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Oxaliplatin-Induced Lung Injury with Allergic Reaction

Chinese Journal of Cancer Research 2011年第3期23卷 232-235页

作者： Tetsuya Homma Masatsugu Kurokawa Yoshitaka Yamamoto Satoshi Matsukura Koushi Ieki Shintaro Suzuki Miho Odaka Shin Watanabe Munehiro Yamaguchi mitsuru adachi Division of Allergology and Respiratory Medicine Division of Internal MedicineSchool of MedicineShowa University

A 79-year-old man was diagnosed as stage IV colon cancer and treated with a modified FOLFOX6 （mFOLFOX6） *** the 12th cycle,we observed erythema and *** showed ground grass *** tests showed elevated levels of eosinophils and immunoglobulin *** diagnosed this finding as response to drug allergy and administered high-dose *** treatment was successful and he was *** drug lymphocyte stimulating test against oxaliplatin was positive,indicating a type I and IV allergic reaction due to *** including oxaliplatin must be carefully monitored and frequent blood tests and chest radiographs are needed.

关键词： Oxaliplatin mFOLFOX6 Drug-induced pneumonia Drug lymphocyte stimulating test Immunoglobulin E

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New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide

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Bone Research 2014年第4期2卷 252-258页

作者： Sakae Tanaka Taiji adachi Tatsuhiko Kuroda Toshitaka Nakamura Masataka Shiraki Toshitsugu Sugimoto Yasuhiro Takeuchi mitsuru Saito John P Bilezikian Department of Orthopaedic Surgery Faculty of MedicineUniversity of TokyoTokyoJapan Department of Biomechanics Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan Medical Affairs Department Asahi Kasei Pharma CorporationTokyoJapan National Center for Global Health and Medicine TokyoJapan Research Institute and Practice for Involutional Diseases NaganoJapan Internal Medicine 1 Shimane University Faculty of MedicineIzumoJapan Toranomon Hospital Endocrine Center TokyoJapan Department of Orthopaedic Surgery Jikei University School of MedicineTokyoJapan Metabolic Bone Diseases Program Division of EndocrinologyDepartment of MedicineCollege of Physicians and SurgeonsColumbia UniversityNew YorkUSA

Daily 20-mg and once-weekly 56.5-mg teriparatide（parathyroid hormone 1–34） treatment regimens increase bone mineral density（BMD） and prevent fractures, but changes in bone turnover markers differ between the two regimens. The aim of the present study was to explain changes in bone turnover markers using once-weekly teriparatide with a simulation model. Temporary increases in bone formation markers and subsequent decreases were observed during once-weekly teriparatide treatment for 72 weeks. These observations support the hypothesis that repeated weekly teriparatide administration stimulates bone remodeling, replacing old bone with new bone and leading to a reduction in the active remodeling surface. A simulation model was developed based on the iterative remodeling cycle that occurs on residual old bone. An increase in bone formation and a subsequent decrease were observed in the preliminary simulation. For each fitted time point, the predicted value was compared to the absolute values of the bone formation and resorption markers and lumbar BMD. The simulation model strongly matched actual changes in bone turnover markers and BMD. This simulation model indicates increased bone formation marker levels in the early stage and a subsequent decrease. It is therefore concluded that remodeling-based bone formation persisted during the entire treatment period with once-weekly teriparatide.

关键词： bone New simulation model for bone formation markers in osteoporosis patients treated with once-weekly teriparatide BMD

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Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study

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World Journal of Gastroenterology 2017年第19期23卷 3488-3495页

作者： Yasushi adachi Masanori Nojima mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi Division of Gastroenterology Department of Internal MedicineSapporo Shirakaba-dai Hospital Department of Gastroenterology Sapporo Medical University The Institute of Medical Science Hospital The University of Tokyo Department of Public Health Sapporo Medical UniversitySchool of Medicine Department of Preventive Medicine Nagoya UniversityGraduate School of Medicine Department of Hygiene and Preventive Medicine Iwate Medical University School of Medicine Department of Public Health Hokkaido University School of Medicine

AIM To assess the relationship between serum levels of insulin-like growth factor-1(IGF1)/IGF-binding protein-3(IGFBP3)and the risk of esophageal *** We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective,nested case-control study of participants from the Japan Collaborative Cohort Study.A baseline survey was conducted from 1988 to *** the 110585 enrolled participants,35%donated blood *** who had been diagnosed with esophageal cancer were considered cases for nested case-control studies.A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 *** Thirty-one cases and 86 controls were eligible for the present *** molar ratio of IGF1/IGFBP3,which represents the free and active form of IGF1,was not correlated with the risk of esophageal carcinoma.A higher molar difference between IGFBP3and IGF1,which estimates the free form of IGFBP3,was associated with a decreased risk of esophageal carcinoma(P=0.0146),and people in the highest tertile had the lowest risk(OR=0.107,95%CI:0.017-0.669).After adjustment for body mass index,tobacco use,and alcohol intake,the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma(P=0.0150).CONCLUSION The free form of IGFBP3,which is estimated by this molar difference,may be inversely associated with esophageal cancer incidence.

关键词：食道的癌症像胰岛素的生长因素像胰岛素的生长因素绑定蛋白质嵌套的盒子控制学习机会比率

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