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Pharmacology & Pharmacy 2016年第4期7卷 176-183页

作者： Masaki Shoji mitsuko onda Yukio Arakawa Clinical Laboratory of Practical Pharmacy Osaka University of Pharmaceutical Sciences Osaka Japan

In Japanese pharmacies, Drug Profile Books (DPBs), which are a type of Personal Health Record (PHR), are incorporated in order to prevent duplicate medication and drug interactions in outpatients (patients) through the uniform management of drug administration information. In this study, we tried to clarify the effect on patient safety of brief interventions via DPBs by pharmacists. The study design was a randomized controlled trial on pharmacies as clusters. 65 pharmacies agreed to participate in the study (intervention group (IG): 33;control group (CG): 32). The primary outcomes were: rate of inquiry occurrence, rate of prescription change, and rates of duplicate medications & drug interactions. 56 pharmacies (IG: 29;CG: 27) completed the study. There was a higher tendency for prescription changes in the IG compared to the CG (IG: 0.03%;CG: 0.02%;P = 0.08). In addition, the rate of duplicate medications & drug interactions accounting for the inquiries was significantly higher in the IG than in the CG (IG: 89.2%;CG: 71.9%;P = 0.01). This implied that brief interventions by pharmacists using DPBs had an effect in raising patient safety.

关键词： Drug Profile Book Pharmaceutical Care Community Pharmacy Patient Safety Brief Intervention Communication Personal Health Record

Effects of Lifestyle Intervention Performed by Community Pharmacists on Glycemic Control in Patients with Type 2 Diabetes: The Community Pharmacists Assist (Compass) Project, a Pragmatic Cluster Randomized Trial

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Pharmacology & Pharmacy 2016年第3期7卷 124-132页

作者： Hiroshi Okada mitsuko onda Masaki Shoji Kazuhiko Kotani Takeo Nakayama Yasushi Nakagawa Naoki Sakane Department of Preventive Medicine Clinical Research Institute for Endocrine and Metabolic Disease National Hospital Organization Kyoto Medical Center Kyoto Japan Department of Health Informatics Kyoto University School of Public Health Kyoto Japan Clinical Laboratory of Practical Pharmacy Osaka University of Pharmaceutical Sciences Osaka Japan Division of Community and Family Medicine Jichi Medical University Tochigi Japan Polon Company Kobe Japan

Background: Community pharmacists should be involved in diabetes care, while there has been less evidence about whether a brief lifestyle intervention is effective for diabetes care in community pharmacies. Objectives: To examine the effects of brief lifestyle intervention on glycemic control in patients with type 2 diabetes mellitus (T2D) by using a coaching style, provided by community pharmacists. Methods: A prospective, cluster-randomized, controlled trial was conducted in 50 groups of community pharmacies in Japan. In all, 132 patients with T2D (age, 20 - 75 years, ≥8.0% of hemoglobin A1c (HbA1c)) were assigned to the intervention group (n = 90) or the usual care group (n = 42). The intervention group (IG) underwent brief lifestyle coaching for self-care of T2D for 6 months. The standard care group (CG) received usual care by pharmacists and was given a general newsletter. The primary outcome was changes in HbA1c levels. Results: After 6 months, the IG had significantly improved HbA1c (IG: -0.6 ± 0.9 vs. CG: -0.2% ± 0.9%;p = 0.021 using the last observation carried forward analysis). Although the number of drugs reduced from 2.3 ± 0.8 to 2.0 ± 1.2 in the IG, the number increased from 2.3 ± 1.1 to 2.5 ± 1.1 in the CG (-0.2 ± 0.9 in IG vs. 0.2 ± 0.6 in CG;p = 0.023). Conclusions: The brief lifestyle intervention by community pharmacists improved glycemic control in patients with T2D. Community pharmacists may more positively participate as lifestyle coaches for diabetes care.

关键词： Diabetes Care HbA1c Drug Adherence Community Pharmacy Lifestyle Intervention

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Pharmacology & Pharmacy 2012年第3期3卷 368-380页

作者： Yoko Nanaumi mitsuko onda Yusuke Mukai Rie Tanaka Kenichi Tubota Syunya Matoba Yuka Tanaka Yukio Arakawa Advance Pharma Research Office Nara Japan Clinical Laboratory of Practical Pharmacy Osaka Japan Clinical Laboratory of Practical Pharmacy Osaka Japan.

Objective: The objective of the study was to identify factors related to donepezil medication adherence ("adherence") of cognitively impaired patients in community pharmacies. Methods: One hundred and twenty community pharmacies in 28 regions in Japan were randomly selected. Questionnaires were mailed to these pharmacies. The pharmacists answered based on the medication profiles ("YAKUREKI") of the patients given donepezil at their pharmacies. The survey items were "adherence", "who is the key person" and ‘the key person’s understanding and awareness of donepazil and its symptoms. The χ2 test and decision tree modeling analysis were performed to examine factors affecting adherence. A 5% level of statistical significance was used in the χ2 test. Results: Questionnaires with data on 479 patients were returned. The most common level of adherence was “take as instructed” (81.2%), followed by “forget once or twice a week” (10.2%). The χ2 test revealed that adherence was good if "key person" was professional caretaker (P = 0.004). Also, adherence was better if key person understood medication about dosage, P < 0.001;effect, P = 0.002;and general side effects,, P < 0.001. According to decision tree analysis, the key person had the strongest relationship with adherence. Conclusions: It was confirmed that the key person’s understanding of the medication and symptoms of cognitive impairment are related to adherence. In particular, it was suggested that there is a strong relationship between the key person and adherence and that factors related to adherence differ according to who the key person is. It is essential in the treatment of cognitive impairment to accurately identify the "key person", in order to provide better pharmaceutical care in community pharmacies.

关键词： Japan Pharmacist Community Pharmacy Medication Adherence Cognitive Impairment

SEPARATION OF METAL IONS AS CHELATES OF 1N2,7O3,6S IN THE PRESENCE OR ABSSENCE OF TBA^+ BY CAPILLARY ELECTROPHORESIS

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Journal of Wuhan University of Technology(Materials Science) 1999年第2期14卷 40-45页

作者： mitsuko Oshima Okayama University

Separation and determination of metal ions based on the formation of chelate anions with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid (1N2, 7O3, 6S) was studied by rising HPCE of the nine metal ions examined, the ions that can be detected sensitively with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid were Fe2+, Co2+, Cu2+, Ni2+, Zn2+ and Pd2+. The cobalt chelate could exist in two oxidation states of cobalt. When TBA(+) were added in electrophoretic solutions, the drastic changes in elertrophoretic mobilities of chelate were observed, which was due to the ion association between chelates anions and TBA(+). The ion association constants of chelate anions with TBA(+) were determined by using the change in electrophoretic mobilities of chelates, metal ions tested were separated within 10 min using 30cm silica capillary (50 m i. d).

关键词： high-performance capillary electrophoresis 1-Nitroso-2,7-dihydrozynaphthalene-3,6-disulfonic acid metal ions

Fat and Oil Oxidation by Electron Spin Resonance （ESR） Spin-Trapping Method

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Journal of Food Science and Engineering 2013年第11期3卷 584-591页

作者： Hiromi Fujino mitsuko Ukai Hokkaido University of Education Hakodate-shi Hokkaido 040-8567 Japan

Oxidation of fats and oils during storage causes their degradation and loss of nutritional value and appearance. Electron spin resonance （ESR） is the only method that can be used to directly observe the radicals. In this study, the authors used an ESR spin-trapping method to study the oxidation of triacylglycerols （TAG） containing different fatty acids （FAs） commonly found in food. The ESR adduct signals were analyzed to study the effect of double bonds and the chain length of the FAs of TAG on oxidation. Oxidation was conducted by applying UV irradiation to TAG by dissolving it in N-tert-buthyl〈t-phenylnitrone （PBN）, which trapped the radicals induced in the TAG as an ESR adduct signal. The detection was clearly successful. There were no differences in the spectra of tristearin （18：0） and tripalmitin （16：0）; thus, it can be concluded that the length of the carbon chain of the FAs of TAG does not affect the oxidation reactions. However, the ESR spectra of tristearin （18：0）, triolein （18：1） and trilinolein （18：3） were clearly different due to the presence/absence of a new peak corresponding to new induced radicals, leading to the conclusion that double bonds play a major role in the oxidation reactions of fats and oils.

关键词： ESR spin trapping fats and oils TAG oxidation UV irradiation.

Photochemical Method to Evaluate Oxidation Levels in Heat-Treated Vegetable Oil： Comparison with Peroxide-Value and Acid-Value

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Journal of Food Science and Engineering 2013年第6期3卷 299-308页

作者： Hiromi Kameya mitsuko Ukai National Food Research Institute Tsukuba-shi Ibaraki 305-8642 Japan Hokkaido University of Education Hakodate-shi Hokkaido 040-8567 Japan

To determine the degree of oxidation in vegetable oil, a photochemical method using the electron spin resonance （ESR） spin trapping technique was developed, and the results were compared with those obtained using conventional peroxide-value （PV） and acid-value （AV） methods. Vegetable oil heat-treated were subjected to short UV illumination, and the produced alkyl-oxyl radicals were identified and quantified using the ESR spin trapping technique. ESR signal intensity was used as an indicator of oil oxidation, which monotonically increased as a function of the heat-treatment time. Commercially, available oils were selected and analyzed. The results were compared with those obtained using the PV and AV methods. The present method displayed some analogies with the PV method at least in the early stage of heating. Overall, the present method had highly sensitive and capable of detecting early-stage oxidation in vegetable oil.

关键词： ESR spin trapping plant oil peroxy radical UV-illumination.

New ESR Detection Method of Hydroxyl Radical Scavenging Activity of Blue Berry

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材料科学与工程（中英文B版） 2011年第3期1卷 347-351页

作者： Hiromi Kameya mitsuko Ukai National Food Research Institute 2-1-12 Kannondai Tsukuba Ibaraki Japan Hokkaido University of Education 1-2 Hachiman-cho Hakodate Hokkaido 040-8567 Japan

A new detection method is proposed for the evaluation of hydroxyl radical scavenging activity of blue berry using electron spin resonance (ESR) spectroscopy. The hydroxyl radical scavenging activity was examined using a new reagent 5-(2,2-dimethy-1,3-propoxycyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO), a colorless crystalline that is very soluble in aqueous solution. This method generated very pure hydroxyl radicals by illuminating phosphate buffer solution containing H2O2 and CYPMPO with Hg-Xe arc lamp. The ESR adduct signal was sensitive and very stable. This method is very useful to determine the hydroxyl radical scavenging activity of blue berry.

关键词：自由基清除活性羟自由基 ESR 检测羟基自由基蓝莓电子自旋共振蓝浆果

A Twenty-Year Follow-up Case Study of an Office Worker Who Returned to Work despite Serious Memory Disorder Caused by Herpes Encephalitis

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Journal of Behavioral and Brain Science 2012年第4期2卷 505-511页

作者： mitsuko Nakano Nobuo Miyashita Kazutaka Tanabe Takeshi Yamamoto Department of Neurology Higashi-Matsudo Municipal Hospital Matsudo City Welfare and Medical Center Chiba Japan Department of Neurology Tokyo Metropolitan Matsuzawa Hospital Tokyo Japan Department of Neurosurgery Juntendo University School of Medicine Tokyo Japan Miyashita Neurological Clinic Nagano Japan

This study followed a 52-year-old male patient, who had suffered from severe impairment in recent memory due to se- quelae of herpes encephalitis, for 20 years. He returned to his highly intellectual work and performed well despite his doctor’s prediction. While the patient showed consistently poor results on various neuropsychological memory tests, he demonstrated incredible performance at work. This case exemplifies an extreme case that declarative memory is formed with the support of semantic memory, procedural memory, and his strong interests. Additionally, it offers lessons that results on memory tests do not necessarily correspond to the actual level of competence. The focal sites were found on both sides of the medial temporal lobe, predominantly on the left side. The T2-weighted magnetic resonance images (MRI) obtained 9 years after the onset confirmed widespread damage to the left brain including parahippocampal gyrus, hippocampus, spindle gyrus, and amygdaloid complex, with microlesions extending from the right parahippocampal gyrus to its antero-interior rim. However, the damage to hippocampus was presumed to be minor.

关键词： Declarative Memory Semantic Memory Procedural Memory Hippocampal Damage Recent Memory Herpes Encephalitis

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荷兰有色兔的虹膜异色症(英文)

国际眼科杂志 2007年第4期7卷 932-933页

作者： mitsuko Toyoguchi 程凌云 William R Freeman 加州大学Shiley眼科中心

一只6mo龄大的荷兰有色兔,被观察存在虹膜异色,检查发现有全身及眼部异常。该兔右眼为蓝色,伴眼底色素过少;左眼为棕色,伴眼底部分区域色素过少。该兔存在白色毛发(白色额发);尽管未行客观听力学检查,但听力障碍不明显。双眼组织学检查... 详细信息

一只6mo龄大的荷兰有色兔,被观察存在虹膜异色,检查发现有全身及眼部异常。该兔右眼为蓝色,伴眼底色素过少;左眼为棕色,伴眼底部分区域色素过少。该兔存在白色毛发(白色额发);尽管未行客观听力学检查,但听力障碍不明显。双眼组织学检查示:右眼虹膜基质色素细胞明显少于左眼,视网膜色素上皮和脉络膜内的色素含量也比左眼少。

关键词：虹膜异色眼部白化病色病理学

Histopathological and Immunohistochemical Study of Peri-Implant Epithelium

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Open Journal of Stomatology 2023年第9期13卷 309-321页

作者： Yoshikazu Nakayama Chieko Taguchi mitsuko Nakayama Masaaki Suemitsu Kayo Kuyama Department of Oral Pathology Nihon University Graduate School Dentistry at Matsudo Chiba Japan Department of Community Oral Health Nihon University School of Dentistry at Matsudo Chiba Japan Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan

Background: Human beta-defensins (HBDs), epithelial-derived antimicrobial peptides, contribute to gingival health and periodontal disease. Particularly, the upregulation of HBD-3 expression in periodontal tissues is described to contribute to periodontal tissue regeneration. Specifically, the upregulation of HBD-3 expression in periodontal tissues is described to contribute to periodontal tissue regeneration. But there has been insufficient investigation of the inner epithelium in peri-implantitis, especially the HBD expression patterns as protection against oral infection. Objectives: The purpose of this study was to investigate the histopathological characteristics of the inner implant epithelium in peri-implantitis using histopathological and immunohistochemical methods and to compare it with the inner marginal epithelium in periodontitis. Materials and Methods: The biopsied cases consisted of 10 peri-implantitis, 11 periodontitis, and 10 controls. HE observation, measurement of the thickness of the inner epithelium, and immunohistochemical analysis for Ki-67 and HBD-3 were conducted. Results: Concerning the thickness of the inner epithelium, it was significantly higher in periodontitis (156.2 [138.0, 186.4] μm) than in peri-implantitis and control, 70.7 [67.5, 97.5] μm and 80.7 [76.6, 89.4] μm, respectively (p Conclusion: Decreased production of HBD-3 in keratinocytes composing the inner implant epithelium may be one of the factors affecting tissue repair in peri-implantitis.

关键词： Peri-Implantitis Periodontitis Ki-67 HBD-3 Inner Epithelium