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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park miyeon Go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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Efficacy and safety of poly-D,L-lactic acid microspheres as subdermal fillers in animals

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Plastic and Aesthetic Research 2019年第7期6卷 10-19页

作者： Chuan-Yuan Lin Jui-Yu Lin Dae-Yeol Yang Seong-Ho Lee Jeoung-Yong Kim miyeon kang Tobeauty Aesthetic Clinic Taipei 10582Taiwan Department of Urology Hallym University Dongtan Sacred Heart HospitalGyeonggi-do 18450South Korea Department of Urology Hallym University Kangdong Sacred Heart HospitalSeoul 05355South Korea Max Urology Clinic Seoul 05051South Korea R&D center Regen BiotechDaejeon 34364South Korea

Aim:This animal study aims to examine the efficacy and safety of poly-D,L-lactic acid(PDLLA)microspheres as subdermal ***:Thirty 2-week-old male Sprague Dawley rats were used as test animals,and 0.5 mL filler solutions were injected into the subdermal tissues on their *** of five rats were randomly selected and sacrificed for examination on the 2nd,4th,8th,12th,16th,and 20th weeks after *** and histological examinations were performed via the hematoxyline-eosin and immunohistochemical(IHC)staining of injected sites after collecting the injected *** body weights of the rats were measured,and the presence of filler substance in other organs was ***:Injected volumes were stable from the 2nd to the 20th week after injection,and no abnormalities were observed around the injection *** injected substance did not migrate to the surrounding *** IHC staining experiments,myofibroblasts were observed from the 2nd week,and collagen was detected from the 4th *** was observed in the spaces between and inside the microspheres in the 8th week after injection,whereas type I collagen was found between and inside the microspheres at 8th and 12th weeks,***:The animal experiments confirm the efficacy and safety of injectable PDLLA as a subdermal filler.

关键词： Poly-D L-lactic acid injectables fillers microspheres biostimulation

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