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BrcaSeg:A Deep Learning Approach for Tissue Quantification and Genomic Correlations of Histopathological Images

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 1032-1042页

作者： Zixiao Lu Xiaohui Zhan Yi Wu Jun Cheng Wei Shao Dong Ni Zhi han Jie zhang Qianjin Feng Kun Huang Guangdong Provincial Key Laboratory of Medical Image Processing School of Biomedical EngineeringSouthern Medical UniversityGuangzhou 510515China National-Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518060China Department of Medicine Indiana University School of MedicineIndianapolisIN 46202USA Department of Medical and molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisIN 46202USA Regenstrief Institute IndianapolisIN 46202USA

Epithelial and stromal tissues are components of the tumor microenvironment and play a major role in tumor initiation and *** stroma from epithelial tissues is critically important for spatial characterization of the tumor ***,we propose BrcaSeg,an image analysis pipeline based on a convolutional neural network(CNN)model to classify epithelial and stromal regions in whole-slide hematoxylin and eosin(H&E)stained histopathological *** CNN model is trained using well-annotated breast cancer tissue microarrays and validated with images from The Cancer Genome Atlas(TCGA)*** achieves a classification accuracy of 91.02%,which outperforms other state-of-the-art *** this model,we generate pixel-level epithelial/stromal tissue maps for 1000 TCGA breast cancer slide images that are paired with gene expression *** subsequently estimate the epithelial and stromal ratios and perform correlation analysis to model the relationship between gene expression and tissue *** Ontology(GO)enrichment analyses of genes that are highly correlated with tissue ratios suggest that the same tissue is associated with similar biological processes in different breast cancer subtypes,whereas each subtype also has its own idiosyncratic biological processes governing the development of these *** all together,our approach can lead to new insights in exploring relationships between image-based phenotypes and their underlying genomic events and biological processes for all types of solid *** can be accessed at https://***/Serian1992/ImgBio.

关键词： Whole-slide tissue image Computational pathology Deep learning Integrative genomics Breast cancer

Simultaneous Stabilization for a Collection of Multi-input Nonlinear Systems with Uncertain Parameters

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自动化学报 2009年第2期35卷 206-209页

作者： CAI Xiu-Shan han Zheng-Zhi zhang Wei College of Mathematics Physics and Information Engineering Zhejiang Normal University Jinhua 321004 P. R. China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China

Simultaneous stabilization for a collection of multi-input nonlinear systems with uncertain parameters is dealt with in this paper. A systematic method for obtaining a control Lyapunov function (CLF) is presented by solving the Lyapunov equation. A sufficient condition that a quadratic CLF is a common CLF for these systems is acquired. A continuous state feedback is designed to simultaneously stabilize these systems. Finally, the effectiveness of the proposed scheme is illustrated by a simulation example.

关键词：不确定非线性系统仿真系统自动化技术分析方法

Synthesis of super absorbent resin from starch/bentonite

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Synthesis of super absorbent resin from starch/bentonite

The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities

第八届中国功能材料及其应用学术会议

作者： WANG Rui-jie YANG Lian-wei zhang han-dan GENG Tie-jun School of Resources and Materials Northeastern University at Qinhuangdao Branch Dalian Changxing Island Senior High School

ISBN: (纸本)9783037859698

The compound super absorbent resin was synthesized by starch,bentonite,acrylic acid and acrylamide,using microwave *** key factors affecting the solution absorbency of the polymer such as the amount of bentonite,acrylamide,initiator and cross-linking agent have been *** results showed that the optimal reaction conditions of cross-linking agent,initiator,neutralization degree,bentonite,phosphate starch are 0.045%,0.32%,70%,10%,3%when the weight ratio of acrylic acid and acrylamide was 2:1,the microwave power was 800 W,the radiation time was 15 *** the conditions,the pure water absorption rate of super absorbent resin was up to 796g/*** the weight ratio of acrylic acid and acrylamide was 1:1,the absorption rate of 0.9%NaCl was 95g/g.

关键词： Bentonite Acrylanide Liquid absorbency rate Microwave irradiation

来源： cnki会议评论

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Food Science and Human Wellness 2023年第5期12卷 1590-1600页

作者： Ningxuan Gao Xu Si Wenzhong han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue zhang Binxu Li Bin Li Department of Food Science College of FoodShenyang Agricultural UniversityShenyang 110161China National R&D Professional Center For Berry Processing Shenyang 110161China Agriculture and Forest Institute in Arid of Liaoning Chaoyang 122000China

Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducted to determine polyphenol composition from 7 chokeberry varieties produced in China. Totally, 11 kinds of main polyphenol monomers were identified and quantified by UPLC-Q-TOF-MS and UPLC-PDA. HepG2 cells were used to evaluate their cellular antioxidant and antiproliferative activities. Partial least squares method was utilized to analyze multivariate correlations between proportion of different composition and monomers in total polyphenols with these activities. The results showed that the highest proportion in chokeberry polyphenols was proanthocyanidins. In comparing the bioactivities of 7 varieties of chokeberry, ‘Viking' and purple chokeberry had the strongest antioxidant activity, while 'Fukangyuan 1#' had the strongest antiproliferative activity. In terms of the contribution sources of these bioactivities, the total antioxidant activity of chokeberry mainly depended on the contribution of free polyphenols. As the main source of cellular antioxidant activity, anthocyanins and neochlorogenic acid can provide more contribution. The antiproliferative activity mainly depended on the proportion of free polyphenols and proanthocyanidins in total polyphenols. The results may provide some new possibilities for the comprehensive utilization of polyphenols from chokeberry.

关键词： Chokeberry Anthocyanins Proanthocyanidins Antioxidant Antiproliferation

Girvanella fossils from the Phanerozoic:Distribution,evolution and controlling factors

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Journal of Palaeogeography 2024年第4期13卷 924-938页

作者： Hua-Shan zhang Ming-Yue Dai Yong-An Qi Lan-Lan han Zhong-Lei Yin Song-Hua Chen Liang-Biao Lin Institute of Sedimentary Geology Chengdu University of TechnologyChengdu 610059Sichuan ProvinceChina School of Resources and Environment Henan Polytechnic UniversityJiaozuo 454003Henan ProvinceChina

Girvanella is one of the common genera of cyanobacteria that plays a monumental role in the evolution of life on Earth and the formation of *** on a detailed search in the literature of Girvanella fossils,we have compiled a global database of Girvanella fossils and revealed the evolution of Girvanella fossils throughout the *** species,Girvanella kasakiensis,Girvanella problematica,Girvanella wetheredii,and Girvanella staminea,are recognized and *** data show that Girvanella fossils have well-defined temporal distribution during the Paleozoic Era,have a significant temporal gap in the Mesozoic Era,and have only been recorded sporadically in the Cenozoic *** were relatively abundant during the Cambrian Epoch 2-Early Ordovician,Late Ordovician,Late Devonian-Mississippian,and tended to lesser degrees during the Silurian-Early Devonian,Lopingian Epoch-Middle Jurassic,and Cretaceous-Present ***,the evolution of the abundance and diversity of Girvanella fossils was fundamentally consistent and showed episodical declining during the *** further explore these relationships,we thoroughly compared them with environmental factors such as seawater carbonate saturation state,Ca^(2+)concentration,pH values,and atmospheric partial pressure of carbon dioxide(p CO_(2)).This study indicates that seawater carbonate saturation state and Ca^(2+)concentration are major controls on secular patterns of the abundance and diversity of Girvanella fossils,together with the secondary factors of pH values and p CO_(2).Considering the long history of Girvanella fossils,their abundance and diversity offer the potential to assist the interpretation of the long-term evolution of marine and atmosphere components during the Phanerozoic.

关键词： Girvanella Temporal distribution Abundance Diversity Control factors

Incidence and prevalence levels of three aphid-transmitted viruses in crucifer crops in China

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Journal of Integrative Agriculture 2022年第3期21卷 774-780页

作者： zhang Xiao-yan PENG Yan-mei XIANG Hai-ying WANG Ying LI Da-wei YU Jia-lin han Cheng-gui State Key Laboratory for Agrobiotechnology Ministry of Agriculture and Rural Affairs/Key Laboratory of Pest Monitoring and Green ManagementChina Agricultural UniversityBeijing 100193P.R.China College of Agriculture Ludong UniversityYantai 264025P.R.China

Poleroviruses,which are distributed worldwide,infect many crops of economic importance and cause severe plant *** yellows virus(Br YV),which has three genotypes,A,B,and C,is a newly identified polerovirus infecting crucifer crops in China,but its distribution is still ***,we report the distribution and prevalence levels of the three Br YV genotypes in crucifer crops in China.A total of 570 crucifer leaf samples randomly collected from 22 provinces,four ethnic minority autonomous regions,and three municipalities in China were tested for Br ***-PCR detection showed that 97 of the field samples were positive for Br YV,and the average incidence of Br YV was 17.0%.The virus was detected in 22 provinces,with high incidences in north,northwest,and northeast *** multiplex RT-PCR amplification of the three Br YV genotypes revealed that both single and mixed infections *** the Br YV infections,38.1% were mixinfected by more than two viral genotypes,and 8.2% samples were mix-infected by three viral *** findings indicated a widespread prevalence of Br YV in China,and Br YV mixed infections with Turnip mosaic virus and Cucumber mosaic virus in crucifer crops are *** study is the first large-scale survey of Br YV in crucifer crops in *** information generated in this investigation will contribute to the national prevention and control of viral diseases.

关键词： Brassica yellows virus three genotypes incidence crucifer crops

Quantitative dual-energy computed tomography texture analysis predicts the response of primary small hepatocellular carcinoma to radiofrequency ablation

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 569-576页

作者： Jin-Ping Li Sheng Zhao Hui-Jie Jiang Hao Jiang Lin-han zhang Zhong-Xing Shi Ting-Ting Fan Song Wang Department of Radiology the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Nuclear Medicine the First Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Radiology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Background:Radiofrequency ablation(RFA)is one of the effective therapeutic modalities in patients with hepatocellular carcinoma(HCC).However,there is no proper method to evaluate the HCC response to *** study aimed to establish and validate a clinical prediction model based on dual-energy com-puted tomography(DECT)quantitative-imaging parameters,clinical variables,and CT texture ***:We enrolled 63 patients with small *** to four weeks after RFA,we performed DECT scanning to obtain DECT-quantitative parameters and to record the patients’clinical baseline *** images were manually segmented,and 56 CT texture features were *** used LASSO al-gorithm for feature selection and data dimensionality reduction;logistic regression analysis was used to build a clinical model with clinical variables and DECT-quantitative parameters;we then added texture features to build a clinical-texture model based on clinical ***:A total of six optimal CT texture analysis(CTTA)features were selected,which were statis-tically different between patients with or without tumor progression(Pmodels showed that albumin-bilirubin grade(ALBI)[odds ratio(OR)=2.77,95%confidence interval(CI):1.35-6.65,P=0.010],λAP(40-100 keV)(OR=3.21,95%CI:3.16-5.65,P=0.045)and IC AP(OR=1.25,95%CI:1.01-1.62,P=0.028)were asso-ciated with tumor progression,while the clinical-texture models showed that ALBI(OR=2.40,95%CI:1.19-5.68,P=0.024),λAP(40-100 keV)(OR=1.43,95%CI:1.10-2.07,P=0.019),and CTTA-score(OR=2.98,95%CI:1.68-6.66,P=0.001)were independent risk factors for tumor *** clinical model,clinical-texture model,and CTTA-score all performed well in predicting tumor progression within 12 months after RFA(AUC=0.917,0.962,and 0.906,respectively),and the C-indexes of the clinical and clinical-texture models were 0.917 and 0.957,***:DECT-quantitative

关键词： Hepatocellular carcinoma Dual-energy Radiofrequency ablation Tumor response Texture analysis

CsI-bowl:an ancillary detector for exit channel selection inγ-ray spectroscopy experiments

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Nuclear Science and Techniques 2023年第9期34卷 32-39页

作者： Xing-Chi han Shuo Wang Hong-Yi Wu Zhi-Huan Li Guo-Zhu Shi Ruo-Fu Chen Yue-Zhao zhang Shou-Yu Wang Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and PhysicsInstitute of Space SciencesShandong UniversityWeihai 264209China WeiHai Research Institute of Industrial Technology of Shandong University Weihai 264209China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China Institute of modern Physics Chinese Academy of SciencesLanzhou 73000China

A particle detector array designed for light-charged particles, known as the CsI-bowl, was built for exit channel selection for in-beam γ-ray spectroscopy experiments. This device is composed of 64 CsI(Tl) detectors, organized in a structure reminiscent of a tea-bowl. High quantum efficiency photodiodes, characterized by their minimal mass, were employed to collect scintillation light. Its design, construction, particle identification resolution, and its effectiveness in relation to exit channel selection are described in this paper. In source tests, the optimal figure of merit for the identification of α-particles and γ-rays using the charge comparison method was found to be 3.3 and 12.1 for CsI detectors coupled to photodiodes and avalanche photodiodes, respectively. The CsI-bowl demonstrated effectiveness in identifying particles, specifically the emission of protons and α-particles in the58Ni(19F, xpyn) fusion–evaporation reaction, thereby enabling the selection of the desired exit channels.

关键词： Light charged particle detector array Particle identification Charge comparison method

Intermediate state of hexagonal close-packed structure to face-centered cubic structure transformation: Direct evidence for basal-type face-centered cubic phase via partial dislocation in zirconium

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Journal of Materials Science & Technology 2022年第3期98卷 44-50页

作者： Fusen Yuan Fuzhou han Yingdong zhang Ali Muhammad Wenbin Guo Jie Ren Chengze Liu Hengfei Gu Geping Li Gaihuan Yuan Shi-changxu Innovation Center For Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of China96 JinZhai RoadBaohe DistrictHefei 230026China University of Chinese Academy of Sciences 19 Yuquan RoadBeijing 100049China State Nuclear Bao Ti Zirconium Industry Company Baoji 721013China

*** Zirconium(Zr)and its alloys show great applications in nuclear and chemical industry thanks to their appropriate mechanical properties,low thermal neutron absorption cross-section and excellent corrosion resistance[1–3].Zr displays three different crystal structures on the temperature-pressure phase diagram:the hexagonal close-packed structure(HCP,α-Zr),the body centered cubic structure(BCC,β-Zr)and the simple hexagonal structure(ω-Zr).

关键词： transformation corrosion hexagonal