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A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

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Asian Journal of Andrology 2012年第5期14卷 703-707页

作者： Yasukazu Nakanishi Hitoshi Masuda Satoru Kawakami mizuaki sakura Yasuhisa Fujii Kazutaka Saito Fumitaka Koga Masaya Ito lunji Yonese Iwao Fukui Kazunori Kihara Department of Urology Tokyo Medical and Dental University Tokyo 113-8519 Japan Department of Urology Cancer institute Hospital Tokyo 135-8550 Japan

Anthropometric measurements, e.g., body weight （BW）, body mass index （BMI）, as well as serum prostate-specific antigen （PSA） and percent-free PSA （%fPSA） have been shown to have positive correlations with total prostate volume （TPV）. We developed an equation and nomogram for estimating TPV, incorporating these predictors in men with benign prostatic hyperplasia （BPH）. A total of 1852 men, including 1113 at Tokyo Medical and Dental University （TMDU） Hospital as a training set and 739 at Cancer Institute Hospital （CIH） as a validation set, with PSA levels of up to 20 ng m1-1, who underwent extended prostate biopsy and were proved to have BPH, were enrolled in this study. We developed an equation for continuously coded TPV and a logistic regression-based nomogram for estimating a TPV grater than 40 mh Predictive accuracy and performance characteristics were assessed using an area under the receiver operating characteristics curve （AUC） and calibration plots. The final linear regression model indicated age, PSA, %fPSA and BW as independent predictors of continuously coded TPV. For predictions in the training set, the multiple correlation coefficient was increased from 0.38 for PSA alone to 0.60 in the final model. We developed a novel nomogram incorporating age, PSA, %fPSA and BW for estimating TPV greater than 40 mh External validation confirmed its predictive accuracy, with AUC value of 0.764. Calibration plots showed good agreement between predicted probability and observed proportion. In conclusion, TPV can be easily estimated using these four independent predictors.

关键词： body weight equation nomogram prediction prostate-specific antigen prostate volume

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“Anna Hu”高定珠宝“蒔花珠韵·芳华绝代”展览现身巴黎高定时装周

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中国宝石 2024年第4期 84-89页

作者： sakura 无不详 “Anna Hu”高定珠宝

2024年6月26日,作为法国高级定制和时尚联合会150年来首位且唯一被邀请入会的华裔女性高定珠宝艺术家、法国高定永久会员,“Anna Hu”高定珠宝创办人、旅欧华裔珠宝艺术家Anna Hu女士再度接受法国高级定制和时尚联合会的邀约,在巴黎高... 详细信息

2024年6月26日,作为法国高级定制和时尚联合会150年来首位且唯一被邀请入会的华裔女性高定珠宝艺术家、法国高定永久会员,“Anna Hu”高定珠宝创办人、旅欧华裔珠宝艺术家Anna Hu女士再度接受法国高级定制和时尚联合会的邀约,在巴黎高定时装周举办展览。展览以她钟爱的蝴蝶与花卉为灵感,以“蒔花珠韵·芳华绝代”为题,展出了“AnnaHu”高定珠宝的10件年度经典杰作。

关键词：时装周创办人华裔女性珠宝高级定制芳华展览

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Genetic resources and precise gene editing for targeted improvement of barley abiotic stress tolerance

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期24卷 1069-1092页

作者： sakura KARUNARATHNE Esther WALKER Darshan SHARMA Chengdao LI Yong HAN Western Crop Genetics Alliance College of ScienceHealthEngineering and EducationMurdoch UniversityMurdochWA6150Australia Department of Primary Industries and Regional Development South PerthWA6151Australia

Abiotic stresses, predominately drought, heat, salinity, cold, and waterlogging, adversely affect cereal crops. They limit barley production worldwide and cause huge economic losses. In barley, functional genes under various stresses have been identified over the years and genetic improvement to stress tolerance has taken a new turn with the introduction of modern geneediting platforms. In particular, clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9) is a robust and versatile tool for precise mutation creation and trait improvement. In this review, we highlight the stress-affected regions and the corresponding economic losses among the main barley producers. We collate about 150 key genes associated with stress tolerance and combine them into a single physical map for potential breeding practices. We also overview the applications of precise base editing, prime editing, and multiplexing technologies for targeted trait modification, and discuss current challenges including high-throughput mutant genotyping and genotype dependency in genetic transformation to promote commercial breeding. The listed genes counteract key stresses such as drought, salinity, and nutrient deficiency, and the potential application of the respective gene-editing technologies will provide insight into barley improvement for climate resilience.

关键词： Clustered regularly interspaced short palindromic repeats(CRISPR) Gene function Drought Genetic improvement Transcription regulation Breeding

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CRISPR/Cas9 gene editing and natural variation analysis demonstrate the potential for HvARE1 in improvement of nitrogen use efficiency in barley

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Journal of Integrative Plant Biology 2022年第3期64卷 756-770页

作者： sakura D.Karunarathne Yong Han Xiao-Qi Zhang Chengdao Li Western Crop Genetics Alliance College of ScienceHealthEngineering and EducationMurdoch UniversityPerthWA6150 Australia Western Australian State Agricultural Biotechnology Centre Murdoch UniversityPerthWA6150 Australia Department of Primary Industries and Regional Development PerthWA6151 Australia

Nitrogen is a major determinant of grain yield and *** excessive use of nitrogen fertilizer leads to environmental pollution and high production costs,improving nitrogen use efficiency(NUE)is fundamental for a sustainable ***,we dissected the role of the barley abnormal cytokinin response1 repressor 1(Hv ARE1)gene,a candidate for involvement in NUE previously identified in a genome-wide association study,through natural variation analysis and clustered regularly interspacedshort palindromic repeats(CRISPR)/CRISPRassociated protein 9(Cas9)-mediated gene *** ARE1 was predominantly expressed in leaves and shoots,with very low expression in roots under low nitrogen ***-mediated genetic transformation of immature embryos(*** Promise)with single guide RNAs targeting Hv ARE1 generated 22 T0 plants,from which four T1 lines harbored missense and/or frameshift mutations based on *** are1 lines exhibited an increase in plant height,tiller number,grain protein content,and ***,we observed a 1.5-to2.8-fold increase in total chlorophyll content in the flag leaf at the grain filling *** senescence by 10–14 d was also observed in mutant *** are1 mutants had high nitrogen content in shoots under low nitrogen *** findings demonstrate the potential of ARE1 in NUE improvement in barley.

关键词： ARE1 barley CRISPR/Cas9 gene editing leaf senescence NUE

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Species-dependent effects of the phenolic herbicide ioxynil with potential thyroid hormone disrupting activity: modulation of its cellular uptake and activity by interaction with serum thyroid hormone-binding proteins

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Journal of Environmental Sciences 2012年第5期24卷 949-955页

作者： sakura Akiyoshi Gobun Sai Kiyoshi Yamauchi Department of Biological Science Faculty of Science Shizuoka University

Ioxynil, a phenolic herbicide, is known to exert thyroid hormone （TH） disrupting activity by interfering with TH-binding to plasma proteins and a step of the cellular TH-signaling pathway in restricted animal species. However, comparative studies are still lacking on the TH disruption. We investigated the interaction of [125I] ioxynil with serum proteins from rainbow trout, bullfrog, chicken, pig, rat, and mouse, using native polyacrylamide gel electrophoresis. Candidate ioxynil-binding proteins, which included lipoproteins, albumin and transthyretin （TTR）, differed among the vertebrates tested. Rainbow trout and bullfrog tadpole serum had the lowest binding activity for ioxynil, whereas the eutherian serum had the highest binding activity. The cellular uptake of, and response to, ioxynil were suppressed by rat serum greater than by tadpole serum. The cellular uptake of [125I]ioxynil competed strongly with phenols with a single ring, but not with THs. Our results suggested that ioxynil interferes with TH homeostasis in plasma and with a step of cellular TH-signaling pathway other than TH-uptake system, in a species-specific manner.

关键词： endocrine disruption ioxynil thyroid hormone serum transthyretin uptake

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定向改良大麦耐逆性的遗传资源和基因编辑策略（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第12期 1069-1093页

作者： sakura KARUNARATHNE Esther WALKER Darshan SHARMA 李承道韩勇西澳作物遗传联盟莫道克大学科学健康工程和教育学院第一产业和地区发展部

逆境胁迫如干旱、高温、盐害、低温和涝渍危害谷类作物生长，这些因素限制了全球大麦产量并造成了巨大的经济损失。随着抗逆基因被不断发掘和验证，以及新型基因编辑系统的引入，精确改良大麦耐逆性迎来了新的发展契机，特别是利用强大... 详细信息

逆境胁迫如干旱、高温、盐害、低温和涝渍危害谷类作物生长，这些因素限制了全球大麦产量并造成了巨大的经济损失。随着抗逆基因被不断发掘和验证，以及新型基因编辑系统的引入，精确改良大麦耐逆性迎来了新的发展契机，特别是利用强大的CRISPR/Cas9工具定点诱导突变和改良性状。本文综述了世界大麦主产地中受主要逆境因素影响的区域以及相应的经济损失，收集了约150个已被验证的关键抗逆基因并构建于同一个大麦物理图谱中，以期用于育种实践。此外，本文还概述了应用碱基编辑、引导编辑和多重编辑等不同策略定向改良性状，并讨论了当前的技术难点，包括高通量突变体筛选和突破大麦遗传转化的基因型依赖，以实现商业化育种。本文罗列的抗逆基因和提出的相应基因编辑策略对增强大麦耐逆性和环境适应性具有理论和实践意义。

关键词： CRISPR 基因功能干旱遗传改良转录调控育种

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Low Pressure Chemical Vapor Deposition of TiO2Layer in Hydrogen-Ambient

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Journal of Crystallization Process and Technology 2014年第4期4卷 185-192页

作者： Satoshi Yamauchi Kazuhiro Ishibashi sakura Hatakeyama Department of Biomolecular Functional Engineering Ibaraki University Hitachi Japan

Low pressure chemical vapor deposition (LPCVD) of anatase TiO2?as a reduction gas was demonstrated at pres- sure of 3 mtorr in comparison to that using TTIP and O2 with study for the property of the layers. Dissociation energy of TTIP in H2 was higher than that in O2 but resistivity of the layer deposited in H2 was significantly decreased to 0.2 Ω cm in contrast to the high resistivity beyond 100 Ω cm of the layer deposited in O2. UV-Vis optical transmission spectra showed absorption around 2.2 eV was increased in the layer deposited by TTIP + H2 in addition to decrease of forbidden energy gap due to increase of Urbach tail. Resistivity at low temperature below 100 K indicating the layer deposited in H2-ambient was degenerated by the high electron density but the resistivity was decreased with temperature above 100 K with the activation energy about 100 meV. A possible electronic conduction model based on kernel, grain boundary and surface trap to clarify the temperature dependent resistivity suggesting resistivity of the layer was limited by depletion region in the grain-boundary extended from the surface and the kernel with significantly low resistivity in 10-3 Ω cm order was formed in the layer.

关键词： LPCVD TTIP+H2 Anatase-TiO2 Low Resistive TiO2

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Drastic Resistivity Reduction of CVD-TiO2Layers by Post-Wet-Treatment in HCl Solution

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Journal of Crystallization Process and Technology 2015年第1期5卷 24-30页

作者： Satoshi Yamauchi Kazuhiro Ishibashi sakura Hatakeyama Department of Biomolecular Functional Engineering Ibaraki University Hitachi Japan

Poly-crystalline anatase TiO2 layer fabricated by LPCVD using titanium-tetra-iso-propoxide and NbF5 in H2-ambient was treated in conc.-HCl solution after thin layer of IIIb-group metal was deposited on the TiO2 layer. Resistivity of the as-deposited layer about 1 × 10-1 Ω·cm was drastically reduced to 3 × 10-3 Ω·cm by the wet-treatment using indium. Temperature dependence of the resistivity increased with temperature above 100 K for the wet-treated layer was quite different from that decreased above 100 K for the as-deposited layer, whereas the resistivity was saturated at lower temperatures. The resistivity at room-temperature was decreased with the thickness before the wet-treatment but independent on the thickness above 100 nm for the wet-treated layer. Indium was more effective for the resistivity reduction than gallium but aluminum was not useful for the treatment. As the results that the wet-treatment using indium was examined for the TiO2 layers deposited by various conditions, the optimum deposition condition to reduce the resistivity of the layer after the wet-treatment was clearly different from that for the as-deposited layer.

关键词： LPCVD Poly-Crystalline TiO2 Post Wet-Treatment Low Resistive TiO2

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Enhanced Photo-Induced Property of LPCVD-TiO2Layer on PCVD-TiOxInitial Layer

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Journal of Materials Science and Chemical Engineering 2015年第7期3卷 28-38页

作者： Satoshi Yamauchi Keisuke Yamamoto sakura Hatakeyama Department of Biomolecular Functional Engineering Hitachi Japan

Plasma-assisted chemical vapor deposition (PCVD) was applied for amorphous TiOx deposition on Pyrex-glass substrate at low temperature below 90°C to control orientation of anatase-TiO2 layer by low pressure chemical vapor deposition (LPCVD) using TTIP-single precursor. Preferentially -oriented anatase-TiO2 layer was successfully deposited with the orientation ratio as high as 68% on the initial layer of the thickness around 70 nm. Contact angle water was quickly decreased by UV-irradiation on the highly -oriented TiO2 layer comparing with the layer directly deposited on glass, whereas surface roughness on the former was significantly reduced in comparison to that on the latter. Methyleneblue (MB) aqueous solution with the concentration of 2 mmol/L was used to evaluate photocatalytic property on the layer. Rate constant of MB-decomposition via first order kinetics increased with the orientation ratio above 60% was resulted in 2.3 × 10-1?min-1 for the layer with -orientation ratio of 68%, whereas the constant was 2.8 × 10-3 min-1 for the layer directly deposited on glass.

关键词： LPCVD Anatase-TiO2 PCVD TiOx Hydrophilicity Photocatalyst

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Low Resistive TiO2Deposition by LPCVD Using TTIP and NbF5in Hydrogen-Ambient

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Journal of Crystallization Process and Technology 2015年第1期5卷 15-23页

作者： Satoshi Yamauchi Kazuhiro Ishibashi sakura Hatakeyama Department of Biomolecular Functional Engineering Ibaraki University Hitachi Japan

Low resistive TiO2 layer was deposited by low pressure chemical vapor deposition (LPCVD) at pressure around 0.25 Pa using titanium-tetra-iso-propoxide (TTIP) and NbF5 in H2-ambient. Acti-vation energy for the deposition rate on the temperature was significantly decreased to 120 kJ/mol as compared with 228 kJ/mol for the deposition in H2 without NbF5. The deposition rate linearly increased with NbF5 supply rate but gradually decreased with H2 supply rate indicated that F on the deposition surface acts as catalyst for TTIP-dissociation but is non-activated by hydrogen. Resistivity of the layer was decreased by NbF5 supply depending on the deposition temperature with the activation energy of 319 kJ/mol, whereas the energy was 244 kJ/mol for the layer deposited in H2 without NbF5. The dependence of resistivity on NbF5. and H2 supply rates suggested that the doping should be performed by sufficient NbF5 and H2 supply rate to improve the crystallinity. As a result of the optimization, the resistivity was successfully reduced to 5 × 10-2 Ω·cm. Optical transmission spectra in UV-Vis region indicated that significant absorption observed for the layer deposited in H2 was notably decreased by using NbF5. The improved optical property was better than that for the layer deposited in O2-ambient.

关键词： LPCVD-TiO2 H2-Ambient Nb and F Doping Low-Resistive TiO2 Optical Transmittance

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