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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan ying Liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun Liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Controlling complex, non-linear dynamical networks

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National Science Review 2014年第3期1卷 339-341页

作者： ying-Cheng lai School of Electrical Computer and Energy Engineering Arizona State University

INTRODUCTION An outstanding problem in the ield of complex dynamical systems is to control non-linear dynamics on complex ***,the physical world in which we live is non-linear,and complex networks are ubiquitous in a ... 详细信息

关键词： work net Controlling complex non-linear dynamical networks

Perspectives on relativistic quantum chaos

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Communications in Theoretical Physics 2020年第4期72卷 112-137页

作者： Liang Huang ying-Cheng lai School of Physical Science and Technology and Key Laboratory for Magnetism and Magnetic Materials of MOELanzhou UniversityLanzhouGansu 730000China School of Electrical Computerand Energy EngineeringArizona State UniversityTempeAZ 85287United States of America Department of Physics Arizona State UniversityTempeAZ 85287United States of America

Quantum Chaos has been investigated for about a half *** is an old yet vigorous interdisciplinary field with new concepts and interesting topics emerging *** years have witnessed a growing interest in quantum chaos in relativistic quantum systems,leading to the still developing field of relativistic quantum *** purpose of this paper is not to provide a thorough review of this area,but rather to outline the basics and introduce the key concepts and methods in a concise way.A few representative topics are discussed,which may help the readers to quickly grasp the essentials of relativistic quantum chaos.A brief overview of the general topics in quantum chaos has also been provided with rich references.

关键词： quantum chaos relativistic quantum systems Dirac billiards

Acute liver injury in a COVID-19 infected woman with mild symptoms:A case report

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World Journal of Clinical Cases 2023年第2期11卷 472-478页

作者： Pei-Hsuan lai Dah-ching Ding Department of Obstetrics and Gynecology Hualien Tzu Chi HospitalHualien 970Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)has spread rapidly,resulting in a pandemic in January *** studies have focused on the natural history and consequences of acute liver injury(ALI)in mild or asymptomatic COVID-19 patients,manifested by elevated aminotransferase *** is usually expected for severe COVID-19 ***,we present a COVID-19 case with mild respiratory symptoms and significantly elevated alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** SUMMARY A 60-year-old woman without medical history or chronic illness received three COVID-19 vaccinations since the start of the *** patient was infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and presented with mild symptoms on July 12th,***-recovery,she underwent an examination at our hospital on August 30th,*** and ALT levels in the liver function test were 207 U/L(normal value<39,5.3-fold increase)and 570 U/L(normal value<52,10.9-fold increase),*** patient was diagnosed with ALI,and no treatment was *** following week,blood tests showed a reduction in both levels(ALT 124 U/L,AST 318 U/L).Two weeks later,AST and ALT levels had decreased to near the expected upper limits(ALT 40 U/L,AST 76 U/L).CONCLUSION Clinicians should pay attention to liver function testing during COVID-19 recovery regardless of the disease’s severity.

关键词： COVID-19 Hepatitis Pneumonia Aspartate aminotransferase Alanine aminotransferase Case report

CNOT extraction attack on “quantum asymmetric cryptography with symmetric keys”

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Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 1001-1003页

作者： LIN ching-ying HWANG Tzonelih Department of Computer Science and Information Engineering National Cheng Kung University

This paper is based on previous quantum encryption proposed by researchers developing a scheme for cryptography using symmetric *** study has pointed out that the scheme consists of a pitfall that could lead to a controlled-NOT(CNOT)extraction attack.A malicious user can obtain the secret message of a sender without being detected by using a sequence of single photons and a controlled-NOT gate.

关键词： quantum asymmetric cryptography symmetric key CNOT extraction attack

Colorectal cancer,one entity or three

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 219-229页

作者： Feng-ying LI Mao-de lai Department of Pathology School of Medicine Zhejiang University Hangzhou 310058 China

Understanding of the mechanism of colorectal carcinogenesis has been gaining momentum for some years on account of its high incidence and impact on the lives of individuals affected. Different genetic abnormalities have been found in colorectal cancers from different sites. For example, proximal colon cancer is usually related to the nucleotide instability pathway, as microsatellite instability （MSI）. However, distal colon cancer is usually associated with specific chromosomal instability （CIN）. The development of cancer at the rectum, though similar to that at the colon, displays its own unique features. These differences might be partially attributed to different embryological development and physiological circumstances. Environmental factors such as diet and alcohol intake also differ in their role in the development of tumors in the three segments, proximal colon, distal colon, and rectum. ＂Proximal shift＂ of colon cancer has been known for some time, and survival rates of colorectal cancer are higher when rectal cancers are excluded, both of which emphasize the three different segments of coloreetal cancer and their different properties. Meanwhile, colonic and rectal cancers are distinctive therapeutic entities. The concept of three entities of coloreetal cancer may be important in designing clinical trails or therapeutic strategies. However, the dispute about the inconsistency of data coneerning the site-specific mechanism of eolorectal carcinoma does exist, and more evidence about molecular events of carcinogenesis and targeted therapy needs to be collected to definitely confirm the conception.

关键词： Colorectal cancer Proximal colon Distal colon Rectum Carcinogenesis Epidemiology and prognosis

molecular genetic analysis of a Chinese patient with Fabry disease

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Chinese Medical Journal 2000年第2期113卷 90-92页

作者： ching-Wan Lam ying-Tat Mak Yuk-Ming Dennis Lo Sui-FanTong Ka-Fai To Fernand Mac-moune lai Department of Chemical Pathology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong China

Identification of flexible buildings with bending deformation and the unmeasured earthquake ground motion

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Science China(Technological Sciences) 2015年第3期58卷 454-461页

作者： LEI ying HE MingYu lai ZhiLu LIN ShuZhi Department of Civil Engineering Xiamen University State Key Laboratory for Disaster Reduction in Civil Engineering Tongji University Department of Civil and Environmental Engineering Rice University Xiamen Construction and Management Bureau

It is important to explore efficient algorithms for the identification of both structural parameters and unmeasured earthquake ground ***,the authors proposed an algorithm for the identification of shear-type buildings and unknown earthquake *** this paper,it is extended to the investigation of the identification of flexible buildings with bending deformation and the unmeasured earthquake ground *** the absolute co-ordinate system,the unmeasured ground motion can be treated as an unknown translational force and a bending moment at the 1st floor level of a flexible *** unknown parameters above the 1st story of the building can be identified by the extended Kalman estimator and the 1st story stiffness and the unmeasured ground motion are subsequently estimated based on the least-squares *** proposed algorithm is further extended to the identification of tall bending-type buildings based on substructure ***-connection effect between sub-buildings is treated as‘additional unknown inputs’to sub-buildings,which are estimated by the extended Kalman estimator without the measurements of rotational *** examples demonstrate the identification of a multi-story,tall bending-type building and its unmeasured earthquake ground motions using only partial measurements of structural absolute responses.

关键词： flexible building bending deformation structural identification unknown ground motion extended Kalman estimator substructure approach

Accurate Location Estimation of Smart Dusts Using Machine Learning

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Computers, Materials & Continua 2022年第6期71卷 6165-6181页

作者： Shariq Bashir Owais Ahmed Malik Daphne Teck ching lai Institute of Applied Data Analytics(IADA) Universiti Brunei Darussalam(UBD)GadongBE1410Brunei Darussalam School of Digital Sciences(SDS) Universiti Brunei Darussalam(UBD)GadongBE1410Brunei Darussalam

Traditional wireless sensor networks(WSNs)are not suitable for rough terrains that are difficult or impossible to access by *** dust is a technology that works with the combination of many tiny sensors which is highly useful for obtaining remote sensing information from rough *** tiny sensors are sprinkled in large numbers on rough terrains using airborne distribution through drones or aircraftwithout manually setting their *** it is clear that a number of remote sensing applications can benefit from this technology,but the small size of smart dust fundamentally restricts the integration of advanced hardware on tiny *** raises many challenges including how to estimate the location of events sensed by the smart *** solutions on estimating the location of events sensed by the smart dusts are not suitable for monitoring rough terrains as these solutions depend on relay sensors and laser patterns which have their own limitations in terms of power constraint and uneven *** study proposes a novel machine learning based localization algorithm for estimating the location of *** approach utilizes timestamps(time of arrival)of sensed events received at base stations by assembling them into a multidimensional vector and input to a machine learning classifier for estimating the *** to the unavailability of real smart dusts,we built a simulator for analysing the accuracy of the proposed approach formonitoring forest *** experiments on the simulator show reasonable accuracy of the approach.

关键词： Smart dust sensor localization remote sensing machine learning algorithms Internet of Things sensor applications