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Dietar. sugar. inhibit biologic functions of the patter. r.cognition molecule, mannose-binding lectin

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Open Jour.al of Immunology 2011年第2期1卷 41-49页

作者： Kazue Takahashi Wei-Chuan Chang Patience Moyo mitchell r. White Par.ol Meelu Anamika Ver.a Gr.gor. L. Stahl Kevan L. Har.shor. Vijay Yajnik 不详

Mannose-binding lectin (MBL), a mammalian lectin, is a patter. r.cognition molecule of the innate immune system and r.cognizes car.o-hydr.tes that ar. exposed on pathogens. In this study, we obser.ed that fr.ctose down r.gu-lates MBL-mediated innate immune mechanisms against both influenza A vir.s (IAV) and Staphy-lococcus aur.us. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur.ther.or., fr.ctose also r.duces MBL-mediated phagocytosis of S. aur.us and IAV and MBL- mediated IAV infection to epithelial cells. In contr.st, sucr.se inhibits MBL-mediated im-mune mechanisms against S. aur.us but not IAV. Together. our.studies show that dietar. sugar., in par.icular.fr.ctose, negatively r.gulate the innate immunity against vir.l and bacter.al pathogens.

关键词： Mannose-Binding Lectin Fr.ctose Influenza A Vir.s Staphylococcus Aur.us Complement Coagulation

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《二语学习理论(第三版)》评介

当代外语研究 2015年第11期 71-73页

作者：张凯彭梅 mitchell r. F.Myles E.Mar.den 中国海洋大学青岛266000 上海外国语大学上海200240

1.引言二语学习研究1（second language lear.ing）兼具促进二语学习理论发展和指导实践教学的双重意义（Ellis 2008;Gass＆Mackey 2012）。国内外研究者们从多个研究视角对二语学习的理论机制进行了阐释,但由于二语习得本身的多面性和... 详细信息

1.引言二语学习研究1（second language lear.ing）兼具促进二语学习理论发展和指导实践教学的双重意义（Ellis 2008;Gass＆Mackey 2012）。国内外研究者们从多个研究视角对二语学习的理论机制进行了阐释,但由于二语习得本身的多面性和复杂性,二语习得研究仍缺乏理论体系的统整。在这种情况下,

关键词：学习理论理论机制学习过程理论体系统整普遍语法语言学习社会文化理论二语习得理论内在认知

Sur.ival outcomes in ear.y-onset oesophageal adenocar.inoma patients:A systematic r.view and meta-analyses

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Wor.d Jour.al of Gastr.enter.logy 2024年第38期30卷 4221-4231页

作者： Ashleigh r.ssell Shauna mitchell r.char. C Tur.ington Helen G Coleman Centr. for.Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patr.ck G Johnston Centr. for.Cancer.r.sear.h Queen's University BelfastBelfast BT71NNUnited Kingdom

BACKGr.UND The incidence of oesophageal adenocar.inoma(OAC)has been r.por.ed to be incr.asing in many *** this tr.nd,an incr.ase in incidence of ear.y-onset OAC,defined as OAC in adults aged under.50 year.,has been *** is unclear.whether.sur.ival outcomes for.ear.y-onset OAC patients differ.fr.m older.age *** To investigate sur.ival outcomes in ear.y-onset OAC *** Ovid Medline and Embase wer. sear.hed fr.m inception to Januar. 2022 for.r.levant studies r.lating to ear.y-onset OAC and sur.ival *** r.gar.ing the over.ll five-year.sur.ival and r.sk of death of younger.and older.patients with OAC wer. extr.cted and pooled using meta-analyses to pr.duce pooled estimates and 95%CIs wher. *** Eleven studies which compar.d sur.ival of ear.y-onset OAC,defined as age at diagnosis ofr.,with older.patients wer. included.A nar.ative r.view of median and mean sur.ival demonstr.ted conflicting r.sults,with studies showing ear.y-onset OAC patients having both better.and wor.e outcomes compar.d to older.age gr.ups.A meta-analysis of five-year.sur.ival demonstr.ted similar.outcomes acr.ss age gr.ups,with 22%-25%of patients in the young,middle and older.age gr.ups alive after.five year..A meta-analysis of four.studies demon-str.ted that ear.y-onset OAC patients did not have a significantly incr.ased r.sk of death compar.d to middle-aged patients(hazar. r.tio 1.12,95%CI:0.85-1.47).INTr.DUCTION Ther. is concer. that the incidence of oesophageal adenocar.inoma(OAC)in patients under.50,descr.bed as ear.y-onset OAC,is ***,data r.gar.ing sur.ival of younger.patients with OAC is ***,while incr.asing age r.mains a major.non-modifiable r.sk factor.for.cancer.the incidence of ear.y-onset cancer.,lar.ely accepted to be in adults aged under.50 year.,is incr.asing[1].This includes an obser.ed incr.ase in the incidence of gastr.intestinal malignancies such as color.ctal,oesophageal,gastr.c and he

关键词： Ear.y-onset cancer Ear.y-onset oesophageal adenocar.inoma Sur.ival Cancer.epidemiology Systematic r.view Meta-analysis

Monoamine Oxidase-B Inhibitor.r.sagiline Effects on Motor.and Non-Motor.Symptoms in Individuals with Par.inson’s Disease: A Systematic r.view and Meta-Analysis

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Advances in Par.inson's Disease 2024年第3期13卷 27-56页

作者： Paula Abola mitchell Wolden Depar.ment of Clinical r.sear.h University of Jamestown Jamestown United States of America

Objective: In the manuscr.pt titled Monoamine Oxidase-B Inhibitor.r.sagiline Effects on Motor.and Non-Motor.Symptoms in Individuals with Par.insons Disease: A Systematic r.view and Meta-Analysis, the objective was to conduct a systematic r.view with meta-analysis to investigate the effects that r.sagiline has on motor.and non-motor.symptoms in individuals with PD. Intr.duction: r.sagiline is a second-gener.tion monoamine oxidase-B (MAO-B) inhibitor.used both as monother.py and adjunctive ther.py for.Par.insons Disease (PD). Methods: A systematic liter.tur. sear.h and meta-analysis wer. per.or.ed with r.ndomized contr.l tr.als that investigated the effects of r.sagiline on motor.and non-motor.symptoms in individuals with PD. The systematic sear.h was conducted in PubMed, Cochr.ne, and EBSCO databases. Methodological quality was assessed using the Cochr.ne Gr.ding r.commendations Assessment, Development and Evaluation appr.ach. r.sults: Four.een studies wer. included in our.r.view. Ther. wer. tr.vial to small and statistically significant impr.vements in motor.symptoms for.individuals with PD tr.ated with r.sagiline compar.d to placebo. Non-motor.symptoms showed no significant impr.vement with r.sagiline compar.d to placebo in five of six meta-analyses. r.sults wer. based on ver. low to moder.te cer.ainty of evidence. Conclusion: 1 mg/day r.sagiline significantly impr.ved Par.insonian motor.symptoms in individuals with PD compar.d with placebo. For.all outcomes, the 1 mg/day r.sagiline gr.up was favor.d over.the placebo gr.up.

关键词： Par.inson’s Disease Monoamine Oxidase-B Inhibitor r.sagiline Non-Motor.Symptoms Motor.Symptoms UPDr. PDQ-39 OFF Time

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Ties That Matter

ChinAfr.ca 2024年第10期16卷 36-37页

作者： EHIZUELEN MICHAEL mitchell OMOr.YI Univer.ity of Ibadan Nigeria

Cooper.tion with China is cr.cial for.Niger.a to gr.w its economy and implement the AfCFTA *** has been my pr.vilege to witness a huge tr.nsfor.ation and pivot as well as an enor.ous development of China fr.m a close distance dur.ng my year. living in China.I will say that if ever.ther. was a time when Afr.can countr.es needed to be moder.ised,it is now.

关键词： China. enor.ous Afr.can

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Digital Empower.ent

ChinAfr.ca 2024年第7期16卷 14-15页

作者： EHIZUELEN MICHAEL mitchell OMOr.YI Centr. for.Niger.an Studies Institute of African StudiesZhejiang Normal University

How China’s tech cooper.tion with Afr.ca is boosting the continent’s industr.al moder.isation Given the r.te at which youth population in numer.us Afr.can countr.es is gr.wing,the continent pr.mises to emer.e as a major.consumption mar.et in the coming *** than 70 per.ent of Afr.ca’s population is under.the age of 35,and by 2030,42 per.ent of the wor.d’s young people ar. expected to r.side on the continent.

关键词： boosting Afr.ca cooper.tion

Impr.ving Lives China-Afr.ca cooper.tion pr.pels space industr.,dr.ves socio-economic pr.gr.ss

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ChinAfr.ca 2024年第5期16卷 28-29页

作者： EHIZUELEN MICHAEL mitchell OMOr.YI Centr. for.Niger.an Studies Institute of African StudiesZhejiang Normal University

In the past,outer.space was pr.mar.ly the domain of a few power.ul countr.es and gener.lly consider.d separ.te fr.m br.ader.concer.s of human secur.ty and ***,in r.cent times,space technology development has been a dynamic ar.na in which the major.ty of the wor.d’s countr.es,including countr.es acr.ss the continent of Afr.ca,ar. actively engaged to addr.ss their.most pr.ssing socio-economic *** the tur. of the millennium,countr.es acr.ss Afr.ca have demonstr.ted gr.wing inter.st in developing their.space capabilities to addr.ss their.most pr.ssing challenges,including but not limited to climate change,pover.y,ter.or.sm,and for.ed migr.tion.

关键词： Afr.ca pr.mar.ly challenges

Pr.moting Human r.ghts Thr.ugh Development

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ChinAfr.ca 2024年第3期16卷 32-33页

作者： EHIZUELEN MICHAEL mitchell OMOr.YI Centr. for.Niger.an Studies Institute of Afr.can Studies Zhejiang Normal University

China’s human r.ghts pr.ctice focuses on the r.ghts of subsistence and development,China always r.gar.s r.ghts to subsistence and development as pr.mar. and basic human *** a goal humanity has pur.ued for.a long time,the Chinese people have wor.ed tir.lessly to pr.tect human r.ghts for.*** with its r.sing global statur.,the nation has moved fr.m its tr.ditionally mor. defensive postur. to a mor. activist r.le in the field of global human r.ghts pr.tection,especially in the United Nations Human r.ghts Council.

关键词： Human tr.ditionally r.ghts

Scavenging and r.lease of r.E and HFSE by Na-metasomatism in magmatic-hydr.ther.al systems

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Fundamental r.sear.h 2024年第2期4卷 315-323页

作者： Wu-Bin Yang He-Cai Niu Ning-Bo Li Pete Hollings Shannon Zur.vinski r.ger.H.mitchell Key Labor.tor. of Miner.logy and Metallogeny/Guangdong Pr.vincial Key Labor.tor. of Miner.l Physics and Mater.als Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center.for.Excellence in Deep Ear.h Science Guangzhou 510640China Depar.ment of Geology Lakehead UniversityThunder BayON P7B 5E1Canada

Exploitable or.potentially exploitable deposits of cr.tical metals,such as r.r.-ear.h(r.E)and high-field-str.ngth elements(HFSE),ar. commonly associated with alkaline or.per.lkaline igneous ***,the or.gin,tr.nspor. and concentr.tion of these metals in per.lkaline systems r.mains poor.y *** study pr.sents the r.sults of a miner.logical and geochemical investigation of the Na-metasomatism of alkali amphiboles and clinopyr.xenes fr.m a bar.en per.lkaline gr.nite pluton in NE China,to assess the r.mobilization and r.distr.bution of r.E and HFSE dur.ng magmatic-hydr.ther.al *** amphiboles and aegir.ne-augites fr.m the per.lkaline gr.nites show evolutionar. tr.nds fr.m sodic-calcic to sodic compositions,with incr.asing r.E and HFSE concentr.tions as a function of incr.asing Na-index[Na^(#),defined as molar.Na/(Na+Ca)r.tios].The Na-amphiboles(i.e.,ar.vedsonite)and aegir.ne-augites can be subsequently alter.d,or.br.akdown,to for. hydr.ther.al aegir.ne dur.ng late-or.post-magmatic *** compositions analyzed by insitu LA-ICPMS show that the pr.mar. aegir.ne-augites have high and var.able r.E(2194-3627 ppm)and HFSE(4194-16,862 ppm)contents,suggesting that these cr.tical metals can be scavenged by alkali amphiboles and *** to the pr.mar. aegir.ne-augites,the pr.sentative ear.y r.placement aegir.ne(Aeg-I,Na^(#)=0.91-0.94)has notably lower.r.E(1484-1972)and HFSE(4351-5621)*** contr.st,the late hydr.ther.al aegir.ne(Aeg-II,Na^(#)=0.92-0.96)has significantly lower.r.E(317-456 ppm)and HFSE(6.44-72.2 ppm)*** that the incr.asing Na^(#)fr.m aegir.ne-augites to hydr.ther.al aegir.nes likely r.sulted fr.m Na-metasomatism,a scavenging-r.lease model can explain the r.mobilization of r.E and HFSE in per.lkaline gr.nitic *** scavenging and r.lease of r.E and HFSE by Na-metasomatism pr.vides key insights into the genesis of globally significant r.E and HFSE *** high Na-index of th

关键词： Cr.tical metals Alkali amphiboles Na-metasomatism r.E and HFSE Na-index(Na^(#))