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Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities

World Journal of Gastroenterology 2014年第27期20卷 8939-8946页

作者： Yohei Shirakami Masahito Shimizu Masaya Kubota Hiroshi Araki Takuji Tanaka Hisataka Moriwaki mitsuru seishima Department of Informative Clinical Medicine Gifu University Graduate School of Medicine Department of Gastroenterology Gifu University Graduate School of Medicine Department of Tumor Pathology Gifu University Graduate School of Medicine

Obesity and its related metabolic disorders, including insulin resistance and chronic inflammation, increase the risk of colorectal cancer(CRC). This observation suggests that the metabolic abnormalities associated with obesity can be effective targets for preventing the development of CRC in obese individuals. In recent years, many studies using obese and diabetic animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Pitavastatin, a medicine used to treat hyperlipidemia, prevents the development of obesityrelated colorectal carcinogenesis by attenuating chronic inflammation. Anti-hypertensive medicines, such as captopril and telmisartan, also suppress the formation of colonic preneoplastic lesions in obese and diabetic mice. In addition, several phytochemicals, including green tea catechins, have been reported to improve metabolic disorders and prevent the development of various cancers, including CRC. Moreover, the administration of branched-chain amino acids, which improves protein malnutrition and prevents the progression of hepatic failure, is effective for suppressing obesityrelated colon carcinogenesis, which is thought to be associated with improvements in insulin resistance. In the present article, we summarize the detailed relationship between metabolic abnormalities and the development of CRC. This review also outlines recent evidence, in particular drawing from basic and clinical examinations using either pharmaceutical or nutritional intervention that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals.

关键词： Colorectal cancer Obesity Green tea catechin Branched-chain amino acid Chemoprevention

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Temporal variation in modal properties of a base-isolated building during an earthquake

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第1期11卷 1-8页

作者： Izuru TAKEWAKI mitsuru NAKAMURA Department of Urban and Environmental Engineering Graduate School of EngineeringKyoto University Technical Research Institute Obayashi Corporation

Temporal variation of dynamical modal properties of a base-isolated building is investigated using earthquake records in the building. A batch processing least-squares estimation method is applied to segment-wise time-series data. To construct an input-output system,an auto-regressive model with exogenous input (ARX) of second-order including a forgetting coefficient as a weighting coefficient is used for the estimation of modal parameters. The fundamental and second natural frequencies and the damping ratios of the fundamental and second natural modes of the base-isolated building are identified in the time domain. The identified results are consistent with the results obtained from the micro-tremor vibration data,forced-vibration test data and earthquake records in the present base-isolated building in the case of taking into account the amplitude-dependency of the isolators and viscous dampers. It is finally pointed out that several factors,e.g.,amplitude dependency of the isolator and damper system and special characteristics of the series-type viscous damper system,may be related complicatedly with the temporal variation in modal properties of the above-mentioned system.

关键词： System identification Shear building model Modal parameters Batch processing least-squares estimation method Forgetting coefficient Auto-regressive model with exogenous input (ARX) model

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Advances in traction methods for endoscopic submucosal dissection:What is the best traction method and traction direction?

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World Journal of Gastroenterology 2022年第1期28卷 1-22页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalKanagawa 251-0041Japan

Endoscopic submucosal dissection(ESD)has been developed as a treatment for superficial gastrointestinal neoplasms,which can achieve en bloc resection regardless of the lesion ***,ESD is technically difficult because endoscopists cannot bring their hand into the gastrointestinal tract,unlike surgeons in regular *** is difficult to obtain sufficient tension in the dissection plane and a good field of ***,ESD is associated with a long procedure time and a high risk of adverse events in comparison with endoscopic mucosal *** methods have been developed to provide sufficient tension for the dissection plane and a good field of vision during the ESD ***,traction direction is limited in most traction methods,resulting in insufficient effect in some *** traction direction is considered important,there have been few investigations of its *** the first half of this review,important traction methods are discussed,including traction *** second half,appropriate traction methods for each organ are *** important considerations for traction method,such as ability to adjust traction strength,interference between traction device and endoscope,and the need for specialized devices are also discussed.

关键词： Endoscopic submucosal dissection Traction method Countertraction Traction direction Vertical traction

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Spermatogonial stem cells： progress and prospects

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Asian Journal of Andrology 2015年第5期17卷 771-775,I0007-I0008页

作者： mitsuru Komeya Takehiko Ogawa Department of Urology Graduate School of Medicine Yokohama City University Yokohama 236-0004 Japan Laboratory of Proteomics Institute of Molecular Medicine and Life Science Yokohama City University Association of Medical Science Yokohama 236-0004 Japan

Twenty years ago, the transplantation of spermatogonial stem cells （SSCs） from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs. Since then, several important new findings and other technical developments have followed, which included a new hypothesis on their cell kinetics and spermatogonial hierarchy in the testis, a culture method allowing their self-renewal and proliferation, a testis tissue organ culture method, which induced their complete differentiation up to sperm, and the in vitro induction of germ cells from embryonic stem cells and induced pluripotent stem cells. These advancements reinforced or advanced our understanding of this unique cell. Nonetheless, there are many unresolved questions in the study of spermatogonial stem cells and a long road remains until these cells can be used clinically in reproductive medicine.

关键词： in vitro spermatogenesis male infertility organ culture

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Functionalization of silica nanoparticles for nucleic acid delivery

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Nano Research 2018年第10期11卷 5219-5239页

作者： Rimpei Kamegawa mitsuru Naito Kanjiro Miyata Department of Materials Engineering Graduate School of Engineering The University of Tokyo Tokyo 113-8656 Japan Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo Tokyo 113-0033 Japan

Silica nanoparticles （SiNPs） have been widely engineered for biomedical applications, such as bioimaging and drug delivery, because of their high tunability, which allows them to perform specific functions. In this review, we discuss the functionalization and performance of SiNPs for nucleic acid delivery. Nucleic acids, including plasmid DNA （pDNA） and small interfering RNA （siRNA）, constitute the next generation molecular drugs for the treatment of intractable diseases. However, their low bioavailability requires delivery systems that can circumvent nuclease attack and kidney filtration to ensure efficient access to the target cell cytoplasm or nucleus. First, we discussed the biological significance of nucleic acids and the parameters required for their successful delivery. Next, we reviewed SiNP designing for nucleic acid delivery with respect to nucleic acid loading and release, cellular uptake, endosomal escape, and biocompatibility. In addition, we discussed the co-delivery potential of SiNPs. Finally, we analyzed the current challenges and future directions of SiNPs for advanced nucleic acid delivery.

关键词： silica nanoparticle mesoporous silica silica coating nucleic acid drug delivery

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Effects of Austenizing Temperature on Reprecipitation of BN

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Journal of Iron and Steel Research International 2013年第9期20卷 99-104页

作者： YIN Shi-ke A Rong mitsuru Tanino China Iron and Steel Research Institute Group Fundamental Research Laboratory Nippon Steel Co.

Most of BN was precipitated around the spherical MnS and formed the compound of MnS and BN during the isothermal treatment at 850 ℃ after austenizing at 950-1050 ℃. Most of MnS was transformed into polygon when austenized at 1 150 ℃ or above, which could not be the nuclei of BN anymore. During the insulation process at 850 ℃, MnS kept the state of monomer. The compound of MnS and BN at earlier time was of fine polycrystalline in spherality and BN was formed as a plate-like monocrystal on a certain part of the polycrystalline when its dimension reached 0.6 μm.

关键词： austenizing temperature BN repreeipitation isothermal treatment

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Index-based assessment of agricultural drought in a semi-arid region of Inner Mongolia, China

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Journal of Arid Land 2014年第1期6卷 3-15页

作者： Rui LI Atsushi TSUNEKAWA mitsuru TSUBO United Graduate School of Agricultural Sciences Koyama-Minami 4-101Tottori University Arid Land Research Center Tottori University

Agricultural drought is a type of natural disaster that seriously impacts food *** the relationships among short-term rainfall,soil moisture,and crop growth are complex,accurate identification of a drought situation is *** this study,using a conceptual model based on the relationship between water deficit and crop yield reduction,we evaluated the drought process in a typical rainfed agricultural region,Hailar county in Inner Mongolia autonomous region,*** quantify drought,we used the precipitation-based Standardized Precipitation Index(SPI),the soil moisture-based Crop Moisture Index(CMI),as well as the Normalized Difference Vegetation Index(NDVI).Correlation analysis was conducted to examine the relationships between dekad-scale drought indices during the growing season(May–September)and final yield,according to data collection from 2000 to *** results show that crop yield has positive relationships with CMI from mid-June to mid-July and with the NDVI anomaly throughout July,but no correlation with *** analysis of the relationship between the two drought indices shows that the NDVI anomaly responds to CMI with a lag of 1 dekad,particularly in *** examine the feasibility of employing these indices for monitoring the drought process at a dekad time scale,a detailed drought assessment was carried out for selected drought *** results confirm that the soil moisture-based vegetation indices in the late vegetative to early reproductive growth stages can be used to detect agricultural drought in the study ***,the framework of the conceptual model developed for drought monitoring can be employed to support drought mitigation in the rainfed agricultural region of Northern China.

关键词： drought assessment drought index dekad time scale rainfed agriculture

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Optimizing Deep Learning Parameters Using Genetic Algorithm for Object Recognition and Robot Grasping

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Journal of Electronic Science and Technology 2018年第1期16卷 11-15页

作者： Delowar Hossain Genci Capi mitsuru Jindai Graduate School of Science and Engineering for Education University of ToyamaToyama 9350343 Department of Mechanical Engineering Hosei UniversityTokyo 184-0002

The performance of deep learning(DL)networks has been increased by elaborating the network structures. However, the DL netowrks have many parameters, which have a lot of influence on the performance of the network. We propose a genetic algorithm(GA) based deep belief neural network(DBNN) method for robot object recognition and grasping purpose. This method optimizes the parameters of the DBNN method, such as the number of hidden units, the number of epochs, and the learning rates, which would reduce the error rate and the network training time of object recognition. After recognizing objects, the robot performs the pick-andplace operations. We build a database of six objects for experimental purpose. Experimental results demonstrate that our method outperforms on the optimized robot object recognition and grasping tasks.

关键词： Deep learning(DL) deep belief neural network(DBNN) genetic algorithm(GA) object recognition robot grasping

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Evaluation of dry-in-place lubricants for cold forging by using an optimal steady combined forward and backward extrusion testing method

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Friction 2023年第10期11卷 1862-1876页

作者： Chengliang HU Shogo OSAKI Baixuan CAI mitsuru AOYAMA Kuniaki DOHDA Institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China Central Research Laboratories Nihon Parkerizing Co.Ltd.Hiratsuka-shi 254-0012Japan Department of Mechanical Engineering Northwestern UniversityEvanston 60208-3111USA

This study evaluated dry-in-place lubricants used for cold forging.A group of isothermal compression tests with a strain rate(ε)e&range of 0.001–1 s^(−1) and temperature(T)range of 30–400℃ were *** flow stress(σ)curves of annealed steel S45C were obtained,and a corresponding Hensel–Spittel model was developed to support finite element(FE)*** sensitivity of the steady combined forward and backward extrusion(SCFBE)test proposed in another study was improved by approximately 20%after it was optimized using the results of the FE *** parameters were identified,and the calibration curves after optimization were *** the basis of the optimized test,a friction testing setup with a heating system was developed,in which the die temperature could be adjusted from room temperature(RT)to 230℃.Three dry-in-place lubricants and conventional phosphating lubricant were tested,and the friction factors(m),forming loads,and ejection loads were *** surface features of the specimens after testing were also *** to the testing results,of the three tested dry-in-place lubricants,the mica type was the *** addition,the optimized friction testing design was verified as effective.

关键词： lubrication optimization sensitivity friction factor(m) forming load cold forging

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A trip of peptides to the brain

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Food Production, Processing and Nutrition 2020年第1期2卷 300-307页

作者： Toshiro Matsui Atsuko Yoshino mitsuru Tanaka Department of Bioresources and Biosciences Faculty of AgricultureGraduate School of Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Research and Development Center for Five-Sense Devices Kyushu University744 MotookaNishi-kuFukuoka 819-0395Japan

Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension,and hypercholesterolemia,*** there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human,limited studies on bioavailability,in particular,beyond the blood-brain barrier(BBB)of candidates in hydrolysate may prevent their extensive physiological ***,this review discusses the updated studies on BBB transport of peptides showing improved cognitive ***,their accumulation in the brain cerebral parenchyma is also introduced.

关键词： Peptide Blood-brain barrier Transport Cognitive decline

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