检索结果-南通市图书馆

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1418-1422页

作者： Eva Kos Valentina Cigić mladen Bušić Mirjana Bjeloš Daliborka Miletić Biljana KuzmanovićElabjer University Eye Clinic University Hospital“Sveti Duh”Sveti Duh 64Zagreb 10000Croatia Faculty of Dental Medicine and Health Care Osijek Faculty of Medicine OsijekUniversity Josip Juraj Strossmayer in OsijekOsijek 31000Croatia

AIM:To invastigate intra-and interobserver reliability of interferometry,tear meniscus height(TMH)measurement and meibography(MBG)of an ocular surface analyzer,LacryDiag(Quantel Medical,France).METHODS:Five consecutive measurements and subsequent analysis of interferometry,TMH,and MBG were recorded by two examiners using the *** assess intra-and interobserver reliability,we used Cohen’s kappa for categorical variables(interferometry),or intraclass correlation coefficient for continuous variables(TMH,MBG).RESULTS:Thirty eyes of 30 examinees were *** both observers,there was excellent intraobserver reliability for MBG(0.955 and 0.970 for observer 1 and 2,respectively).Intraobserver reliability for observer 1 was substantial for interferometry(0.799),and excellent for TMH(0.863).Reliability for observer 2 was moderate for interferometry(0.535)and fair to good for TMH(0.431).Interobserver reliability was poor for interferometry(0.074)and fair to good for TMH(0.680)and MBG(0.414).CONCLUSION:LacryDiag ocular surface analyzer in our study proves to be a reliable noninvasive tool for the evaluation of TMH and *** for interferometry,poor interobserver reliability,fair to good intraobserver reliability for observer 1,and moderate for observer 2,leave room for improvement.

关键词： dry eye ocular surface analyzer interferometry tear meniscus height meibography

Emergency Management in Critical Infrastructures: A Complex-Event-Processing Paradigm

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2019年第1期28卷 37-62页

作者： Vuk Mijovic Nikola Tomasevic Valentina Janev mladen Stanojevic Sanja Vranes The Mihajlo Pupin Institute University of Belgrade Volgina 1511060 Belgrade Serbia

Critical infrastructures (CI) are difficult to handle due to their complexity, size and the number of stakeholders involved. During emergency situations (e.g. fire or terrorist attack), a CI operator in the control room is faced with a flood of information coming from different sensors and legacy monitoring systems. Since in these situations, time is critical and the operators are under a great deal of pressure, a holistic management of all the technical systems and actors involved is needed, reinforced by the Recommendation and Decision Support System (RDSS) that helps emergency managers to take correct and timely decisions. One way to provide an adequate RDSS support to the operator is proposed in this paper which is based on an intelligent, event driven layer that sits on top of the legacy CI monitoring system. Powered by the complex event processing capabilities and facility data model implemented in the form of CI ontology, this layer processes events originating from different sources, conducts the situation and risk assessment, and reacts accordingly, either automatically or via recommendations proposed to emergency personnel. To validate the proposed approach, an event-driven RDSS was deployed on an airport use case (Nikola Tesla airport in Belgrade), as one of the most complex CIs.

关键词： Emergency management event-driven decision support complex event processing emergency personnel training

项目管理的未来趋势:数字化、道德监管与人类决策的适应性

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

项目管理技术 2024年第7期22卷 2-4页

作者：马登·武科曼诺维奇周密刘琰 IPMA 克罗地亚萨格勒布大学国际项目管理协会南京大学

在当今快速发展的商业环境中,数字化技术成为推动各产业、各领域变革和创新的重要力量。在项目管理领域,数字化彻底改变了项目管理的方式,使智能、高效地管理项目成为可能。本期前沿论坛,我们与国际项目管理协会(International Project ... 详细信息

在当今快速发展的商业环境中,数字化技术成为推动各产业、各领域变革和创新的重要力量。在项目管理领域,数字化彻底改变了项目管理的方式,使智能、高效地管理项目成为可能。本期前沿论坛,我们与国际项目管理协会(International Project Management Association,IPMA)主席马登·武科曼诺维奇(mladen Vukomanovic)教授进行一场关于项目管理未来发展趋势、项目管理中国贡献及青年项目管理领袖培养的探讨。

关键词：项目管理前沿论坛数字化技术诺维奇未来趋势变革和创新

Modelling Dry Port Systems in the Framework of Inland Waterway Container Terminals

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第10期137卷 1019-1046页

作者： Milovan Kovac Snezana Tadic mladen Krstic Violeta Roso Faculty of Transport and Traffic Engineering University of BelgradeBelgrade11000Serbia Department of Technology Management and Economics Chalmers University of TechnologyGothenburg41296Sweden

Overcoming the global sustainability challenges of logistics requires applying solutions that minimize the negative effects of logistics *** most efficient way of doing so is through intermodal transportation(IT).Current IT systems rely mostly on road,rail,and sea transport,not inland waterway *** dry port(DP)terminals has been proven as a sustainable means of promoting and utilizing IT in the hinterland of seaport container *** DP systems consolidate container flows from/to seaports and integrate road and rail transportation modes in the hinterland which improves the sustainability of the whole logistics *** this article,to extend literature on the sustainable development of different categories of IT terminals,especially DPs,and their varying roles,we examine the possibility of developing DP terminals within the framework of inland waterway container terminals(IWCTs).Establishing combined road–rail–inland waterway transport for observed container flows is expected to make the IT systems *** such,this article is the first to address the modelling of such DP *** mathematically formulating the problem of modelling DP systems,which entailed determining the number and location of DP terminals for IWCTs,their capacity,and their allocation of container flows,we solved the problem with a hybrid metaheuristic model based on the Bee Colony Optimisation(BCO)algorithmand themeasurement of alternatives and ranking according to compromise solution(i.e.,MARCOS)multi-criteria decision-making *** results from our case study of the Danube region suggest that planning and developingDP terminals in the framework of IWCTs can indeed be sustainable,as well as contribute to the development of logistics networks,the regionalisation of river ports,and the geographic expansion of their ***,the main contributions of this article are in proposing a novel DP concept variant,mathematically formulating

关键词： Dry port intermodal transport terminal sustainability Bee Colony Optimization MARCOS inland waterway transport

Multiple metastases to the small bowel from large cell bronchial carcinomas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第9期11卷 1399-1402页

作者： Davor Tomas Mario Ledinsky mladen Belicza Bozo Kru(s|ˇ)lin Ljudevit Jurak University Department of Pathology University Department of Surgery

AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODS: Formalin-fixed, paraffin-embedded tissues were cut into 5 urn thick sections and routinely stained with hematoxylin and eosin. Some slides were also stained with Alcian-PAS. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117. RESULTS: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells, were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine. CONCLUSION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected.

关键词： Small intestine tumors Bronchial carcinomas Large cell carcinoma Tumor metastases

Problems in screening colorectal cancer in the elderly

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2003年第10期9卷 2335-2337页

作者： DavidoviM.mladen Milosevic P.Dragoslav Zdravkovic Sanja Bojic Bozidar Djurica Snezana Center of Geriatric Medicine 11050 BeogradRifata Burdzevica 31Yugoslavia

AIM:To explore the problems in the screening of colorecta carcinoma in the elderly. METHODS:Three models of colorectal cancer prevention were examined:standard screening,active check-up of suspected cases and summons to have endoscopic check- up for previously diagnosed colorectal *** study was performed among three groups of elderly individuals: Group 1 (167 cases),hospitalized asymptomatic individuals without symptoms in large *** 2 (612 cases): old individuals at home for the aged,out of which 32 showed symptoms of colon disorders;Group 3 (44 cases):elderly people with diagnosed *** a result of 1788 rectosigmoidoscopies,we identified 61 individuals with polyps,out of which 44 patients were over 65 years old. However,only 9 of these 44 individuals agreed to have the endoscopy performed again. RESULTS:One cancer and 13 polyps were detected in Group 1,and two polyps in Group ***,it should be noted that only eleven individuals from Group 2 agreed to have the *** Group 3,there were no relapses of the polyps among the nine individuals who came back for the endoscopy. CONCLUSION:Poor understanding of the screening procedures is one of the greatest problems in early detection of the cancer in the ***,the cooperation is better with hospitalized patients,than with 'successfully old' persons.

关键词： Aged Aged, 80 and over Colonic Polyps control Colonoscopy Colorectal Neoplasms Humans Mass Screening Motivation Patient Acceptance of Health Care Patient Compliance

An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2019年第7期17卷 490-497页

作者： CHEN Jia-Yin Jürgen Brockmoller mladen V.Tzvetkov WANG Li-Jun CHEN Xi-Jing Department of Pharmacy Peking University Shenzhen Hospital Shenzhen 518036 China Institute for Clinical Pharmacology University Medical Center Gottingen Georg-August University Gottingen 37075 Germany Clinical Pharmacokinetics Lab China Pharmaceutical University Nanjing 211198 China

Current study systematically investigated the interaction of two alkaloids, anisodine and monocrotaline, with organic cation transporter OCT1, 2, 3, MATE1 and MATE2-K by using in vitro stably transfected HEK293 cells. Both anisodine and monocrotaline inhibited the OCTs and MATE transporters. The lowest IC50 was 12.9 μmol·L-1 of anisodine on OCT1 and the highest was 1.8 mmol·L-1 of monocrotaline on OCT2. Anisodine was a substrate of OCT2(Km = 13.3 ± 2.6 μmol·L-1 and Vmax = 286.8 ± 53.6 pmol/mg protein/min). Monocrotaline was determined to be a substrate of both OCT1(Km = 109.1 ± 17.8 μmol·L^-1, Vmax = 576.5 ± 87.5 pmol/mg protein/min) and OCT2(Km = 64.7 ± 14.8 μmol·L^-1, Vmax = 180.7 ± 22.0 pmol/mg protein/min), other than OCT3 and MATE transporters. The results indicated that OCT2 may be important for renal elimination of anisodine and OCT1 was responsible for monocrotaline uptake into liver. However neither MATE1 nor MATE2-K could facilitate transcellular transport of anisodine and monocrotaline. Accumulation of these drugs in the organs with high OCT1 expression(liver) and OCT2 expression(kidney) may be expected.

关键词： Anisodine Monocrotaline Organic cation transporter OCT MATE

Combined liver-kidney transplantation for rare diseases

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2020年第10期12卷 722-737页

作者： mladen Knotek Rafaela Novak Alemka Jaklin-Kekez Anna Mrzljak Department of Medicine Tree Top HospitalHulhumale 23000Maldives Department of Medicine Merkur University HospitalZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia Clinic for Pediatric Diseases Helena Zagreb 10000Croatia

Combined liver and kidney transplantation(CLKT)is indicated in patients with failure of both organs,or for the treatment of end-stage chronic kidney disease(ESKD)caused by a genetic defect in the *** aim of the present review is to provide the most up-to-date overview of the rare conditions as indications for *** are major indications for CLKT in ***,in some of them(e.g.,atypical hemolytic uremic syndrome or primary hyperoxaluria),CLKT may be required in adults as *** hyperoxaluria is divided into three types,of which type 1 and 2 lead to *** has been proven effective in renal function replacement,at the same time preventing recurrence of the *** is associated with liver fibrosis in 5%of cases and these patients are candidates for *** alpha 1-antitrypsin deficiency,hereditary C3 deficiency,lecithin cholesterol acyltransferase deficiency and glycogen storage diseases,glomerular or tubulointerstitial disease can lead to chronic kidney *** transplantation as a part of CLKT corrects underlying genetic and consequent metabolic *** atypical hemolytic uremic syndrome caused by mutations in the genes for factor H,successful CLKT has been reported in a small number of ***,for this indication,CLKT has been largely replaced by eculizumab,an anti-C5 *** has been well established to provide immune protection of the transplanted kidney against donor-specific antibodies against class I HLA,facilitating transplantation in a highly sensitized recipient.

关键词： Combined liver-kidney transplantation Methylmalonic aciduria Hereditary complement C3 deficiency Glycogen storage diseases Homozygous protein C deficiency Primary hyperoxaluria Atypical hemolytic uremic syndrome Sensitization Donorspecific antibodies

Study of TiO_2 thin films on Si substrate by the photoacoustic elastic bending method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2013年第7期56卷 1285-1293页

作者： TODOROVI Dragan M RABASOVI Mihailo D MARKUSHEV Dragan D FRANKO mladen TANGAR Urka Lavreni Institute for Multidisciplinary Research University of Belgrade Institute of Physics University of Belgrade Laboratory for Environmental Research University of Nova Gorica

The quantitative photoacoustic investigation of different TiO2 thin films on Si substrates is presented using the elastic bending method. Photoacoustic signal amplitude and phase spectra versus modulation frequency were measured and analyzed using different sample thicknesses. Within the proposed method particular attention is given to the analysis of optical, thermal, elastic and structural sample parameters. Considerable focus is devoted to the fitting procedure of experimental results using the two-layer sample theoretical model. Characteristics of previously developed photoacoustic apparatus are discussed, attempting to search the ideal experimental conditions which can provide a good signal-to-noise ratio and sensitivity.

关键词： photoacoustic TiO2 thin films