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基于欠焦像调制处理的生物高分辨透射电镜的发展

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现代科学仪器 2006年第Z1期23卷 10-11页

作者：高井羲造 hayashida M NOMAGUCHI T KIMURA Y 大阪大学材料与生命科学系日本

　　Biologieal samples which are composed of light atoms show very little contrast in transmission electron microscopy (TEM),and only small amount of electron dose is allowed to take the image because they are easily damaged by the electron beam ***,to achieve high-resolution observation of the biological samples,it is crucially important to improve the instrument so as to obtain higher image contrast and to use the total electron dose as emciently as possible.……

关键词：调制处理生物 electron beam irradiation electron microscopy biological samples

A Single-Center Open-Label Single-Arm Study Evaluating Efficacy and Safety of Skin Adhesive Epinexus<sup>TM</sup>in Surgical Patients

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Modern Plastic Surgery 2017年第4期7卷 31-38页

作者： Kazuo Kishi Noriko Aramaki-Hattori Yoshiaki Sakamoto Keisuke Okabe Tetsu hayashida Maiko Takahashi Yuko Kitagawa Masataka Saito Takeya Adachi Aki Honda Hiromitsu Jinno Department of Plastic and Reconstructive Surgery Keio University School of Medicine Tokyo Japan Department of Surgery Keio University School of Medicine Tokyo Japan Department of Dermatology Keio University School of Medicine Tokyo Japan Department of Surgery Teikyo University School of Medicine Tokyo Japan

Existing skin adhesives may, however, cause inflammatory response to toxicity of formaldehyde generated as hydrolysate of polycyanoacrylate (the main ingredient), delay in wound closure due to the adhesive’s flowing into the wound from the edges, or a wide scar. EpinexusTM (Mitsui Chemicals, Inc.), the skin adhesive used for this study, was developed to prevent these risks. For the method of this study, This was a single-center, open-label, single-arm, intervention study of an acrylate skin adhesive, EpinexusTM. The primary endpoint was safety. The secondary endpoints were wound closure, cosmetic outcome (Manchester Scar Scale), and usability. Failures and adverse events were also appropriately evaluated. As a result, there were no particular adverse events such as inflammatory findings, which demonstrated that there is no problem in safety. Some common adverse events were observed, but no adverse events for which a causal relationship cannot be ruled out or failures. As a conclusion, there was no problem in wound closure, cosmetic outcome, or usability. This was a pilot study of EpinexusTM of an ongoing, single-center, open-label, parallel-group, comparative study in 60 subjects comparing EpinexusTMwith an existing skin adhesive, Dermabond? Advanced.

关键词： Cosmetic Techniques Clinical Study Wounds and Injury

自体口腔黏膜上皮构建的组织工程细胞薄片进行角膜重建

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 3-4页

作者： Nishida K. Yamato M. hayashida Y. 杨建刚 Department of Ophtha lmology Osaka University Medical School Yamadaoka 2-2 Suita Osaka 565-0871 Japan Dr.

BACKGROUND: Ocular trauma or disease may lead to severe corneal opacification and, consequently, severe loss of vision as a result of complete loss of corneal epithelial stem cells. Transplantation of autologous corneal stem-cell sources is an alternative to allograft transplantation and does not require immunosuppr ession, but it is not possible in many cases in which bilateral disease produces total corneal stem-cell deficiency in both eyes. We studied the use of autolog ous oral mucosal epithelial cells as a source of cells for the reconstruction of the corneal surface. METHODS: We harvested 3-by-3-mm specimens of oral mucos al tissue from four patients with bilateral total corneal stem-cell deficiencie s. Tissue-engineered epithelial-cell sheets were fabricated exvivo by culturin g harvested cells for two weeks on temperature responsive cell-culture surfaces with 3T3 feeder cells that had been treated with mitomycin C. After conjunctiva l fibrovascular tissue had been surgically removed from the ocular surface, shee ts of cultured autologous cells that had been harvested with a simple reducedtem perature treatment were transplanted directly to the denuded corneal surfaces (o ne eye of each patient) without sutures. RESULTS: Complete reepithelialization o f the corneal surfaces occurred within one week in all four treated eyes. Cornea l transparency was restored and postoperative visual acuity improved remarkably in all four eyes. During a mean follow-up period of 14 months, all corneal surf aces remained transparent. There were no complications. CONCLUSIONS: Sutureless transplantation of carrier-free cell sheets composed of autologous oral mucosal epithelial cells may be used to reconstruct corneal surfaces and can restore vi sion in patients with bilateral severe disorders of the ocular surface.

关键词：口腔黏膜上皮组织工程口腔黏膜组织纤维血管组织视力损害眼外伤眼疾病表面上皮术后视力同种异体移植

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Climatic change record of the sediments in Lake Biwa,Japan during the last 1 Ma

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地球环境学报 2011年第1期 324-324页

作者： Takemura K hayashida A Danhara T Institute of Geothermal Sciences Kyoto University

Lake Biwa is the largest and oldest lake in *** drilled core in 1982-1983（1400 m core） has revealed900 m lake and terrestrial sediments overlying the basement *** age data obtained from fission-track dating and tephra correlation indicated the discontinuity of the sedimentary sequence in present Lake ***,the doubt on discontinuity of the sequence in present Lake Biwa was completely cleared by the reinvestigation of the fission-track ages and tephra identification of Danhara et al（2010）.Improvements on fission track timescale have successfully identified the paleomagnetic data from middle Matuyama reversed Epoch including the Jaramillo event,determining time coverage of the Lake Biwa sediment as-1.5 Ma.A highly linear sediment accumulation rate curve is thus given to the 900 m deep Lake Biwa *** secures the stable sedimentary environment of the basin,and the significance of Lake Biwa sediment as a good record for paleoclimate *** Biwa is,therefore,an ideal terrestrial site to explore paleoclimate and tectonic history during the past 1 Ma of East Asia.

关键词： Lake Climatic change record of the sediments in Lake Biwa,Japan during the last 1 Ma

The effects of benzodiazepine hypnotics on static balance function in human- comparison between Quazepam and Triazolam

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The effects of benzodiazepine hypnotics on static balance fu...

The effects of hypnotics on static balance function in human comparison between zoipidem and triazolam

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作者： Ozone M. Itoh H. Yamadera W. Obuchi K. hayashida K. Sato M. Shin M. Ushijima S. Ishi M. Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Oto-Rhino-Laryngology Tokyo-welfare-annuity hospitalTokyo162-8543Japan

＜正＞Benzodiazepine （BZP） hypnotic Quazepam （QZP）, which is a ω1-selective-acting agent, has been reported to have less effect on balance function than the other BZP hypnotics. However, the effects of QZP on human balance function have not been reported in objective methods. So, we intended to examine the effects of QZP and Triazolam （TZM）, which is a non -selective-

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The effects of hypnotics on static balance function in human...

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作者： Itoh H. Ozone M. Yamadera W. Obuchi K. hayashida K. Sato M. Shin M. Ushijima S. Ishi M. Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Psychiatry The Jikei UniversitySchool of MedicineTokyo105-8471Japan Dept.Of Oto-Rhino-Laryngology Tokyo-welfare-annuity hospitalTokyo162-8543Japan

＜正＞The benzodiazepine （BZP） hypnotics may causes falls at nights, due to its muscle-relaxing effect （MLE）. Zolpidem （ZLP） which is ω1 -selective-hypnotic has been reported to have less MLE than that of conventional BZP hypnotics in mice, but it is not clear in human. So, we intended to examine the effects of ZLP and Triazolam （TZM） which is a conventional ω1 and ω

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《宋书·谢灵运传论》和文学史的自觉

铜仁学院学报 2014年第2期16卷 11-18页

作者：林田慎之助[日](撰) 曹旭(译) 上海师范大学人文与传播学院上海200234

对文学历史的自觉认识,在这种自觉认识上,对过去作家群和众多的作品在文学史的流变中加以比较研究,给予他们各种不同的与之相适合的位置。这就是所谓对文学史的考察。与以魏建安时期作为自己文学理念时代的刘勰与钟嵘不同的是,沈约以西... 详细信息

对文学历史的自觉认识,在这种自觉认识上,对过去作家群和众多的作品在文学史的流变中加以比较研究,给予他们各种不同的与之相适合的位置。这就是所谓对文学史的考察。与以魏建安时期作为自己文学理念时代的刘勰与钟嵘不同的是,沈约以西晋太康时期为自己诗史理想时代。在《宋书·谢灵运传论》中,沈约论述了东晋以降至刘宋时期的诗史论,给刘勰、钟嵘、裴子野、萧子显的诗史论以决定性的影响。可见,沈约在中国文学批评史上开始确立文学史的自觉,其意义十分深远。在西晋太康时期,即潘岳、陆机等文学的辞采和音调中,发现了与至今还保留古风的建安文学不同的特点,揭开了六朝新的一幕。

关键词：沈约《宋书·谢灵运传论》文学史自觉

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Evolution of the East Asian monsoon inferred from environmental magnetic record from Lake Biwa,central Japan

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地球环境学报 2011年第1期 313-313页

作者： hayashida A Yamamoto T Yasuda M Tanigawa Y Ishikawa N Kitagawa H Torii M Haraguchi T Takemura K Affiliated Institution Doshisha University Institute of Geothermal Sciences Kyoto University

Lake Biwa,located in central Japan,contains a thick sedimentary sequence deposited in lacustrine or fluvial environments during the *** and magnetostratigraphic analysis of deep-drilling cores from the central basin showed that about 800 m thick sediment has been deposited for the last 1.3 *** uppermost 250 m clay unit has provided important paleoclimate records,which can be correlated to major glacial-interglacial cycles for the last 0.45 ***,the Lake Biwa sediment is expected to offer detailed records of Asian monsoon activity from the Middle Pleistocene to the *** demonstrate that anhysteretic remanent magnetization(ARM),a measure of magnetic mineral content in sediment,provides a good proxy of hydrological changes around Lake Biwa since the last glacial *** low-field magnetic susceptibility is most widely used for stratigraphic correlation of core samples and detection of paleoenvironmental changes,ARM is more sensitive to concentration of ferrimagnetic minerals such as small magnetite *** previous study on a piston-core recovered in 1995 revealed that the ARM increases in the postglacial interval and that the variation in the lower part is likely linked to millennial-scale climate changes during the last glacial *** finding was confirmed by analysis of new piston-cores recovered from other sites in *** ARM records reproducibly extend back to 46 ka,featuring major interstadials of Dansgaard-Oeschger cycles and Heinrich *** ARM record shows variation similar to total organic carbon(TOC) content,suggesting that flux of finegrained magnetite was increased during the post-glacial and interstadial warm periods as well as flux of wash in nutrients and organic matter.A high-resolution pollen analysis showed that the ARM peaks correspond to regional vegetation response with rapid climate changes in the last glacial *** interpret that the increased ARM represents enhanced precipitation pro

关键词： Lake Evolution of the East Asian monsoon inferred from environmental magnetic record from Lake Biwa,central Japan ARM

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哈纳斯自然保护区兽类区系与分布特征

干旱区研究 1999年第2期16卷 25-30页

作者：阿布力米提.阿布都卡迪尔大泰司纪之马合木提.哈力克林田绘里子中国科学院新疆生态与地理研究所日本北海道大学大学院兽医学系生态教研室新疆大学生物系日本北海道大学兽医学系

本文以阿勒泰地区哈纳斯国家级自然保护区兽类为主，初步分析了其在调查区内各生态地理单元中的组成、分布特点和区系成份等。结果表明，该区哺乳动物种类甚多，有５０种。区系组成明显。区系特征上以耐湿性的北方种类（或泰加林种类）... 详细信息

本文以阿勒泰地区哈纳斯国家级自然保护区兽类为主，初步分析了其在调查区内各生态地理单元中的组成、分布特点和区系成份等。结果表明，该区哺乳动物种类甚多，有５０种。区系组成明显。区系特征上以耐湿性的北方种类（或泰加林种类）为主，占５２％；其它类型与北方类型在不同地段的渗透有明显差异。该区是国家级自然保护区，作为北方泰加林哺乳动物为主体的生存空间。

关键词：哈纳斯保护区兽类区系分布型自然保护区

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