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Consecutive-Day Intake of Whey Protein Upregulates mTOR mRNA and Protein Expression in Resting Skeletal Muscle of Mice

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Food and Nutrition Sciences 2019年第9期10卷 1035-1044页

作者： Hajime sasaki Department of Nutrition and Life Sciences Kanagawa-Institute of Technology Atsugi Japan

Background: Although the effect of whey protein intake on protein metabolism in exercise-loaded skeletal muscle has been well documented, little has been reported on its effect on resting muscle. The effects of whey protein intake on protein metabolism in resting mouse skeletal muscle were investigated. Methods: Mice were fed AIN-93G composed of either casein or whey protein as the protein source for 3 or 7 consecutive days. The gastrocnemius muscle was excised, and the expression levels of the regulatory factor, mTOR, and its subunits, Raptor and Rictor, were measured by real-time PCR. The protein expression levels of mTOR and its phosphorylated form were measured by immunofluorescent western blotting. The effects of whey protein were compared to those of the case in control. Results: mTOR expression increased in the gastrocnemius muscle of mice fed whey protein for 7 consecutive days. The expression of Raptor significantly increased, whereas that of Rictor did not change, suggesting a dominant formation of mTORC1 relating to the upregulation of protein synthesis. The protein levels of mTOR and its phosphorylated form significantly increased in mice fed whey protein, indicating enhanced protein synthesis. Increased mTOR expression was not seen in the gastrocnemius muscle of mice fed whey protein for 3 consecutive days. Conclusions: These results indicate that the intake of whey protein for 7 consecutive days, but not 3 days, upregulates the mRNA and protein expression of mTOR in the resting gastrocnemius muscle of mice, suggesting its ability to enhance protein synthesis. Consecutive-day intake of whey protein may induce constitutive alteration of the skeletal muscle, including continuous upregulation of muscle protein synthesis.

关键词： Whey Protein Intake Resting Skeletal Muscle Enhancement Protein Synthesis mTOR Pathway

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The Best Constant of Discrete Sobolev Inequality on a Weighted Truncated Tetrahedron

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World Journal of Engineering and Technology 2015年第3期3卷 149-154页

作者： Yoshikatsu sasaki Department of Mathematics Hiroshima University Higashi-Hiroshima Japan

The best constant of discrete Sobolev inequality on the truncated tetrahedron with a weight which describes 2 kinds of spring constants or bond distances. Main results coincides with the ones of known results by Kametaka et al. under the assumption of uniformity of the spring constants. Since the buckyball fullerene C60 has 2 kinds of edges, destruction of uniformity makes us proceed the application to the chemistry of fullerenes.

关键词： The Best Constant Sobolev Inequality Discrete Laplacian Weighted Graph Truncated Polyhedron

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Spin Polarization of Fractional Quantum Hall States with <i>ν</i><2

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Journal of Modern Physics 2015年第6期6卷 794-810页

作者： Shosuke sasaki Center for Advanced High Magnetic Field Science Graduate School of Science Osaka University Osaka Japan

The spin polarization of a fractional quantum Hall state shows very interesting properties. The curve of polarization versus magnetic field has wide plateaus. The fractional quantum Hall effect is caused by the Coulomb interaction because the 2D electron system without the Coulomb interaction yields no energy gap at the fractional filling factor. Therefore, the wide plateau in the polarization curve is also caused by the Coulomb interaction. When the magnetic field is weak, some electrons have up-spins and the others down-spins. Therein the spin-exchange transition occurs between two electrons with up and down spins via the Coulomb interaction. Then the charge distribution before the transition is the same as one after the transition. So these two states have the same classical Coulomb energy. Accordingly, the partial Hamiltonian composed of the spin exchange interaction should be treated exactly. We have succeeded in diagonalizing the spin exchange interaction for the first and second nearest electron pairs. The theoretical results reproduce the wide plateaus very well. If the interval modulations between Landau orbitals are taken into the Hamiltonian, the total energy has the Peierls instability. We can diagonalize the Hamiltonian with the interval modulation. The results reproduce wide plateaus and small shoulders which are in good agreement with the experimental data.

关键词： Spin Polarization Fractional Quantum Hall Effect 2D Electron System Quantum Theory

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Novel Fused Taper 1x4 Star Coupler for Full-Band Operation

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光学学报 2003年第S1期23卷 119-120页

作者： Masakazu Ohashi Hideki sasaki Ryoukichi Matsumoto Daiichiro Tanaka Akira Wada Optics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 JapanOptics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 JapanOptics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 JapanOptics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 JapanOptics and Electronics Laboratory Fujikura Ltd. 1440 Mutsuzaki Sakura Chiba 285-8550 Japan

A novel fused taper 1×4 coupler for full-band operation is proposed. Wavelength flattened characteristics and excellent branching uniformity less than 0.4 dB have been achieved in wavelength range from 1200 nm to 170... 详细信息

关键词： Star nm been 一弓 Novel Fused Taper 1x4 Star Coupler for Full-Band Operation in than high have Wave

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Fractional Quantum Hall States for Filling Factors 2/3 <<i>ν</i><2

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Journal of Modern Physics 2015年第5期6卷 584-600页

作者： Shosuke sasaki Center for Advanced High Magnetic Field Science Graduate School of Science Osaka University Osaka Japan

Fractional quantum Hall effect (FQHE) is investigated by employing normal electrons and the fundamental Hamiltonian without any quasi particle. There are various kinds of electron configurations in the Landau orbitals. Therein only one configuration has the minimum energy for the sum of the Landau energy, classical Coulomb energy and Zeeman energy at any fractional filling factor. When the strong magnetic field is applied to be upward, the Zeeman energy of down-spin is lower than that of up-spin for electrons. So, all the Landau orbitals in the lowest level are occupied by the electrons with down-spin in a strong magnetic field at 1 ν . On the other hand, the Landau orbitals are partially occupied by up-spins. Two electrons with up-spin placed in the nearest orbitals can transfer to all the empty orbitals of up-spin at the specific filling factors and so on. When the filling factor ν deviates from ν0, the number of allowed transitions decreases abruptly in comparison with that at ν0. This mechanism creates the energy gaps at ν0. These energy gaps yield the fractional quantum Hall effect. We compare the present theory with the composite fermion theory in the region of 2/3 ν .

关键词： Fractional Quantum Hall Effect 2D Electron System Quantum Theory

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Hand-assisted laparoscopic colorectal resections:the preferred option

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中华结直肠疾病电子杂志 2012年第2期1卷 1-4页

作者： Larry sasaki 美国路易斯安那州伯锡尔城外科专科医院美国外科学院美国路易斯安娜州大学医学中心外科国际外科医师学院美国区

作者对1995年至2009年间该院的微创结直肠手术进行了总结和综述,2002年后,作者开始实施手辅助下腔镜结直肠手术。在这14年间,一共实施了155例开腹手术,225例全腔镜手术和504例手辅助腔镜结肠手术。全腔镜组和手辅助组总的手术并发症发... 详细信息

作者对1995年至2009年间该院的微创结直肠手术进行了总结和综述,2002年后,作者开始实施手辅助下腔镜结直肠手术。在这14年间,一共实施了155例开腹手术,225例全腔镜手术和504例手辅助腔镜结肠手术。全腔镜组和手辅助组总的手术并发症发生率是2.9%,其中全腔镜组为5.3%,手辅助组为1.8%。吻合口瘘发生率在开腹组、全腔镜组和手辅助组分别为1.9%(3/155)、1.3%(3/225)和1.3%(7/504)。开腹组、全腔镜组和手辅助组的平均住院天数分别为6.4 d、3.1 d和2.9 d。腔镜组住院时间的缩短抵消了手术费用的增加,腔镜组的总费用明显少于开腹组(平均节省5053美元)。得益于手术时间的缩短和较少的器械费用,手辅助组的成本效益(7334美元)甚至优于全腔镜组(4215美元)。结果显示微创手术在并发症发生率、住院时间和总费用方面优于开腹手术,而且与开腹手术相比,手辅助下腔镜手术不仅具有腹腔镜手术的先天优势,而且手术时间更短,费用更少。

关键词：手控腹腔镜检查技术外科手术微创性结直肠肿瘤

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Fulminant amoebic colitis during chemotherapy for advanced gastric cancer

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World Journal of Gastroenterology 2009年第27期15卷 3445-3447页

作者： Noboru Hanaoka Katsuhiko Higuchi Satoshi Tanabe Tohru sasaki Kenji Ishido Takako Ae Wasaburo Koizumi Katsunori Saigenji Department of Gastroenterology Kitasato University School of Medicine2-1-1 Asamizodai Sagamihara-City Kanagawa 228-8520 Japan

A 52-year-old man had bloody stools during chemo-therapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis with intestinal perforation developed, and emergency peritoneal lavage and colostomy were performed. After surgery, endotoxin adsorption therapy was performed and metronidazole was given. Symptoms of peritonitis and colonitis resolved. However, the patient's general condition worsened with the progression of gastric cancer. The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy.

关键词： Fulminant amoebic colitis Gastric cancer Chemotherapy Amoebiasis

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Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

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World Journal of Gastroenterology 2010年第10期16卷 1252-1257页

作者： Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu sasaki Shoichi Nishise Sumio Kawata Department of Gastroenterology Yamagata University Faculty of Medicine Division of Endoscopy Yamagata University Hospital

AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression ***: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced ***: A decreased level of adiponectin is str

关键词： Adenoma Early colorectal cancer Metabolic syndrome Adipokines Colonoscopy Resistin Leptin Body mass index

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Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen

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World Journal of Gastroenterology 2009年第44期15卷 5579-5585页

作者： Satoshi Yamaoka Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Taniguchi Yasushi Adachi Shigeru sasaki Yoshiaki Arimura Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical UniversitySapporo 060-8543 Japan Sapporo Medical University Sapporo 060-8556 Japan

AIM： To clarify the significance of JC virus （JCV） T-antigen （T-Ag） expression in human gastric cancer. METHODS： We investigated the relationship between TAg detected by immunohistochemistry and Epstein- Barr virus （EBV） infection, microsatellite instability （MSI）, and genetic and epigenetic alterations in gastric cancers. Mutations in the p53,β-catenin, K/MS, BRAF, PIK3CA genes were analyzed by PCR- single strand conformation polymorphism and DNA sequencing. Allelic losses were determined by PCR at 7 microsatellite loci. Aberrant DNA methylation was analyzed by MethyLight assay. RESULTS： JCV T-Ag protein expression was found in 49% of 90 gastric cancer tissues. TAg positivity was not correlated with clinicopathological characteristics. TAg expression was detected in a similar percentage of EBV positive cancers （4 of 9, 44%） and EBV negative cancers （35 of 73, 48%）. TAg expression was detected in a significantly lower percentage of MSI-H cancers （14%） than in non MSI-H cancers （55%, P = 0.005）. TAg expression was detected in a significantly higher percentage of cancers with nuclear/cytoplasmic localization of β-catenin （15 of 21, 71%） than in cancers without （42%, P = 0.018）. p53 mutations were detected in a significantly lower percentage of T-Ag positive cancers （32%） than in TAg negative cancers （57%, P = 0.018）. TAg positive gastric cancers showed a significant increase in the allelic losses and aberrant methylation compared with T-Ag negative gastric cancers （P = 0.008 and P = 0.003）. CONCLUSION： The results suggest that JCV T-Ag is involved in gastric carcinogenesis through multiple mechanisms of genetic and epigenetic alterations.

关键词： JC virus T-antigen Epstein-Barr virus Microsatellite instability Gastric cancer

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High voltage-controlled magnetic anisotropy and interface magnetoelectric effect in sputtered multilayers annealed at high temperatures

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Science China(Physics,Mechanics & Astronomy) 2020年第7期63卷 114-119页

作者： LeZhi Wang Xiang Li Taisuke sasaki Kin Wong GuoQiang Yu ShouZhong Peng Chao Zhao Tadakatsu Ohkubo Kazuhiro Hono WeiSheng Zhao KangLong Wang Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang UniversityBeijing 100191China School of Computer Science&Engineering Beihang UniversityBejing 100191China Department of Electrical Engineering University of CaliforniaLos AngelesLos Angeles 90095USA School of Microeletronics Beihang UniversityBeijing 100191China Inston IncLos Angeles 90095USA National Institute for Materials Science(NIMS) Tsukuba 305-0047Japan Institute of Microelectronics Chinese Academy of SciencesBejing 100029China

Voltage control of magnetism promises great energy efficiency in writing magnetic memory. Here, using Cr/Mo/CoFeB/MgO multilayers stable under high annealing temperatures up to 590°C, we significantly enhance the interfacial crystallinity, thereby the interface-originated perpendicular magnetic anisotropy(PMA), voltage-controlled magnetic anisotropy(VCMA), and interface magnetoelectric(ME) effect. High interfacial PMA of 1.35 mJ/m^2, VCMA coefficient of-138 fJ/(V m), and interface ME coefficient, which is 2-3 orders of magnitude larger than ab initio calculation results are simultaneously achieved after annealing at 500°C. These promising results enabled by the industry-applicable sputtering process will pave the way for highdensity voltage-controlled spintronic devices.

关键词： voltage-controlled magnetic anisotropy(VCMA) magnetoelectric(ME)effect perpendicular magnetic anisotropy

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