甲烷在钠基蒙脱土吸附的第一性原理研究

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原子与分子物理学报 2025年第2期42卷 8-14页

作者：方志杰李博宋昌辉刘美玲何秋芝刘翔莫曼广西科技大学电子工程学院柳州545006 广西科技大学土木建筑工程学院柳州545006 广西科技大学医学部柳州545006

随着经济的发展,能源需求日益增加,为了弥补国内少油缺气短板,页岩气的开发成为近期新能源的热点,探索页岩气储存规律是页岩气能源开发的关键所在.本文采用密度泛函理论的第一性原理方法,计算甲烷(CH_(4))在钠基蒙脱土表面和层间的吸附... 详细信息

随着经济的发展,能源需求日益增加,为了弥补国内少油缺气短板,页岩气的开发成为近期新能源的热点,探索页岩气储存规律是页岩气能源开发的关键所在.本文采用密度泛函理论的第一性原理方法,计算甲烷(CH_(4))在钠基蒙脱土表面和层间的吸附能,对比吸附前后的态密度和物理结构以及差分电荷密度.结果表明:钠基蒙脱土表面吸附中,甲烷最佳选择是桥位,吸附能为-0.08eV,被吸附后甲烷的键长和键角变化率均小于0.96%.层间吸附中,伴随着甲烷吸附量增加,纳基蒙脱土体积向c轴方向线性增加,a、b轴方向则变化不大.总态密度随着吸附量的增加,总能级数量也增加,甲烷分子的分波态密度峰向低能级移动.本文的研究成果,从原子角度分析了甲烷在蒙脱石表面以及层间的吸附能力,为解释页岩气在页岩储存规律提供理论依据.

关键词：钠基蒙脱土第一性原理甲烷吸附态密度

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Low-cost and high-strength Mg-Al-Ca-Zn-Mn wrought alloy with balanced ductility

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1396-1405页

作者： Kun Yang Hucheng Pan Sen du man Li Jingren Li Hongbo Xie Qiuyan Huang Huajun mo Gaowu Qin Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China The First Sub-Institute Nuclear Power Institute of ChinaChengdu 610005China

A novel low-cost Mg-Al-Ca-Zn-Mn-based alloy was developed to simultaneously improve its strength and *** high yield strength of 411 MPa and the high elongation to failure of~8.9%have been achieved in the as-extruded Mg-1.3Al-1.2Ca-0.5Zn-0.6Mn(wt%)*** characterizations showed that the high strength is mainly associated with the ultra-fined dynamically recrystallized(dRXed)***,high-density dislocations in the un-dRXed region and nano-precipitates are distributed among theα-Mg *** high ductility property can be ascribed to the high volume fraction of dRXed grains with a much randomized texture,as well as the formations of high-density subgrains in the un-dRXed grain regions.

关键词： Mg wrought alloy mechanical property dynamic recrystallization texture nano-precipitation

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温度和水分对寒温带典型森林类型土壤有机碳矿化的影响

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东北林业大学学报 2025年第2期53卷 127-136页

作者：李雪朱宾宾满秀玲东北林业大学哈尔滨150040 内蒙古呼伦贝尔市林业和草原事业发展中心

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0 详细信息

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0d,白桦林土壤有机碳矿化速率峰值波动在13.38~77.47 mg·kg^(-1)·h^(-1),兴安落叶松林峰值波动在10.82~48.08 mg·kg^(-1)·h^(-1),白桦林土壤有机碳矿化速率高于兴安落叶松林,随培养时间延长矿化速率迅速降低,并趋于平缓;(2)两种林型土壤矿化速率和累积矿化量与温度和水分呈显著正相关。白桦林土壤有机碳矿化速率和累积矿化量在不同土层均高于兴安落叶松林,0

关键词：寒温带白桦林兴安落叶松林土壤有机碳矿化温度敏感性

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Formation of TiN Grid on NiTi by Laser Gas Nitriding for Improving Wear Resistance in Hanks' Solution

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Journal of Materials Science & Technology 2016年第5期32卷 459-464页

作者： C.H.Ng o.K.Chan H.C.man department of Industrial and Systems Engineering The Hong Kong Polytechnic University

Laser gas nitriding （LGN） is a common surface modification method to enhance the wear resistance of titanium （Ti） alloys, which are known to have poor tribological properties. In the present study, a titanium nitride （TIN） grid network was fabricated on the surface of nickel titanium （NiTi） by LGN. The laser processing parameters were selected to achieve nitriding without surface melting and hence to＇maintain a smooth surface finish. The characteristics of the grid-nitrided samples were investigated by scanningelectron microscopy, X-ray diffractometry, optical microscopy, 2-d profilometry, contact angle measurements and nanoindentation. The wear resistance of the nitrided samples was evaluated using reciprocating wear test against ultra-high-molecular-weight polyethylene （UHMWPE） in Hanks＇ solution. The results indicate that the wear rates of the grid-nitrided samples and the UHMWPE counter-body in the wear pair are both significantly reduced. The decrease in wear rates can be attributed to the combination of a hard TiN grid and a soft NiTi substrate. In Hanks＇ solution, the higher hydrophilicity of the nitrided samples also contributes to the better perfo.mance in wear test against hydrophobic UHMWPE.

关键词： Laser Nitriding Surface patterning Titanium alloys Wear

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Comparison of pyrolysis characteristics of two Chinese oil shales based onthe migration and conversion of organic carbon

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Carbon Resources Conversion 2018年第3期1卷 209-217页

作者： Zhi-bing Chang mo Chu Chao Zhang Shu-xia Bai Sheng-tao Wang Bao.man Liu School of Chemical and Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China

In this study,the Huadian oil shale(Hd-R)and Balikun oil shale(BLK-R)were pyrolyzed in a fixed-bed pyrolyzer at 360–530℃.Based on the migration and conversion of organic carbon,their pyrolysis characteristics were investigated and *** aliphaticity of Huadian kerogen(Hd-K)and Balikun kerogen(BLK-K)are 80.53%and 52.83%,*** Hd-K contains more C=o,which will render the depolymerization and decomposition of kerogen to occur at low temperatures to produce volatile ***,the cumulative conversion of the Huadian shale oil is greater than the Balikun shale oil at 390–435℃.The aliphatic carbons of the BLK-K are mainly present as short methylene chains attached to aromatic *** will leave the kerogen matrix with the breakage of relatively weaker CeC bonds at β-sites from aromatic rings at medium *** contrast,aliphatic carbons of the Hd-K are dominated by long aliphatic *** temperature is necessary to break other stronger CeC to form shale oil and gaseous species,which appears to make the oil accumulation conversion of BLK-R exceed that of Hd-R at 450–510℃.

关键词： oil shale Pyrolysis Kerogen organic carbon Thermal bitumen Shale oil

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