检索结果-南通市图书馆

Coupling virio-and bacterioplankton populations with environmental variable changes in the Bohai sea

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica sinica 2020年第6期39卷 72-83页

作者： Caixia Wang Lin Wu Yibo Wang James s.Paterson James G.mitchell Xiaoke Hu Key Laboratory of Coastal Biology and Bioresource Utilization Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Laboratory for Marine Biology and Biotechnology Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of sciences Beijing 100049China Ocean school Yantai UniversityYantai 264003China College of science and Engineering Flinders UniversityAdelaideSA 5001Australia

Uncovering the role of environmental factors and finding critical factors which harbor significant fractions in governing microbial communities remain key questions in coastal marine *** detect the interactions between environmental factors and distributions of virio-and bacterioplankton in trophic coastal areas,we used flow cytometry to investigate the abundance of virio-and bacterioplankton covering 31 stations in the Bohai sea of *** results suggested that the average abundance of total virus(TV)in winter(~2.29×108 particles/mL)was slightly lower than in summer(~3.83×108 particles/mL).The mean total bacterial abundance(TB)was much lower in winter(~2.54×107 particles/mL)than in summer(~5.43×107 particles/mL).Correlation analysis via redundancy analysis(RDA)and network analysis among virioplankton,bacterioplankton and environmental factors revealed that the abundances of viral and bacterial subpopulations depend on environmental *** winter,only temperature significantly influenced the abundances of virio-and *** summer,in addition to temperature,both salinity and nutrient(siO2)had a remarkable impact on the distribution of virioand *** results showed a clear seasonal and trophic pattern throughout the whole water system,which revealed that temperature and eutrophication may play crucial roles in microbial distribution pattern.

关键词： virioplankton bacterioplankton flow cytometry network Bohai sea

Modern treatment of gastric gastrointestinal stromal tumors

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第46期18卷 6720-6728页

作者： Kevin K Roggin mitchell C Posner Department of surgery Pritzker School of Medicine University of Chicago

Gastrointestinal stromal tumors (GIsT) are rare mesenchymal smooth muscle sarcomas that can arise anywhere within the gastrointestinal tract. sporadic mutations within the tyrosine kinase receptors of the interstitial cells of Cajal have been identified as the key molecular step in GIsT carcinogenesis. Although many patients are asymptomatic, the most common associated symptoms include: abdominal pain, dyspepsia, gastric outlet obstruction, and anorexia. Rarely, GIsT can perforate causing life-threatening hemoperitoneum. Most are ultimately diagnosed on cross-sectional imaging studies (i.e., computed tomography and/or magnetic resonance imaging in combination with upper endoscopy. Endoscopic ultrasonographic localization of these tumors within the smooth muscle layer and acquisition of neoplastic spindle cells harboring mutations in the c-KIT gene is pathognomonic. Curative treatment requires a complete gross resection of the tumor. Both open and minimally invasive operations have been shown to reduce recurrence rates and improve long-term survival. While there is considerable debate over whether GIsT can be benign neoplasms, we believe that all GIsT have malignant potential, but vary in their propensity to recur after resection and metastasize to distant organ sites. Prognostic factors include location, size (i.e., > 5 cm), grade (> 5-10 mitoses per 50 high power fields and specific mutational events that are still being defined. Adjuvant therapy with tyrosine kinase inhibitors, such as imatinib mesylate, has been shown to reduce the risk of recurrence after one year of therapy. Treatment of locally-advanced or borderline resectable gastric GIsT with neoadjuvant imatinib has been shown to induce regression in a minority of patients and stabilization in the majority of cases. This treatment strategy potentially reduces the need for more extensive surgical resections and increases the number of patients eligible for curative therapy. The modern surgical treatment of

关键词： Gastrointestinal stromal tumors Laparoscopic resections of gastrointestinal stromal tumors Imatinib mesylate Gastrectomy

Transhiatal versus transthoracic esophagectomy for esophageal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第30期16卷 3804-3810页

作者： J Camilo Barreto mitchell C Posner section of General surgery and surgical Oncology Department of SurgeryUniversity of Chicago Pritzker School of Medicine5841 S. Maryland AveMC 5094ChicagoIL 60637United States

Esophageal cancer continues to represent a formidable challenge for both patients and clinicians. Relative 5-year survival rates for patients have improved over the past three decades, probably linked to a combination of improved surgical outcomes, progress in systemic chemotherapy and radiotherapy, and the increasing acceptance of multimodality treatment. surgical treatment remains a fundamental component of the treatment of localized esophageal adenocarcinoma. Multiple approaches have been described for esophagectomy, which can be thematically grouped under two major categories: either transthoracic or transhiatal. The main controversy rests on whether a more extended resection through thoracotomy provides superior oncological outcomes as opposed to resection with relatively limited morbidity and mortality through a transhiatal approach. After numerous trials have addressed these issues, neither approach has consistently proven to be superior to the other one, and both can provide excellent short-term results in the hands of experienced surgeons. Moreover, the available literature suggests that experience of the surgeonand hospital in the surgical management of esophageal cancer is an important factor for operative morbidity and mortality rates, which could supersede the type of approach selected. Oncological outcomes appear to be similar after both procedures.

关键词： Esophageal cancer Transhiatal esophageal resection Transthoracic esophageal resection

Tinker,tailor,soldier,cell:the role of C-type lectins in the defense and promotion of disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2023年第1期14卷 4-16页

作者： James N.Arnold Daniel A.mitchell school of Cancer and Pharmaceutical sciences King's College LondonLondon SE11ULUK Warwick Medical school University of WarwickCoventry CV22DXUK

C-type lectins(CTLs)represent a large family of soluble and membrane-bound proteins which bind calcium dependently via carbohydrate recognition domains(CRDs)to glycan residues presented on the surface of a variety of *** deconvolution of a cell’s glycan code by CTLs underpins several important physiological processes in mammals such as pathogen neutralization and opsonization,leukocyte trafficking,and the inflammatory ***,as our knowledge of CTLs has developed it has become apparent that the role of this innate immune family of proteins can be double-edged,where some pathogens have developed approaches to subvert and exploit CTL interactions to promote infection and sustain the pathological ***,CTL interactions with host glycoproteins can contribute to inflammatory diseases such as arthritis and cancer whereby,in certain contexts,they exacerbate inflammation and drive malignant *** review discusses the‘dual agent’roles of some of the major mammalian CTLs in both resolving and promoting infection,inflammation and inflammatory disease and highlights opportunities and emerging approaches for their therapeutic modulation.

关键词： C-type lectins DC-sIGN MBL selectins infection arthritis cancer

General Theoretical Model for Resonantly Enhanced Optical Modulators

在线全文

学校读者我要写书评

暂无评论

光学学报 2003年第S1期23卷 337-338页

作者： Yuvaraja s. Visagathilagar Arnan mitchell Michael W. Austin Australian Photonics CRC SECE RMIT University GPO Box 2476V MelbourneVictoria3001Australia.Australian Photonics CRC SECE RMIT University GPO Box 2476V MelbourneVictoria3001Australia.Australian Photonics CRC SECE RMIT University GPO Box 2476V MelbourneVictoria3001Australia.

1 IntroductionLiNbO3 optical modulators have become essential transmission devices for current and future wideband fibre-optic communications for both military and telecommunications applications. For many telecommunications applications, only a narrow bandwidth is required and thus resonantly enhancedMach-Zehndermodulators(RE-MZMs)have been developed to improve modulation efficiency at the expense of bandwidth.

关键词： for on et of in be General Theoretical Model for Resonantly Enhanced Optical Modulators MZM

Triage for resource-limited emergency care:why it matters

在线全文

学校读者我要写书评

暂无评论

Emergency and Critical Care Medicine 2023年第4期3卷 139-141页

作者： Rob mitchell Emergency and Trauma Centre Alfred HealthMelbourneAustralia school of Public Health and Preventive Medicine Monash UniversityMelbourneAustralia

Triage aims to identify and prioritize patients with time-sensitive health care *** process is particularly important when demand for emergency care exceeds the available resources.A small number of triage instruments have been purpose designed for low-and middle-income *** recently,the World Health Organization,in collaboration with the International Committee of the Red Cross and Médecins sans Frontières,has released the Interagency Integrated Triage Tool(IITT).Despite endorsement by leading global health agencies,little has been published regarding the IITT’s validity and *** triage is widely regarded as a critical tool for organizing emergency care services,many instruments have demonstrated suboptimal sensitivity for the detection of time-critical *** is a pressing need therefore to assess the performance of the IITT relative to other *** efforts to implement and evaluate the tool in the Western Pacific region will provide valuable insights into its validity,reliability and acceptability.

关键词： Emergency care Triage Low-and middle-income country

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机器故障的分析与监测

stable isotope analysis of diet confirms niche separation of two sympatric species of Namib Desert lizard

1990年

作者： J.s.·米切尔(J.s. mitchell)

来源：南通市图书馆图书汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

Integrative Zoology 2016年第1期11卷 60-75页

作者： Ian W.MURRAY Hilary M.LEAsE Robyn s.HETEM Duncan mitchell Andrea FULLER stephan WOODBORNE Brain Function Research Group School of PhysiologyFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Biology Department Whitman CollegeWalla WallaWashingtonUSA iThemba Laboratories GautengSouth Africa stable Isotope Laboratory Mammal Research InstituteDepartment of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa

We used stable isotopes of carbon and nitrogen to study the trophic niche of two species of insectivorous lizards,the Husab sand lizard Pedioplanis husabensis and Bradfield’s Namib day gecko living sympatrically in the Namib *** measured theδ13C andδ15N ratios in lizard blood tissues with different turnover times(whole blood,red blood cells and plasma)to investigate lizard diet in different *** also measured theδ13C andδ15N ratios in available arthropod prey and plant tissues on the site,to identify the avenues of nutrient movement between lizards and their *** the use of stable isotope mixing models,we found that the two lizard species relied on a largely non-overlapping but seasonally variable array of arthropods:*** primarily fed on termites,beetles and wasps,while *** fed mainly on ants,wasps and *** originating from C3 plants were proportionally higher for *** than for *** during autumn and late autumn/early winter,although not *** to the few available data estimating the trophic transfer of nutrients in ectotherms in mixed C3 and C4/crassulacean acid metabolism(CAM)plant landscapes,we found that our lizard species primarily acquired nutrients that originated from C4/CAM *** work adds an important dimension to the general lack of studies using stable isotope analyses to estimate lizard niche partitioning and resource use.

关键词： Namib Desert niche partitioning Pedioplanis Rhoptropus stable isotopes

Urban agriculture in Kathmandu as a catalyst for the civic inclusion of migrants and the making of a greener city

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Architectural Research 2020年第1期9卷 169-190页

作者： Maurice mitchell Amara Roca lglesias CAss school of Art Architecture and DesignLondon Metropolitan UniversityUK

This research explores the opportunities offered for the creation of a green city on the recently secured Bagmati riverbanks in Kathmandu,which is subject to rapid inward migration from landless rural *** research asks what architectural theory and practice can contribute to this setting to support the fit between emergent bottom-up initiatives and topdown city *** this end,it deepens and extends loose fit theory,research methods,and reflective practices to investigate latent possibilities,assemble a narrative of embedded change,and create spatial imaginaries of topographical change on the Bagmati ***,it argues that architectural theory and practice can play a vital role in integrating migrants into civic institutions and helping generate a highly green city by making the relation-ships between setting and occupant explicit,stimulating and representing alternative imaginaries,and framing a civic discourse.

关键词： Architecture Urban agriculture Urban rivers Urban migrants Loose-fit city Kathmandu