检索结果-南通市图书馆

Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

引用

World Journal of Gastroenterology 2012年第13期18卷 1508-1516页

作者： Masahide Hamaguchi Noriyuki takeda Takao Kojima Akihiro Ohbora Takahiro Kato Hiroshi Sarui Michiaki Fukui Chisato Nagata Jun takeda Immunology Frontier Research Center at Osaka University Osaka 5650871Japan Department of Endocrinology and Metabo lism Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Epidemiology and Preventive Medicine Graduate School of MedicineGifu UniversityGifu 5008523Japan Department of Diabetes and Endocrinology Division of Molecule and StructureGraduate School of MedicineGifu UniversityGifu 5008523Japan

AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal *** study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of *** was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of *** revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic ***:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in *** NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic *** sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in *** subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.

关键词： Nonalcoholic fatty liver Metabolic syndrome Population based study Methodology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distribution and relative activity of matrix metalloproteinase-2 in human coronal dentin

引用

International Journal of Oral Science 2011年第4期3卷 192-199页

作者： Lee W. Boushell Masaru Kaku Yoshiyuki Mochida mitsuo Yamauchi Department of Operative Dentistry School of Dentistry University of North Carolina Department of Bio-Prosthodontics Medical and Dental Science Niigata University Graduate School Chuo-ku Department of Periodontology and Oral Biology Division of Oral Biology Boston University Henry M. Goldman School of Dental Medicine Center for Advanced Biomedical Research Dental Research Center School of Dentistry University of North Carolina

The presence of matrix metalloproteinase-2 （MMP-2） in dentin has been reported, but its distribution and activity level in mature human coronal dentin are not well understood. The purpose of this study was to determine the MMP-2 distribution and relative activity in demineralized dentin. Crowns of twenty eight human molars were sectioned into inner （ID）, middle （MD）, and outer dentin （OD） regions and demineralized. MMP-2 was extracted with 0.33 mol·L-1 EDTA/2 mol·L-1 guanidine-HCl, pH 7.4, and MMP-2 concentration was estimated with enzyme-linked immunoabsorbant assay （ELISA）. Further characterization was accomplished by Western blotting analysis and gelatin zymography. The mean concentrations of MMP-2 per mg dentin protein in the dentin regions were significantly different （P=0.043）： 0.9 ng （ID）, 0.4 ng （MD）, and 2.2 ng （OD）, respectively. The pattern of MMP-2 concentration was OD〉ID〉MD. Western blotting analysis detected -66 and -72 kDa immunopositive proteins corresponding to pro- and mature MMP-2, respectively, in the ID and MD, and a -66 kDa protein in the OD. Gelatinolytic activity consistent with MMP-2 was detected in all regions. Interestingly, the pattern of levels of Western blot immunodetection and gelatinolytic activity was MD〉ID〉OD. The eoneentration of MMP-2 in human coronal dentin was highest in the region of dentin that contains the dentinoenamel junction and least in the middle region of dentin. However, levels of Western blot immunodetection and gelatinolytic activity did not correlate with the estimated regional concentrations of MMP-2, potentially indicating region specific protein interactions.

关键词： matrix metalloproteinase-2 human coronal dentin distribution gelatinolytic activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

FOUR NEW TAXANES FROM THE ROOTS OF TAXUS YUNNANENSIS

引用

Chinese Chemical Letters 1995年第6期6卷 483-486页

作者： Zhang, HJ Sun, HD takeda, Y Acad Sinica Kunming Inst Bot Phytochem Lab Kunming 650204 Peoples R China Univ Tokushima Fac Integrated Arts & Sci Tokushima 770 Japan

Four new taxanes were isolated from the roots of Taxus yunnanensis. Among them, two were determined to contain isobutyrate group and propionyloxy group on C-14 respectively, and one was determined as the least oxygena...

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NOVEL TAXANES FROM TAXUS YUNNANENSIS

引用

Chinese Chemical Letters 1995年第6期6卷 479-482页

作者： Zhang, HJ Sun, HD takeda, Y Acad Sinica Kunming Inst Bot Phytochem Lab Kunming 650204 Peoples R China Univ Tokushima Fac Integrated Arts & Sci Tokushima 770 Japan

Two new taxane diterpenoids from Taxus yunnanensis were elucidated by spectroscopic techniques, one of which was identified as a unique taxane with 2,20-oxo group.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-particle-diagnosis approach： An efficient strategy for discovering new nitride phosphors

引用

Journal of Rare Earths 2018年第1期36卷 42-63页

作者： Xiaojun Wang Takashi takeda Naoto Hirosaki Shiro Funahashi Rong-Jun Xie Jiangsu Key Laboratory of Advanced Laser Materials and Devices School of Physics and Electronic EngineeringJiangsu Normal University Xuzhou 221116 China Sialon Group Environment and Energy Materials DivisionNational Institute for Materials Science (NIMS)Namiki Tsukuba Ibaraki 305-0044 Japan College of Materials Xiamen UniversityXiamen 361005 China

Discovery of novel phosphors is extremely important to target the ever change of the solid state lighting technology. In this paper, we present a high-speed way to discover new phosphors, namely single- particle-diagnosis approach. This approach is based on investigating the crystal structure and lumines- cence of a tiny single crystal, without the necessity of the growth of large-size single crystals or the preparation of single phase powder samples. The concept of the approach and some new nitride phosphors explored by this approach are shown in this paper.

关键词： Solid state lightingsPhosphorsLuminescenceCrystal structureSingle-particle-diagnosis approach

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deep learning image segmentation and extraction of blueberry fruit traits associated with harvestability and yield

引用

Horticulture Research 2020年第1期7卷 1399-1412页

作者： Xueping Ni Changying Li Huanyu Jiang Fumiomi takeda College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhouChina College of Engineering University of GeorgiaAthensGAUSA Appalachian Fruit Research Station USDA-ARSKearneysvilleWVUSA

Fruit traits such as cluster compactness,fruit maturity,and berry number per clusters are important to blueberry breeders and producers for making informed decisions about genotype selection related to yield traits and harvestability as well as for plant *** goal of this study was to develop a data processing pipeline to count berries,to measure maturity,and to evaluate compactness(cluster tightness)automatically using a deep learning image segmentation method for four southern highbush blueberry cultivars(‘Emerald’,‘Farthing’,‘Meadowlark’,and‘Star’).An iterative annotation strategy was developed to label images that reduced the annotation time.A Mask R-CNN model was trained and tested to detect and segment individual blueberries with respect to *** mean average precision for the validation and test dataset was 78.3%and 71.6%under 0.5 intersection over union(IOU)threshold,and the corresponding mask accuracy was 90.6%and 90.4%,*** regression of the detected berry number and the ground truth showed an R2 value of 0.886 with a root mean square error(RMSE)of *** of the traits collected from the four cultivars indicated that‘Star’had the fewest berries per clusters,‘Farthing’had the least mature fruit in mid-April,‘Farthing’had the most compact clusters,and‘Meadowlark’had the loosest *** deep learning image segmentation technique developed in this study is efficient for detecting and segmenting blueberry fruit,for extracting traits of interests related to machine harvestability,and for monitoring blueberry fruit development.

关键词： cluster union image

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Difference between low-volume and high-volume Andersen samplers in measuring atmospheric aerosols

引用

Particuology 2008年第3期6卷 218-222页

作者： Fengfu Fu Nobuo Shinohaya mitsuo Ito Xueqin Xu Mincong Shen Liangjun Xu Key Lab of Analysis and Detecting Technology for Food Safety (Fuzhou University) of Ministry of Education Department of Chemistry Fuzhou University Fuzhou Fujian 350002 China Division of Environment and Radiation Sciences Japan Atomic Energy Agency (JAEA) Tokai-mura Naka-gun lbaraki 319-1195 Japan

The mass concentration and size distribution of aerosols in Tokaimura were investigated using a high-volume and a low-volume Andersen sampler. A difference was found using the two samplers： the concentration of total aerosols determined with the high-volume sampler is smaller than that of the low-volume sampler by 70-90% throughout the year. Compared to the high-volume sampler, low-volume sampler gave lower concentration for aerosols 〉7 μm, higher concentration for aerosols of 3.3-7.0 μm and 〈 1.1 μm, though similar results for aerosols of 1.1-3.3 μm. The low-volume sampler was found to have better separation efficiency and higher accuracy.

关键词： Aerosols Cascade impactor Andersen air sampler Atmospheric particles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optical Nonlinearity in a Novel Optical Signal Regeneration System Based on Cross-Gain Modulation Using Cascaded Semiconductor Optical Amplifiers

引用

光学学报 2003年第S1期23卷 544-545页

作者： Hidekazu takeda Hiroyuki Uenohara Microsystem Research Center P&I Lab. Tokyo Tech. 4259 Nagatsuta Midori-ku Yokohama 226-8503 JapanMicrosystem Research Center P&I Lab. Tokyo Tech. 4259 Nagatsuta Midori-ku Yokohama 226-8503 Japan

We propose a novel optical signal regeneration system based on wavelength converters by use of cross gain modulation in cascaded semiconductor optical amplifiers. The nonlinearity in optical input/output characteristi... 详细信息

关键词： into of In this SOA Optical Nonlinearity in a Novel Optical Signal Regeneration System Based on Cross-Gain Modulation Using Cascaded Semiconductor Optical Amplifiers dBm for on NRZ from

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk factors and diagnostic biomarkers for nonalcoholic fatty liver disease-associated hepatocellular carcinoma:Current evidence and future perspectives

引用

World Journal of Gastroenterology 2022年第27期28卷 3410-3421页

作者： Masayuki Ueno Haruhiko takeda Atsushi Takai Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 6068507Japan

High rates of excessive calorie intake diets and sedentary lifestyles have led to a global increase in nonalcoholic fatty liver disease(NAFLD).As a result,this condition has recently become one of the leading causes of hepatocellular carcinoma(HCC).Furthermore,the incidence of NAFLD-associated HCC(NAFLD-HCC)is expected to increase in the near *** liver fibrosis is the most common risk factor for ***,up to 50%of NAFLDHCC cases develop without underlying liver *** studies have revealed many other risk factors for this condition;including diabetes,other metabolic traits,obesity,old age,male sex,Hispanic ethnicity,mild alcohol intake,and elevated liver *** gene variants,such as single-nucleotide polymorphisms of patatin-like phospholipase domain 3,transmembrane 6 superfamily member 2,and membrane-bound O-acyl-transferase domaincontaining 7,are also associated with an increased risk of HCC in patients with *** clinical and genetic information should be interpreted together for accurate risk ***-fetoprotein(AFP)is the only biomarker currently recommended for HCC ***,it is not sufficiently sensitive in addressing this diagnostic *** GALAD score can be calculated based on sex,age,lectin-bound AFP,AFP,and des-carboxyprothrombin and is reported to show better diagnostic performance for *** addition,emerging studies on genetic and epigenetic biomarkers have also yielded promising diagnostic ***,further research is needed to establish an effective surveillance program for the early diagnosis of NAFLD-HCC.

关键词： Nonalcoholic fatty liver disease Hepatocellular carcinoma Risk factors Biomarkers Tumor markers Genetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Skeletal muscle generated from induced pluripotent stem cells-induction and application

引用

World Journal of Stem Cells 2017年第6期9卷 89-97页

作者： Yuko Miyagoe-Suzuki Shin’ichi takeda Department of Molecular Therapy National Institute of NeuroscienceNational Center of Neurology and PsychiatryKodairaTokyo 187-8502Japan

Human induced pluripotent stem cells(hiPS cells or hiPSCs) can be derived from cells of patients with severe muscle disease. If skeletal muscle induced from patientiPSCs shows disease-specific phenotypes, it can be useful for studying the disease pathogenesis and for drug development. On the other hand, human iPSCs from healthy donors or hereditary muscle diseaseiPSCs whose genomes are edited to express normal protein are expected to be a cell source for cell therapy. Several protocols for the derivation of skeletal muscle from human iPSCs have been reported to allow the development of efficient treatments for devastating muscle diseases. In 2017, the focus of research is shifting to another stage:(1) the establishment of mature myofibers that are suitable for study of the pathogenesis of muscle disease;(2) setting up a highthroughput drug screening system; and(3) the preparation of highly regenerative, non-oncogenic cells in large quantities for cell transplantation, etc.

关键词： Human induced pluripotent stem cells Skeletal muscle Transplantation Disease Modeling Muscle progenitors Muscular dystrophy MYOD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：