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真菌发酵对中药化学成分的转化及应用研究进展

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中国酿造 2024年第6期43卷 21-26页

作者：赖晓微邓可众罗梦甜刘佳李楠熊英江西中医药大学药学院江西南昌330004

真菌发酵可以使中药化学成分发生糖基化、羟基化、甲基化等多种化学反应,并产生丰富的次生代谢产物,具有效率高、条件温和、选择性强、不污染环境、反应类型多等优势,但发酵过程的稳定性和可控性一直是个难题。该文概括了中药发酵技术... 详细信息

真菌发酵可以使中药化学成分发生糖基化、羟基化、甲基化等多种化学反应,并产生丰富的次生代谢产物,具有效率高、条件温和、选择性强、不污染环境、反应类型多等优势,但发酵过程的稳定性和可控性一直是个难题。该文概括了中药发酵技术及常用于发酵中药的真菌,综述了中药化学成分(黄酮、生物碱、甾体、萜类、醌类、苯丙素)的转化机制,并总结了真菌发酵中药常见菌种在中药成分转化中的应用,为后续合理利用真菌进行中药成分研究与开发提供参考依据。

关键词：真菌发酵中药化学成分转化机制应用

重庆市居民膳食n-3多不饱和脂肪酸摄入与2型糖尿病相关性研究

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现代预防医学 2024年第10期51卷 1780-1786页

作者：赖英旭罗书全陈京蓉李继斌重庆医科大学公共卫生学院重庆市疾病预防控制中心

目的分析重庆市居民膳食n-3多不饱和脂肪酸与2型糖尿病发病关系，为2型糖尿病防治措施提供参考。方法利用中国居民营养与健康随访研究(2021)CNNHS在重庆市收集的横断面调查数据，结合中国食物成分表计算能量与营养素摄入量，使用单因... 详细信息

目的分析重庆市居民膳食n-3多不饱和脂肪酸与2型糖尿病发病关系，为2型糖尿病防治措施提供参考。方法利用中国居民营养与健康随访研究(2021)CNNHS在重庆市收集的横断面调查数据，结合中国食物成分表计算能量与营养素摄入量，使用单因素和多因素Logistic回归模型分析n-3多不饱和脂肪酸摄入与2型糖尿病的关联。结果本次研究最终纳入1 511例研究对象，2型糖尿病患者共280例，占18.80%。与动物性来源n-3多不饱和脂肪酸最低四分位数的研究对象相比，较高四分位数研究对象患糖尿病的风险更低(OR=0.61,95%CI:0.42～0.88),调整后的模型1与模型2结果相似(模型1,OR=0.64,95%CI:0.44～0.94;模型2,OR=0.66,95%CI:0.44～0.98)。其中，模型2中摄入植物性来源n-3多不饱和脂肪酸较高者患糖尿病的风险更低(OR=0.48,95%CI:0.24～0.98)。结论膳食中动物性来源n-3 PUFA和植物性来源n-3 PUFA与2型糖尿病发病呈负相关，动物性来源n-3 PUFA与2型糖尿病相关性在调整混杂因素后减弱，但摄入植物性来源n-3 PUFA较高对糖尿病发病的保护作用最强。

关键词： n-3多不饱和脂肪酸 2型糖尿病横断面研究

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误诊为疱疹样皮炎的小疱性类天疱疮1例

中国皮肤性病学杂志 2024年第1期38卷 97-99页

作者：洪毅勇高亦冯黄影朱琳赖维龚子鉴中山大学附属第三医院皮肤性病科广东广州510630

患者女,33岁,反复面部红斑、水疱伴痒1年,泛发全身12 d。皮损组织病理示:(左小腿皮损)表皮下水疱形成,疱腔内见纤维素样坏死及较多嗜酸性粒细胞,疱下真皮浅层中等量淋巴细胞、少量嗜酸性粒细胞浸润。免疫荧光结果:基底膜线性C3(+)。HLA... 详细信息

患者女,33岁,反复面部红斑、水疱伴痒1年,泛发全身12 d。皮损组织病理示:(左小腿皮损)表皮下水疱形成,疱腔内见纤维素样坏死及较多嗜酸性粒细胞,疱下真皮浅层中等量淋巴细胞、少量嗜酸性粒细胞浸润。免疫荧光结果:基底膜线性C3(+)。HLA-B8、HLA-DRB1、HLA-DQB1基因检测阴性。诊断:小疱性类天疱疮。予米诺环素、烟酰胺及复方甘草酸苷口服治疗后皮疹减轻。

关键词：类天疱疮小疱性疱疹样皮炎

Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia risk:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第11期10卷 3449-3460页

作者： Li-ying Zhao Xue-lai Zhou Department of Geriatrics Traditional Chinese Medical Hospital of ZhujiZhuji 311800Zhejiang ProvinceChina Department of Respiratory Medicine Traditional Chinese Medical Hospital of ZhujiZhuji 311800Zhejiang ProvinceChina

BACKGROUND Chronic obstructive pulmonary disease(COPD)is a common public health issue that has been linked to cognitive *** To investigate the relationship between COPD and a risk of mild cognitive impairment(MCI)and *** A comprehensive literature search of the PubMed,Embase,Google Scholar,and Cochrane Library electronic databases was *** odds ratios(OR)and mean differences(MD)with 95%confidence intervals(CIs)were calculated using a random or fixed effects *** that met the inclusion criteria were assessed for quality using the Newcastle Ottawa *** Twenty-seven studies met all the inclusion ***-analysis yielded a strong association between COPD and increased risk of MCI incidence(OR=2.11,95%CI:1.32-3.38).It also revealed a borderline trend for an increased dementia risk in COPD patients(OR=1.16,95%CI:0.98-1.37).Pooled hazard ratios(HR)using adjusted confounders also showed a higher incidence of MCI(HR=1.22,95%CI:-1.18 to-1.27)and dementia(HR=1.32,95%CI:-1.22 to-1.43)in COPD patients.A significant lower mini-mental state examination score in COPD patients was noted(MD=-1.68,95%CI:-2.66 to-0.71).CONCLUSION Our findings revealed an elevated risk for the occurrence of MCI and dementia in COPD *** clinical management and attention are required to prevent and control MCI and dementia incidence in COPD patients.

关键词： Mild cognitive impairment Chronic obstructive pulmonary disease Dementia Meta-analysis

A Novel C2-Domain Phospholipid-Binding Protein, OsPBP1, Is Required for Pollen Fertility in Rice

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molecular Plant 2008年第5期1卷 770-785页

作者： Wen-Qiang Yang ying lai Mei-Na Li Wen-ying Xu Yong-Biao Xue Institute of Genetics and Developmental Biology Chinese Academy of Sciences and National Centre for Plant Gene Research Beijing 100190 China Graduate School of Chinese Academy of Sciences Beijing 100049 China

Pollen fertility is a crucial factor for successful pollination and essential for seed formation. Recent studies have suggested that a diverse range of internal and external factors, signaling components and their related pathways are likely involved in pollen fertility. Here, we report a single C2-domain containing protein, OsPBP1, initially identified through cDNA microarray analysis. OsPBP1 is a single copy gene and preferentially expressed in pistil and pollen but downregulated by pollination. OsPBP1 had a calcium concentration-dependent phospholipid-binding activity and was localized mainly in cytoplasm and nucleus, but translocated onto the plasma membrane in response to an intracellular Ca^2＋ increase. Pollen grains of antisense OsPBP1 transgenic lines were largely nonviable, germinated poorly in vitro and of low fertility. OsPBP1 protein was localized in a region peripheral to pollen wall and vesicles of elongating pollen tube, and its repressed expression reduced substantially this association and led to alteration of microfilament polymerization during pollen germination. Taken together, these results indicate that OsPBP1 is a novel functional C2-domain phospholipids-binding protein that is required for pollen fertility likely by regulating Ca^2＋ and phospholipid signaling pathways.

关键词： rice (Oryza sativa L.) pollination pollen fertility OsPBP1 C2-domain phospholipid.

单层动力驱动双轨双层交叉带分拣机功率计算及仿真

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制造业自动化 2024年第4期46卷 129-136页

作者：唐英张靖赖志武李阳北京科技大学机械工程学院北京100089 中科微至智能制造科技江苏股份有限公司无锡214000

为应对包裹量的暴增局面,瞬时处理能力强的单层动力驱动双轨双层交叉带分拣机日受青睐。该类分拣机上下层结构复杂,运动部件众多,使用工况多变,其功率设计是设计人员首先遇到一个难题。为此,通过理论计算、建模仿真的功率分析方法来解... 详细信息

为应对包裹量的暴增局面,瞬时处理能力强的单层动力驱动双轨双层交叉带分拣机日受青睐。该类分拣机上下层结构复杂,运动部件众多,使用工况多变,其功率设计是设计人员首先遇到一个难题。为此,通过理论计算、建模仿真的功率分析方法来解决。首先,采用逐点计算法计算分拣机在直线段和圆弧段运行阻力,推导出驱动功率理论计算公式。其次,在基于Adams搭建的单层动力驱动双轨双层交叉带分拣机动力学模型和基于Simulink搭建的感应直线电机速度控制模型的基础上,进行Adams-Simulink联合动力学仿真,获得分拣机电机驱动力和驱动功率的仿真数据。最后,通过现场实验功率测试,与理论计算和仿真结果进行对比。结果显示,空载分拣机在常用的2.5m/s和2m/s两种分拣速度下,经过理论计算、仿真模拟以及现场实验测试获得功率数据基本相符。上述结果有效地证明了,理论计算公式和所建立的Adams-Simulink联合动力学仿真模型的正确性。功率计算公式方便了设计人员适应场地灵活安排设计方案进行电机选型;Adams-Simulink联合动力学仿真模型为设计人员后续有效实施关键零部件强度校核与优化创造了条件。

关键词：单层动力驱动双轨双层交叉带分拣机功率计算 Adams-Simulink联合仿真

Analytical and experimental bearing capacities of system scaffolds

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 82-92页

作者： Jui-lin PENG Tsong YEN ching-chi KUO Siu-lai CHAN Department of Construction Engineering National Yunlin University of Science and Technology Taiwan 64002 China Department of Civil Engineering Chaoyang University of Technology Taiwan 41349 China Department of Civil Engineering National Chung-Hsing University Taiwan 402 China Department of Civil and Structure Engineering Hong Kong Polytechnic University Hong Kong China

We investigated the structural behavior and bearing capacity of system *** research showed that the critical load of a system scaffold structure without diagonal braces is similar to that of a door-shaped steel scaffold *** stiffness between vertical props in system scaffolds can be defined based on a comparison between analytical and experimental *** the number of scaffold stories increases,the critical loads of system scaffolds *** braces markedly enhance the critical load of system *** coupling joint position between vertical props should be kept away from story-to-story joints to prevent a reduction in critical *** critical load of a system scaffold decreases as the quantity of extended vertical props at the bottom of the structure increases.A large Christmas tree set up by system scaffolds under various loads was used as an example for analysis and to check the design of system scaffolds.

关键词： Bearing capacity Critical Load System scaffold

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2023年肝脏疾病研究进展

中华肝脏病杂志 2024年第1期32卷 3-15页

作者：窦晓光徐小元南月敏魏来韩涛茅益民韩英任红贾继东庄辉中国医科大学附属盛京医院感染科沈阳110022 北京大学第一医院北京100034 河北医科大学第三医院中西医结合肝病科石家庄050051 清华大学附属北京清华长庚医院肝胆胰中心北京102218 南开大学人民医院天津300121 上海交通大学医学院附属仁济医院上海200001 空军军医大学第一附属医院消化内科西安710032 重庆医科大学附属第二医院感染病科重庆401336 首都医科大学附属北京友谊医院肝病中心北京100050 北京大学医学部基础医学院病原生物学系和感染病研究中心北京100191

2023年在肝脏疾病各研究领域都有重大进展,现就病毒性肝炎、肝纤维化和肝硬化、肝细胞癌(hepatocellular carcinoma,HCC)、肝衰竭和人工肝、代谢性(脂肪性)肝病、药物性肝损伤(drug-induced liver injury,DILI)及自身免疫性肝病(autoimm... 详细信息

2023年在肝脏疾病各研究领域都有重大进展,现就病毒性肝炎、肝纤维化和肝硬化、肝细胞癌(hepatocellular carcinoma,HCC)、肝衰竭和人工肝、代谢性(脂肪性)肝病、药物性肝损伤(drug-induced liver injury,DILI)及自身免疫性肝病(autoimmune liver disease,ALD)等领域研究进展进行简要介绍。

关键词：病毒性肝炎肝纤维化肝硬化肝细胞癌脂肪肝肝功能衰竭药物性肝损伤肝移植自身免疫性肝病

Volatilization behaviors of diesel oil from the soils

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Journal of Environmental Sciences 2004年第6期16卷 1033-1036页

作者： LIYu-ying ZHENGXi-lai LIBing MAYu-xin CAOJing-hua InstituteofEnvironmentalScienceandEngineering OceanUniversityofChinaQingdao266003China.

The volatilization of diesel oil, Shengli crude oil and 90# gasoline on glass surface of petri dishes were conducted at the ambient temperature of 25℃. Diesel oil evaporates in a power manner, where the loss of mass is approximately power with time. 90# gasoline evaporates in a logarithmic with time. Where as the volatilization of Shengli crude oil fit either the logarithmic or power equation after different time, and has similar R2. And the effects of soil type and diesel oil and water content on volatilization behavior in unsaturated soil were studied in this paper. Diesel oil and water content in the soils play a large role in volatilization from soils. Appropriate water helps the wicking action but too much water stops it. The wicking action behaves differently in four different types of soils in the same volatilization experiment of 18% diesel oil content and air-dry condition.

关键词： volatilization diesel oil power curve