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Understanding Patients’ Symptoms Management Using Objective and Subjective Indicators among Patients with Systemic Lupus Erythematosus

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Open Journal of Nursing 2023年第5期13卷 314-328页

作者： Kiyoko Makimoto Kazuko Shiozawa Yoshihito Shima Toru Hirano mitsuyo inoue Osaka University Osaka Japan Rheumatology & Collagen Disease Center Hyogo Prefectural Kakogawa Medical Center Kakogawa Japan Laboratory of Thermo-Therapeutics for Vascular Dysfunction Osaka University Graduate School of Medicine Osaka Japan Division of Rheumatology Nishinomiya Municipal Central Hospital Nishinomiya Japan School of Nursing Hyogo Medical University Kobe Japan

Background: Descriptive statistics have been used to document the high prevalence of sleep disorders, fatigue, and pain in patients with systemic lupus erythematosus (SLE). Objectives: To describe day-to-day variations in sleep indicators, physical activity level, pain, and fatigue measured using objective and subjective indicators in lupus patients with sleep disorders. Methods: We selected three patients with sleep disorders, measured by the Pittsburgh Sleep Quality Index score (≥9), out of 20 participants followed up for 4 weeks. We compared the self-rated quality of life (QoL) measured using the Pittsburgh Sleep Quality Index (PSQI) with that of objectively measured sleep indicators monitored using the Nemuri scan. The detailed data collection methods have been previously published. Results: The sleep status generated by the Nemuri scan revealed that Case A with a flare and Case B without a flare required frequent daytime rest. The PSQI sleep duration and sleep latency were generally in agreement with the monitored data, although the PSQI failed to capture the complexity of sleep disorders, particularly the fluctuations in the quality of sleep indicators. Patient C approximately 4 hours on weekdays and 10 hours on Saturday nights. All three cases had high fatigue levels, and their moderate-to-vigorous physical activity duration was less than one-half of duration that recommended by the World Health Association. Conclusion: Visual display for objective monitoring of sleep quality is an excellent tool for understanding patients who require frequent resting and irregular sleep indicators. Objective monitoring of sleep quality, along with self-rated pain and fatigue, promotes an understanding of how patients with SLE cope with severe symptoms.

关键词： Symptoms Management Sleep Indicator Physical Activity Pain Fatigue QoL

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Monitoring of Sleep Indicators, Physical Activity, Pain, and Fatigue in Patients with Systemic Lupus Erythematosus and Relations among These Variables: A Pilot Study

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Open Journal of Nursing 2023年第1期13卷 22-44页

作者： mitsuyo inoue Kazuko Shiozawa Ryosuke Yoshihara Yoshihito Shima Toru Hirano Kiyoko Makimoto School of Nursing Hyogo Medical University Kobe Japan Rheumatology & Collagen Disease Center Hyogo Prefectural Kakogawa Medical Center Kakogawa Japan Laboratory of Thermo-Therapeutics for Vascular Dysfunction Graduate School of Medicine Osaka University Suita Japan Division of Rheumatology Nishinomiya Municipal Central Hospital Nishinomiya Japan Graduate School of Medicine Osaka University Suita Japan

Background: Poor sleep, fatigue, and pain are major health problems in patients with systemic lupus erythematosus (SLE). However, only cross-sectional surveys on these health outcomes have been conducted, and the association between day-to-day fluctuations remains unknown. Objectives: We aimed to characterize daily fluctuations in sleep quality, physical activity, pain, and fatigue in patients with SLE. Method: Exploratory study with a cross-sectional design. Two rheumatology centers (a university hospital and a prefectural hospital) in Japan between September 2017 and May 2019. The sample size was set to 20. Demographic and clinical data were collected. Sleep and physical activity were measured with monitoring devices;pain and fatigue levels were recorded daily during the 4-week period. The Pittsburgh Sleep Quality Index, Short Form Health Survey-12, the Japanese version of the Lupus Patient Outcome, and SLE Disease Activity Index 2000 were collected at the start and end of the study. Descriptive statistics and coefficients of variation (CV) were tabulated to examine daily fluctuations. Pearson correlation coefficients were obtained for monitored variables. Results: The mean age was 43.7 ± 8.5 years, and the mean SLE duration was 16.0 ± 7.2 years. The mean moderate-to-vigorous physical activity (MVPA) duration was 7.8 ± 5.8 min/day, and the mean total sleep duration was 391.8 ± 65.3 min, with a mean sleep efficiency of 88.6% ± 6.1%. Daily fluctuations were high for leaving the bed frequency, MVPA duration, pain, and waking after sleep onset. Seventeen participants showed correlations between some of the variables, such as fatigue or longer MVPA duration and poorer sleep outcomes;longer sleep latency and increased frequency of leaving the bed;and higher physical activity and increased pain and fatigue. Conclusion: The quality of sleep and fatigue fluctuated daily, and correlations existed between these variables, as well as for pain and physical activity. The impact

关键词： Daily Fluctuation Sleep Indicator Physical Activity Pain Fatigue

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Understanding Patients’ Symptoms Management Using Objective and Subjective Indicators among Patients with Systemic Lupus Erythematosus

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Open Journal of Nursing（护理学期刊） 2023年第5期

作者： Kiyoko Makimoto Kazuko Shiozawa Yoshihito Shima Toru Hirano mitsuyo inoue

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Monitoring of Sleep Indicators, Physical Activity, Pain, and Fatigue in Patients with Systemic Lupus Erythematosus and Relations among These Variables: A Pilot Study

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Open Journal of Nursing（护理学期刊） 2023年第1期

作者： mitsuyo inoue Kazuko Shiozawa Ryosuke Yoshihara Yoshihito Shima Toru Hirano Kiyoko Makimoto

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Comparative study on pharmacokinetics and toxicity of intravitreal and sub-Tenon injection of triamcinolone acetonide in ocular tissues

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1864-1871页

作者： Yuko Arie Hiroko Miyai Ayako Suzuki Takeshi Okabe mitsuyo Takashima Mayumi Takata Takashi Kurasawa Masaki Ito Reijiro Arakawa Yuichiro Ogura Akira Naito Sagami Research Laboratories Wakamoto Pharmaceutical Corporation Ltd.Kanagawa 2580018Japan Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoya 4678601Japan

AIM:To compare the differences in kinetics,distribution,and toxicity of triamcinolone acetonide(TA)between the injection methods,sub-Tenon and intravitreal injections in rabbit ocular ***:TA was injected into the vitreous or the sub-Tenon in *** pharmacokinetic study,rabbits were sacrificed periodically and then TA in blood and ocular tissues(retina/choroids,vitreous,and aqueous humor)were measured over 91 *** toxicological study,clinical signs,slit-lamp microscopic examination,ophthalmological test were *** eyeballs and surrounding tissues were collected and fixed with glutaraldehyde-formalin solution,and then paraffin embedded for histological ***:Higher levels of TA were distributed in the intraocular tissues when injected into the vitreous compared to the ***,TA level was remarkably lower in the rabbits which received intravitreal TA injections than those treated with sub-Tenon injection throughout the study period in *** discharge probably caused by systemic circulation of TA was observed by receiving sub-Tenon TA ***,technicassociated toxicological ocular symptoms and findings were more frequently observed in intravitreal injection than in sub-Tenon ***:There are significant differences in kinetics and distribution of TA in vitreous body,aqueous humor and plasma,between the two injection *** further study is needed to explain the species difference between human and rabbit,it is assumed that the difference in the frequency of intraocular pressure elevation and cataract formation by TA between the two injection methods are directly related to the TA concentrations in aqueous humor and vitreous body in each injection *** toxicity and technic-associated toxicity are also closely related to kinetics of TA in plasma and each injection method itself,respectively.

关键词： corticosteroid(s) pharmacokinetics injection ophthalmic drug delivery toxicity

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Diagnosis of extent of early gastric cancer using flexible spectral imaging color enhancement

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World Journal of Gastrointestinal Endoscopy 2012年第8期4卷 356-361页

作者： Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano Department of Internal Medicine Division of Gastroen- terology Jichi Medical University Tochigi 329-0498 Japan

The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC.

关键词： Early gastric cancer Flexible spectral imag- ing color enhancement Nonmagnified image Magnified image Endoscopic submucosal dissection

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花生条纹病毒的定名

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中国油料 1989年第2期11卷 99-100页

作者： James W.Demski D.V.R.Reddy Sopone Wongkeaw mitsuyo Kameya-Iwaki Nasw Saleh 许泽永张宗义

近年来,自然侵染花生(Arachis hypogaea L.)马铃薯y病毒组病毒的命名变得愈来愈混乱。1965年,Kuhn报道美国花生上一种种传病毒,定名为花生斑驳病毒(PMV)。1980年,Dubern和Dollel发现西非一种侵染花生病毒,称为花生眼斑病毒(GEV)。1981年... 详细信息

近年来,自然侵染花生(Arachis hypogaea L.)马铃薯y病毒组病毒的命名变得愈来愈混乱。1965年,Kuhn报道美国花生上一种种传病毒,定名为花生斑驳病毒(PMV)。1980年,Dubern和Dollel发现西非一种侵染花生病毒,称为花生眼斑病毒(GEV)。1981年,Sreanivasulu等报道印度一种侵染花生病毒,取名为花生绿色花叶病毒(PGMV)。1983年,许泽永等报道中国一种引起花生轻斑驳的病毒(VPMM),但没有给该病毒定名,

关键词：花生条纹病毒病毒定名

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日本体育大学备战2020年东京奥运会和残奥会的措施

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中国体育科技 2019年第9期55卷 89-96,115页

作者：依田充代赵倩颖清宮孝文日本体育大学日本东京158-8508 公益财团法人日本体育协会体育科学研究室日本东京160-0013 顺天堂大学体育健康科学部日本千叶270-1695 和光大学日本东京195-8585

在热门话题“东道主日本是如何备战2020年东京奥运会”的背景下,本文以1989年—2016年的7届奥运会上获得奖牌数最多的日本体育大学为研究对象,通过收集分析相关资料明确其备战措施。日本体育大学为了培养70名运动员参加2020年东京奥运会... 详细信息

在热门话题“东道主日本是如何备战2020年东京奥运会”的背景下,本文以1989年—2016年的7届奥运会上获得奖牌数最多的日本体育大学为研究对象,通过收集分析相关资料明确其备战措施。日本体育大学为了培养70名运动员参加2020年东京奥运会,启动了日本体育厅委托的“NSSU Coach Developer Academy(NCDA)”项目,同时日本体育大学实施了独有的“Nittaidai Athlete Support System(NASS)”项目,NASS主要包括医科学、财政、研究、教育、训练等支援。其中医科学支援项目主要包括成绩成果分析、训练支援、医疗支援、心理支援、营养支援和女子运动员支援。日体大通过启动上述2个支援项目,促进达成备战2020年奥运会目标实现的同时,使自身的在国内外的影响力得到了更进一步的提高。

关键词：日本 2020年东京奥运会 2020年东京残奥会日本体育大学培养选手支援系统

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