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A Fully-Printed Wearable Bandage-Based Electrochemical Sensor with pH Correction for Wound Infection Monitoring

NANO-MICRO LETTERS 2025年第1期17卷 1-21页

作者： Kaewpradub, Kanyawee Veenuttranon, Kornautchaya Jantapaso, Husanai mittraparp-arthorn, pimonsri Jeerapan, Itthipon Prince Songkla Univ Ctr Excellence Trace Anal & Biosensor Hat Yai 90110 Songkhla Thailand Prince Songkla Univ Fac Sci Div Phys Sci Hat Yai 90110 Songkhla Thailand Prince Songkla Univ Fac Sci Ctr Excellence Innovat Chem Hat Yai 90110 Songkhla Thailand Prince Songkla Univ ijE Electrochem All Lab Hat Yai 90110 Songkhla Thailand Prince Songkla Univ Fac Sci Div Biol Sci Hat Yai 90110 Songkhla Thailand

The first example of a flexible array capable of detecting pyocyanin, a bacterial virulence factor, while correcting dynamic pH *** a screen-printable conductive nanocomposite ink for fabricating the pyocyanin sensor and utilized a polyaniline/carbon nanocomposite as a pH-sensitive film for the pH *** inks are advantageous in terms of flexible printed sensing array integrated onto a bandage surface, capable of monitoring both pyocyanin and pH levels in wound exudate. Wearable sensing systems have been designed to monitor health conditions in real-time by detecting analytes in human biofluids. Wound diagnosis remains challenging, necessitating suitable materials for high-performance wearable sensors to offer prompt feedback. Existing devices have limitations in measuring pH and the concentration of pH-dependent electroactive species simultaneously, which is crucial for obtaining a comprehensive understanding of wound status and optimizing biosensors. Therefore, improving materials and analysis system accuracy is essential. This article introduces the first example of a flexible array capable of detecting pyocyanin, a bacterial virulence factor, while correcting dynamic pH fluctuations. We demonstrate that this combined sensor enhances accuracy by mitigating the impact of pH variability on pyocyanin sensor response. Customized screen-printable inks were developed to enhance analytical performance. The analytical performances of two sensitive sensor systems (i.e., fully-printed porous graphene/multiwalled carbon nanotube (CNT) and polyaniline/CNT composites for pyocyanin and pH sensors) are evaluated. Partial least square regression is employed to analyze nonzero-order data arrays from square wave voltammetric and potentiometric measurements of pyocyanin and pH sensors to establish a predictive model for pyocyanin concentration in complex fluids. This sensitive and effective strategy shows potential for personalized applications due to

关键词： Pyocyanin Bandages Wound monitoring Biosensor Wearable device

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Economic burden of childhood diarrhea in Burundi

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Global Health Research and Policy 2021年第1期6卷 380-391页

作者： Fulgence Niyibitegeka arthorn Riewpaiboon Sitaporn Youngkong Montarat Thavorncharoensap Master of Science Program in Social Economicand Administrative PharmacyFaculty of PharmacyMahidol UniversityBangkokThailand Division of Social and Administrative Pharmacy Department of PharmacyFaculty of PharmacyMahidol University447 Sri-Ayuthaya RoadRajatheviBangkokThailand

Background:In 2016,diarrhea killed around 7 children aged under 5 years per 1000 live births in *** objective of this study was to estimate the economic burden associated with diarrhea in Burundi and to examine factors affecting the cost to provide economic evidence useful for the policymaking about clinical management of ***:The study was designed as a prospective cost-of-illness study using an incidence-based approach from the societal *** study included patients aged under 5 years with acute non-bloody diarrhea who visited Buyenzi health center and Prince Regent Charles hospital from November to December *** were collected through interviews with patients’caregivers and review of patients’medical and financial *** linear regression was performed to identify factors affecting cost,and a cost model was used to generate predictions of various clinical and care management *** costs were converted into international dollars for the year ***:One hundred thirty-eight patients with an average age of 14.45 months were included in this ***-one percent of the total patients included were *** average total cost per episode of diarrhea was Int$*** visit and hospitalization costs per episode of diarrhea were Int$59.87 and Int$292,*** costs were significantly affected by the health facility type,patient type,health insurance scheme,complications with dehydration,and duration of the episode before *** model indicates that the prevention of one case of dehydration results in savings of Int$16.81,accounting for approximately 11 times of the primary treatment cost of one case of diarrhea in the community-based management program for diarrhea in ***:Diarrhea is associated with a substantial economic burden to *** from this study provides useful information to support health interventions aimed at prevention of diarrhea and dehydrati

关键词： prevention admitted policy

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