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Effectiveness of omega-3 polyunsaturated fatty acids against microbial pathogens

Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2018年第4期19卷 253-262页

作者： Warren CHANDA Thomson P.JOsEPH Xue-fang GUO Wen-dong WANG Min LIU miza s.vuai Arshad A.PADHIAR Min-tao ZHONG Department of Microbiology College of Basic Medical Sciences Dalian Medical University

Microorganisms provide both beneficial and harmful effects to human beings. Beneficial effects come from the symbiotic relationship that exists between humans and microbiota, but then several human illnesses have turned some friendly microbes into opportunistic pathogens, causing several microbial-related diseases. Various efforts have been made to create and utilize antimicrobial agents in the treatment and prevention of these infections, but such efforts have been hampered by the emergence of antimicrobial resistance. Despite extensive studies on drug dis- covery to alleviate this problem, issues with the toxicity and tolerance of certain compounds and continuous microbial evolution have forced researchers to focus on screening various phytochemical dietary compounds for antimicrobial activity. Linolenic acid and its derivatives （eicosapentaenoic acid and docosahexaenoic acid） are omega-3 fatty acids that have been studied due to their role in human health, being important for the brain, the eye, the cardiovascular system, and general human growth. However, their utilization as antimicrobial agents has not been widely appreciated, perhaps due to a lack of understanding of antimicrobial mechanisms, toxicity, and route of administration. Therefore, this review focuses on the efficacy, mechanism, and toxicity of omega-3 fatty acids as alternative therapeutic agents for treating and preventing diseases associated with pathogenic microorganisms.

关键词： Linolenic acid Omega-3 fatty acid Eicosapentaenoic acid (EPA) Docosahexaenoic acid (DHA) Antimicrobial agent Fatty acid

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