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Small RNAs:An expanding world with therapeutic promises

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Fundamental Research 2023年第5期3卷 676-682页

作者： Lan-Tao Gou Qifan Zhu mo-fang liu State Key Laboratory of molecular Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China

Small non-coding RNAs(sncRNAs),such as microRNAs(miRNAs),small interfering RNAs(siRNAs),PIWIinteracting RNAs(piRNAs),and transfer RNA(tRNA)-derived small RNAs(tsRNAs),play essential roles in regulating various cellular and developmental *** the past three decades,researchers have identified novel sncRNA species from various *** molecules demonstrate dynamic expression and diverse functions,and they are subject to intricate regulation through RNA modifications in both healthy and diseased ***,certain sncRNAs in gametes,particularly sperm,respond to environmental stimuli and facilitate epigenetic ***,the in-depth understanding of sncRNA functions and mechanisms has accelerated the development of small RNA-based *** this review,we present the recent advances in the field,including new sncRNA species and the regulatory influences of RNA *** also discuss the current limitations and challenges associated with using small RNAs as either biomarkers or therapeutic drugs.

关键词： Small non-coding RNAs RNA modifications Human diseases RNA therapeutics Biomarkers

Exploring noncoding variants in genetic diseases:from detection to functional insights

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Journal of Genetics and Genomics 2024年第2期51卷 111-132页

作者： Ke Wu Fengxiao Bu Yang Wu Gen Zhang Xin Wang Shunmin He mo-fang liu Runsheng Chen Huijun Yuan Institute of Rare Diseases West China Hospital of Sichuan UniversityChengduSichuan 610041China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China Key Laboratory of RNA Biology Center for Big Data Research in HealthInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of molecular Biology State Key Laboratory of Cell BiologyShanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceChinese Academy of SciencesShanghai 200031China

Previous studies on genetic diseases predominantly focused on protein-coding variations, overlooking the vast noncoding regions in the human genome. The development of high-throughput sequencing technologies and functional genomics tools has enabled the systematic identification of functional noncoding variants. These variants can impact gene expression, regulation, and chromatin conformation, thereby contributing to disease pathogenesis. Understanding the mechanisms that underlie the impact of noncoding variants on genetic diseases is indispensable for the development of precisely targeted therapies and the implementation of personalized medicine strategies. The intricacies of noncoding regions introduce a multitude of challenges and research opportunities. In this review, we introduce a spectrum of noncoding variants involved in genetic diseases, along with research strategies and advanced technologies for their precise identification and in-depth understanding of the complexity of the noncoding genome. We will delve into the research challenges and propose potential solutions for unraveling the genetic basis of rare and complex diseases.

关键词： Noncoding variation Genetic disease Research approach Challenge

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The new function of PIWI and pi RNAs in mammalian spermiogenesis

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The new function of PIWI and pi RNAs in mammalian spermiogen...

Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

中国生物化学与分子生物学会2016年全国学术会议

作者： mo-fang liu Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological SciencesChinese Academy of Sciences

mouse contains three PIWI homologs,MIWI,MILI and MIWI2,whichare highly expressed in testesandrequired for male *** miceis characterized by two waves of pi RNA expression:one corresponds to classic pi RNAs responsible for silencing retrotransponsons and the second wave is predominantly derived from non-transposon intergenic regions in pachytene spermatocytes,but the

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Tungsten 2025年第1期7卷 80-87页

作者： fang-Qian Wang Yin Zhang Wei-Wei Wang Mei-Qian Fu Hong-Bing mo Wei-Dong Yu Chao liu Jun Yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

LARP7-Mediated U6 snRNA modification Ensures Splicing Fidelity and Spermatogenesis in Mice

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LARP7-Mediated U6 snRNA Modification Ensures Splicing Fideli...

Pachytene piRNAs Instruct Massive mRNA Elimination during LateSpermiogenesis

中国生物化学与分子生物学会2019年全国学术会议暨学会成立四十周年

作者： Xin Wang Zhi-Tong Li Yue Yan mo-fang liu State Key Laboratory of molecular Biology Shanghai Key Laboratory of Molecular Andrology CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences-University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University

U6 snRNA, as an essential component of the catalytic core of the pre-mRNA processing spliceosome, is heavily modified post-transcriptionally with 2’-O-methylation being most common. The role of these modifications in pre-mRNA splicing, as well as their physiological function in mammals, has remained largely unclear. Here, we report that the La-related protein LARP7 functions as a critical cofactor for the 2’-O-methylation of U6 in mouse male germ cells. Mechanistically, LARP7 promotes U6 loading onto box C/D snoRNP, thereby facilitating U6 2’-O-methylation by box C/D snoRNP. Importantly, ablation of LARP7 in the male germline causes defective U6 2’-O-methylation, massive alterations in pre-mRNA splicing, and spermatogenic failure in mice, which can be rescued by ectopic expression of wildtype LARP7 but not an U6-loading deficient mutant LARP7. Our data uncover a novel role for LARP7 in regulating U6 2’-O-methylation and demonstrate the functional requirement of such modification for splicing fidelity and spermatogenesis in mice.

关键词： U6 snRNA 2’-O-methylation LARP7 box C/D snoRNP pre-mRNA splicing spermatogenesis

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Pachytene piRNAs Instruct Massive mRNA Elimination during La...

Preparation and applications of calcium ferrite as a functional material:A review

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： Lan-Tao Gou Peng Dai Jian-Hua Yang En-Duo Wang mo-fang liu Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences State Key Laboratory of Biocontrol Sun Yat-sen University

Spermatogenesis in mammals is characterized by two waves of piRNA expression:one correspondsto classic piRNAs responsible for silencing retrotransponsons and the secondwave is predominantly derived from non-transposon intergenic regions in pachytene spermatocytes,but the function of these pachytene piRNAs is largely ***,we reportthe involvement of pachytene piRNAs in instructing massive mRNA elimination inmouse elongating *** demonstrate that a piRNA-induced silencing complex(pi-RISC)containing murine PIWI(MIWI)and deadenylase CAF1 is selectively assembled inelongating spermatids,which is responsible for inducing mRNA deadenylation and decayvia a mechanism that resembles the action of miRNAs in somatic *** a highly orchestratedprogram appears to take full advantage of the enormous repertoire of diversifiedtargeting capacity of pachytene piRNAs derived from non-transposon intergenic *** findings suggest that pachytene piRNAs are responsible for inactivating vastcellular programs in preparation for sperm production from elongating spermatids.

关键词： pachytene piRNAs MIWI CAF1 pi-RISC mRNA deadenylation elongatings permatids

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen Duan Lei liu Shilong fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei liu Yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin liu Xiaodong Li Junfeng fang Zhiwei fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

Different outcome of the PIWI-APC/C interplay during spermatogenesis and tumorigenesis

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Different outcome of the PIWI-APC/C interplay during spermat...