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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5270-5302页

作者： Brittany Dewdney misty RJenkins Sarah ABest Saskia Freytag Krishneel Prasad Jeff Holst Raelene Endersby Terrance GJohns Cancer Centre Telethon Kids InstituteNedlandsWA6009Australia Centre For Child Health Research University of Western AustraliaPerthWA6009Australia Immunology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia Department of medical Biology University of MelbourneMelbourne3010Australia Personalised Oncology Division The Walter and Eliza Hall Institute of Medical ResearchMelbourne3052Australia School of Biomedical Sciences University of New South WalesSydney2052Australia

Glioblastoma,a rare,and highly lethal form of brain cancer,poses significant challenges in terms of therapeutic resistance,and poor survival rates for both adult and paediatric patients *** advancements in brain cancer research driven by a technological revolution,translating our understanding of glioblastoma pathogenesis into improved clinical outcomes remains a critical unmet *** review emphasises the intricate role of receptor tyrosine kinase signalling pathways,epigenetic mechanisms,and metabolic functions in glioblastoma tumourigenesis and therapeutic *** also discuss the extensive efforts over the past two decades that have explored targeted therapies against these *** therapeutic approaches,such as antibody-toxin conjugates or CAR T cell therapies,offer potential by specifically targeting proteins on the glioblastoma cell *** strategies incorporating protein-targeted therapy and immune-based therapies demonstrate great promise for future clinical ***,gaining insights into the role of cell-of-origin in glioblastoma treatment response holds the potential to advance precision medicine *** these challenges is crucial to improving outcomes for glioblastoma patients and moving towards more effective precision therapies.

关键词： glioblastoma therapies targeted

A bio-instructive parylene-based conformal coating suppresses thrombosis and intimal hyperplasia of implantable vascular devices

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Bioactive materials 2023年第10期28卷 467-479页

作者： Dake Hao Jonathan Lin Ruiwu Liu Christopher Pivetti Kaeli Yamashiro Linda m.Schutzman Junichiro Sageshima mimmie Kwong Nataliya Bahatyrevich Diana L.Farmer misty D.Humphries Kit S.Lam Alyssa Panitch Aijun Wang Department of Surgery School of MedicineUniversity of California DavisSacramentoCA95817United States Institute for Pediatric Regenerative medicine Shriners Hospitals for ChildrenSacramentoCA95817United States Department of Biochemistry and molecular medicine School of MedicineUniversity of California DavisSacramentoCA95817United States Wallace H.Coulter Department of Biomedical Engineering Georgia Institute of Technology and Emory UniversityAtlant1GA30332United States Department of Biomedical Engineering University of California DavisDavisCA95616United States

Implantable vascular devices are widely used in clinical treatments for various vascular diseases. However, current approved clinical implantable vascular devices generally have high failure rates primarily due to their surface lacking inherent functional endothelium. Here, inspired by the pathological mechanisms of vascular device failure and physiological functions of native endothelium, we developed a new generation of bioactive parylene (poly(p-xylylene))-based conformal coating to address these challenges of the vascular devices. This coating used a polyethylene glycol (PEG) linker to introduce an endothelial progenitor cell (EPC) specific binding ligand LXW7 (cGRGDdvc) onto the vascular devices for preventing platelet adhesion and selectively capturing endogenous EPCs. Also, we confirmed the long-term stability and function of this coating in human serum. Using two vascular disease-related large animal models, a porcine carotid artery interposition model and a porcine carotid artery-jugular vein arteriovenous graft model, we demonstrated that this coating enabled rapid generation of self-renewable “living” endothelium on the blood contacting surface of the expanded polytetrafluoroethylene (ePTFE) grafts after implantation. We expect this easy-to-apply conformal coating will present a promising avenue to engineer surface properties of “off-the-shelf” implantable vascular devices for long-lasting performance in the clinical settings.

关键词： Parylene coating Integrin ligand Thrombosis Intimal hyperplasia Implantable vascular devices

Color of Vertically-Suspended Structure Does Not Impact the Growth of Rainbow Trout Reared in Circular Tanks

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Open Journal of Animal Sciences 2020年第4期10卷 706-713页

作者： Edgar meza misty D. Jones Nathan Huysman Jill m. Voorhees michael E. Barnes Department of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA

This study examined the effects of five different colors of vertically-suspended environmental enrichment on the growth of juvenile Shasta strain rainbow trout (Oncorhynchus mykiss) during hatchery rearing in circular tanks. The colors used were silver (unpainted aluminum—control), safety red, semi-gloss black, hunter green, and safety blue. After 86 days, total tank weight, weight gain, and feed conversion ration were not significantly different among any of the color treatments. Individual fish weights, lengths, and condition factors were also not significantly different among the treatments. The results of this study indicate that the relatively small amount of color present on the suspended structure did not affect rainbow trout growth. Thus, the inherent silver color of the aluminum angles does not need to be changed.

关键词： Environmental Enrichment Oncorhynchus mykiss Salmonids Color

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名利场第1版

Rearing Performance of Atlantic Salmon Grown in Circular Tanks with Vertically-Suspended Environmental Enrichment

丛书名：九十年代英语系列丛书.简易世界文学名著系列

1982年

作者： W.m.Thackeray原 E.m.attwood改写孙静渊译叶林校

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Open Journal of Animal Sciences 2019年第2期9卷 249-257页

作者： misty D. Jones Eric Krebs Nathan Huysman Jill m. Voorhees michael E. Barnes South Dakota Game Fish and Parks McNenny State Fish Hatchery Spearfish SD USA

Environmental enrichment is the incorporation of materials into hatchery tanks to simulate a more natural rearing environment. This study investigated the use of a vertically-suspended plastic conduit array as enrichment in 3.63 m circular tanks during Atlantic salmon (Salmo salar) rearing. After 168 days, feed conversion ratio was significantly improved for salmon reared in tanks with enrichment compared to the barren control tanks. Final tank weights and weight gain were not significantly different, although the difference in mean gain of 182.0 kg in the enriched tanks compared to 162.9 kg in the control tanks approached significance. There were no significant differences in individual fish length, weight, or condition factor between the treatments, likely because of large variances in body size due to sexual dimorphism and small sample sizes. The suspended array did not interfere with the hydraulic self-cleaning of the circular tanks. The results of this study support the use of vertically-suspended structures to improve the hatchery rearing performance of Atlantic salmon in circular tanks.

关键词： Salmonids Growth Salmo salar Vertically-Suspended Array

Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma

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World Journal of Gastroenterology 2008年第27期14卷 4389-4394页

作者： Jeffrey K Lee Pradipta Ghosh Valerie mcWhorter misty Payne Ryan Olson mary L Krinsky Sonia Ramamoorthy John m Carethers Department of medicine University of California San Diego California and Veteran Affairs medical Center San Diego Healthcare System Department of Pathology University of CaliforniaSan Diego California Department of Surgery University of California

Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the "monoclonal theory" of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma.

关键词：肉瘤样癌腺瘤腺癌结肠直肠癌

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小型纸机的发展

小型纸机的发展

Cancer Res:HDAC抑制剂可促进单抗药物对HER2阳性肿瘤的治疗效果

1999中国造纸学会学术报告会

作者： BW attwood N Jopson m Taylor 宋德龙 St．Anne’s Paper ＆ Paperboard Developments Ltd PIRA PIRA

本文讨论了小型纸机的发展与应用。作者认为新的紧凑小型纸机概念可以采用一些新技术,例如,压力成形、同步多层成形、高浓成形、成形织物应用与初始压榨的组合、后面有高强度压榨和干燥的热压榨（如Conde Belt系统干燥及脉冲干燥）。作...

本文讨论了小型纸机的发展与应用。作者认为新的紧凑小型纸机概念可以采用一些新技术,例如,压力成形、同步多层成形、高浓成形、成形织物应用与初始压榨的组合、后面有高强度压榨和干燥的热压榨（如Conde Belt系统干燥及脉冲干燥）。作者对这些新技术给予了评述,并对应用其中某些概念生产的一台典型小型纸机的实例进行了描述。本文详细介绍了已经完成的一些研究,包括中间试验工厂的应用,同时还对未来的研究进行了说明。

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现代生物医学进展 2017年第18期17卷 I0001-I0002页

作者： mikolaj medon Eva Vidacs Stephin J Vervoort Jason Li misty R. Jenkins Kelly m. Ramsbottom Joseph A. Trapani mark J. Smyth Phillip K. Darcy Peter W. Atadja michael A. Henderson Ricky W. Johnstone Nicole m. Haynes Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia. Bioinformatics Consulting Core Facility Cancer Research Division Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Immunology in Cancer and Infection Laboratory QIMR Berghofer Medical Research Institute Herston Queensland Australia. Cancer Immunology Research Program Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. China Novartis Institute for Biomedical Research Shanghai China. Division of Surgical Oncology Peter MacCallum Cancer Centre VCCC Melbourne Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australia.Sir Peter MacCallum Department of Oncology The University of Melbourne Parkville Victoria Australia. Cancer Therapeutics Program Peter MacCallum Cancer Centre Victorian Comprehensive Cancer Centre (VCCC) Melbourne Victoria Australi

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究... 详细信息

最近来自澳大利亚墨尔本的研究人员发现组蛋白去乙酰化酶抑制剂可以发动宿主免疫作为其抗肿瘤效应的一个基础。该研究为增强一些肿瘤免疫治疗药物的杀伤作用提供了新的方向。在这项发表在国际学术期刊Cancer Research上的研究中，研究人员发现组蛋白去乙酰化酶抑制剂panobinostat可以通过宿主免疫增强trastuzumab这种单抗治疗药物的抗肿瘤效果。

关键词：组蛋白去乙酰化酶抑制剂抗肿瘤效应治疗药物治疗效果 HDAC 单抗 Res 阳性

Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms

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World Journal of Gastroenterology 2016年第48期22卷 10601-10608页

作者： Eli D Ehrenpreis Grigory Roginsky Richard m Gore University of Chicago Center for the Study of Complex Diseases Gastroenterology North Shore University Health System Highland Park Hospital Department of Radiology North Shore University HealthS ystem

AIm To clarify the association of malignancy with mesenteric panniculitis-like changes on computed tomography(CT).mETHODS All abdominal CT scans performed at North Shore University HealthS ystem showing mesenteric panniculitis from January 2005 to August 2010 were identified in the Radnet(Rad Net Corporation, Los Angeles, CA) database. Patients with a new or known diagnosis of a malignancy were included for this analysis. Longitudinal clinical histories were obtained from electronic medical *** In total, 147794 abdominal CT scans were performed during the study period. Three hundred and fiftynine patients had mesenteric panniculitis(mP)-like abnormalities on their abdominal CT. Of these patients, 81 patients(22.6%) had a known history of cancer at the time of their CT scan. Nineteen(5.3%) had a new diagnosis of cancer in concurrence with their CT, but the majority of these(14/19, 74%) were undergoing CT as part of a malignancy evaluation. Lymphomas were the most common cancers associated with mPlike findings on CT(36 cases, 36%), with follicular lymphoma being the most frequent subtype(17/36). A variety of solid tumors, most commonly prostate(7) and renal cell cancers(6) also were seen. CT follow up was obtained in 56 patients. Findings in the mesentery were unchanged in 45(80%), worsened in 6(11%), and improved in 5 patients(9%). Positron emission tomography(PET) scans performed in 44 patients only showed a positive uptake in the mesenteric mass in 2 patients(5%). CONCLUSION A new diagnosis of cancer is uncommon in patients with CT findings suggestive of mP. mP-like mesenteric abnormalities on CT generally remain stable in patients with associated malignancies. PET scanning is not recommended in the evaluation of patients with mesenteric panniculitis-like findings on CT.

关键词： Panniculitis Peritoneal X ray Neoplasms Computed tomography Small intestine misty mesentery Lymphoma Tomography Positron emission tomography