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RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts

Bone Research 2024年第2期12卷 407-420页

作者： Minhee Kim Jin Hee Park miyeon go Nawon Lee Jeongin Seo Hana Lee Doyong Kim Hyunil Ha Taesoo Kim Myeong Seon Jeong Suree Kim Taesoo Kim Han Sung Kim Dongmin Kang Hyunbo Shim Soo Young Lee Department of Life Science Ewha Womans UniversitySeoul 03760South Korea The Research Center for Cellular Homeostasis Ewha Womans UniversitySeoul 03760South Korea Department of Biomedical Engineering Yonsei UniversityWonju 26493South Korea KM Convergence Research Division Korea Institute of Oriental MedicineDaejeon 34054South Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341South Korea Fluorescence Core Imaging Center and Bioimaging Data Curation Center Ewha Womans UniversitySeoul 03760South Korea Multitasking Macrophage Research Center Ewha Womans UniversitySeoul 03760South Korea

Mature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled ***,the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely ***,we show with GeneChip analysis that RUN and FYVE domain-containing protein 4(RUFY4)is strongly upregulated during *** lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in ***,deleting Rufy4 did not affect osteoclast differentiation,but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes,their trafficking to the membrane,and their secretion of cathepsin K into the extracellular ***,RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary ***,Rufy4-deficient mice were highly protected from lipopolysaccharide-and ovariectomy-induced bone ***,RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.

关键词： osteoclast inhibited traffic

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A qualitative approach to aberrations of optical elements

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Chinese Optics Letters 2010年第11期8卷 1022-1023页

作者： Jerry Barretto Clark Kendrick go Department of Physics School of Science and EngineeringAteneo de Manila University Department of Mathematics School of Science and EngineeringAteneo de Manila University

A qualitative method to analyze wavefront aberrations is *** of the primary type,expressed in their matrix forms,are used to write the generalized ray transfer matrix of an optical *** aberrations were treated collectively by examining the pseudospectra of an augmented matrix constructed from the aberration *** show that aberrations can be distinguished and relative strengths pronounced using this qualitative method.

关键词： A qualitative approach to aberrations of optical elements

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Key changes across valley floors in mountain areas affected by different levels of human impact: a case study of the Ochotnica river catchment in the Polish Carpathians

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Journal of Mountain Science 2024年第11期21卷 3567-3583页

作者： Agata goŁĄB Anna MICHNO Doctoral School of Exact and Natural Sciences Jagiellonian UniversityProf.St.Łojasiewicza St 11Cracow 30348Poland Faculty of Geography and Geology Jagiellonian UniveristyGronostajowa St 3Cracow 30387Poland

The goal of this paper was to present knowledge on changes in the morphodynamic structure of the Ochotnica River(Polish Carpathians)and transformations within its active river zone since the end of the 19th *** study used a set of archival and contemporary cartographic materials and the results of three-fold field mapping of the morphodynamic structure of the *** and indirect human interference with the natural environment of the catchment and the fluvial system was taken into account in the *** of changes in the morphodynamic structure of the Ochotnica and its active river zone since the end of the 19th century indicated significant changes in the development trend of the *** contemporary structure of the Ochotnica is more complex than in the *** has been a fragmentation of the riverbed into sections with different morphodynamic *** proportion of erosive sections has increased,which explains the reduced in the width of the active river zone of the *** average width of the active river zone of the river between 1861 and 2022 has changed from 80 m to 18 *** impact has been identified as the main reason for the changes in the morphodynamic structure of the riverbed and its active river ***,only the unregulated sect ion is characterised by free lateral migration of the riverbed and the widest active river zone(~28 m).

关键词： Active river zone Channel changes Mountain river Human impact

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Metal chalcogenide-based photoelectrodes for photoelectrochemical water splitting

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Journal of Energy Chemistry 2022年第10期31卷 189-213,I0005页

作者： Marwa Mohamed Abouelela go Kawamura Atsunori Matsuda Department of Electrical and Electronic Information Engineering Toyohashi University of TechnologyToyohashi 441-8580AichiJapan Petrochemical Department Egyptian Petroleum Research InstituteCairo 11727Egypt

Photoelectrochemical water splitting(PEC-WS)is a promising technique for transforming solar energy into storable and environmentally friendly chemical *** semiconductor photoelectrodes with high light absorption capability,rapid e-/h+separation and transfer,and sufficient chemical stability is vital for developing an efficient PEC-WS *** chalcogenides(MCs)have emerged as promising candidates for light absorbers because of their unique electrical and optical *** this review,we present recent developments in hydrogen generation via PEC-WS using MC-based ***,we present a simple illustration of PEC-WS ***,the current performance of various metal(mono-,di-,and tri-)chalcogenide/semiconductor photoelectrodes in PEC-WS is ***,the charge transfer mechanism at the MC/semiconductor interface and the PEC-WS mechanism is thoroughly ***,we discuss future research perspectives toward developing efficient and stable MC/semiconductor photoelectrodes.

关键词： Photoelectrochemical water splitting Metal chalcogenides Photoelectrode Energy conversion

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Characteristics of Nb/Al superconducting tunnel junctions fabricated using ozone gas

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Chinese Physics B 2015年第9期24卷 182-186页

作者： Masahiro Ukibe go Fujii Masataka Ohkubo Nanoelectronics Research Institute (nano) National Institute of Advanced Industrial Science and Technology (AIST)

To improve the energy resolution（？E） of Nb/Al superconducting tunnel junctions（STJs）, an ozone（O3） oxidation process has been developed to fabricate a thin defect-free tunnel barrier that simultaneously shows high critical current JC〉 1000 A/cm^2 and high normalized dynamic resistance RDA 〉 100 MΩ·μm^2, where A is the size of the STJ. The 50-μm^2 STJs produced by O3 exposure of 0.26 Pa·min with an indirect spray of O3 gas, which is a much lower level of exposure than the O2 exposure used in a conventional O2 oxidation process, exhibit a maximum JC= 800 A/cm^2 and a high RDA = 372 MΩ ·μm^2. The 100-pixel array of the 100-μm^2STJs produced using the same O3 oxidation conditions exhibits a constant leak current I leak= 14.9 ± 3.2 n A at a bias point around △ /e（where e is half the energy gap of an STJ）,and a high fabrication yield of 87%. Although the I leak values are slightly larger than those of STJs produced using the conventional O2 oxidation process, the STJ produced using O3 oxidation shows a ？E = 10 eV for the C-Kα line, which is the best value of our Nb/Al STJ x-ray detectors.

关键词： Nb/Al superconducting tunnel junctions high critical current density high energy resolution ozone

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First quarter century of laparoscopic liver resection

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World Journal of Gastroenterology 2017年第20期23卷 3581-3588页

作者： Zenichi Morise go Wakabayashi Department of Surgery Fujita Health University School of Medicine Department of Surgery Center for Advanced Treatment of HBP DiseasesAgeo Central General Hospital

The beginnings of laparoscopic liver resection(LLR)were at the start of the 1990s,with the initial reports being published in 1991 and *** were followed by reports of left lateral sectionectomy in *** the years following,the procedures of LLR were expanded to hemi-hepatectomy,sectionectomy,segmentectomy and partial resection of posterosuperior segments,as well as the parenchymal preserving limited anatomical resection and modified anatomical(extended and/or combining limited)resection *** expanded range of LLR procedures,mimicking the expansion of open liver resection in the past,was related to advances in both technology(instrumentation)and technical skill with conceptual *** this period of remarkable development,two international consensus conferences were held(2008 in Louisville,KY,United States,and 2014 in Morioka,Japan),providing up-to-date summarizations of the status and perspective of *** advantages of LLR have become clear,and include reduced intraoperative bleeding,shorter hospital stay,and-especially for cirrhotic patients-lower incidence of complications(e.g.,postoperative ascites and liver failure).In this paper,we review and discuss the developments of LLR in operative procedures(extent and style of liver resections)during the first quarter century since its inception,from the aspect of relationships with technological/technical developments with conceptual changes.

关键词： Hepatectomy Laparoscopic surgery Liver cancer History Technology Technique Concept Approach Posture Simulation

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Investigation of newly developed added damping and stiffness device with low yield strength steel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2004年第3期5卷 77-85页

作者： SHIH Ming-hsiang go Cheer-germ Department of Construction Engineering National Kaoshiang First University of Science and TechnologyDepartment of Civil Engineering National Chung Hsing University Taiwan 824 ChinaTaiwan 40227 China

Energy dissipators, isolated-resistant and specific structural forms for earthquake resistance are popular topics in the research to improve shock-resistance. In this work, experimental methods were used to investigate the property of low yield strength steel. Carbon content in LYS material is lower than that in other steels; the ultimate stress is three times the yield stress. The ultimate elongation rate is about 62% and the ductility is 23 times that of A36 steel. In order to overcome some defects of ordinary use metallic dampers, the mechanical characteristic of low yield strength steel is used to develop added damping and stiffness for rhombic steel plate absorber. Test of the energy dissipation behavior for this newly de-veloped device indicated that LYS could stably dissipate or absorb the input energy of earthquake. Then, the analytical model for the hysteretic behavior of this new device is proposed. Comparison of experimental data and numerical simulation results showed that this analytical model is suitable for simulating the hysteretic energy behavior of this new device.

关键词： Seismic shock absorbance elements Capability of seismic resistance Hysteretic behavior of rhombic steel plate Nonlinear analytical model

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Development and Applications of Ruggedized VIS/NIR Spectrometer System for Oilfield Wellbores

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Photonic Sensors 2013年第4期3卷 289-294页

作者： go FUJISAWA Tsutomu YAMATE Schlumberger gouM Research Cambridge UK Schlumberger K.K. Sagamihara Japan

The development and applications of a ruggedized visible to near-infrared （VIS/NIR） spectrometer system capable of measuring fluid spectra in oilfield wellbores are presented. Real-time assessment of formation fluid properties penetrated by an oilfield wellbore is critically important for oilfield operating companies to make informed decisions to optimize the development plan of the well and hydrocarbon reservoir. A ruggedized VIS/NIR spectrometer was designed and built to measure and analyze hydrocarbon spectra reliably under the harsh conditions of the oilfield wellbore environment, including temperature up to 175 ~C, pressure up to 170MPa, and severe mechanical shocks and vibrations. The accuracy of hydrocarbon group composition analysis was compared well with gas chromatography results in the laboratory.

关键词： VIS/NIR spectroscopy hydrocarbon compositions oilfield wellbore in situ measurement real time

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Optical and scintillation properties of Nd-doped SrAl2O4 crystals

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Journal of Rare Earths 2016年第8期34卷 757-762页

作者： Daisuke Nakauchi go Okada Masanori Koshimizu Takayuki Yanagida Graduate School of Materials Science.Nara Institute of Science and Technology(NAIST)8916-5 Takayama-cho lkoma-shiNara 630-0192Japan Department of Applied Chemistry Graduate School of EngineeringTohoku University 6-6-07 AobaAramakiAoba-ku.Sendai 980-8579.Japan

Nd-doped SrA1204 （Nd：SrA1204） crystals were prepared by a floating zone （FZ） method with different dopant concentra- tions. The photoluminescence （PL） measurements under visible light excitations confirmed strong near infrared （NIR） emissions around 890 nm, which is due to the 4f-4f transitions of Nd3＋, and the decay time constants were 300-400 μs. Furthermore, VUV ex- citations revealed two broad emissions around 250450 and 500-700 run, which were attributed to self-trapped excitons （STEs） perturbed by Nd3＋. Moreover, the X-ray induced scintillation spectra showed some small peaks at around 380 nm in addition to NIR emissions at 1064 nm similarly seen in PL. The former scintillation decay time constants were 30-40 Its. In the undoped sample, these emissions mentioned above were not present but a weak broad emission around 450 nm appeared. In thermally stimulated lu- minescence （TSL） after X-ray irradiation, strong TSL glow peaks were observed in the Nd-doped samples at around 100 and 250 ℃.

关键词： scintillation photoluminescence storage luminescence single crystal rare earths

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Fabrication of Shape-Controlled Au Nanoparticles in a TiO_2-Containing Mesoporous Template Using UV Irradiation and Their Shape-Dependent Photocatalysis

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Journal of Materials Science & Technology 2014年第1期30卷 8-12页

作者： Teruhisa Okuno go Kawamura Hiroyuki Muto Atsunori Matsuda Department of Environmental and Life Sciences Toyohashi University of Technology Department of Electrical and Electronic Information Engineering Toyohashi University of Technology

A SiO2-TiO2 template with ordered tubular mesochannels has been prepared by the sol-gel method. Au nanorods are deposited in the tubular mesochannels of the SiO2-TiO2 template, and the shape of Au is changed from nanorods to nanospheres by ultraviolet irradiation during thermal deposition. The photocatalytic activity of mesoporous SiO2-TiO2 with/without Au nanorods/nanospheres is evaluated. Deposition of Au in the mesoporous SiO2-TiO2 template enhances the photocatalysis of TiO2. Interestingly, the sample containing Au nanorods exhibits higher photocatalytic activity than that with Au nanospheres. Photocatalysis by exciting surface plasmon resonance is not detected in the composite samples regardless of the shape of the deposited Au nanoparticles.

关键词： Mesoporous Titania gold Shape control Photocatalysis Surface plasmon resonance

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