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Journal of Plant Ecology 2023年第6期16卷 92-107页

作者： Mustapha Ennajeh mitchell coleman Jaycie C.Fickle Viridiana Castro Robert Brandon Pratt Anna L.Jacobsen Department of Biology California State UniversityBakersfieldCA 93311USA Laboratory of Biodiversity and Valorization of Bioresources in Arid Zones Faculty of Sciences of GabesUniversity of Gabes6072 GabesTunisia Tejon Ranch Conservancy Frazier ParkCA 93225USA

两种以前广泛分布的滨藜属(Atriplex)物种如今在南加州圣华金河谷沙漠的一系列微栖息地中以碎片化的种群出现。我们推测,由于土壤盐度和干旱程度的不同,大滨藜(***)和多果滨藜(***)在叶片和茎的结构和功能性状上存在种间和种内差异。我... 详细信息

两种以前广泛分布的滨藜属(Atriplex)物种如今在南加州圣华金河谷沙漠的一系列微栖息地中以碎片化的种群出现。我们推测,由于土壤盐度和干旱程度的不同,大滨藜(***)和多果滨藜(***)在叶片和茎的结构和功能性状上存在种间和种内差异。我们比较了3个大滨藜种群和4个多果滨藜种群的水势、木质部结构功能和叶片性状。两个物种的木质部性状差异显著,其中大滨藜的木质部密度较低,导管平均直径和最大直径较宽,导水率较高。这两个物种的叶片性状也具有显著差异,其中大滨藜与多果滨藜相比,具有更大的叶片和更高的比叶面积。叶片性状在大滨藜不同种群间存在显著差异。相反,茎木质部结构特征(平均管壁厚度、平均管径和最大管长)在多果滨藜不同种群间存在差异。这些差异在很大程度上与大滨藜的土壤盐度有关,而与多果滨藜的季节性水势关系不大。总体而言,两种滨藜属灌木均表现出较高的种内和种间性状变异。这可能是理解这些本地物种进化的关键考虑因素,对它们的保护和恢复具有重要意义。

关键词：干旱叶面积比水导电率圣华金河谷沙漠水势木质部解剖

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Survival outcomes in early-onset oesophageal adenocarcinoma patients:A systematic review and meta-analyses

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World Journal of Gastroenterology 2024年第38期30卷 4221-4231页

作者： Ashleigh Russell Shauna mitchell Richard C Turkington Helen G coleman Centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johnston Centre for Cancer Research Queen's University BelfastBelfast BT71NNUnited Kingdom

BACKGROUND The incidence of oesophageal adenocarcinoma(OAC)has been reported to be increasing in many *** this trend,an increase in incidence of early-onset OAC,defined as OAC in adults aged under 50 years,has been *** is unclear whether survival outcomes for early-onset OAC patients differ from older age *** To investigate survival outcomes in early-onset OAC *** Ovid Medline and Embase were searched from inception to January 2022 for relevant studies relating to early-onset OAC and survival *** regarding the overall five-year survival and risk of death of younger and older patients with OAC were extracted and pooled using meta-analyses to produce pooled estimates and 95%CIs where *** Eleven studies which compared survival of early-onset OAC,defined as age at diagnosis of<50 years,with older patients were included.A narrative review of median and mean survival demonstrated conflicting results,with studies showing early-onset OAC patients having both better and worse outcomes compared to older age groups.A meta-analysis of five-year survival demonstrated similar outcomes across age groups,with 22%-25%of patients in the young,middle and older age groups alive after five years.A meta-analysis of four studies demon-strated that early-onset OAC patients did not have a significantly increased risk of death compared to middle-aged patients(hazard ratio 1.12,95%CI:0.85-1.47).INTRODUCTION There is concern that the incidence of oesophageal adenocarcinoma(OAC)in patients under 50,described as early-onset OAC,is ***,data regarding survival of younger patients with OAC is ***,while increasing age remains a major non-modifiable risk factor for cancer,the incidence of early-onset cancers,largely accepted to be in adults aged under 50 years,is increasing[1].This includes an observed increase in the incidence of gastrointestinal malignancies such as colorectal,oesophageal,gastric and he

关键词： Early-onset cancer Early-onset oesophageal adenocarcinoma Survival Cancer epidemiology Systematic review Meta-analysis

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The thermal and storage stability of bovine haemoglobin by ultraviolet-visible and circular dichroism spectroscopies

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Journal of Pharmaceutical Analysis 2016年第4期6卷 242-248页

作者： Ruchir Bhomia Vivek Trivedi Nichola J.coleman John C.mitchell School of Science University of GreenwichCentral Avenue

The effects of temperature,pH and long-term storage on the secondary structure and conformation changes of bovine haemoglobin（bHb） were studied using circular dichroism（CD） and ultraviolet-visible（UV-vis） *** network software was used to deconvolute the CD data to obtain the fractional content of the five secondary *** storage stability of bHb solutions in pH 6,7 and8 buffers was significantly higher at 4 ℃ than at 23 ℃ for the first 3 days.A complete denaturation of bHb was observed after 40 days irrespective of storage temperature or *** bHb solutions were also exposed to heating and cooling cycles between 25 and 65 ℃ and structural changes were followed by UVvis and CD *** experiments demonstrated that α-helix content of bHb decreased steadily with the increasing temperature above 35 ℃ at all pH *** loss in a-helicity and gain in random coil conformations was pH-dependent and the greatest under alkaline ***,there was minimal recovery of the secondary structure content upon cooling to 25 ℃.The use of bHb as a model drug is very common and this study elucidates the significance of storage and processing conditions on its stability.

关键词： Bovine haemoglobin Circular dichroism Thermal stability Storage stability Ultraviolet-visible spectroscopy

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