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Journal of Cancer Therapy 2017年第12期8卷 1079-1085页

作者： Shigeru Fujisaki Motoi Takashina Kenichi Sakurai Ryouichi Tomita Tadatoshi takayama Department of Surgery Fujisaki Hospital Tokyo Japan Division of Digestive Surgery Nihon University School of Medicine Tokyo Japan Division of Breast and Endocrine surgery Nihon University School of Medicine Tokyo Japan Department of Surgery Nippon Dental School at Tokyo Tokyo Japan

Primary undifferentiated pleomorphic sarcoma (UPS) of the small intestine is extremely rare. The prognosis of UPS is basically poor, and particular, when accompanied with metastatic lesions. This paper reports the case of a long-term survivor of primary UPS of the jejunum with lymph node metastases and a skip lesion in the jejunum. The patient was a 50-year-old Japanese man who presented with a chief complaint of breathlessness. Small bowel X-ray series revealed an approximately 4-cm size with protruded lesion (image shows a filling defect) in the proximal jejunum. Based on a presumptive diagnosis of the hemorrhagic small bowel tumor, he underwent a laparotomy. A tumor was observed in the jejunum at approximately 90-cm from the Treitz ligament;some swollen mesenteric lymph nodules were also observed. Segmental resection of the jejunum was performed 20-140 cm from the Treitz ligament. A complete surgical excision with en-bloc regional lymph node dissection was performed. The final histopathological diagnosis was UPS of the jejunum with metastatic lymph nodes and a skip lesion in the jejunum. The postoperative course was uneventful. The patient was not given adjuvant chemotherapy and was discharged on postoperative day 16. He is currently well without any evidence of recurrence for >10 years after the operation.

关键词： Undifferentiated Pleomorphic Sarcoma Jejunum Metastatic Lymph Nodes

Protective effect of fermented papaya preparation on stress-induced acute gastric mucosal lesion

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Journal of Biophysical Chemistry 2012年第4期3卷 311-316页

作者： Shinki Murakami Fusako takayama Toru Egashira Mitsuko Imao Akitane Mori Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan Department of Clinical Pharmaceutical Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan SAIDO Corporation Fukuoka Japan

Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investigated the protective effects and the mechanism of action of FPP on stress-induced AGML in rats, induced by water immersion restraint stress (WIRS). Exposure of rats to 6-hour WIRS resulted in the appearance of splinter hemorrhages and mucosal lesions in the stomach. WIRS induced significant increase in lipid peroxidation and decrease in superoxide dismutase-like activity in both the plasma and gastric mucosa. WIRS also significantly increased myeloperoxidase activity together with Nuclear factor-kappaB (NF-kB) activation in gastric mucosa. FPP reduced all the above changes. The results suggest that oral administration of FPP provides protection against WIRS-induced acute gastric mucosal lesions through its anti-oxidative and anti-inflammatory properties.

关键词： Acute Gastric Mucosal Lesion Fermented Papaya Preparation Oxidative Stress Inflammation

Fermented papaya preparation halts the progression of non-alcoholic steatohepatitis in rats

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Journal of Biophysical Chemistry 2013年第2期4卷 84-90页

作者： Shinki Murakami Fusako takayama Toru Egashira Mitsuko Imao Akitane Mori Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan Department of Clinical Pharmaceutical Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan SAIDO Corporation Fukuoka Japan

Non-alcoholic steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma. Oxidative stress is implicated in NASH progression. Fermented papaya preparation (FPP) has oxygen radical scavenging activity and is effective in oxidative stress-related diseases. We investigated the effects of FPP on NASH progression using a rat NASH model. Plasma biochemical parameters and lipid peroxidation in the liver were elevated in NASH rats. Histologically, the liver of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation were also markedly increased in NASH. Oral administration of FPP ameliorated these changes in NASH rats. These results suggest that FPP halts NASH progression through its anti-oxidative and antiinflammatory properties.

关键词： Fermented Papaya Preparation Non-Alcoholic Steatohepatitis Oxidative Stress Antioxidant Activity Inflammation

Management before hepatectomy for hepatocellular carcinoma with cirrhosis

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World Journal of Hepatology 2015年第20期7卷 2292-2302页

作者： Hisashi Nakayama Tadatoshi takayama Department of Digestive Surgery Nihon University School of Medicine

The global distribution of hepatocellular carcinoma(HCC) varies markedly among regions, and patients in East Asia and Central Africa account for about 80% of all cases. The risk factors are hepatitis B, hepatitis C, alcohol, and etc. The risk of carcinogenesis further increases with progression to hepatic cirrhosis in all liver disorders. Radical treatment of HCC by liver resection without causing liver failure has been established as a safe approach through selection of an appropriate range of resection of the damaged liver. This background indicates that both evaluation of hepatic functional reserve and measures against concomitant diseases such as thrombocytopenia accompanying portal hypertension, prevention of rupture of esophageal varices, reliable control of ascites, and improvement of hypoalbuminemia are important issues in liver resection in patients with hepatic cirrhosis. We review the latest information on perioperative management of liver resection in HCC patients with hepatic cirrhosis.

关键词： Hepatocellular carcinoma Liver resection Liver cir

Role of surgical resection for hepatocellular carcinoma based on Japanese clinical guidelines for hepatocellular carcinoma

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World Journal of Hepatology 2015年第2期7卷 261-269页

作者： Hisashi Nakayama Tadatoshi takayama Department of Digestive Surgery Nihon University School of Medicine

In the Algorithm for Diagnosis and Treatment in the Japanese Evidence-Based Clinical Practice Guidelines for Hepatocellular Carcinoma, the treatment strategy is determined by three major factors: liver function and the number and size of tumors. The algorithm is quite simple, consisting of fewer components than the Barcelona-Clinic Liver Cancer staging system. In this article, we describe the roles of the treatment algorithmin hepatectomy and perioperative management of hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Guideline Liverresection Treatment algorithm

Long-Term Survival of Resected Pancreatic Carcinoma Which Was Coincidentally Detected at the Occurrence of Incarcerated Inguinal Hernia: A Case Report

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Journal of Cancer Therapy 2018年第6期9卷 516-521页

作者： Shigeru Fujisaki Motoi Takashina Ryouichi Tomita Ken-Ichi Sakurai Tadatoshi takayama Department of Surgery Fujisaki Hospital Tokyo Japan Department of Surgery Nippon Dental University Tokyo Japan Division of Breast and Endocrine Surgery Nihon University School of Medicine Tokyo Japan Division of Digestive Surgery Nihon University School of Medicine Tokyo Japan

Surgical intervention of asymptomatic and accidentally detected pancreatic carcinoma can prolong survival. A 67-year-old man with the right incarcerated inguinal hernia was referred to our hospital, he immediately underwent manipulative treatment followed by hernioplasty on the next day. Upon the first visit, a pancreatic tumor was accidentally detected in CT images in the pancreatic tail. About approximately a month, abdominal CT revealed a slightly developed tumor;accordingly, distal pancreatectomy with lymph node dissection was performed. The patient was histopathologically diagnosed with tubular adenocarcinoma, and his final pathological stage was ypT2, pN0, cM0, Stage Ib, based on the TNM classification of malignant tumors (8th edition). For postoperative six months, he was treated with adjuvant chemotherapy using gemcitabine (1000 mg/m2). Remarkably, the patient reported no recurrence and has been alive for postoperative 7.5 years, thereby attaining excellent outcomes for accidentally detected pancreatic carcinoma at the occurrence of an incarcerated inguinal hernia.

关键词： Pancreatic Carcinoma Incarcerated Inguinal Hernia Long-Term Survival

Fibrosis in nonalcoholic fatty liver disease: Noninvasive assessment using computed tomography volumetry

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World Journal of Gastroenterology 2016年第40期22卷 8949-8955页

作者： Nobuhiro Fujita Akihiro Nishie Yoshiki Asayama Kousei Ishigami Yasuhiro Ushijima Yukihisa takayama Daisuke Okamoto Ken Shirabe Tomoharu Yoshizumi Kazuhiro Kotoh Norihiro Furusyo Tomoyuki Hida Yoshinao Oda Taisuke Fujioka Hiroshi Honda Department of Clinical Radiology Graduate School of Medical Sciences Kyushu University Department of Advanced Imaging and Interventional Radiology Graduate School of Medical Sciences Kyushu University Department of Radiology Informatics and Network Graduate School of Medical Sciences Kyushu University Department of Surgery and Sciences Graduate School of Medical Sciences Kyushu University Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Department of General Internal Medicine Graduate School of Medical Sciences Kyushu University Department of Anatomic Pathology Graduate School of Medical Sciences Kyushu University CT Application Philips Electronics Japan Medical Systems

AIM To evaluate the diagnostic performance of computed tomography(CT) volumetry for discriminating the fibrosis stage in patients with nonalcoholic fatty liver disease(NAFLD).METHODS A total of 38 NAFLD patients were enrolled. On the basis of CT imaging, the volumes of total, left lateral segment(LLS), left medial segment, caudate lobe, and right lobe(RL) of the liver were calculated with a dedicated liver application. The relationship between the volume percentage of each area and fibrosis stage was analyzed using Spearman's rank correlation coefficient. A receiver operating characteristic(ROC) curve analysis was performed to determine the accuracy of CT volumetry for discriminating fibrosis *** The volume percentages of the caudate lobe and the LLS significantly increased with the fibrosis stage(r = 0.815, P < 0.001; and r = 0.465, P = 0.003, respectively). Contrarily, the volume percentage of the RL significantly decreased with fibrosis stage(r =-0.563, P < 0.001). The volume percentage of the caudate lobe had the best diagnostic accuracy for staging fibrosis, and the area under the ROC curve values for discriminating fibrosis stage were as follows: ≥ F1, 0.896; ≥ F2, 0.929; ≥ F3, 0.955; and ≥ F4, 0.923. The best cut-off for advanced fibrosis(F3-F4) was 4.789%, 85.7% sensitivity and 94.1% *** The volume percentage of the caudate lobe calculated by CT volumetry is a useful diagnostic parameter for staging fibrosis in NAFLD patients.

关键词： Nonalcoholic fatty liver disease Computed tomography volumetry Fibrosis stage Nonalcoholic steatohepatitis

臂形草内生菌特异DNA片段的克隆及其分子鉴定

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热带作物学报 2002年第4期23卷 58-61页

作者：黄贵修 Yuka takayama Segenet Kelemu 华南热带农业大学农学院海南儋州571737 19-1-203 Minamitomigaoka Nara-shi Nara 631-0023 Tropical Forages Pathology Laboratory International Center for Tropical Agriculture. A.A.6713 Cali Colombia

进行了臂形草内生菌特异DNA片段的克隆及分子鉴定方法的研究。从5个臂形草品种分离的5个内生菌纯培养物中,提取基因组DNA,通过140条随机引物的RAPD分析,引物OPAK10扩增出1条约500bp的共有PCR谱带。此DNA片段命名为BE1。对BE1进行分离、... 详细信息

进行了臂形草内生菌特异DNA片段的克隆及分子鉴定方法的研究。从5个臂形草品种分离的5个内生菌纯培养物中,提取基因组DNA,通过140条随机引物的RAPD分析,引物OPAK10扩增出1条约500bp的共有PCR谱带。此DNA片段命名为BE1。对BE1进行分离、纯化,经点杂交证实BE1为臂形草内生菌特异DNA片段。进一步将BE1片段进行回收、克隆和DNA序列分析。BE1在基因库中进行序列分析,未发现相关同源片段。臂形草内生菌特异DNA片段的获得,为建立一种准确、快速检测臂形草内生菌及特异内生菌方法奠定了分子生物学基础。

关键词：臂形草内生菌特异DNA片段克隆

Control strategy and methods for continuous direct compression processes

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Asian Journal of Pharmaceutical Sciences 2021年第2期16卷 253-262页

作者： Yasuhiro Suzuki Hirokazu Sugiyama Manabu Kano Ryutaro Shimono Gosuke Shimada Ryoichi Furukawa Eichi Mano Keiichi Motoyama Tatsuo Koide Yasuhiro Matsui Kazuki Kurasaki Issei takayama Shunin Hikage Noriko Katori Masahiko Kikuchi Hiroshi Sakai Yoshihiro Matsuda Formulation Technology Research Laboratories Daiichi Sankyo Co.Ltd.Kanagawa 254-0014Japan Department of Chemical System Engineering The University of TokyoTokyo 113-8656Japan Department of Systems Science Kyoto UniversityKyoto 606-8501Japan CMC Sciences Department Regulatory Affairs DivisionR&D DivisionJanssen Pharmaceutical K.K.Tokyo 101-0065Japan EuroTechno Ltd. Kanagawa 223-0057Japan Pharmaceutical Research Department Mitsubishi Tanabe Pharma CorporationOsaka 532-8505Japan Chemical Products CMC Regulatory Affairs Area Japan DevelopmentMSD K.K.Tokyo 102-8667Japan Graduate School of Pharmaceutical Sciences Kumamoto UniversityKumamoto 862-0973Japan Division of Drugs National Institute of Health SciencesKawasaki 210-9501Japan Technology Research&Development Sumitomo Dainippon Pharma Co.Ltd.Osaka 564-0053Japan Formulation Development Department Chugai pharmaceutical Co.Ltd.Tokyo 115-8543Japan Office of New Drug IV Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan Office of Generic Drugs Pharmaceuticals and Medical Devices AgencyShin-Kasumigaseki Bldg.Tokyo 100-0013Japan KOKANDO Co. Ltd.Toyama 930-8580Japan Pharmaceuticals and Medical Devices Agency Shin-Kasumigaseki Bldg.Tokyo 100-0013Japan

We presented a control strategy for tablet manufacturing processes based on continuous direct *** work was conducted by the experts of pharmaceutical companies,machine suppliers,academia,and regulatory authority in *** different items in the process,the component ratio and blended powder content were selected as the items requiring the control method specific to continuous manufacturing different from the conventional batch *** control and management of the Loss in Weight(LIW)feeder were deemed the most important,and the Residence Time Distribution(RTD)model were regarded effective for setting the control range and for controlling of the LIW *** on these ideas,the concept of process control using RTD was summarized.

关键词： Continuous manufacturing Solid drug products Process control Residence time distribution Loss in weight feeder Regulatory science

Deep learning-based magnetic resonance imaging reconstruction for improving the image quality of reduced-field-of-view diffusionweighted imaging of the pancreas

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World Journal of Radiology 2023年第12期15卷 338-349页

作者： Yukihisa takayama Keisuke Sato Shinji Tanaka Ryo Murayama Nahoko Goto Kengo Yoshimitsu Department of Radiology Faculty of MedicineFukuoka UniversityFukuoka 8140180Japan

BACKGROUND It has been reported that deep learning-based reconstruction(DLR)can reduce image noise and artifacts,thereby improving the signal-to-noise ratio and image ***,no previous studies have evaluated the efficacy of DLR in improving image quality in reduced-field-of-view(reduced-FOV)diffusionweighted imaging(DWI)[field-of-view optimized and constrained undistorted single-shot(FOCUS)]of the *** hypothesized that a combination of these techniques would improve DWI image quality without prolonging the scan time but would influence the apparent diffusion coefficient *** To evaluate the efficacy of DLR for image quality improvement of FOCUS of the *** This was a retrospective study evaluated 37 patients with pancreatic cystic lesions who underwent magnetic resonance imaging between August 2021 and October *** evaluated three types of FOCUS examinations:FOCUS with DLR(FOCUS-DLR+),FOCUS without DLR(FOCUS-DLR−),and conventional FOCUS(FOCUS-conv).The three types of FOCUS and their apparent diffusion coefficient(ADC)maps were compared qualitatively and *** FOCUS-DLR+(3.62,average score of two radiologists)showed significantly better qualitative scores for image noise than FOCUS-DLR−(2.62)and FOCUS-conv(2.88)(P<0.05).Furthermore,FOCUS-DLR+showed the highest contrast ratio and 600 s/mm^(2)(0.72±0.08 and 0.68±0.08)and FOCUS-DLR−showed the highest CR between cystic lesions and the pancreatic parenchyma for the b-values of 0 and 600 s/mm2(0.62±0.21 and 0.62±0.21)(P<0.05),***-DLR+provided significantly higher ADCs of the pancreas and lesion(1.44±0.24 and 3.00±0.66)compared to FOCUS-DLR−(1.39±0.22 and 2.86±0.61)and significantly lower ADCs compared to FOCUS-conv(1.84±0.45 and 3.32±0.70)(P<0.05),*** This study evaluated the efficacy of DLR for image quality improvement in reduced-FOV DWI of the *** can significantly denoise images without prolonging the scan time or

关键词： Deep learning-based reconstruction Magnetic resonance imaging Reduced field-of-view Diffusion-weighted imaging Pancreas