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Short Term Prediction of Infectious Diseases Patients from Prescription Surveillance

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Journal of Biosciences and Medicines 2018年第9期6卷 61-68页

作者： Tamie Sugawara Yasushi Ohkusa Hirokazu Kawanohara miwako kamei National Institute of Infectious Diseases Tokyo Japan EM Systems Co. Ltd. Osaka Japan School of Pharmacy Nihon University Chiba Japan

In Japan, the incidence of almost all common pediatric infectious diseases has been monitored, with 7 - 10 day delays, at medical institutions through the National Official Sentinel Surveillance of Infectious Diseases (NOSSID). On the other hand, based on prescriptions filled at external pharmacies, Prescription Surveillance (PS) collects information and provides estimated numbers of influenza, varicella, and gastroenteritis infectious (GI) patients to the public the following morning. For precise, and real-time estimation of incidences of common pediatric infectious diseases, we evaluated predictive power of PS for diseases other than influenza, varicella, and GI. Results demonstrated that PS information has sufficient predictive power for pharyngoconjunctival fever, group A streptococcal pharyngitis, exanthem subitum, and mumps, some predictive power for RS virus infection, erythema infectiosum and herpangina, but insufficient predictive power for hand, foot and mouth disease.

关键词： Prescription Surveillance Pharmacy Sentinel Surveillance Pediatric Infectious Disease

Retrospective Evaluation for ORCA Surveillance Comparison with Prescription Surveillance

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Journal of Biosciences and Medicines 2019年第12期7卷 1-8页

作者： Tomoaki Ueno Tamie Sugawara Yasushi Ohkusa Hirokazu Kawanohara miwako kamei ORCA Management Organization Co. Ltd. Tokyo Japan National Institute of Infectious Diseases Tokyo Japan EM Systems Co. Ltd. Osaka Japan School of Pharmacy Nihon University Chiba Japan

Background: “Online Receipt Computer Advantage” (ORCA) surveillance, an online medical claim service produced and provided freely to medical facilities by the Japan Medical Association, has been available for public use since 2010. However, its preciseness has not been evaluated. The object of the present study is comparison with ORCA surveillance and prescription surveillance (PS), which is the most reliable daily surveillance for influenza nationwide in Japan, and evaluating preciseness of ORCA surveillance. Method: We specifically examined influenza as a targeted disease. We regarded PS as the gold standard daily real-time monitoring system for influenza nationwide and for each prefecture. This study assesses correlation and discrepancies between ORCA and PS results for influenza nationwide and by prefecture. Results: Nationwide, the correlation coefficient of PS and ORCA was 0.9653;the discrepancy rate was 27%. Among prefectures, results show that Mie and Fukui prefectures had two quite similar epidemic curves. Conclusion: Results demonstrate that ORCA surveillance is comparable to PS nationwide. However, some prefectures exhibited comparable results whereas others did not. ORCA surveillance cannot break down to the municipal level.

关键词： ORCA Surveillance Prescription Surveillance Influenza Real-Time Daily Surveillance Preciseness

Evaluation of bacterial contamination and medium-term oncological outcomes of intracorporeal anastomosis for colon cancer:A propensity score matching analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 670-680页

作者： Hajime Kayano Nana Mamuro Yutaro kamei Takashi Ogimi Hiroshi Miyakita Toshio Nakagohri Kazuo Koyanagi Masaki Mori Seiichiro Yamamoto Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Although intracorporeal anastomosis(IA)for colon cancer requires longer operative time than extracorporeal anastomosis(EA),its short-term postoperative results,such as early recovery of bowel movement,have been reported to be equal or *** IA requires opening the intestinal tract in the abdominal cavity under pneumoperitoneum,there are concerns about intraperitoneal bacterial infection and recurrence of peritoneal dissemination due to the spread of bacteria and tumor ***,intraperitoneal bacterial contamination and medium-term oncological outcomes have not been *** cavity in *** Of 127 patients who underwent laparoscopic colon resection for colon cancer from April 2015 to December 2020,75 underwent EA(EA group),and 52 underwent IA(IA group).After propensity score matching,the primary endpoint was 3-year disease-free survival rates,and secondary endpoints were 3-year overall survival rates,type of recurrence,surgical site infection(SSI)incidence,number of days on antibiotics,and postoperative biological *** Three-year disease-free survival rates did not significantly differ between the IA and EA groups(87.2%and 82.7%,respectively,P=0.4473).The 3-year overall survival rates also did not significantly differ between the IA and EA groups(94.7%and 94.7%,respectively;P=0.9891).There was no difference in the type of recurrence between the two *** addition,there were no significant differences in SSI incidence or the number of days on antibiotics;however,postoperative biological responses,such as the white blood cell count(10200 vs 8650/mm^(3),P=0.0068),C-reactive protein(6.8 vs 4.5 mg/dL,P=0.0011),and body temperature(37.7 vs 37.5℃,P=0.0079),were significantly higher in the IA *** IA is an anastomotic technique that should be widely performed because its risk of intraperitoneal bacterial contamination and medium-term oncological outcomes are comparable to those of EA.

关键词： Colon cancer Intracorporeal anastomosis 3-year disease-free survival Recurrence Surgical site infection Postoperative biological response

Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury

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Neural Regeneration Research 2018年第3期13卷 536-540页

作者： Atsushi Takazawa Naosuke kamei Nobuo Adachi Mitsuo Ochi Department of Orthopaedic Surgery Graduate School of Biomedical & Health Sciences Hiroshima University Medical Center for Translational & Clinical Research Hiroshima University Hospital

Old astrocyte specifically induced substance （OASIS） is an endoplasmic reticulum （ER） stress transducer specifically expressed in astrocytes and osteoblasts. OASIS regulates the differentiation of neural precursor cells into astrocytes in the central nervous system. This study aimed to elucidate the involvement of ER stress responses stimulated via OASIS in astrogliosis following spinal cord injury. In a mouse model of spinal cord contusion injury, OASIS mRNA and protein expression were evaluated at days 7 and 14. A significant increase in OASIS mRNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Immunostaining on day 7 revealed co-localization of OASIS and astrocytes in the periphery of the injury site. Furthermore, anti-OASIS small interfering RNA （siRNA） was injected at the injury sites on day 5 to elucidate the function of OASIS. Treatment with anti-OASIS siRNA caused a significant decrease in OASIS mRNA on day 7 and protein on days 7 and 14, and was associated with the inhibition of astrogliosis and hindlimb motor function recovery. Results of our study show that OASIS expression synchronizes with astrogliosis and is functionally associated with astrogliosis after spinal cord injury.

关键词： unfolded protein response cAMP-response element binding protein/activating transcription factor protein family C57BL/6 contusion injury reactive astrocyte functional recovery real-time polymerase chain reaction western blot immunohistochemistry glial fibrillary acidic protein

Moisture Detection of SF_6 Gas Instruments by Solid Electrolyte

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稀有金属材料与工程 2006年第A3期35卷 353-356页

作者： Eiichi Nagao Tadao Minagawa Chieko Nishida Mitsuhito kamei Mitsubishi Electric Corporation 8-1-1Tsukaguchi-HonmachiAmagasakiHyogo661-8661Japan

Humidity measurement in a very low moisture atmosphere was studied by using solid electrolyte film coated with porous electrodes,considering its application to the moisture monitoring of SF_6 gas-insulated high voltage instruments such as gas-insulated switchgear (GIS) and gas circuit breakers (GCBs).Compared to the AC impedance values measured in an ambient atmosphere where the moisture atmosphere is far higher than that in these instruments,considerably large impedance values were obtained in a very low moisture *** impedance was systematically measured in accordance with the conditions of these instruments whose moisture contents were less than 1 000×10^(-6).A good correlation was obtained between the impedance values and the moisture *** frequency characteristics of the impedance were analyzed based on a conventional equivalent circuit where a number of CR circuits were connected in *** the dielectric relaxation of each circuit,it was found that the frequency characteristics of the impedance can be explained by the equivalent circuit. Two semicircles were clearly obtained in the Cole-Cole impedance plot which are thought to reflect the impedance characteristics of the film and the *** AC impedance can be a good indicator of the moisture content of SF_6 gas-insulated high voltage instruments.

关键词： humidity moisture solid electrolyte impedance ion conductivity

Multiple carcinosarcomas of the esophagus with adenocarcinomatous components: A case report

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World Journal of Gastroenterology 2020年第17期26卷 2111-2118页

作者： Hiroshi Okamoto Hiroshi Kikuchi Hiroshi Naganuma Takashi kamei Department of Gastroenterological Surgery Graduate School of MedicineTohoku UniversitySendai 980-8574Japan Department of Surgery South Miyagi Medical CenterMiyagi 989-1253Japan Department of Pathology Sendai City HospitalSendai 982-8502Japan

BACKGROUND Carcinosarcoma(spindle cell carcinoma) of the esophagus is an extremely rare event;the etiology and origins of this neoplasm have not yet been ***-mesenchymal transition(EMT) has been associated with invasion and metastasis, and may be related to the generation of a stem cell population within this *** SUMMARY We present the case of a 61-year-old male with nausea and fever. Upper gastrointestinal endoscopy revealed the presence of type 1 and 0-Ⅱc lesions located 35 cm from the incisors toward the esophago-gastric *** esophagectomy was performed. Macroscopic analysis revealed three polypoid lesions in the abdominal esophagus that accompanied the main lesion in the lower thoracic esophagus and 0-Ⅱc lesions that spread continuously with them. Histologically, the lesions included proliferating spindle cells. Adenocarcinomatous components were detected in a section near the foot, and squamous cell carcinoma was identified in the mucosa at the base of the *** patient was diagnosed with multiple carcinosarcomas, staged at pT1b(SM3),pN1(#110, #7), cM0, Stage Ⅱ(sarcomatous metastasis to the lymph nodes).Spindle cells did not express E-cadherin but were positive for EMT markers,including zinc finger E-box-binding homeobox 1, TWIST, and snail family transcriptional repressor 2. The patient has experienced no recurrence at 5 years and 2 mo after *** This report suggests that multiple sarcomatous tumors may be generated from primary squamous cell carcinoma via mechanisms related to EMT.

关键词： Esophagus Multiple carcinosarcomas Multiple spindle cell carcinomas Epithelial-mesenchymal transition Epithelial-mesenchymal transition markers Case report

Sigma-2 receptor as a potential therapeutic target for treating central nervous system disorders

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Neural Regeneration Research 2019年第11期14卷 1893-1894页

作者： Kazuki Terada Keisuke Migita Yukari Matsushima Chiaki kamei Laboratory of Drug Design and Drug Delivery Faculty of Pharmaceutical SciencesFukuoka UniversityFukuokaJapan Department of Drug Informatics Faculty of Pharmaceutical SciencesFukuoka UniversityFukuokaJapan Department of Pharmacology Faculty of Pharmaceutical SciencesYasuda Women’s UniversityHiroshimaJapan

The sigma receptor (Sig-R) was first reported by Martin et al.(1976) and was initially classified into the opioid receptor family. However, Sig-R was subsequently found to differ from the opioid receptor in various studies including ligand binding assays and autoradiography analysis (Tam and Cook, 1984). Sig-R is widely distributed in tissues such as central nervous, digestive, immune, and endocrine tissues. There are two types of Sig-R: sigma-1 (Sig-1R) and sigma-2 receptors (Sig-2R).

关键词： sigma receptor(Sig-R) Martin Sigma-2

Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 337-342页

作者： Nobuhiko Kurata Yasuhiro Ogura Satoshi Ogiso Yasuharu Onishi Hideya kamei Yasuhiro Kodera Department of Transplantation and Endocrine Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan Department of Transplantation Surgery Nagoya University Hospital65 Tsurumai-choShowa-kuNagoya 466-8560Japan Department of Gastroenterological Surgery(Surgery II) Nagoya University Graduate School of MedicineNagoyaJapan

Background:Graft inflow modulation(GIM)during adult-to-adult living donor liver transplantation(LDLT)is a common strategy to avoid small-for-size syndrome,and some transplant surgeons attempt small size graft strategy with frequent GIM procedures,which are mostly performed by splenectomy,in ***,splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy ***:Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively *** applied the graft selection criteria,which routinely fulfill graft-to-recipient weight ratio≥0.8%,and consider GIM as a backup strategy for high portal venous pressure(PVP).Results:In our current strategy of LDLT,splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms,but splenectomy for GIM was intended to only one patient(2.1%).The final PVP values≤20 mmHg were achieved in all recipients,and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or ***,6 of 18 patients with splenectomy(33.3%)developed postsplenectomy portal vein thrombosis(PVT),while none of the 30 patients without splenectomy developed PVT after *** was identified as a risk factor of PVT in this study(P<0.001).Our study revealed that a lower final PVP could be risk factor of postsplenectomy ***:Using sufficient size grafts was one of the direct solutions to control PVP,and allowed GIM to be reserved as a backup *** should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of *** splenectomy cases with a lower final PVP,a close follow-up is required for early detection and treatment of PVT.

关键词： Living donor liver transplantation Splenectomy Portal venous pressure Graft-to-recipient weight ratio Portal vein thrombosis

Classification of rectal cancer according to recurrence types-comparison of Japanese guidelines and Western guidelines

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World Journal of Clinical Cases 2022年第36期10卷 13284-13292页

作者： Hiroshi Miyakita Yutaro kamei Lin Fung Chan Kazutake Okada Hajime Kayano Seiichiro Yamamoto Department of Digestive System Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

BACKGROUND Rectal cancer is characterized by more local recurrence(LR)and lung metastasis than colon ***,the diagnosis of rectal cancer is not standardized as there is no global consensus on its definition and *** classification of rectal cancer differs between Japanese and Western *** To clarify the characteristics of rectal cancer by comparing the tumor location and characteristics of rectal cancer with those of colon cancer according to each set of *** A total of 958 patients with Stage II and III colorectal cancer were included in the analysis:607 with colon cancer and 351 with rectal *** of rectal cancers was assessed by enema examination and rigid *** to Japan guidelines,rectal cancer is classified as Rb(below the peritoneal inversion),Ra(between the inferior margin of second sacral vertebrae and Rb)or RS(between Ra and sacral promontory).RESULTS There were no significant differences between RS rectal cancer and colon cancer in the rates of liver and lung metastasis or *** metastasis and LR were significantly more common among Rb rectal cancer(in Japan)than in colon cancer(P=0.0043 and P=0.0002,respectively).Lung metastases and LR occurred at significantly higher rates in rectal cancer measuring≤12 cm and≤10 cm than in colon cancers(P=0.0117,P=0.0467,P=0.0036,P=0.0010).Finally,the rates of liver metastasis,lung metastasis,and LR in rectal cancers measuring 11 cm to 15 cm were 6.9%,2.8%,and 5.7%,*** were equivalent to the rates in colon *** High rectal cancer may be treated with the same treatment strategies as colon *** was no difference in the classification of colorectal cancer between Japan and Western countries.

关键词： Colon cancer Metastasis Local recurrence Classification of rectal cancer Western guidelines Japanese guideline