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Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review.and meta-analyses

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w.rld Journal of Gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna mitchell Richard C Turkington Helen G Coleman Centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johnston Centre for Cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BACKGROUND The incidence of oesophageal adenocarcinoma(OAC)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAC,defined as OAC in adults aged under 50 years,has been *** is unclear w.ether survival outcomes for early-onset OAC patients differ from older age *** To investigate survival outcomes in early-onset OAC *** Ovid Medline and Embase w.re searched from inception to January 2022 for relevant studies relating to early-onset OAC and survival *** regarding the overall five-year survival and risk of death of younger and older patients w.th OAC w.re extracted and pooled using meta-analyses to produce pooled estimates and 95%CIs w.ere *** Eleven studies w.ich compared survival of early-onset OAC,defined as age at diagnosis ofw.th older patients w.re included.A narrative review.of median and mean survival demonstrated conflicting results,w.th studies show.ng early-onset OAC patients having both better and w.rse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,w.th 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAC patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%CI:0.85-1.47).INTRODUCTION There is concern that the incidence of oesophageal adenocarcinoma(OAC)in patients under 50,described as early-onset OAC,is ***,data regarding survival of younger patients w.th OAC is ***,w.ile increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival Cancer epidemiology Systematic review Meta-analysis

Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals w.th Parkinson’s Disease: A Systematic Review.and Meta-Analysis

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Advances in Parkinson's Disease 2024年第3期13卷 27-56页

作者： Paula Abola mitchell w.lden Department of Clinical Research University of Jamestown Jamestown United States of America

Objective: In the manuscript titled Monoamine Oxidase-B Inhibitor Rasagiline Effects on Motor and Non-Motor Symptoms in Individuals w.th Parkinsons Disease: A Systematic Review.and Meta-Analysis, the objective w.s to conduct a systematic review.w.th meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals w.th PD. Introduction: Rasagiline is a second-generation monoamine oxidase-B (MAO-B) inhibitor used both as monotherapy and adjunctive therapy for Parkinsons Disease (PD). Methods: A systematic literature search and meta-analysis w.re performed w.th randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals w.th PD. The systematic search w.s conducted in PubMed, Cochrane, and EBSCO databases. Methodological quality w.s assessed using the Cochrane Grading Recommendations Assessment, Development and Evaluation approach. Results: Fourteen studies w.re included in our review. There w.re trivial to small and statistically significant improvements in motor symptoms for individuals w.th PD treated w.th Rasagiline compared to placebo. Non-motor symptoms show.d no significant improvement w.th Rasagiline compared to placebo in five of six meta-analyses. Results w.re based on very low.to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals w.th PD compared w.th placebo. For all outcomes, the 1 mg/day Rasagiline group w.s favored over the placebo group.

关键词： Parkinson’s Disease Monoamine Oxidase-B Inhibitor Rasagiline Non-Motor Symptoms Motor Symptoms UPDRS PDQ-39 OFF Time

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Digital Empow.rment

ChinAfrica 2024年第7期16卷 14-15页

作者： EHIZUELEN MICHAEL mitchell OMORUYI Centre for Nigerian Studies Institute of African StudiesZhejiang Normal University

How.China’s tech cooperation w.th Africa is boosting the continent’s industrial modernisation Given the rate at w.ich youth population in numerous African countries is grow.ng,the continent promises to emerge as a major consumption market in the coming *** than 70 percent of Africa’s population is under the age of 35,and by 2030,42 percent of the w.rld’s young people are expected to reside on the continent.

关键词： boosting Africa cooperation

Improving Lives China-Africa cooperation propels space industry,drives socio-economic progress

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ChinAfrica 2024年第5期16卷 28-29页

作者： EHIZUELEN MICHAEL mitchell OMORUYI Centre for Nigerian Studies Institute of African StudiesZhejiang Normal University

In the past,outer space w.s primarily the domain of a few.pow.rful countries and generally considered separate from broader concerns of human security and ***,in recent times,space technology development has been a dynamic arena in w.ich the majority of the w.rld’s countries,including countries across the continent of Africa,are actively engaged to address their most pressing socio-economic *** the turn of the millennium,countries across Africa have demonstrated grow.ng interest in developing their space capabilities to address their most pressing challenges,including but not limited to climate change,poverty,terrorism,and forced migration.

关键词： Africa primarily challenges

Promoting Human Rights Through Development

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ChinAfrica 2024年第3期16卷 32-33页

作者： EHIZUELEN MICHAEL mitchell OMORUYI Centre for Nigerian Studies Institute of African Studies Zhejiang Normal University

China’s human rights practice focuses on the rights of subsistence and development,China alw.ys regards rights to subsistence and development as primary and basic human *** a goal humanity has pursued for a long time,the Chinese people have w.rked tirelessly to protect human rights for *** w.th its rising global stature,the nation has moved from its traditionally more defensive posture to a more activist role in the field of global human rights protection,especially in the United Nations Human Rights Council.

关键词： Human traditionally Rights

Scavenging and release of REE and HFSE by Na-metasomatism in magmatic-hydrothermal systems

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Fundamental Research 2024年第2期4卷 315-323页

作者： w.-Bin Yang He-Cai Niu Ning-Bo Li Pete Hollings Shannon Zurevinski Roger H.mitchell Key Laboratory of Mineralogy and Metallogeny/Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China Department of Geology Lakehead UniversityThunder BayON P7B 5E1Canada

Exploitable or potentially exploitable deposits of critical metals,such as rare-earth(REE)and high-field-strength elements(HFSE),are commonly associated w.th alkaline or peralkaline igneous ***,the origin,transport and concentration of these metals in peralkaline systems remains poorly *** study presents the results of a mineralogical and geochemical investigation of the Na-metasomatism of alkali amphiboles and clinopyroxenes from a barren peralkaline granite pluton in NE China,to assess the remobilization and redistribution of REE and HFSE during magmatic-hydrothermal *** amphiboles and aegirine-augites from the peralkaline granites show.evolutionary trends from sodic-calcic to sodic compositions,w.th increasing REE and HFSE concentrations as a function of increasing Na-index[Na^(#),defined as molar Na/(Na+Ca)ratios].The Na-amphiboles(i.e.,arfvedsonite)and aegirine-augites can be subsequently altered,or breakdow.,to form hydrothermal aegirine during late-or post-magmatic *** compositions analyzed by insitu LA-ICPMS show.that the primary aegirine-augites have high and variable REE(2194-3627 ppm)and HFSE(4194-16,862 ppm)contents,suggesting that these critical metals can be scavenged by alkali amphiboles and *** to the primary aegirine-augites,the presentative early replacement aegirine(Aeg-I,Na^(#)=0.91-0.94)has notably low.r REE(1484-1972)and HFSE(4351-5621)*** contrast,the late hydrothermal aegirine(Aeg-II,Na^(#)=0.92-0.96)has significantly low.r REE(317-456 ppm)and HFSE(6.44-72.2 ppm)*** that the increasing Na^(#)from aegirine-augites to hydrothermal aegirines likely resulted from Na-metasomatism,a scavenging-release model can explain the remobilization of REE and HFSE in peralkaline granitic *** scavenging and release of REE and HFSE by Na-metasomatism provides key insights into the genesis of globally significant REE and HFSE *** high Na-index of th

关键词： Critical metals Alkali amphiboles Na-metasomatism REE and HFSE Na-index(Na^(#))

Three-dimensional analysis of age and sex differences in femoral head asphericity in asymptomatic hips in the United States

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w.rld Journal of Orthopedics 2024年第8期15卷 754-763页

作者： Mahad M Hassan Aliya G Feroe Brenton w.Douglass Andrew.E Jimenez Benjamin Kuhns Charles F mitchell Robert L Parisien Daniel A Maranho Eduardo N Novais Young-Jo Kim Ata M Kiapour Department of Orthopedic Surgery University of MinnesotaMinneapolisMN 55454United States Department of Orthopedic Surgery TRIA Orthopaedic CenterBloomingtonMN 55122United States Department of Orthopedic Surgery Boston Children’s HospitalBostonMA 02115United States Department of Orthopedic Surgery Mayo ClinicRochesterMN 55901United States Department of Orthopaedics and Rehabilitation Yale School of MedicineNew HavenCT 06510United States Department of Orthopedic Surgery American Hip Institute Research FoundationDes PlainesIL 60018United States Department of Orthopedic Surgery Mount SinaiNew YorkNY 10029United States Department of Biomechanics Medicineand Rehabilitation of the Locomotor SystemRibeirao Preto Medical SchoolUniversity of São PauloRibeirao Preto 14048-900São PauloBrazil

BACKGROUND The sphericity of the femoral head is a metric used to evaluate hip pathologies and is associated w.th the development of osteoarthritis and femoral-acetabular *** To analyze the three-dimensional asphericity of the femoral head of asymptomatic pediatric *** hypothesized that femoral head asphericity w.ll vary significantly betw.en male and female pediatric hips and increase w.th age in both *** Computed tomography scans w.re obtained on 158 children and adolescents from a single institution in the United States(8-18 years;50%male)w.thout hip *** femoral measurements including the femoral head diameter,femoral head volume,residual volume,asphericity index,and local diameter difference w.re used to evaluate femoral head *** In both sexes,the residual volume increased by age(P13 years)in females,there w.re no sex-differences in residual volume and aspherity *** w.re no age-related changes in mean diameter difference in both sexes(P=0.07)w.th no significant sex-differences across different age groups(P=0.06).In contrast,there w.re significant increases in local aspherity(maximum diameter difference)across w.ole surface of the femoral head and all quadrants except the inferior regions in males(P=0.03).There w.re no sex-differences in maximum diameter difference at any regions and age group(P>0.05).Increased alpha angle w.s only correlated to increased mean diameter difference across overall surface of the femoral head(P=0.024).CONCLUSION There is a substantial localized asphericity in asymptomatic hips w.ich increases w.th age *** 2D measured alpha angle can capture overall asphericity of the femoral head,it may not be sensitive enough to represent regional asphericity patterns.

关键词： Hip Femoral head Sphericity Skeletal grow.h Sex differences

Des racines et des ailes La culture du droit humain a la subsistance en Chine

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中国与非洲（法文版） 2024年第3期16卷 32-33页

作者： EHIZUELEN MICHAEL mitchell OMORUYI Centre d'etudes nigerianes Institut d'etudes africainesUniversite normale du Zhejiang

La Chine met en avant les droits a la subsistance et au développement commeétant les plus fondamentaux des droits *** peuple chinois s'est engage avec determination dans la protection des droits de I'homme,un idéal que I'humanite cherche a atteindre depuis de nombreuses *** son influence croissante sur la scene mondiale,la Chine aévolue d'une posture traditionnellement defensive vers un engagement plus actif dans la defense des droits de I'homme a I'eéchelle internationale,notamment au sein du Conseil des droits de I'homme des Nations unies.

关键词： des les culture

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Ties That Matter

ChinAfrica 2024年第10期16卷 36-37页

作者： EHIZUELEN MICHAEL mitchell OMORUYI University of Ibadan Nigeria

Cooperation w.th China is crucial for Nigeria to grow.its economy and implement the AfCFTA *** has been my privilege to w.tness a huge transformation and pivot as w.ll as an enormous development of China from a close distance during my years living in China.I w.ll say that if ever there w.s a time w.en African countries needed to be modernised,it is now.

关键词： China. enormous African