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Pituicytoma Associated with Serum Adrenocorticotropic Hormone Elevation

Open Journal of Modern Neurosurgery 2016年第4期6卷 105-110页

作者： Issei Fukui Yasuhiko Hayashi Iku Nambu mitsutoshi nakada Department of Neurosurgery Graduate School of Medical Science Kanazawa University Kanazawa Japan

Background: Pituicytoma is a rare benign tumor of the neurohypophysis or hypophyseal stalk. Endocrinological abnormalities derived from this tumor are even rarer. Although three cases of pituicytoma with elevated plasma adrenocorticotropic hormone (ACTH) have been reported previously, the etiological mechanisms remain unknown. Case Description: We present a 47-year-old woman who was referred to a hospital complaining of headache. On investigation using magnetic resonance imaging (MRI), a tumor was detected in the sellar region. Elevation of basal ACTH and serum cortisol was identified, suggesting an ACTH-producing pituitary adenoma. However, physical findings and results of other hormonal examination showed no evidence of Cushing disease. The tumor had been detected incidentally eight years earlier when MRI was performed, and showed considerable enlargement on this consultation. Endoscopic endonasal transsphenoidal surgery was performed in order to remove the tumor completely. The histopathological diagnosis was pituicytoma. The patient’s postoperative clinical course was excellent, and both ACTH and cortisol levels returned to normal following surgery. Conclusions: It appears that ACTH was being secreted from the tumor cells. We discuss the possible mechanism of ACTH elevation in cases of pituicytoma.

关键词： Pituicytoma Adrenocorticotropic Hormone Transsphenoidal Surgery

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The association between recurrence pattern and impaired blood flow around the resection cavity due to the glioblastoma surgery

The association between recurrence pattern and impaired bloo...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Takuya FURUTA mitsutoshi nakada Yutaka HAYASHI Jun-ichiro HAMADA Department of Neurosurgery Kanazawa University

＜正＞PURPOSE: Initial treatment for glioblastoma multiforme （GBM） is tumor resection. In the acute stage after GBM surgery, hyperintensity lesion around the resection cavity caused by the impairment of vessels is c...

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EphB1 signaling modulates glioma cell invasion via the ligand dependent signaling and correlates with favorable survival in malignant glioma

EphB1 signaling modulates glioma cell invasion via the ligan...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： mitsutoshi nakada Natsuki Furuyama Yutaka Hayashi Jun-ichiro Hamada Department of Neurosurgery Graduate School of Medical ScienceKanazawa University

＜正＞Introduction The largest family of tyrosine kinases,Eph receptors and their ligands,the ephrins,are frequently overexpressed in glioma,which suggests important roles for their bidirectional signals in pathobiolo...

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Relation of surgical extent of glioblastoma resection to survival in the standard therapy

Relation of surgical extent of glioblastoma resection to sur...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Shingo Tanaka mitsutoshi nakada Yutaka Hayashi Jun-ichiro Hamada Department of Neurosurgery Kanazawa University

＜正＞Introduction: It remains to be elucidated whether the extent of glioblastoma （GBM） resection is associated with patient survival although the extent of surgical resection tends

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The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients

The expression level of sphingosine-1-phosphate receptor typ...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Yuya Yoshida mitsutoshi nakada Tomoya Harada Shingo Tanaka Takuya Furuta Yasuhiko Hayashi Daisuke Kita Naoyuki Uchiyama Yutaka Hayashi Jun-ichiro Hamada Department of Neurosurgery Graduate School of Medical ScienceKanazawa University13-1 Takara-machiKanazawa 920-8641Japan

Although there are many reports on the clinical use of the MIB-1 labeling index（LI）,which is a measure of proliferative activity in astrocytomas;its significance varies between *** are no known molecules that are directly linked to the MIB-1 LI in *** evaluated the clinical value of the MIB-1 LI in our human glioblastoma cases and determined the molecules that possibly influenced the MIB-1 *** immunohistochemical study of the MIB-1 protein was performed and MIB-1 LIs of 38 glioblastomas were *** the same cases,epidermal growth factor receptor（EGFR）,plateletderived growth factor receptor-a（PDGFRA）,and sphingosine-1-phosphate receptor type 1（S1P1）,which are known regulators of glioma cell proliferation,were detected and quantified by quantitative real-time-PCR or western ***-Meier survival curves for 38 patients with glioblastomas showed that a high MIB-1 LI correlated with poor survival（P ＜ 0.05）.Among the molecules tested,only the low expression of S1P1 was significantly correlated with the high MIB-1 LI in glioblastomas（P ＜ 0.05）.Multivariate analysis revealed that the S1P1 expression level was a significant prognostic *** results indicate that the MIB-1 LI is an important prognostic factor in human ***,downregulation of S1P1 expression increases proliferative activity,and thus enhances the malignancy of glioblastomas,resulting in a poor survival.

关键词： Glioblastoma MIB-1 labeling index S1P1 receptor Survival Cell proliferation

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Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival

Sphingosine-1-phosphate receptor type 1 regulates glioma cel...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Yuya Yoshida mitsutoshi nakada Naotoshi Sugimoto Tomoya Harada Yasuhiko Hayashi Daisuke Kita Naoyuki Uchiyama Yutaka Hayashi Akihiro Yachie Yoh Takuwa Jun-ichiro Hamada Department of Neurosurgery Graduate School of Medical ScienceKanazawa University Department of Physiology Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan Department of Pediatrics Graduate School of Medical ScienceKanazawa UniversityKanazawaJapan

Sphingosine-1-phosphate（S1P） is a bioactive lipid that signals through a family of G protein-coupled receptors consisting of 5 members termed S1P1-5,and it regulates cellular proliferation,migration and *** investigated the expression and role of S1P receptors in *** glioma expressed S1P1,S1P2,S1P3,and S1P5 by quantitative real-time PCR *** of the S1P1 was significantly lower in glioblastoma than in the normal brain（p ＜ 0.01） and diffuse astrocytoma（p ＜ 0.05）.Immunoblotting showed that normal brain expressed more S1P1 protein than did *** showed that S1P1 was localized predominantly in the astrocytes in the normal brain,but no staining was observed in *** of S1P1 expression correlated with poor survival of patients with glioblastoma（p ＜ 0.05）.S1P1 small interfering RNA promoted cell proliferation in high-expressor glioma cell lines（T98G,G112）.Cell proliferation was promoted by the pertussis toxin,which deactivates Gi/o type of G proteins;the S1P1 is exclusively coupled to these *** expression of the S1P1 in low-expressor cell lines（U87,U251） resulted in decreased cell growth and led to suppressed tumor growth in transplanted gliomas in ***,we found a significant association between the S1P1 expression and early growth response-1,a transcriptional factor that exhibits tumor suppression in glioblastoma cells（p ＜ 0.05）.These data indicate that the downregulation of S1P1 expression enhances the malignancy of glioblastoma by increasing cell proliferation and correlates with the shorter survival of patients with glioblastoma.

关键词： glioblastoma S1P receptors S1P1 receptor proliferation survival

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Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy

Silencing of ferrochelatase enhances 5-aminolevulinic acid-b...

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中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Lei Teng1,2,mitsutoshi nakada1,Shi-Guang Zhao2,Yutaka Hayashi1,and Jun-Ichiro Hamada1 1Department of Neurosurgery,Graduate School of Medical Science,Kanazawa University,Kanazawa,Ishikawa 920-8641,Japan 2Department of Neurosurgery,The First Clinical College of Harbin Medical University,Nangang Harbin 150001,People''s Republic of China

BACKGROUND:Recurrence of glioma frequently occurs within the marginal area of the surgical cavity due to invading residual cells.5-aminolevulinic acid（5-ALA） fluorescence-guided resection has been used as effective therapeutic modalities to improve discrimination of brain tumor margins and patient ***,the marginal areas of glioma usually show vague fluorescence,which makes tumor identification difficult,and the applicability of 5-ALA-based photodynamic therapy（PDT） is hampered by insufficient therapeutic efficacy in glioma ***:To overcome these issues,we assessed the expression of ferrochelatase（FECH） gene,which encodes a key enzyme that catalyzes the conversion of protoporphyrin IX（PpIX） to heme,in glioma surgical specimens and manipulated FECH in human glioma cell ***:Prominent down-regulation of FECH mRNA expression was found in glioblastoma tissues compared to normal brain tissues,suggesting that FECH is responsible for PpIX accumulation in glioblastoma *** of FECH by small interference RNA enhanced PpIX fluorescence after exposure to 5-ALA concomitant with increased intracellular PpIX accumulation in glioma *** of FECH caused marked growth inhibition and apoptosis induction by PDT in glioma ***:These results suggest that knockdown of FECH is a potential approach to enhancing PpIX fluorescent quality for optimizing the subjective discrimination of vague fluorescence and improving the effect of 5-ALA-PDT.

关键词： glioma ferrochelatase 5-aminolevulinic acid fluorescence photodynamic therapy

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