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Open Journal of Orthopedics 2013年第2期3卷 102-105页

作者： Koun yamauchi Akira Hioki Kazunari Fushimi Kei Miyamoto Katsuji Shimizu Department of Orthopaedic Surgery Gifu University School of Medicine Gifu Japan Department of Orthopaedic Surgery Hikone Municipal Hospital Shiga Japan Department of Orthopaedic Surgery Kizawa Memorial Hosptial Gifu Japan Department of Reconstructive Surgery for Spine Bone and Joint Gifu University School of Medicine Gifu Japan

We report a unique case of lumbar disc herniation, in particular, with end-plate and surrounded by extensive ossification, mimicking a tumor with calcification. A 69-year-old female suffered from right buttock and leg pain. Computed tomography (CT) showed an intracanalar mass with calcification or ossification, which most likely originated from the vertebral body at the L1/2 level epidural space. On a T1-weighted gadolinium magnetic resonance image, the capsule of the mass was enhanced and not only the content of the mass but also that of the L2 vertebral body were partially and slightly enhanced. The final pathological diagnosis was disc herniation with end-plate fracture and secondary ossification. A combination of these pathological conditions as accompanied by both end-plate fractures and extensive secondary ossifications has not been previously reported. This rare pathological condition needs to be recognized as a differential diagnosis.

关键词： Disc Herniation Extensive Ossifications End-Plate Fractures

The polybasic region of cytohesin-2 determines paxillin binding specificity to mediate cell migration

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Advances in Biological Chemistry 2012年第3期2卷 291-300页

作者： Tomohiro Torii Yuki Miyamoto Kohji Nishimura Masahiro Maeda Akito Tanoue Junji yamauchi Department of Molecular and Functional Genomics Shimane University Matsue Japan Department of Pharmacology National Research Institute for Child Health and Development Tokyo Japan Immuno-Biological Laboratories (IBL) Co. Ltd. Fujioka Japan The Japan Health Sciences Foundation (JHSF) Tokyo Japan

The intracellular signaling pathways through ADP-ribosylation factors (Arfs) of the small GTPase family control cell morphological changes by regulating membrane components and/or cytoskeletal protein dynamics. We previously reported that cytohesin-2 (CYTH2), an Arf-guanine-nucleotide exchange factor (GEF), binds to the cytoskeletal scaffold protein paxillin through C-terminal region of CYTH2 and promotes the migration of mouse 3T3-L1 fibroblasts. In mammals, CYTH family GEFs are composed of four subfamilies. Among them, CYTH2 and CYTH3 are widely expressed in tissues and it remains to be clarified to determine whether they have specific biochemical and cellular functions or are redundant. Here, we show that the C-terminal short polybasic region of CYTH2 is necessary and sufficient for binding to paxillin to mediate cell migration. Although 3T3-L1 cells primarily express CYTH2 and CYTH3 of four CYTH family members, neither knockdown of CYTH3 by the specific siRNA nor expression of its C-terminal region inhibits migration. Importantly, replacing the C-terminal region of CYTH3 with that of CYTH2 adds the ability of paxillinbinding and mediating migration to CYTH3. Conversely, replacing the C- terminal region of CYTH2 with that of CYTH3 leads to loss of these abilities of CYTH2. These results reveal that paxillin is a unique binding partner with CYTH2 in migrating cells, presenting the first CYTH family GEF’s region that is involved in the selectivity of the binding protein.

关键词： Cytohesin-2 Polybasic Region Paxillin Migration

Clinical Significance of Platelet-Derived Growth Factor-C Expression in Colorectal Cancer

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Journal of Cancer Therapy 2014年第1期5卷 11-20页

作者： Shinichi yamauchi Satoru Iida Megumi Ishiguro Toshiaki Ishikawa Hiroyuki Uetake Kenichi Sugihara Department of Surgical Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan Department of Translational Oncology Graduate School Tokyo Medical and Dental University Tokyo Japan

Platelet-derived growth factors (PDGFs) are known to be associated with tumor growth and angiogenesis through their activation of the receptor tyrosine kinases, PDGF receptors alpha and beta. Several studies revealed the participation of the PDGF family in colorectal cancer (CRC). However, the role of platelet derived growth factor-C (PDGFC) in CRC is less well studied. This study aimed to determine the correlation between PDGFC expression and the prognosis of patients with CRCs. Tumor samples were obtained from patients with CRC who underwent surgical resection between 2002 and 2006. The mRNA expression of PDGFC was investigated by quantitative reverse transcription-polymerase chain reaction in 85 patients with stage I-IV CRC. PDGFC protein expression was analyzed by immunohistochemistry, and the relationship between PDGFC protein expression and clinicopathologic features was investigated in 245 patients with stage I-III CRC. PDGFC mRNA expression in cancer tissues was significantly higher in patients with distant metastases than in those without metastases (P = 0.016). PDGFC protein overexpression was associated with significantly worse overall and relapse-free survival (P P < 0.0001, respectively). Moreover, PDGFC protein overexpression was an independent risk factor for CRC recurrence (relative risk = 3.395, 95% confidence interval = 1.895 - 6.081, P < 0.001). In the present study, PDGFC overexpression appeared to be predictive of recurrence and poor prognosis in patients with CRC.

关键词： Platelet-Derived Growth Factor-C Colorectal Cancer Prognosis mRNA Expression Immunohistochemistry

Stretching Induces the Rearrangement of the Periodontal Ligament Cells without Altering the Orientation of Oxytalan Fibers Relative to the Cell Axis in Vitro

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Open Journal of Stomatology 2016年第12期6卷 252-260页

作者： Sachio Tamaoki Kazuki Nakashima Yoshinori yamauchi Kaori Yamanouchi Takahiro Fujita Eichi Tsuruga Hiroyuki Ishikawa Section of Orthodontics Department of Oral Growth & Development Division of Clinical Dentistry Fukuoka Dental College Fukuo-ka Japan Department of Radiation Science Graduate School of Health Sciences Hirosaki University Hirosaki Japan Fukuoka Dental College Fukuoka Japan

The periodontal ligament (PDL) contains oxytalan fibers as well as collagen fibers, which helps it to withstand the mechanical stress to which it is constantly exposed. The oxytalan fibers are produced by PDL fibroblasts. However, the arrangement of PDL fibroblasts and the orientation of oxytalan fibers relative to the fibroblast cell axis have not been investigated under the condition of mechanical stress. We hypothesized that such stress would alter the arrangement and orientation of these cells and their oxytalan fibers. The aim of this study was to evaluate the effects of stretching strain on PDL fibroblasts, focusing on the cellular arrangement and orientation of oxytalan fibers relative to the long cell axis in cell/matrix layers by staining the major component of the fibers, fibrillin-1. The angle between the long cell axis and the oxytalan fibers was approximately 70 degrees under both non-stretching and stretching conditions. Moreover, stretching induced the rearrangement of the cells. This is the first study to demonstrate that stretching induces the rearrangement of the PDL fibroblasts without altering the angle between the long cell axis and the oxytalan fibers. These results may reflect the orientation of oxytalan fibers in the PDL under the condition of mechanical stress.

关键词： Oxytalan Fibers Mechanical Stress Fibrillin Microfibrils Periodontal Ligament

STRUCTURE OF 1,3-BISDIPHENYLENE2-(p-CHLOROPHENYL)-ALLYL RADICAL AT ROOM TEMPERATURE:AN ORGANIC ANTIFERROMAGNET

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STRUCTURE OF 1,3-BISDIPHENYLENE2-(p-CHLOROPHENYL)-ALLYL RADI...

Sixteenth Congress of the International Union of Crystallography

作者： N.Azuma T.Ozawa J.yamauchi Faculty of General Education Ehime UniversityMatsuyama 790Japan

The neutral organic free radical is characterized by a one-dimensional *** the low temperature examined so far,most of the organic radicals show no magnetic phase transition into long-range ordered *** titled radical(p-Cl-BDPA),however,undergoes phase transition to an antiferromagnetic state at T-3.25K(yamauchi, *** al.(1973) ***.35,443-446).This indicates. appreciable exchange interaction between the magnetic ***

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汽车信息系统设计参考

世界电子元器件 2005年第5期 62-64页

作者： Naoki yamauchi 瑞萨科技

在几十年前,汽车内的电子设备还局限在无线电设备和点火系统.现在,半导体器件渗入到各种类型的汽车中,在高端汽车中更是成为功能实现的决定因素.在产品不断更新换代的背后,半导体器件扮演着重要角色.以汽车导航系统和远程信息处理为代... 详细信息

在几十年前,汽车内的电子设备还局限在无线电设备和点火系统.现在,半导体器件渗入到各种类型的汽车中,在高端汽车中更是成为功能实现的决定因素.在产品不断更新换代的背后,半导体器件扮演着重要角色.以汽车导航系统和远程信息处理为代表的汽车信息系统(CIS)产品,例证了汽车工业的发展趋势.CIS产品功能不断改进,并将在未来更多的汽车中成为必备的标准功能.

关键词：信息系统设计参考半导体器件远程信息处理汽车导航系统无线电设备点火系统电子设备决定因素功能实现发展趋势汽车工业产品

Influence of Heat Treatment Temperature and of Sb2O3 addition on Photoluminescence Properties of ZnO Ceramics Prepared by Sol-Gel Technique Preparation

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Engineering（科研） 2010年第12期2卷 969-972页

作者： Hiroyuki Nasu Tomoyuki yamauchi Sachio Ninagawa Daisuke Hirota Tadanori Hashimoto Atsushi Ishihara 不详

To explore thin transparent electroluminescence and electric conductive films by sol-gel technique, Sb2O3 doped n-type ZnO ceramics powders were prepared by sol-gel technique and photoluminescence properties were measured. Then, the influences of composition and heat treatment temperature on photoluminescence properties were investigated in detail. With respect to the dopant concentration, about 1mol% addition of Sb2O3 was effective to increase photoluminescence intensity. With respect to heat treatment temperature, 800℃ was appropriate, and rather higher heat treatment temperature resulted in the formation of Zn7Sb2O12 and decrease the intensity. The excited ultraviolet wavelength of 200nm was proper to intense photoluminescence.

关键词： Zno Ceramics Sb2O3 Doping Photoluminescence Heat Treatment Temperature Sol-Gel

Surgical Correction of Bifid Nose Due to Tessier’s No. 0 Cleft

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Modern Plastic Surgery 2014年第1期4卷 1-4页

作者： Hiroki Shibayama Takatoshi Yotsuyanagi Tamotsu Saito Ken Yamashita Makoto yamauchi Tetsuya Suda Department of Plastic and Reconstructive Surgery Fujisawa City Hospital Kanagawa Japan Department of Plastic and Reconstructive Surgery Sapporo Medical University School of Medicine Hokkaido Japan Department of Plastic and Reconstructive Surgery Sunagawa City Medical Center Hokkaido Japan

Bifid nose is a rare congenital abnormality and its surgical correction is difficult. We represent a case of bifid nose with mild nasal deformity without cerebral or lip deformity. We performed rhinoplasty with a kind... 详细信息

关键词： Bifid Nose Rhinoplasty Forked Flap Tessier’s No. 0 Cleft

Effects of Mango Skin or Mango Skin Combined with Paprika Extracts on Production Performance, Egg Quality and Egg Yolk Polyphenols

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Journal of Agricultural Science and Technology(A) 2011年第8期1卷 1257-1260页

作者： K. Lokaewmanee K. yamauchi T. Komori K. Saito Kagawa University Miki-cho Kagawa-ken 761-0795 Japan Kohkin Chemical Co. Ltd. Nakaoshikiri-cho Higashiosaka 579-8014 Japan

The phenolic compounds found in mango fruit are antioxidants, and contribute to a reduction in the risk of cardiovascular diseases. Mango carotenoids are synthesized in mango fruit during ripening. A major by-product of mango fruit is the skin, which is available after the fruits is consumed or used, particularly in the preparation of jams and fruit juices by the fruit canning industry. The objective of this study was to investigate the effects of dietary mango skin (MS) or mango skin combined with paprika extracts (PE) on production performance, egg quality, and egg yolk polyphenols. Total of 60 44-week-old Boris Brown hens was assigned, based on egg production rate and body weight, to 6 groups (10 birds in each group). The laying hens were fed a basal diet (control group, 18 CP, 2,800 kcal/kg ME), a basal diet supplemented with 0.1% PE, 1% or 5% MS, or with a mixture of 0.1% PE with 1% or 5% MS respectively. During the three-week experimental feeding period, the birds had free access to feed and water. Feed consumption was measured weekly and egg production was recorded daily. The results for initial body weight, feed consumption, hen-day production, egg mass, mortality, and final body weight did not indicate any effects of the different treatments (P > 0.05). There were no significant differences (P > 0.05) in shell-breaking strength, shell thickness, shell ratio, yolk ratio or Haugh units, except in the case of egg yolk color. Roche yolk color fan scores were better in all experimental groups than in the control (P < 0.0001). The yolk color, yellow index, and ratio of redness to yellowness were greater (P < 0.0001) in the 0.1% PE, the 0.1% PE + 1% MS, and the 0.1 % PE + 5% MS group than in the 1%, 5% MS, and control groups. Compared with the control, lightness was decreased significantly in the 0.1% PE, the 0.1% PE + 1% MS, and the 0.1% PE + 5% MS groups (P < 0.05), whereas redness was increased significantly in the 0.1% PE, 0.1% PE + 1% MS, and 0.1% PE + 5% MS

关键词：蛋黄颜色生产性能芒果皮茶多酚提取物蛋品质皮肤辣椒

Ab Initio MO Studies of the Weak Interaction in Cu-Histamine-Tyrosine Complex as an Model of Pseudoazurin M16Y Mutant

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Ab Initio MO Studies of the Weak Interaction in Cu-Histamine...