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Network pharmacology and molecular dynamics study of the effect of the Astragalus-Coptis drug pair on diabetic kidney disease

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World Journal of Diabetes 2024年第7期15卷 1562-1588页

作者： mo-yan zhang Shu-Qin Zheng Liaoning University of Traditional Chinese Medicine Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110032Liaoning ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is the primary cause of end-stage renal *** Astragalus-Coptis drug pair is frequently employed in the management of ***,the precise molecular mechanism underlying its therapeutic effect remains *** To investigate the synergistic effects of multiple active ingredients in the Astragalus-Coptis drug pair on DKD through multiple targets and *** The ingredients of the Astragalus-Coptis drug pair were collected and screened using the TCMSP database and the SwissADME *** targets were predicted using the SwissTargetPrediction database,while the DKD differential gene expression analysis was obtained from the Gene Expression Omnibus *** targets were acquired from the GeneCards,Online Mendelian Inheritance in Man database,and DisGeNET databases,with common targets identified through the Venny *** protein-protein interaction network and the“disease-active ingredient-target”network of the common targets were constructed utilizing the STRING database and Cytoscape software,followed by the analysis of the interaction relationships and further screening of key targets and core active *** Ontology(GO)function and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed using the DAVID *** tissue and organ distributions of key targets were *** and AutoDock software validate the molecular docking between the core ingredients and key ***,molecular dynamics(MD)simulations were conducted to simulate the optimal complex formed by interactions between core ingredients and key target *** A total of 27 active ingredients and 512 potential targets of the Astragalus-Coptis drug pair were *** were 273 common targets between DKD and the Astragalus-Coptis drug *** protein-protein interaction network topology analysis,we identified 9 core active ingredients and 10 key *** and KEGG pathwa

关键词： Astragalus membranaceus Coptis chinensis Franch Diabetic kidney disease Network pharmacology molecular docking molecular dynamics simulation

Synthesis and magnetic properties of CoPt nanoparticles

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Rare Metals 2006年第Z1期25卷 613-616页

作者： zhang Zhongyan WANG Hao WANG Hanbin mo Qi CHEN yan zhang Cong Faculty of Physics and Electronic Technology Hubei UniversityWuhan 430062China

CoPt nanoparticles were prepared by simultaneous thermally reducing Co(CH_(3)COO)_(2)and Pt(acac)_(2)in oleylamine with a small quantity of oleic *** composition of the particles was controlled by changing the amount of the *** electronic microscopy reveals that Co_(48)Pt_(52)particles with an average diameter of 8.4 nm are steadily dispersed in octane in the presence of oleylamine and oleic *** area electron diffraction indicates that the as-prepared particles have a face center cubic *** properties of these particles measured by a vibrate sample magnetometer yield a coercivity of 1.194×10^(4)A·m^(-1)and a saturation magnetization of 5.3 emu·g^(-1).After annealing at 650℃for 2 h under the flowing Ar,the coercivity increases to 9.552×10^(4)A·m^(-1)according to partly phase transformation from face center cubic structure to face center tetragonal structure for the nanoparticles.

关键词： magnetic media nanoparticles CoPt

Construction and Characterization of Novel Staphylokinase Variants with Antiplatelet Aggregation Activity and Reduced Immunogenecity

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Acta Biochimica et Biophysica Sinica 2004年第5期36卷 336-342页

作者： Hua-Bo SU, Yu-Gao zhang, Jin-Tian HE, Wei mo, yan-Ling zhang, Xian-Mei TAO, and Hou-yan SONG* Department of molecular Genetics, Shanghai Medical School, Fudan University, Key Laboratory of molecular Medicine, Ministry of Education, Shanghai 200032, China Department of molecular Genetics Shanghai Medical School Fudan University Key Laboratory of Molecular Medicine Ministry of Education Shanghai 200032 China

To develop target thrombolytic agents with fibrinolytic activity, antiplatelet aggregation activity and reduced immunogenicity, two staphylokinase variants containing Arg-Gly-Asp (RGD) motif were constructed. Gene expression was induced in E. coli JF1125 and the variants, designated DGR and RL1, were purified with gel filtration and ion-exchange chromatography and the purity was over 95%. The fibrinolytic activity and kinetic constants of the two variants were comparable to those of recombinant wild-type staphylokinase. Both the variants can inhibit the platelet aggregation at a final concentration of 2 μM. The titers of antibodies against variants were much lower than those against recombinant staphylokinase in guinea pigs, which indicated that the immunogenicity of the variants was greatly reduced. These results confirm that it is possible to design and produce a bifunctional protein that possesses fibrinolytic and antiplatelet aggrega- tion activities.

关键词： staphylokinase RGD antiplatelet aggregation immunogenicity

Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2018年第45期24卷 5154-5166页

作者： Li-yan Xue Xiu-Min Qin Yong Liu Jun Liang Hua Lin Xue-Min Xue Shuang-Mei Zou mo-yan zhang Bai-Hua zhang Zhou-Guang Hui Zi-Tong Zhao Li-Qun Ren Yue-Ming zhang Xiu-Yun Liu yan-Ling Yuan Jian-Ming Ying Shu-Geng Gao Yong-Mei Song Gui-Qi Wang Sanford M Dawsey Ning Lu Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Center for Cancer Precision Medicine Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Endoscopy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Record National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College The 2nd Department of Thoracic Surgery Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine CSU State Key Laboratory of molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology Chengde Medical College Metabolic Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute

AIM To identify the clinicopathological characteristics of pT1 N0 esophageal squamous cell carcinoma(ESCC) that are associated with tumor recurrence. METHODS We reviewed 216 pT1 N0 thoracic ESCC cases who underwent esophagectomy and thoracoabdominal two-field lymphadenectomy without preoperative chemoradiotherapy. After excluding those cases with clinical follow-up recorded fewer than 3 mo and those who died within 3 mo of surgery, we included 199 cases in the current analysis. Overall survival and recurrencefree survival were assessed by the Kaplan-Meier method, and clinicopathological characteristics associated with any recurrence or distant recurrence were evaluated using univariate and multivariate Cox proportional hazards models. Early recurrence(≤ 24 mo) and correlated parameters were assessed using univariate and multivariate logistic regression *** Forty-seven(24%) patients had a recurrence at 3 to 178(median, 33) mo. The 5-year recurrence-free survival rate was 80.7%. None of 13 asymptomatic cases had a recurrence. Preoperative clinical symptoms, upper thoracic location, ulcerative or intraluminal mass macroscopic tumor type, tumor invasion depth level, basaloid histology, angiolymphatic invasion, tumor thickness, submucosal invasion thickness, diameter of the largest single tongue of invasion, and complete negative aberrant p53 expression were significantly related to tumor recurrence and/or recurrence-free survival. Upper thoracic tumor location, angiolymphatic invasion, and submucosal invasion thickness were independent predictors of tumor recurrence(Hazard ratios = 3.26, 3.42, and 2.06, P mogram for predicting recurrence-free survival with these three predictors was constructed. Upper thoracic tumor location and angiolymphatic invasion were independent predictors of distant recurrence. Upper thoracic tumor location, angiolymphatic invasion, submucosal invasion thickness, and diameter o

关键词： Esophageal squamous cell carcinoma Tumor recurrence Lymph node negative esophageal cancer Recurrence-free survival Clinicopathological parameters

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang yanyu zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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太阳线性无力场评注和快速傅氏分析法的应用

天文学报 2004年第4期45卷 361-380页

作者：宋慕陶张延安中国科学院紫金山天文台南京210008

首先对30年来用无力场计算太阳活动区磁场方法作了一些评注,特别研究了线性无力场解中的几个误区.提出了准线性无力场方法并探讨了快速傅氏变换在线性无力场计算中的应用.以2000年9月15日NOAA 9165活动区磁场为例,应用3种不同的方法计... 详细信息

首先对30年来用无力场计算太阳活动区磁场方法作了一些评注,特别研究了线性无力场解中的几个误区.提出了准线性无力场方法并探讨了快速傅氏变换在线性无力场计算中的应用.以2000年9月15日NOAA 9165活动区磁场为例,应用3种不同的方法计算出磁力线走向,然后同紫金山天文台赣榆观测站观测的精细Hα图形对比.

关键词：力场线性磁场准线图形分析法太阳活动紫金山天文台 NOAA 快速傅氏变换

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun zhang Xiaoyun Wang Shuai Wang yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng zhang Fenrong Liu Haorun Li yan Wang Xiaojun Gu Shanghong Zeng Inner mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Oxygen vacancy Hydrocarbon production Reaction mechanism