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精原干细胞：进展和前景

Asian Journal of Andrology 2015年第5期17卷 771-775,I0007-I0008页

作者： mitsuru komeya Takehiko Ogawa Department of Urology Graduate School of Medicine Yokohama City University Yokohama 236-0004 Japan Laboratory of Proteomics Institute of Molecular Medicine and Life Science Yokohama City University Association of Medical Science Yokohama 236-0004 Japan

20年前，小鼠精原干细胞（SSC）移植取得成功，使功能性精原干细胞的鉴定成为可能。随之有关SSC的研究逐步展开，主要包括SSC动态假说、睾丸内SSC分层假说、SSC的培养（自我更新和增殖）、睾丸组织有机培养体系（SSC分化至精子）、胚胎... 详细信息

20年前，小鼠精原干细胞（SSC）移植取得成功，使功能性精原干细胞的鉴定成为可能。随之有关SSC的研究逐步展开，主要包括SSC动态假说、睾丸内SSC分层假说、SSC的培养（自我更新和增殖）、睾丸组织有机培养体系（SSC分化至精子）、胚胎干细胞和诱导多能干细胞的体外定向分化等。这些研究促进我们进一步了解SSC，但是距离SSC的临床应用还有很长的路要走，很多相关问题亟待解决。

关键词：体外精子生成男子小育有机培养

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日本站前广场的建设特征及对我国的启示

都市快轨交通 2024年第3期37卷 170-177页

作者：马飞太田充徐畅日本筑波大学系统情报工学院日本筑波北京大学城市规划与设计学院广东深圳518055

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案... 详细信息

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案例的空间规划和开发方式,总结出日本站前广场的规划经验:重视站前广场在站城一体化开发中的空间调节作用,根据规划需求调整广场的城市功能;广场建设要结合站点周边地区发展特点,注重广场的灵活布局和多样化利用;广场规划各阶段设立合作组织,注重广场各建设部门的相互沟通和责任划分以及制定持续的利用者参与机制和完善的广场运营制度等,以期为中国轨道交通可持续发展和合理的城市空间规划提供参考和借鉴。

关键词：日本铁路公共交通城市空间站点开发站前广场

Advances in traction methods for endoscopic submucosal dissection:What is the best traction method and traction direction?

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World Journal of Gastroenterology 2022年第1期28卷 1-22页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalKanagawa 251-0041Japan

Endoscopic submucosal dissection(ESD)has been developed as a treatment for superficial gastrointestinal neoplasms,which can achieve en bloc resection regardless of the lesion size.However,ESD is technically difficult because endoscopists cannot bring their hand into the gastrointestinal tract,unlike surgeons in regular surgery.It is difficult to obtain sufficient tension in the dissection plane and a good field of vision.Therefore,ESD is associated with a long procedure time and a high risk of adverse events in comparison with endoscopic mucosal resection.Traction methods have been developed to provide sufficient tension for the dissection plane and a good field of vision during the ESD procedure.However,traction direction is limited in most traction methods,resulting in insufficient effect in some cases.Although traction direction is considered important,there have been few investigations of its effect.In the first half of this review,important traction methods are discussed,including traction direction.In second half,appropriate traction methods for each organ are considered.Other important considerations for traction method,such as ability to adjust traction strength,interference between traction device and endoscope,and the need for specialized devices are also discussed.

关键词： Endoscopic submucosal dissection Traction method Countertraction Traction direction Vertical traction

Evaluation of dry-in-place lubricants for cold forging by using an optimal steady combined forward and backward extrusion testing method

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Friction 2023年第10期11卷 1862-1876页

作者： Chengliang HU Shogo OSAKI Baixuan CAI mitsuru AOYAMA Kuniaki DOHDA Institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China Central Research Laboratories Nihon Parkerizing Co.Ltd.Hiratsuka-shi 254-0012Japan Department of Mechanical Engineering Northwestern UniversityEvanston 60208-3111USA

This study evaluated dry-in-place lubricants used for cold forging.A group of isothermal compression tests with a strain rate(ε)e&range of 0.001–1 s^(−1) and temperature(T)range of 30–400℃ were completed.The flow stress(σ)curves of annealed steel S45C were obtained,and a corresponding Hensel–Spittel model was developed to support finite element(FE)simulation.The sensitivity of the steady combined forward and backward extrusion(SCFBE)test proposed in another study was improved by approximately 20%after it was optimized using the results of the FE simulations.Key parameters were identified,and the calibration curves after optimization were obtained.On the basis of the optimized test,a friction testing setup with a heating system was developed,in which the die temperature could be adjusted from room temperature(RT)to 230℃.Three dry-in-place lubricants and conventional phosphating lubricant were tested,and the friction factors(m),forming loads,and ejection loads were measured.The surface features of the specimens after testing were also investigated.According to the testing results,of the three tested dry-in-place lubricants,the mica type was the best.In addition,the optimized friction testing design was verified as effective.

关键词： lubrication optimization sensitivity friction factor(m) forming load cold forging

Device-assisted traction methods in colorectal endoscopic submucosal dissection and options for difficult cases

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 265-272页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalFujisawa 251-0041KanagawaJapan

Endoscopic submucosal dissection(ESD)procedure has a longer procedure time and higher perforation rate than endoscopic mucosal resection owing to technical complications,including a poor field of vision and inadequate tension for the submucosal dissection plane.Various traction devices were developed to secure the visual field and provide adequate tension for the dissection plane.Two randomized controlled trials demonstrated that traction devices reduce colorectal ESD procedure time compared with conventional ESD(C-ESD),but they had limitations,including a single-center fashion.The CONNECT-C trial was the first multicenter randomized controlled trial comparing the C-ESD and traction device-assisted ESD(T-ESD)for colorectal tumors.In the T-ESD,one of the device-assisted traction methods(S-O clip,clip-with-line,and clip pulley)was chosen according to the operator’s discretion.The median ESD procedure time(primary endpoint)was not significantly different between C-ESD and T-ESD.For lesions≥30 mm in diameter or in cases treated by nonexpert operators,the median ESD procedure time tended to be shorter in T-ESD than in C-ESD.Although T-ESD did not reduce ESD procedure time,the CONNECT-C trial results suggest that T-ESD is effective for larger lesions and nonexpert operators in colorectal ESD.Compared with esophageal and gastric ESD,colorectal ESD has some difficulties,including poor endoscope maneuverability,which may be associated with prolonged ESD procedure time.T-ESD may not effectively improve these issues,but a balloon-assisted endoscope and underwater ESD may be promising options and these methods can be combined with T-ESD.

关键词： Endoscopic submucosal dissection Traction Traction direction Balloonassisted endoscope Underwater endoscopic submucosal dissection

Two traction methods that can facilitate esophageal endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 259-264页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalFujisawa 251-0041KanagawaJapan

Different traction devices that can provide a visual field and attain appropriate tension at the dissection plane during endoscopic submucosal dissection(ESD)have been developed.Clip-with-line(CWL)is a classic traction device that can offer per-oral traction toward the direction where the line is drawn.A multicenter randomized controlled trial(CONNECT-E trial)comparing the conventional ESD and CWL-assisted ESD(CWL-ESD)for large esophageal tumors was conducted in Japan.This study showed that CWL-ESD was associated with a shorter procedure time(defined as the time from initiating submucosal injection to completing tumor removal)without increasing the risk of adverse events.Multivariate analysis revealed that whole-circumferential lesion and abdominal esophageal lesion were independent risk factors for technical difficulties,which were defined as a procedure time of>120 min,perforation,piecemeal resection,inadvertent incision(any accidental incision caused by the electrosurgical knife within the marked area),or handover to another operator.Therefore,techniques other than CWL should be considered for these lesions.Several studies have shown the usefulness of endoscopic submucosal tunnel dissection(ESTD)for such lesions.A randomized controlled trial conducted at five Chinese institutions showed that compared with the conventional ESD,ESTD had a significantly reduced median procedure time for lesions covering≥1/2 of the esophageal circumference.In addition,a propensity score matching analysis conducted at a single Chinese institution showed that compared with the conventional ESD,ESTD had a shorter mean resection time for lesions at the esophagogastric junction.With the appropriate use of CWL-ESD and ESTD,esophageal ESD can be performed more efficiently and safely.Moreover,the combination of these two methods may be effective.

关键词： Endoscopic submucosal dissection Traction Clip-with-line Endoscopic submucosal tunnel dissection

Eustachian tube involvement in a patient with relapsing polychondritis detected by magnetic resonance imaging:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1441-1446页

作者： Daisuke Yunaiyama Akiko Aoki Hiroshi Kobayashi Miwako Someya mitsuru Okubo Kazuhiro Saito Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Radiology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Rheumatology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan

BACKGROUND Relapsing polychondritis(RP)is a rare inflammatory disease involving the systemic cartilage,such as the auricle,trachea,and bronchiole,among others.A patient with RP shows variable symptoms based on the involved cartilage.CASE SUMMARY A 72-year-old Japanese woman with a history of redness of the bilateral auricles for 3 d was referred to a clinician.The clinician prescribed antibiotics to the patient;however,the symptoms worsened;thus,she was referred to our hospital.Head and neck magnetic resonance imaging(MRI)showed edematous auricle with remarkable contrast,fluid collection in the bilateral mastoid cells,suggesting otitis media.The eustachian tube(ET)on the right side was also edematous with contrast enhancement.The patient was suspected of RP according to the diagnostic criteria.A biopsy of the auricular cartilage was performed by an otorhinolaryngologist,confirming pathological proof of RP.Treatments with steroids were immediately administered thereafter.CONCLUSION We highlight a rare case of RP with radiologically confirmed involvement of ET in the MRI.

关键词： Relapsing polychondritis Magnetic resonance imaging Contrast enhancement Otitis media with effusion Eustachian tube Case report

Optimal traction direction in traction-assisted gastric endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 667-671页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalFujisawa 251-0041KanagawaJapan

Various traction devices have been developed to secure a visual field and sufficient tension at the dissection plane during endoscopic submucosal dissection(ESD).However,few large-scale studies have investigated the effectiveness of traction devices in gastric ESD.Clip-with-line(CWL)is one such traction device that is widely used in cases of gastric ESD.The CONNECT-G trial was the first multicenter randomized controlled trial to compare conventional ESD with CWLassisted ESD(CWL-ESD)for superficial gastric neoplasms.Overall,no significant intergroup difference was observed in terms of the gastric ESD procedure time.However,subgroup analysis according to lesion location revealed a significant reduction in the procedure time of gastric ESD for the lesion located at the greater curvature of the middle and upper third of the stomach in the CWL-ESD group.In this subgroup analysis,lesion location was categorized as follows:anterior wall,posterior wall,lesser curvature,and greater curvature of the upper,middle,and lower thirds of the stomach.However,the gastric ESD procedure time showed no significant difference,except for lesions located at the greater curvature of the upper and middle thirds of the stomach.The traction direction of CWL in the stomach was limited to the cardia and changed depending on the lesion location.Therefore,outcomes of the CONNECT-G trail suggest that the effectiveness of CWL was influenced by lesion location,i.e.,traction direction.Further studies are warranted to investigate the optimal traction direction in gastric ESD.

关键词： Endoscopic submucosal dissection ESD Traction device Clip-with-line Traction direction Vertical traction

Brachiocephalic to left brachial vein thrombotic vasculitis accompanying mediastinal pancreatic fistula:A case report

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World Journal of Clinical Cases 2022年第32期10卷 11882-11888页

作者： Reiji Kokubo Daisuke Yunaiyama Yu Tajima Natsumi Kugai mitsuru Okubo Kazuhiro Saito Takayoshi Tsuchiya Takao Itoi Department of Radiology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology and Hepatology Tokyo Medical UniversityTokyo 160-0023Japan

BACKGROUND Pancreatitis is a severe inflammatory pancreatic disease commonly due to bile duct stones or excessive alcohol usage,with clinical manifestations of abdominal pain,nausea,fever,and fluid collections.Healthy persons with less symptomatic pancreatitis are quite rare.Herein,we report a case of a patient with an undetermined onset of pancreatitis mimicking left arm cellulitis due to thrombotic vasculitis of the brachiocephalic vein.CASE SUMMARY A 50-year-old woman visited our hospital for tenderness in the left arm over several recent days.She was diagnosed with cellulitis on the left arm due to left elbow tenderness.Intravenous antibiotics administration did not improve symptoms and laboratory data worsened;thus,chest and abdominal computed tomography(CT)was performed.CT demonstrated pancreatitis with pseudocyst around the pancreas extending to the mediastinum.Thrombotic vasculitis of the brachiocephalic to left brachial vein was observed,which could be the cause of left elbow pain.A pancreatic fistula was found in the head of the pancreas by endoscopic retrograde cholangiopancreatography,so a pancreatic cyst drainage tube via the duodenum was placed in the pseudocyst.Cyst content culture was positive for Escherichia coli infection.Clinical symptoms,imaging findings,and inflammatory reactions resolved gradually after starting therapeutic intervention.The mediastinal pancreatic pseudocysts shrunk,and the venous thrombi remained but shrunk.CONCLUSION The case of a patient with pancreatitis with an undetermined onset that mimics left arm cellulitis is reported.Deep vein thrombosis should be kept in mind when treating patients with severe inflammatory disease.

关键词： Pancreatic fistula Thrombotic vasculitis Pancreatitis Computed tomography Case report