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Branch Processes of Regular Magnetic monopole

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Communications in Theoretical Physics 2009年第2期51卷 293-298页

作者： mo shu-Fan REN Ji-Rong ZHU Tao Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper, by making use of Duan＇s topological current theory, the branch process of regular magnetic monopoles is discussed in detail. Regular magnetic monopoles are found generating or annihilating at the limit point and encountering, splitting, or merging at the bifurcation point and the degenerate point systematically of the vector order parameter field φ（x）. Furthermore, it is also shown that when regular magnetic monopoles split or merge at the degenerate point of field function φ, the total topological charges of the regular magnetic monopoles are stilI unchanged.

关键词： topological tensor current magnetic monopole branch theory high-dimensional topological defect

Knotted Topological Phase Singularities of Electromagnetic Field

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Communications in Theoretical Physics 2008年第11期50卷 1071-1076页

作者： REN Ji-Rong ZHU Tao mo shu-Fan Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper,knotted objects (RS vortices) in the theory of topological phase singularity in electromagneticfield have been investigated in *** using the Duan's topological current theory,we rewrite the topological currentform of RS vortices and use this topological current we reveal that the Hopf invariant of RS vortices is just the sum ofthe linking and self-linking numbers of the knotted RS ***,the conservation of the Hopf invariant inthe splitting,the mergence and the intersection processes of knotted RS vortices is also discussed.

关键词： knotted optical vortex topological current phase singularity

Branch Processes of Vortex Filaments and Hopf Invariant Constraint on Scroll Wave

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Communications in Theoretical Physics 2009年第12期52卷 1149-1156页

作者： ZHU Tao REN Ji-Rong mo shu-Fan Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

In this paper, by making use of Duan＇s topological current theory, the evolution of the vortex filaments in excitable media is discussed in detail. The vortex filaments are found generating or annihilating at the limit points and encountering, splitting, or merging at the bifurcation points of a complex function Z（x, t）. [t is also shown that the Hopf invariant of knotted scroll wave filaments is preserved in the branch processes （splitting, merging, or encountering） during the evolution of these knotted scroll wave filaments. Furthermore, it also revealed that the ＂exclusion principle＂ in some chemical media is just the special case of the Hopf invariant constraint, and during the branch processes the ＂exclusion principle＂ is also protected by topology.

关键词： scroll wave Hopf invariant topology of knot vortex filament

Progress in mechanisms of acetylcholinesterase inhibitors and memantine for the treatment of Alzheimer’s disease

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 274-280页

作者： Shao-Min Li Ming-shu mo Ping-Yi Xu Center for Neurologic Disease Department of NeurologyBrigham and Women’s HospitalHarvard Medical SchoolBostonMassachusetts 02115USA Department of Neurology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080GuangdongChina

Alzheimer’s disease(AD)is the most common causes of dementia in the ***,only two classes of drugs,acetylcholinesterase inhibitors(AChEIs)and memantine are *** ameliorate cognitive and psychiatric symptoms in AD patients through activation of acetylcholine(ACh)receptors by increased synaptic ACh levels and also have protective effects against glutamate neurotoxicity and inflammation,whereas memantine appears to mainly protect against excitotoxicity and ***,we review the pharmacologic properties of the available AChEIs and memantine,and focus on recent progress in the mechanisms of AD in relation to acetylcholinergic and glutamatergic involvement.

关键词： Alzheimer’s disease amyloid‑βpeptide donepezil memantine tau

Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function

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Translational Neurodegeneration 2015年第1期4卷 76-83页

作者： Lei Wei Li Ding Ming-shu mo Ming Lei Limin Zhang Kang Chen Pingyi Xu Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Neurology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of pathology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Neurology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Division of Clinical Laboratory Zhongshan Hospital of Sun Yat-sen UniversityZhongshan 528403China

Background:Wnt/β-catenin signal has been reported to exert cytoprotective effects in cellular models of several diseases,including Parkinson’s disease(PD).This study aimed to investigate the neuroprotective effects of actived Wnt/β-catenin signal by Wnt3a on SH-SY5Y cells treated with 6-hydroxydopamine(6-OHDA).Methods:Wnt3a-conditioned medium(Wnt3a-CM)was used to intervene dopaminegic SH-SY5Y cells treated with *** toxicity was determined by cell viability and lactate dehydrogenase leakage(LDH)*** mitochondria function was measured by the mitochondrial membrane potential,while oxidative stress was monitored with intracellular reactive oxygen species(ROS).Western blot analysis was used to detect the expression of GSK3β,β-catenin as well as ***:Our results showed that 100μM 6-OHDA treated for 24 h significantly decreased cell viability and mitochondrial transmembrane potential,reduced the level ofβ-catenin and p-Akt,increased LDH leakage,ROS production and the ratio of p-GSK3β(Tyr216)to p-GSK3β(Ser9).However,Wnt3a-conditioned medium reversing SH-SY5Y cells against 6-OHDA-induced neurotoxicity by reversing these ***:Activating of Wnt/β-catenin pathway by Wnt3a-CM attenuated 6-OHDA-induced neurotoxicity significantly,which related to the inhibition of oxidative stress and maintenance of normal mitochondrial function.

关键词： Wnt3a 6-OHDA Mitochondria function Parkinson’s disease

miR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis

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World Journal of Gastroenterology 2014年第46期20卷 17439-17447页

作者： Juan Xie Zhi-Hui Tan Xia Tang Ming-shu mo Yan-Ping Liu Run-Liang Gan Yi Li Li Zhang Guo-Qing Li Department of Gastroenterology the Second Affiliated Hospital of University of South China Department of Diagnostics Medical College of University of South China

AIM: To profile expression of microRNAs (miRNAs) in gastric cancer cells and investigate the effect of miR-374b-5p on gastric cancer cell invasion and metastasis.

关键词： Gastric cancer microRNAs microarray miR-374b-5p RECK Invasion and metastasis

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具有角速度和输入约束的航天器姿态协同控制

自动化学报 2021年第6期47卷 1444-1452页

作者：郑重李鹏钱默抒南京工业大学电气工程与控制科学学院南京211816 湘潭大学信息工程学院湘潭411105

提出了基于有向图的航天器姿态协同控制算法,并且系统的角速度和控制输入满足有界性的约束.当外部扰动存在时,设计了自适应算法估计扰动的上界,采用滤波器补偿的方法处理控制输入饱和问题,并且设计了新的自适应姿态协同控制算法.对于所... 详细信息

提出了基于有向图的航天器姿态协同控制算法,并且系统的角速度和控制输入满足有界性的约束.当外部扰动存在时,设计了自适应算法估计扰动的上界,采用滤波器补偿的方法处理控制输入饱和问题,并且设计了新的自适应姿态协同控制算法.对于所设计的控制算法,给出了稳定性分析,证明了系统具有几乎全局渐近稳定性.进一步把控制算法推广到时变通信时滞情况,当控制器参数满足一定条件时,仍然能够保证编队系统的几乎全局渐近稳定性.通过数值仿真,验证了所提出的控制方案的有效性.

关键词：角速度约束输入饱和姿态协同通信时滞渐近稳定

252kVSF6断路器灭弧室压力特性试验研究

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中国电机工程学报 2008年第15期28卷 130-135页

作者：林莘狄谦韩书谟沈阳工业大学电气工程学院辽宁省沈阳市110023 河南平高电气股份有限公司河南省平顶山市467001

SF6断路器内部机理的理论研究已相当深入,但多年来由于断路器灭弧室内部参数测量费用较高和试验周期较长,以及需要考虑测量方法对试验结果精确性的影响等,相应的试验验证工作却很少,理论工作缺乏指导。针对这一状况,该文对252kVSF6断路... 详细信息

SF6断路器内部机理的理论研究已相当深入,但多年来由于断路器灭弧室内部参数测量费用较高和试验周期较长,以及需要考虑测量方法对试验结果精确性的影响等,相应的试验验证工作却很少,理论工作缺乏指导。针对这一状况,该文对252kVSF6断路器的灭弧室内空载压力特性进行测量,并在灭弧室内压力缸、动静弧触头以及喷口上游、喉部和下游埋设7支微型硅压阻式压力传感器,通过改变断路器的基压和速度特性等结构参数,实现多点、多位置的多次测量,取得完整的灭弧室内动态压力特性变化的试验数据;分析了灭弧室动态压力变化与开断时间的关系。试验结果符合断路器的开断规律。

关键词： SF6断路器灭弧室压力特性试验

Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo

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Translational Neurodegeneration 2018年第1期7卷 175-186页

作者： Ming-shu mo Gui-Hua Li Cong-Cong Sun shu-Xuan Huang Lei Wei Li-Min Zhang Miao-Miao Zhou Zhuo-Hua Wu Wen-Yuan Guo Xin-Ling Yang Chao-Jun Chen Shao-Gang Qu Jian-Xing He Ping-Yi Xu Department of Neurology First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120GuangdongChina Department of Neurology Qilu Hospital of Shandong UniversityJinan 250012ShandongChina Department of Neurology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina Department of Neurology Second Affiliated Hospital of Xinjiang Medical UniversityUrumchi 830011XinjiangChina Clinic Brain Center Guangzhou Hospital of Integrated Traditional and Western MedicineGuangzhou 510800GuangdongChina Department of Blood Transfusion Fifth Affiliated Hospital Southern Medical UniversityGuangzhou 510900GuangdongChina Department of Thoracic Surgery First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120Guangdong China

Background:Abnormal expression of major histocompatibility complex class I(MHC-I)is increased in dopaminergic(DA)neurons in the substantia nigra(SN)in Parkinson’s disease(PD).Low-molecular-mass protein 7(β5i)is a proteolytic subunit of the immunoproteasome that regulates protein degradation and the MHC pathway in immune ***:In this study,we investigated the role of β5i in DA neurons using a 6-hydroxydopamine(6-OHDA)model in vitro and ***:We showed that 6-OHDA upregulatedβ5i expression in DA neurons in a concentration-and time-dependent *** and downregulation ofβ5i induced the expression of glucose-regulated protein(Bip)and exacerbated 6-OHDA neurotoxicity in DA *** inhibition of β5i further promoted the activation of Caspase 3-related pathways induced by 6-OHDA.β5i also activated transporter associated with antigen processing 1(TAP1)and promoted MHC-I expression on DA ***:Taken together,our data suggest that β5i is activated in DA neurons under 6-OHDA treatment and may play a neuroprotective role in PD.

关键词： Parkinson’s disease 6-hydroxydopamine Immunoproteasome TAP1