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Photonics Research 2024年第08期12卷 1681-1688页

作者： RUI TANG SHUHEI OHNO KEN TANIZAWA KAZUHIRO IKEDA MAKOTO OKANO KASIDIT TOPRASERTPONG SHINICHI TAKAGI mitsuru TAKENAKA Department of Electrical Engineering and Information Systems The University of Tokyo Quantum ICT Research Institute Tamagawa University National Institute of Advanced Industrial Science and Technology

Photonic integrated circuits are emerging as a promising platform for accelerating matrix multiplications in deep learning, leveraging the inherent parallel nature of light. Although various schemes have been proposed and demonstrated to realize such photonic matrix accelerators, the in situ training of artificial neural networks using photonic accelerators remains challenging due to the difficulty of direct on-chip backpropagation on a photonic chip. In this work, we propose a silicon microring resonator(MRR) optical crossbar array with a symmetric structure that allows for simple on-chip backpropagation, potentially enabling the acceleration of both the inference and training phases of deep learning. We demonstrate a 4 × 4 circuit on a Si-on-insulator platform and use it to perform inference tasks of a simple neural network for classifying iris flowers, achieving a classification accuracy of 93.3%. Subsequently, we train the neural network using simulated on-chip backpropagation and achieve an accuracy of 91.1% in the same inference task after training. Furthermore, we simulate a convolutional neural network for handwritten digit recognition, using a 9 × 9 MRR crossbar array to perform the convolution operations. This work contributes to the realization of compact and energy-efficient photonic accelerators for deep learning.

关键词： Deep learning Neural networks Optical signals Photonic integrated circuits Silicon Stochastic gradient descent

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日本站前广场的建设特征及对我国的启示

都市快轨交通 2024年第3期37卷 170-177页

作者：马飞太田充徐畅日本筑波大学系统情报工学院日本筑波北京大学城市规划与设计学院广东深圳518055

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案... 详细信息

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案例的空间规划和开发方式,总结出日本站前广场的规划经验:重视站前广场在站城一体化开发中的空间调节作用,根据规划需求调整广场的城市功能;广场建设要结合站点周边地区发展特点,注重广场的灵活布局和多样化利用;广场规划各阶段设立合作组织,注重广场各建设部门的相互沟通和责任划分以及制定持续的利用者参与机制和完善的广场运营制度等,以期为中国轨道交通可持续发展和合理的城市空间规划提供参考和借鉴。

关键词：日本铁路公共交通城市空间站点开发站前广场

Temporal variation in modal properties of a base-isolated building during an earthquake

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第1期11卷 1-8页

作者： Izuru TAKEWAKI mitsuru NAKAMURA Department of Urban and Environmental Engineering Graduate School of EngineeringKyoto University Technical Research Institute Obayashi Corporation

Temporal variation of dynamical modal properties of a base-isolated building is investigated using earthquake records in the building. A batch processing least-squares estimation method is applied to segment-wise time-series data. To construct an input-output system,an auto-regressive model with exogenous input (ARX) of second-order including a forgetting coefficient as a weighting coefficient is used for the estimation of modal parameters. The fundamental and second natural frequencies and the damping ratios of the fundamental and second natural modes of the base-isolated building are identified in the time domain. The identified results are consistent with the results obtained from the micro-tremor vibration data,forced-vibration test data and earthquake records in the present base-isolated building in the case of taking into account the amplitude-dependency of the isolators and viscous dampers. It is finally pointed out that several factors,e.g.,amplitude dependency of the isolator and damper system and special characteristics of the series-type viscous damper system,may be related complicatedly with the temporal variation in modal properties of the above-mentioned system.

关键词： System identification Shear building model Modal parameters Batch processing least-squares estimation method Forgetting coefficient Auto-regressive model with exogenous input (ARX) model

Advances in traction methods for endoscopic submucosal dissection:What is the best traction method and traction direction?

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World Journal of Gastroenterology 2022年第1期28卷 1-22页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalKanagawa 251-0041Japan

Endoscopic submucosal dissection(ESD)has been developed as a treatment for superficial gastrointestinal neoplasms,which can achieve en bloc resection regardless of the lesion ***,ESD is technically difficult because endoscopists cannot bring their hand into the gastrointestinal tract,unlike surgeons in regular *** is difficult to obtain sufficient tension in the dissection plane and a good field of ***,ESD is associated with a long procedure time and a high risk of adverse events in comparison with endoscopic mucosal *** methods have been developed to provide sufficient tension for the dissection plane and a good field of vision during the ESD ***,traction direction is limited in most traction methods,resulting in insufficient effect in some *** traction direction is considered important,there have been few investigations of its *** the first half of this review,important traction methods are discussed,including traction *** second half,appropriate traction methods for each organ are *** important considerations for traction method,such as ability to adjust traction strength,interference between traction device and endoscope,and the need for specialized devices are also discussed.

关键词： Endoscopic submucosal dissection Traction method Countertraction Traction direction Vertical traction

Spermatogonial stem cells： progress and prospects

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Asian Journal of Andrology 2015年第5期17卷 771-775,I0007-I0008页

作者： mitsuru Komeya Takehiko Ogawa Department of Urology Graduate School of Medicine Yokohama City University Yokohama 236-0004 Japan Laboratory of Proteomics Institute of Molecular Medicine and Life Science Yokohama City University Association of Medical Science Yokohama 236-0004 Japan

Twenty years ago, the transplantation of spermatogonial stem cells （SSCs） from a mouse to other recipient mice was shown to be feasible, which clearly demonstrated the functional identity of SSCs. Since then, several important new findings and other technical developments have followed, which included a new hypothesis on their cell kinetics and spermatogonial hierarchy in the testis, a culture method allowing their self-renewal and proliferation, a testis tissue organ culture method, which induced their complete differentiation up to sperm, and the in vitro induction of germ cells from embryonic stem cells and induced pluripotent stem cells. These advancements reinforced or advanced our understanding of this unique cell. Nonetheless, there are many unresolved questions in the study of spermatogonial stem cells and a long road remains until these cells can be used clinically in reproductive medicine.

关键词： in vitro spermatogenesis male infertility organ culture

Functionalization of silica nanoparticles for nucleic acid delivery

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Nano Research 2018年第10期11卷 5219-5239页

作者： Rimpei Kamegawa mitsuru Naito Kanjiro Miyata Department of Materials Engineering Graduate School of Engineering The University of Tokyo Tokyo 113-8656 Japan Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo Tokyo 113-0033 Japan

Silica nanoparticles （SiNPs） have been widely engineered for biomedical applications, such as bioimaging and drug delivery, because of their high tunability, which allows them to perform specific functions. In this review, we discuss the functionalization and performance of SiNPs for nucleic acid delivery. Nucleic acids, including plasmid DNA （pDNA） and small interfering RNA （siRNA）, constitute the next generation molecular drugs for the treatment of intractable diseases. However, their low bioavailability requires delivery systems that can circumvent nuclease attack and kidney filtration to ensure efficient access to the target cell cytoplasm or nucleus. First, we discussed the biological significance of nucleic acids and the parameters required for their successful delivery. Next, we reviewed SiNP designing for nucleic acid delivery with respect to nucleic acid loading and release, cellular uptake, endosomal escape, and biocompatibility. In addition, we discussed the co-delivery potential of SiNPs. Finally, we analyzed the current challenges and future directions of SiNPs for advanced nucleic acid delivery.

关键词： silica nanoparticle mesoporous silica silica coating nucleic acid drug delivery

Enhancement of Antitumor Effect of Tegafur/Uracil(UFT) plus Leucovorin by Combined Treatment with Protein-Bound Polysaccharide,PSK,in Mouse Models

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Cellular & Molecular Immunology 2007年第4期4卷 295-299页

作者： Ryoji Katoh mitsuru Ooshiro Department of Surgery Toho University Sakura Medical CenterSakura-shiChibaJapan

We evaluated the antitumor effect of combined therapy with tegafur/uracil （UFT） plus leucovorin （LV）（UFT/LV） and protein-bound polysaccharide, PSK, in three mouse models of transplantable tumors. UFT/LV showed antitumor effect against Meth A sarcoma, and the antitumor effect was enhanced when PSK given concomitantly. UFT/LV showed antitumor effect to Lewis lung carcinoma and PSK alone also showed antitumor effect at high dose, but a combination of UFT/LV and PSK resulted in no enhanced antitumor effect. Colon 26 carcinoma was weakly responsive to UFT/LV, and no enhancement of antitumor effect was found even PSK was used in combination. In conclusion, while the effect of PSK varies depending on tumor, combined use of UFT/LV and PSK may be expected to augment the antitumor effect.

关键词： UFF leucovorin PSK Meth A Lewis lung carcinoma colon 26 antitumor effect

Effects of Austenizing Temperature on Reprecipitation of BN

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Journal of Iron and Steel Research International 2013年第9期20卷 99-104页

作者： YIN Shi-ke A Rong mitsuru Tanino China Iron and Steel Research Institute Group Fundamental Research Laboratory Nippon Steel Co.

Most of BN was precipitated around the spherical MnS and formed the compound of MnS and BN during the isothermal treatment at 850 ℃ after austenizing at 950-1050 ℃. Most of MnS was transformed into polygon when austenized at 1 150 ℃ or above, which could not be the nuclei of BN anymore. During the insulation process at 850 ℃, MnS kept the state of monomer. The compound of MnS and BN at earlier time was of fine polycrystalline in spherality and BN was formed as a plate-like monocrystal on a certain part of the polycrystalline when its dimension reached 0.6 μm.

关键词： austenizing temperature BN repreeipitation isothermal treatment

Optimizing Deep Learning Parameters Using Genetic Algorithm for Object Recognition and Robot Grasping

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Journal of Electronic Science and Technology 2018年第1期16卷 11-15页

作者： Delowar Hossain Genci Capi mitsuru Jindai Graduate School of Science and Engineering for Education University of ToyamaToyama 9350343 Department of Mechanical Engineering Hosei UniversityTokyo 184-0002

The performance of deep learning(DL)networks has been increased by elaborating the network structures. However, the DL netowrks have many parameters, which have a lot of influence on the performance of the network. We propose a genetic algorithm(GA) based deep belief neural network(DBNN) method for robot object recognition and grasping purpose. This method optimizes the parameters of the DBNN method, such as the number of hidden units, the number of epochs, and the learning rates, which would reduce the error rate and the network training time of object recognition. After recognizing objects, the robot performs the pick-andplace operations. We build a database of six objects for experimental purpose. Experimental results demonstrate that our method outperforms on the optimized robot object recognition and grasping tasks.

关键词： Deep learning(DL) deep belief neural network(DBNN) genetic algorithm(GA) object recognition robot grasping

Evaluation of dry-in-place lubricants for cold forging by using an optimal steady combined forward and backward extrusion testing method

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Friction 2023年第10期11卷 1862-1876页

作者： Chengliang HU Shogo OSAKI Baixuan CAI mitsuru AOYAMA Kuniaki DOHDA Institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China Central Research Laboratories Nihon Parkerizing Co.Ltd.Hiratsuka-shi 254-0012Japan Department of Mechanical Engineering Northwestern UniversityEvanston 60208-3111USA

This study evaluated dry-in-place lubricants used for cold forging.A group of isothermal compression tests with a strain rate(ε)e&range of 0.001–1 s^(−1) and temperature(T)range of 30–400℃ were *** flow stress(σ)curves of annealed steel S45C were obtained,and a corresponding Hensel–Spittel model was developed to support finite element(FE)*** sensitivity of the steady combined forward and backward extrusion(SCFBE)test proposed in another study was improved by approximately 20%after it was optimized using the results of the FE *** parameters were identified,and the calibration curves after optimization were *** the basis of the optimized test,a friction testing setup with a heating system was developed,in which the die temperature could be adjusted from room temperature(RT)to 230℃.Three dry-in-place lubricants and conventional phosphating lubricant were tested,and the friction factors(m),forming loads,and ejection loads were *** surface features of the specimens after testing were also *** to the testing results,of the three tested dry-in-place lubricants,the mica type was the *** addition,the optimized friction testing design was verified as effective.

关键词： lubrication optimization sensitivity friction factor(m) forming load cold forging