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Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

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World Journal of Gastroenterology 2006年第40期12卷 6473-6499页

作者： Yoshiyuki Takahara mitsuo Takahashi Hiroki Wagatsuma Fumihiko Yokoya Qing-Wei Zhang Mutsuyo Yamaguchi Hiroyuki Aburatani Norifumi Kawada Exploratory and Applied Pharmaceutical Research Department Pharmaceutical Company Ajinomoto Co. Inc Kawasaki 210-8681 Japan Biochemical Information project BiolT Business Development Group Fujitsu Limited Tokyo Japan Center for Collaborative Research Research Center for Advanced Science and Technology the University of Tokyo Tokyo Japan Department of Hepatology Graduate School of Medicine Osaka City University Osaka Japan

AIM: To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic ***: Marker genes were identified for different types of hepatic cells, including hepatic stellate cells (HSCs), Kupffer cells (including other inflammatory cells), and hepatocytes, using independent temporal DNA microarray data obtained from isolated hepatic cells. RESULTS: The cell-type analysis of gene expression gave several key results and led to formation of three hypotheses: (1) changes in the expression of HSC-specific marker genes during fibrosis were similar to gene expression data in in vitro cultured HSCs, suggesting a major role of the self-activating characteristics of HSCs in formation of fibrosis; (2) expression of mast cell-specific marker genes reached a peak during liver fibrosis, suggesting a possible role of mast cells in formation of fibrosis; and (3) abnormal expression of hepatocyte-specific marker genes was found across several metabolic pathways during fibrosis, including sulfur-containing amino acid metabolism, fatty acid metabolism, and drug metabolism, suggesting a mechanistic relationship between these abnormalities and symptoms of liver fibrosis. CONCLUSION: Analysis of marker genes for specific hepatic cell types can identify the key aspects of fibro-genesis. Sequential activation of inflammatory cells and the self-supporting properties of HSCs play an important role in development of fibrosis.

关键词： Liver fibrosis Gene expression Microarray Dimethylnitrosamine Marker genes Hepatic stellate cell Kupffer cell Hepatocytes Metabolic pathway

Simultaneous removal of trihalomethanes by bimetallic Ag/Zn:kinetics study

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Frontiers of Chemical Science and Engineering 2010年第3期4卷 322-327页

作者： Ahmed H A DABWAN Satoshi KANECO Hideyuki KATSUMATA Tohru SUZUKI Kiyoyuki EGUSA Kiyohisa ohta Faculty of Chemical Engineering Technology Tati University CollegeJalan PanchorTeluk Kalong24000 KemamanTerengganuMalaysia Department of Chemistry for Materials Graduate School of EngineeringMie UniversityMie 514-8507Japan Environmental Preservation Center Mie UniversityMie 514-8507Japan

In the present work,bimetallic silver/zinc was applied into the degradation of trihalomethanes,THMs:CHCl_(3),CHBrCl_(2),CHBr_(2)Cl,and CHBr_(3).The kinetics reaction rates and removal efficiencies of the THM compound mixtures,in the aqueous solutions,were *** experiments were conducted under mild conditions,ambient temperature,and *** primary degradation reaction followed a pseudo-first-order kinetic *** first-order rate constants and the degradation efficiencies followed the decreasing order of CHBr_(3)>CHBr_(2)Cl>CHBrCl_(2)>CHCl_(3).The bond dissociation energy and hydrophilic/hydrophobic characteristics of the THM compounds may become the most important parameters affecting the degradation kinetics and efficiency by bimetallic Ag/Zn.

关键词： degradation trihalomethanes bimetallic silver/zinc halogenated pollutants kinetics

Corrosion Behavior of MgZnCa Bulk Amorphous Alloys Fabricated by Spark Plasma Sintering

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Acta Metallurgica Sinica(English Letters) 2016年第9期29卷 793-799页

作者： Feng-Xiang Qin Chuan Ji Zhen-Hua Dan Guo-Qiang Xie Hao Wang Shin-Ichi Yamaura mitsuo Niinomi Yang-De Li School of Materials Science and Engineering Nanjing University of Science and Technology Institute for Materials Research Tohoku University College of Materials Science and Engineering Nanjing TECH University WPI-AIMR Tohoku University Dongguan Eontech Co. Ltd

Centimeter-sized Mg65Zn30Ca5 bulk amorphous alloys were fabricated by the spark plasma sintering process from the amorphous powders with a size smaller than 5 la m prepared by ball-milling. The sintered Mg65Zn30Ca5 samples were in an amorphous state when the spark plasma sintering was performed at a temperature of 383 K under a pressure of 600 MPa. The data of polarization curves presented that the sintered Mg65Zn30Ca5 bulk amorphous alloys exhibited higher corrosion resistance than pure Mg and AZ31B alloy owing to high content of Zn and homogeneous structure. A calcium phosphate compound layer was formed on the sintered Mg65Zn30Ca5 bulk amorphous sample after immersion in Hanks＇ solution, which is effective in improving corrosion resistance and bioactivity. The sintered MgZnCa bulk amorphous alloys with large dimensions broaden the potential application of bulk amorphous alloys in the biomedical fields.

关键词： Mg Bulk amorphous alloys Spark plasma sintering Corrosion behavior Biomedical applications

Review: Prediction of Unexpected Fluid-Induced Vibration in Pipeline Network

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World Journal of Mechanics 2022年第2期12卷 17-40页

作者： Ryuhei Yamaguchi Makoto ohta Institute of Fluid Science Tohoku University Sendai Japan

This review considers unexpected destructive disasters involving fluid power plants, such as nuclear electric power plants and fluid power plants. It specifically addresses the possibility of fluid vibration induced in a pipeline network of such a plant. The authors investigate the flow oscillation induced within a T-junction for laminar steady flow at a Reynolds number less than 103 and clarify that there is a periodic fluid oscillation with a constant Strouhal number independent of several flow conditions. Generally, a nuclear electric power plant is constructed using straight pipes, elbows, and T-junctions. Indeed, a T-Junction is a basic fluid element of a pipeline network. The flow in a fluid power plant is turbulent. There are peculiar flow phenomena that occur at high Reynolds numbers, which are also seen in other flow situations;e.g., Kaman vortices are observed around a circular cylinder in low Reynolds numbers, around structures like bridges and downstream of islands in oceans. Although the flow situation of a T-junction and elbow in a fluid power plant, such as the fluid suddenly changing its flow direction is turbulent flow, the authors mention the possibility of the fluid-induced vibration of a pipeline network.

关键词： Fluid-Induced Vibration Flow Oscillation Tube Flow Laminar Steady Flow Fluid Power Plant

Interests of Asian Countries in the Review of the Dispute Settlement Procedure

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时代法学 2004年第3期2卷 118-121页

作者： mitsuo Matsushita 日本东京大学

Features of DS procedure.

关键词： Interests of Asian Countries in the Review of the Dispute Settlement Procedure

Autoimmune pancreatitis with IgG4-positive plasma cell infiltration in salivary glands and biliary tract

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World Journal of Gastroenterology 2005年第35期11卷 5577-5581页

作者： Masashi Taguchi Gentaro Aridome Shintaro Abe Keiichiro Kume mitsuo Tashiro Mitsuyoshi Yamamoto Yasuyuki Kihara Hayato Nakamura Makoto Otsuki Third Department of Internal Medicine University of Occupational and Environmental Health Japan School of Medicine Kitakyushu Japan

A 62-year-old male was referred to our hospital because of liver dysfunction, diffuse pancreatic swelling, and trachelophyma. At admission, the patient was free of pain. Physical examination showed enlarged and palpable bilateral submandibular masses, but no palpable mass or organomegaly in the abdomen. Laboratory findings were as follows： total protein 90 g/L with γ-globulin of 37.3% （33 g/L）, total bilirubin 4 mg/L, aspartate aminotransferase 39 IU/L, alanine aminotransferase 67 IU/L,γ-glutamyl transpeptidase 1 647 IU/L, and amylase 135 IU/L. Autoantibodies were negative, and tumor markers were within the normal range. Serum IgG4 level was markedly elevated （18 900 rag/L）. Computed tomography （CT） showed diffuse swelling of the pancreas and dilatation of both common and intra-hepatic bile ducts. Endoscopic retrograde pancreatography （ERP） revealed diffuse irregular and narrow main pancreatic duct and stenosis of the lower common bile duct. Biopsy specimens from the pancreas, salivary gland and liver showed marked periductal IgG4-positive plasma cell infiltration with fibrosis. We considered this patient to be autoimmune pancreatitis （AIP） with fibrosclerosis of the salivary gland and biliary tract, prescribed prednisolone at an initial dose of 40 mg/d. Three months later, the laboratory data improved almost to normal. Abdominal CT reflected prominent improvement in the pancreatic lesion. Swelling of the salivary gland also improved. At present, the patient is on 10 mg/d of prednisolone without recurrence of the pancreatitis. We present here a case of AIP with fibrosclerosis of salivary gland and biliary tract.

关键词： Autoimmune pancreatitis Fibrosclerosis IgG4-positive plasma cell Salivary gland

Background-Free Optical Sampling System Using Si Avalanche Photodiode as Two-Photon Absorber

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光学学报 2003年第S1期23卷 587-588页

作者： Kenji Taira Ryo ohta Yasuyuki Ozeki Yutaka Fukuchi Kazuhiro Katoh Kazuro Kikuchi Optical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 JapanOptical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 JapanOptical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 JapanOptical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 JapanOptical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 JapanOptical Device Laboratory Research Center for Advanced Science and Technology University of Tokyo 4-6-1 Komaba Meguro-Ku Tokyo 153-8904 Japan

The introduction of a double-chopping scheme eliminates the background level in the optical sampling system, where a Si avalanche photodiode acts as a two-photon absorber. We successfully demonstrate background-free o... 详细信息

关键词： APD of for in as TPA Background-Free Optical Sampling System Using Si Avalanche Photodiode as Two-Photon Absorber EAM GHz test were dBm rate MLL

Metacognition in Solving Process of Basic Electric Circuit ProblemmComparison of Metacognitive Characteristics between Non-major and Major Students in Electric Engineering

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Computer Technology and Application 2013年第8期4卷 415-423页

作者： Atsuo Murata Yukio ohta Graduate School of Natural Science and Technology Okayama University Okayama 700-8530 Japan

There are learners who cannot solve practical problems in spite of mastering basic scientific knowledge and formula necessary for the solution. One of the reasons might be attributed to the lack in metacognitive abilities. The aim of this study was to compare the metacognitive characteristics between non-major and major students in electric engineering and clarify the difference of metacognitive process between these two groups when solving basic problems of electronic circuit. In the experiment, the solving process was compared between non-major and major students in electric engineering using five basic problems. We found that the scores on prediction of result and confidence of own answer differed significantly between non-major and major students, and inferred that the difference of performance was due to the lack in metacognitive ability, especially the plan and the execution abilities. Both prediction of results and confidence of own answer were also found to play a significant role in effective problem solving as important components （subsystems） of metacognition.

关键词： Metacognition plan execution prediction of result confidence of answer major and non-major in electric engineering.

Tumor differentiation phenotype in gastric differentiated-type tumors and its relation to tumor invasion and genetic alterations

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World Journal of Gastroenterology 2006年第24期12卷 3803-3809页

作者： Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato Masaaki Sakamoto Koji Morohara Tsutomu Kaetsu mitsuo Kusano Department of Surgery Division of General and Gastroenterological Surgery Showa UniversitySchool of Medicine1-5-8HatanodaiShina-gawa-kuTokyo 142-8666Japan Department of Surgery Division of General and Gastroenterological Surgery Showa UniversitySchool of Medicine1-5-8HatanodaiShina-gawa-kuTokyo 142-8666Japan Clinical Research LaboratoryShowa UniversitySchool of Medicine1-5-8HatanodaiShinagawa-kuTokyo 142-8666Japan

AIM： To clarify the relations between tumor differentiation phenotype and tumor invasion or genetic alterations in gastric differentiated-type tumors. METHODS： We examined the tumor differentiation phenotype, the presence of mutations in APC and p53, and the microsatellite instability （MSI） status in 48 gastric adenomas and 171 differentiated-type carcinomas, The tumor differentiation phenotype was determined by examining the expression of human gastric mucin （HGM）, NUC6, MUC2 and CD10, The tumors were then classified into gastric- （G-）, gastric and intestinal mixed （GI-）, or intestinal- （I-） phenotypes, according to the immunopositivity of the above markers, The presence of mutations in APC and p53 and the MSI status were also investigated in all the tumors, RESULTS： Gastric adenomas were significantly associated with CDIO expression, I-phenotype tumors and the presence of APC mutations, compared with carcinomas （66.7% vs 25.1%, P 〈 0.0001; 56.3% vs 14.6%, P 〈 0.0001; 39.6% vs 14.0%, P 〈 0.0001, respectively） and inversely associated with expressions of HGM and MUC6 and the presence of p53 mutations （10.4% vs 62.6%, P 〈 0.0001; 39.6% vs 64.3%, P = 0.003; 2.0% vs 26.3%, P = 0.001, respectively）. The frequency of APC mutations was significantly higher in HGM-negative tumors, MUC6-negative tumors, CD10-positive tumors and I-phenotype tumors than in HGM-positive tumors, MUC6- positive tumors, CD10-negative tumors and G-phenotype tumors （32.7% vs 7.1%, P 〈 0.0001; 27.8% vs 14.0%, P = 0.0182; 37.3% vs 10.4%, P 〈 0.0001; and 38.5% vs 9.5%, P = 0.0017, respectively）. The frequency of MSI was significantly higher in MUC6-positive tumors, CD10- negative tumors and G-phenotype tumors than in MUC6- negative tumors, CD10-positive tumors and I-phenotype tumors （24.8% vs 6.7%, P = 0.0009; 22.2% vs 8.0%, P = 0.0143; and 28.6% vs 9.6%, P = 0.0353, respectively）. CONCLUSION： The tumor differentiation phenotype is closely related to tumor invasion and genetic alterations in gastric d

关键词： Gastric carcinoma Tumor differentiation phe-notype APC p53 Microsatellite instability