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Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases

World Journal of Gastrointestinal Endoscopy 2022年第11期14卷 704-717页

作者： Keisuke Kosumi Kosuke Mima Kosuke Kanemitsu Takuya Tajiri Toru Takematsu Yuki Sakamoto mitsuhiro inoue Yuji Miyamoto Takao Mizumoto Tatsuo Kubota Nobutomo Miyanari Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan Department of Surgery National Hospital Organization Kumamoto Medical CenterKumamoto 860-0008Japan Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto UniversityHonjo 860-8556KumamotoJapan

BACKGROUND Experimental studies suggest that self-expanding metal stents(SEMSs)enhance the aggressive behavior of obstructive colorectal cancer.The influence of SEMS placement on pathological alterations remains to be elucidated.AIM To determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues.METHODS Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers,we examined the association of SEMS placement with molecular or pathological features,including tumor size,histological type,American Joint Committee on Cancer(AJCC)-pTNM stage,and mutation statuses in colorectal cancer tissues compared with the use of transanal tubes.A multivariable logistic regression model was used to adjust for potential confounders.RESULTS SEMS placement was significantly associated with venous invasion(P<0.01),but not with the other features examined,including tumor size,disease stage,mutation status,and lymphatic invasion.In both the univariable and multivariable models with adjustment for potential factors including tumor location,histological type,and AJCC-pT stage,SEMS placement was significantly associated with severe venous invasion(P<0.01).For the outcome category of severe venous invasion,the multivariable odds ratio for SEMS placement relative to transanal tube placement was 19.4(95%confidence interval:5.24–96.2).No significant differences of disease-free survival and overall survival were observed between SEMS and transanal tube groups.CONCLUSION SEMS placement might be associated with severe venous invasion in colorectal cancer tissue,providing an impetus for further investigations on the pathological alterations by SEMSs in colorectal cancer development.

关键词： Bridge to surgery Colorectal carcinoma Obstruction Stent Venous invasion

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Surface Modification of NaCl Particles with Metal Films Using the Polygonal Barrel-Sputtering Method

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Materials Sciences and Applications 2013年第7期4卷 29-34页

作者： Satoshi Akamaru mitsuhiro inoue Takayuki Abe Hydrogen Isotope Research Center University of Toyama Toyama Japan

In this study, the surfaces of NaCl particles were modified with metal films using the polygonal barrel-sputtering method. When Pt was sputtered on NaCl particles, the individual particles changed from white to metallic. Characterization of the treated samples indicated that thin Pt metal films were uniformly deposited on the NaCl particles. Immersion of the treated NaCl particles in water revealed that they floated to the surface of the water with the increase in the immersion time, although their original cubic shapes remained unchanged. The floating phenomenon of the Pt-coated NaCl particles, as mentioned above, suggests that NaCl was dissolved by the permeation of water through invisible defects such as grain boundaries in the Pt films, leading to the formation of hollow particle-like materials. It should be noted that uniform film deposition on the NaCl particles could also be achieved by sputtering with Au or Cu. Based on the obtained results, our sputtering method allows uniform surface modification of water-soluble and water-reactive powders that cannot be treated by conventional wet process using water.

关键词： Particle Surface Modification Ionic Crystal Dry Process Sputtering Technique NaCl

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Oxidation behavior and improvement in nonflammability of LPSO-type Mg–Zn–Y–Sr alloy

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Journal of Magnesium and Alloys 2024年第2期12卷 742-749页

作者： Shin-ichi inoue Kazumasa Iwanaga Yoshihito Kawamura Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Materials Science Graduate School of Science and TechnologyKumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg_(97)Zn_(1)Y_(2)alloys with high ignition temperatures were developed by adding Sr.The addition of Sr resulted in the formation of a uniform and thin Y_(2)O_(3)film.Mg–Zn–Y alloys containing at least 0.25 at.%Sr exhibited ignition temperatures of 1270–1320 K.As a result of EDS measurement,Sr was found to be concentrated in the Y_(2)O_(3)film.In addition,a mixed film of MgO and Sr O formed on the outer layer in the 1.5 at.%Sr-containing Mg_(97)Zn_(1)Y_(2)alloy.These findings suggest that the uniform and thin Y_(2)O_(3)film that maintains high soundness at high temperatures was formed owing to valence control and the formation of a protective outer oxide film.

关键词： Magnesium alloy Yttrium Strontium High-temperature oxidation Nonflammability

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Effects of Carboxymethylcelluloses (CMC) on Some Hydraulic Properties of Sandy Soil

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Journal of Northeast Agricultural University(English Edition) 2010年第4期17卷 30-36页

作者： ANDRY Henintsoa inoue mitsuhiro MORITANI Shigeoki UZOMA Kingsley Chinyere Arid Land Research Center Tottori University The United Graduate School of Agricultural Science Tottori University

The property of hydrophilic polymers capable absorbing huge volumes of water led to many practical applications of these new materials in arid regions for improving the water retention in sandy soils. Effects of four carboxymethylcelluloses （CMC） mixed at various rates with the sandy soil, on the water-holding capacity and hydraulic conductivity （Ks） when leached with distilled water （simulating rain）, tap water, and saline water were evaluated. The maximum water absorption of CMCs ranged between 80 and 100 kg. kg^-1 of polymer; however, the absorbent swelling capacity decreased significantly with increasing the salt concentration in the solution. The water absorption capacity of CMCs decreased significantly when incorporated in the sandy soil compared to that of the absorbent alone. Application of CMC increased significantly the available water content up to 3 ± 0.5 times. All soils treated with CMCs showed a significant lower in Ks compared to the control soil. Meanwhile, Ks was found increased with increasing the salt concentration in the leaching solution. This understanding of characteristics of the absorbents and the interactions among absorbents, soil, and irrigation water quality would be of help in water management of sandy soil

关键词： sandy soil water quality carboxymethylcelluloses hydraulic property

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Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno Department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan Department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan Department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan Medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the

关键词： Colorectal neoplasms Cancer registry Diagnostic route Cancer screening Stage at diagnosis

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In-situ study of the microstructure evolution during tension of a Mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jen? Gubicza Kristián Máthis Péter Nagy Péter Jenei Zoltán Heged?s Andrea Farkas Jozef Vesely Shin-ichi inoue Daria Drozdenko Yoshihito Kawamura Department of Materials Physics Faculty of Science E?tv?s Loránd University Department of Physics of Materials Faculty of Mathematics and Physics Charles University Deutsches Elektronen-Synchrotron DESY Magnesium Research Center Kumamoto University

Mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation（RSRC） technique exhibit an exceptional mechanical performance indicating promising application potential. This material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers（CALs） and nanoplates（CANaPs）, or complete long period stacking ordered（LPSO） phase. In order to reveal the deformation mechanisms, in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in Mg-0.9% Zn-2.05% Y-0.15%Al（at%） alloy. For uncovering the effect of the initial microstructure on the mechanical performance, additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400 ℃ for 2 h. The heat treatment at 300 ℃ had no significant effect on the initial microstructure, its evolution during tension and, thus, the overall deformation behavior under tensile loading. On the other hand,annealing at 400 ℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density, leading to only minor degradation of the mechanical strength. The maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20 × 1014m-2. The diffraction profile analysis indicated that most dislocations formed during tension were of non-basaland pyramidaltypes, what was also in agreement with the Schmid factor values revealed independently from orientation maps. It was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value, which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： Mg-Zn-Y-Al alloy Long period stacking ordered (LPSO) phase Cluster arranged nanoplates (CANaPs) Annealing Tension Dislocation density Hardening

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SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

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Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada Kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi Nagai Yasuhiro inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is necessary.The organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business risk.Chiyoda has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization stage.Currently,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as possible.In this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

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Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders

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Neural Regeneration Research 2022年第10期17卷 2153-2156页

作者： Koichi inoue Department of Integrative Anatomy Nagoya City University Graduate School of Medical SciencesNagoyaJapan

Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could be a major factor of future therapeutic strategies for neurological disorders.Microglia,derived from myelogenous cells,respond to a number of stimuli and make immune responses,resulting in a prominent role as cells that act on inflammation in the central nervous system.Fractalkine(FKN or CX3CL1)signaling is an important factor that influences the inflammatory response of microglia.The receptor for FKN,CX3CR1,is usually expressed in microglia in the brain,and therefore the inflammatory response of microglia is modified by FKN.Reportedly,FKN often suppresses inflammatory responses in microglia and activation of its receptor may be effective in the treatment of inflammatory neurological disorders.However,it has also been suggested that inflammatory responses facilitated by FKN signaling aggravate neurological disorders.Thus,further studies are still required to resolve the conflicting interpretation of the protective or deleterious contribution of microglial FKN signaling.Yet notably,regulation of FKN signaling has recently been shown to be beneficial in the treatment of human diseases,although not neurological diseases.In addition,a CX3CR1 inhibitor has been developed and successfully tested in animal models,and it is expected to be in human clinical trials in the future.In this review,I describe the potential therapeutic consideration of microglial CX3CR1 dynamics through altered FKN signaling.

关键词： Alzheimer’s disease CX3CR1 fractalkine inflammation knockout mice microglia resilience SARS-CoV-2 stress stroke

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秸秆还田方式对春播期土壤温度的影响

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东北农业大学学报 2011年第5期42卷 117-120页

作者：常晓慧孔德刚井上光弘刘立意张影微苏锦涛东北农业大学农学院哈尔滨150030 日本鸟取大学干燥地研究中心

在黑龙江旱作耕地土壤和春播期气候条件下,对秸秆深施还田和覆盖还田耕地以及对照地的土壤温度进行了测试和分析。结果表明,秸秆深施还田耕地土壤日平均温度(9.1℃)高于覆盖还田耕地和对照地的土壤温度(8.3和7.9℃),秸秆深施还田与秸秆... 详细信息

在黑龙江旱作耕地土壤和春播期气候条件下,对秸秆深施还田和覆盖还田耕地以及对照地的土壤温度进行了测试和分析。结果表明,秸秆深施还田耕地土壤日平均温度(9.1℃)高于覆盖还田耕地和对照地的土壤温度(8.3和7.9℃),秸秆深施还田与秸秆覆盖还田和对照地的土壤温度具有显著差异(P<0.05);并且随着秸秆深施还田量的增加,对土壤的保温和调控作用加强;深施秸秆处周围的土壤温度随其距离的增大而减弱,呈线性规律变化,对其两侧幅宽30cm的土壤温度有明显的提升作用。

关键词：秸秆还田秸秆深施秸秆覆盖土壤温度

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Troubleshooting of reinterventions after stent-by-stent placement for malignant hilar biliary obstruction(with videos)

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 500-502页

作者： Tadahisa inoue Rena Kitano Masashi Yoneda Department of Gastroenterology Aichi Medical University1-1 YazakokarimataNagakuteAichi 480-1195Japan

To the Editor:Biliary drainage is essential for controlling cholangitis and/or jaundice in patients with malignant hilar biliary obstruction,and endoscopy is the first choice of approach due to its less invasiveness.For unresectable cases,placement of self-expandable metal stents(SEMSs)has been recommended over that of plastic stents due to their longer patency,and bilateral placement is also recommended to achieve higher clinical success and patency rates[1].

关键词： obstruction malignant stent

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