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Effects of Hip Arthroplasties on Bone Adaptation in Lower Limbs: A Computational Study

Journal of Biosciences and Medicines 2015年第4期3卷 1-7页

作者： Abdul Halim Abdullah mitsugu mitsugu todo Interdisciplinary Graduate School of Engineering and Sciences Kyushu University Fukuoka Japan Fakulti Kejuruteraan Mekanikal Universiti Teknologi MARA Shah Alam Malaysia Research Institute for Applied Mechanics Kyushu University Fukuoka Japan

Gait disorders contribute to the risk of falls and successive injuries, especially to elderly populations. The risk of falls becomes higher for hip osteoarthritis (OA) and hip arthroplasties patients due to poor balancing and gait impairment. Bone adaptation and bone loss are fundamental issues in considering the changes of bone behavior and gait pattern. In this study, computational analysis of the lower limbs was conducted to estimate the bone adaptation after hip arthroplasties procedure. 3D inhomogeneous model of lower limb was developed from computed topography (CT- based) data of 79 years old patient with hip osteoarthritis problem in left limb. Two types of arthroplaties were constructed in the left limb, namely total hip arthroplasty and resurfacing hip arthroplasty using commercial biomedical software, Mechanical Finder v6.1. Prosthesis stem and acetabular cup of THA were modelled as titanium alloy material (E = 114 GPa, v = 0.34), femoral ball and bearing insert as alumina properties (E = 370 GPa, v = 0.22). Meanwhile, RHA implant was assigned as Co-Cr-Mo material (E = 230 GPa, v = 0.30). Contact between both implants and bone were considered to be perfectly bonded at the interface. A load case of quiet standing position was conducted in this analysis with 60 kg of the patients’ body weight. The load was applied at the cross sectional lumbar vertebra and fixed at the distal of femoral shafts. Results show different patterns of stress distribution in right and left (operated) limbs for hip OA, THA and RHA models. An indication of stress alteration on both limbs after arthroplasties suggested that the bone adaptation occurred. The higher percentage of change in the left limb projected that the adaptation was more critical in operated limb.

关键词： Lower Limbs Osteoarthritis Total Hip Arthroplasty Resurfacing Hip Bone Adaptation

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Engineered chitosan for improved 3D tissue growth through Paxillin-FAK-ERK activation

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Regenerative Biomaterials 2020年第2期7卷 141-151页

作者： Md Abdul Kafi Khudishta Aktar mitsugu todo Ravinder Dahiya BEST Group School of EngineeringUniversity of GlasgowGlasgow G128QQUK Department of Microbiology and Hygiene Bangladesh Agricultural UniversityMymensingh 2202Bangladesh Research Institute for Applied Mechanics Kyushu UniversityKasugaFukuokaJapan

Scaffold engineering has attracted significant attention for three-dimensional(3D)growth,prolifer-ation and differentiation of stem cells in *** available scaffolds suffer from issues such as poor ability for cell adhesion,migration and *** paper addresses these issues with 3D porous chitosan scaffold,fabricated and functionalized with cysteine-terminated Arg-Gly-Asp(Cys-RGD)tri-peptide on their *** study reveals that the compressive moduli of the scaffold is independent to RGD functionalization but shows dependence on the applied freezing temperature(TM)during the fabrication *** low freezing TM(-80℃)produces scaffold with high compressive moduli(14.64±1.38 kPa)and high TM(-30℃)produces scaffold with low compressive moduli(5.6±0.38 kPa).The Cys-RGD functionalized scaffolds lead to significant improvements in adhesion(150%)and proliferation(300%)of human mesenchymal stem cell(hMSC).The RGD-integrin coupling activates the focal adhesion signaling(Paxillin-FAK ERK)path-ways,as confirmed by the expression of p-Paxillin,p-FAK and p-ERK protein,and results in the observed improvement of cell adhesion and *** proliferation of hMSC on RGD func-tionalized surface was evaluated with scanning electron microscopy imaging and distribution though pore was confirmed by histochemistry of transversely sectioned *** hMSC adhe-sion and proliferation in scaffold with high compressive moduli showed a constant enhancement(with a slope value 9.97)of compressive strength throughout the experimental period of 28 *** improved cell adhesion and proliferation with RGD functionalized chitosan scaffold,together with their mechanical stability,will enable new interesting avenues for 3D cell growth and differen-tiation in numerous applications including regenerative tissue implants.

关键词： adhesion signaling chitosan hMSC porous scaffold proliferation Cys-RGD tssue engineering

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Experimental and Numerical Analysis of Thermal Deformation of Electronic Packages,QFP and MCM

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实验力学 2006年第1期21卷 11-19页

作者： Yasuyuki Morita Kazuo Arakawa mitsugu todo Research Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga-shi Fukuoka 816-8580 Japan

Moiré inteferometry and FEA (finite element analysis) were used to evaluate the thermal deformation of two electronic packages, QFP (quad flat package) and MCM (multi chip module).Thermal loading was applied by cooling the packages from 100℃ to room temperature (25℃). Moiré fringes were obtained on the cross sections of the packages to clarify the effect of the CTE (coefficient of thermal expansion) mismatch of the micro components, such as silicon, metal and resin. In QFP, the effects of packaging resin and PCB (printed circuit board) on the thermal deformation were investigated. The effect of location of three silicon chips in MCM was also examined.

关键词：数字分析热形变电子仪器组件 QFP MCM

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Development of New Sliver Probe for Cooling Power Test of Polymer Quenchants

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材料热处理学报 2004年第5期25卷 437-442页

作者： Michiharu NARAZAKI Mamoru TAJIMA Shigeru ASADA Katsumi ICHITANI Hideo YOKOTA mitsugu TANAKA Youichi WATANABE Utsunomiya University Utsunomiya JapanKanagawa University Yokohama JapanNippon Grease Co. Ltd. Osaka JapanIdemitsu Kosan Co. Ltd. Chiba JapanNippon Oil Corporation Yokohama JapanNissho Engineering Co. Ltd. Kobe JapanNissan Motor Co. Ltd. Yokohama Japan

Working group on cooling power test of quenchants of Japanese Heat Treatment Society has studied on the new method for testing cooling power of aqueous quenchants. This method employed the cooling curve test of a new sliver rod probe, which has a metal-sheathed thermocouple at its geometrical center. The experimental study has clarified that the new silver probe has more excellent durability than the JIS silver probe employed for cooling power test of heat treating oils (JIS K 2242) and an aluminum alloy probe. Good repeatability and reproducibility of the cooling curves during polymer quenching have been confirmed. This new method is useful especially for cooling power test of aqueous quenchants used for solution heat treatment of aluminum alloys. This new silver rod probe is expected to be adopted for the revised version of JIS K 2242 as the cooling power test method for aqueous quenchants.

关键词：聚合物淬火剂动力试验冷却曲线银探测器

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Biomechanical Effects of Implant Materials on Posterior Lumbar Interbody Fusion: Comparison of Polyetheretherketone and Titanium Spacers Using Finite Element Analysis and Considering Bone Density

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Journal of Biomedical Science and Engineering 2018年第4期11卷 45-59页

作者： Tatsuya Sato Ikuho Yonezawa mitsugu todo Hiromitsu Takano Kazuo Kaneko Department of Orthopaedic Surgery Juntendo University Tokyo Japan Renewable Energy Center Research Institute for Applied Mechanics Kyushu University Kasuga Japan

Few biomechanical data exist regarding whether the polyetheretherketone (PEEK) spacer or titanium spacer is better for posterior lumbar interbody fusion (PLIF). This study evaluated the biomechanical influence that these types of spacers with different levels of hardness exert on the vertebra by using finite element analysis including bone strength distribution. To evaluate the risk of spacer subsidence for PLIF, we built a finite element model of the lumbar spine using computed tomography data of osteoporosis patients. Then, we simulated PLIF in L3/4 and built models with the hardness of the interbody spacer set as PEEK and titanium. Bones around the spacer were subjected to different load conditions. Then, fracture elements and some stress states of the two modalities were compared. In both models of PLIF simulation, fracture elements and stress were concentrated in the bones around the spacer. Fracture elements and stress values of the model simulating the PEEK spacer were significantly smaller compared to those of the titanium simulation model. For PLIF of osteoporotic vertebrae, this suggested that the PEEK spacer is in a mechanical environment less susceptible to subsidence caused by microfractures of bone tissue and bone remodeling-related fusion aspects. Therefore, PEEK spacers are bio-mechanically more useful.

关键词： Posterior Lumbar Interbody Fusion Biomechanics Finite Element Analysis Cage Polyetheretherketone Titanium Osteoporosis

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Use of Nonlinear Finite Element Analysis of Bone Density to Investigate the Biomechanical Effect in the Bone around Intervertebral Cages in Posterior Lumbar Interbody Fusion

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Journal of Biomedical Science and Engineering 2017年第10期10卷 445-455页

Preventing subsidence of intervertebral cages in posterior lumbar interbody fusion (PLIF) requires understanding its mechanism, which is yet to be done. We aimed to describe the mechanism of intervertebral cage subsidence by using finite element analysis through simulation of the osteoporotic vertebral bodies of an elderly woman. The data from computed tomography scans of L2-L5 vertebrae in a 72-year-old woman with osteoporosis were used to create 2 FE models: one not simulating implant placement (LS-INT) and one simulating L3/4 PLIF using polyetheretherketone (PEEK) cages (LS-PEEK). Loads and moments simulating the living body were applied to these models, and the following analyses were performed: 1) Drucker-Prager equivalent stress distribution at the cage contact surfaces;2) the distribution of damage elements in L2-L5 during incremental loading;and 3) the distribution of equivalent plastic strain at the cage contact surfaces. In analysis 1, the Drucker-Prager equivalent stress on the L3 and L4 vertebral endplates was greater for LS-PEEK than for LS-INT under all loading conditions and tended to be particularly concentrated at the contact surfaces. In analysis 2, compared with LS-INT, LS-PEEK showed more damage elements along the bone around the cages in the L3 vertebral body posterior to the cage contact surfaces, followed by the area of the L4 vertebral body posterior to the cage contact surfaces. In analysis 3, in the L3 inferior surface in LS-PEEK the distribution of equivalent plastic strain was visualized as gradually expanding along the cages from the area posterior to the cages to the area anterior to them with increased loading. These analyses suggested that in PLIF for osteoporotic vertebral bodies, the localized stress concentration generated by the use of PEEK cages may cause accumulation of microscopic damage in the fragile osteoporotic vertebral bodies around the cages, which may result in cage subsidence.

关键词： Biomechanics Finite Element Analysis Posterior Lumbar Interbody Fusion Osteoporosis Computational Analysis Method

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CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 75-80页

作者： Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda mitsugu Sekimoto Shoji Nakamori Department of Surgery National Hospital Organization Osaka National Hospital

Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from ***: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December *** patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate ***: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL.

关键词： Pancreatic cancer CA19-9 Para-aortic lymph node

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A high-resolution environmental change record since 19 cal ka BP in Pumoyum Co, southern Tibet

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Chinese Science Bulletin 2011年第27期56卷 2931-2940页

作者： LU XinMiao ZHU LiPing NISHIMURA mitsugu MORITA Yoshimune WATANABE Takahiro NAKAMURA Toshio WANG Yong Key Laboratory of Tibetan Environment Changes and Land Surce Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100085 China School of Marine Scinece and Technology Tokai University Shizuoka 424-8610 Japan Botanical Garden Okayama University of Science Okayama 700-0005 Japan Graduate School of Science Tohoku University Sendai 980-8578 Japan Centre for Chronological Research Nagoya University Nagoya 464-8602 Japan Graduate University of Chinese Academy of Sciences Beijing 100049 China

A 380-cm-long sediment core was acquired from the deep water area of Pumoyum Co, southern Tibet. Twenty-five plant residue samples were selected, and organic carbon stable isotopes were obtained using the AMS 14 C chronological method. The 14 C age and carbon reservoir effect were calibrated with surface sedimentation rate measurements using 210 Pb dating. Results showed that the core sediment deposited over 19 cal ka BP. Based on a multi-proxy analysis of TOC and IC contents, grain size and pollen assemblage data, the palaeoclimatic evolution of Pumoyum Co was reconstructed since the last glacial. Pumoyum Co was a shallow lake prior to 16.2 cal ka BP; although the glacier around the lake began to melt due to increasing temperatures, climate was still cold and dry. In the interval of 16.2-11.8 cal ka BP, the sedimentary environment fluctuated drastically and frequently. Two cold-events occurred at 14.2 and 11.8 cal ka BP, and these may correspond to the Older Dryas and the Younger Dryas events, respectively. After 11.8 cal ka BP, Pumoyun Co developed into the deep lake as it is now. The lake water temperature was relatively lower at that time because of influx of cold water from glacial meltwater entering the lake. As a result, the multi-proxy indicators showed no sign of warm conditions. Comparisons between the sedimentary record of Pumoyum Co with that of other lakes of the same age in southern Tibet indicate a warmer climate following the last deglaciation influenced the southeastern Tibetan Plateau. These results imply that the southwest Asian monsoon gradually became stronger since the deglaciation during its expansion to the inner plateau. The glacial-supplied water of the lake responded sensitively to cold-events. The entire southern Tibet region was dominantly influenced climatically by the southwest Asian monsoon during the Holocene.

关键词：西藏南部环境变化 CAL BP 合作高分辨率青藏高原东南部古气候演变

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Biomechanical Study of the Effects of Balloon Kyphoplasty on the Adjacent Vertebrae

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Journal of Biomedical Science and Engineering 2016年第10期9卷 478-487页

作者： Hiromitsu Takano Ikuho Yonezawa mitsugu todo Muhammad Hazli Mazlan Tatsuya Sato Kazuo Kaneko Division of Spine Surgery Department of Orthopedic Surgery School of Medicine Juntendo University Tokyo Japan Research Institute for Applied Mechanics Kyushu University Kasuga-City Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu University Kasuga-City Japan Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn Malaysia Parit Raja Malaysia

We used the finite element method (FEM) to investigate the stress profiles of vertebrae in patients who underwent balloon kyphoplasty (BKP) for vertebral fracture. BKP is often performed for persistent pain after vertebral fractures. However, fractures are frequently reported in the adjacent vertebrae after BKP. The purpose was to clarify the mechanism of fractures that occur in the adjacent vertebrae after BKP. The subjects were two patients (first case: 74-year-old woman;second case: 88-year-old woman) who had BKP for osteoporotic vertebral fractures (L1). A bone analysis software program, Mechanical Finder, was used to construct three-dimensional finite element models (T11-L3) from computed tomographic (CT) digital imaging and communications in medicine (DICOM) data. Moment loadings were examined to evaluate stress concentrations on the vertebrae. Young’s moduli were lower in the second case than in the first case at all vertebral levels. Maximum Drucker-Prager stresses after BKP were larger in the second case than in the first case for compression, flexion, extension, and axial rotation. Strain energy density decreased in L1 and increased in the adjacent ver-tebrae. Our results suggest that post-BKP fractures of the adjacent vertebrae not only are due to bone fragility, but also can be caused by increased rigidity in the vertebrae filled with bone cement, which increases stress concentration on the adjacent verte-brae and raises the likelihood of fracture.

关键词： Biomechanics Finite Element Method Vertebral Compression Fracture Balloon Kyphoplasty Mechanical Analysis

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Biomechanical Study of Vertebral Compression Fracture Using Finite Element Analysis

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Journal of Applied Mathematics and Physics 2017年第4期5卷 953-965页

This research aimed to mechanically analyze vertebral stress concentration in one healthy subject and one subject with osteoporotic first lumbar (L1) vertebral compression fracture by using finite element analysis (FEA). We constructed three-dimensional image-based finite element (FE) models (Th12L2) by using computed tomographic (CT) digital imaging and communications in medicine (DICOM) for each patient and then conducted exercise stress simulations on the spine models. The loadings on the 12th thoracic vertebra (Th12) due to compression, flexion, extension, lateral bending, and axial rotation were examined within the virtual space for both spine models. The healthy and vertebral compression fracture models were then compared based on the application of equivalent vertebral stress. The comparison showed that vertebral stress concentration increased with all stresses in the vertebral compression fracture models. In particular, compression and axial rotation caused remarkable increases in stress concentration in the vertebral compression fracture models. These results suggest that secondary vertebral compression fractures are caused not only by bone fragility but possibly also by the increase in vertebral stress concentration around the site of the initial

关键词： Biomechanics Finite Element Analysis Vertebral Compression Fracture

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