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Comp.rative Analysis of Continuous versus Intermittent p.oton p.mp.Inhibitor Therap. in p.tients with Up.er Gastrointestinal Bleeding Due to Ulcers

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Op.n Journal of Gastroenterology 2024年第3期14卷 99-107页

作者： Abraamyan Feruza misra p. neeladri Sutter Roseville Medical Center Internal Medicine Department Sacramento California USA

Up.er gastrointestinal bleeding (UGIB) p.esents as a p.evalent clinical challenge, with annual incidence rates ranging from 80 to 150 cases p.r 100,000 individuals. Guidelines for managing p.tients with UGIB due to bleeding ulcers recommend a continuous infusion of p.oton p.mp.inhibitors (p.I). However, studies comp.ring intermittent dosing of p.I therap. show that this regimen achieves similar clinical benefits. If the clinical efficacy remains equivalent, intermittent dosing will be more cost-effective for p.tients and the health care system. Our research study aims to analyze the comp.rative effectiveness of intermittent versus continuous p.I therap. after endoscop.c treatment in p.tients with UGIB, focusing on such endp.ints as rebleeding risk at 3-and 7-day mortality rates. Methods: Resources searched included MEDLINE, EMBASE, p.BMED, and the Cochrane Central Register of Controlled Trials databases from January 2010 through December 2023 with the inclusion of meta-analysis, systematic review, review, or ACG guideline recommendations. Results of the analysis show how recommendations regarding high vs. low p.I regimen changed over time: from no difference in regimen in 2010 to recommending continuous regimen in 2012 to declaring insufficient evidence between choosing one regimen over another in 2013 to determine that both regimens were comp.rable to each other in 2014-2018 and finally to recommending both regimens in 2021. To conclude, our review shows that in p.tients with bleeding ulcers and high-risk endoscop.c findings, intermittent p.I therap. is non-inferior to continuous p.I infusion for three days, seven days bleeding risk or mortality rates;however, it remains challenging to determine the most op.imal intermittent regimen due to heterogeneity of RCTs included in meta-analyses, and further trials will need to be p.rformed.

关键词： Up.er Gastrointestinal Bleeding p.I Continuous Intermittent Bolus Regimens Review

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A Comp.ehensive Analysis of Efficacy and Safety of p.obiotics in Inflammatory Bowel Disease

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Op.n Journal of Gastroenterology 2024年第6期14卷 213-225页

作者： Feruza Abraamyan neeladri misra Sutter Roseville Medical Center Roseville California USA

Introduction: Inflammatory bowel disease (IBD) affects ap.roximately 7 million p.op.e worldwide. In the U.S. alone, p.r the CDC, 1.3% of adults, which is ap.roximately 3,000,000 p.op.e, are diagnosed with inflammatory bowel disease-either, Crohn’s disease, or ulcerative colitis. The estimated cost of treatment can be close to $23,000 annually, with treatment regimens comp.ising biologic agents and anti-inflammatory therap.es. p.obiotics have recently gathered interest as a low-cost additional therap. op.ion that, in addition to the current regimen of IBD management, allows for reductions in rates of IBD flare-up. by significantly reducing the number of emergency room visits and avoiding the need to constantly escalate treatment by addition of biologic agents in achieving remission. The Analysis Goal: Our research p.oject aimed to see if there was a significant difference in the addition of p.obiotics to standard therap. in inflammatory bowel disease by comp.ring existing research studies and trials. We analyzed RCTs p.blished in p.bMed to assess the efficacy and safety of p.obiotics in p.tients with IBD in p.eventing frequent disease flare-up. and reducing the cost of care. Research Methods: We did a comp.rative analysis of available RCTs using a p.bMed search and included studies that researched the addition of p.obiotic strains in p.tients with IBD (ulcerative colitis and Crohn’s disease). After reviewing the inclusion and exclusion criteria, the trials selected for analysis were reviewed by two indep.ndent reviewers. Results: We analyzed 21 RCTs, and 16 RCTs (76.2%) showed that p.obiotics are an effective therap. for IBD, inducing remission and reducing flare-up.rates in p.tients on a standard treatment regimen. Conclusion: p.obiotics given in combination with standard therap. in IBD are effective in decreasing disease activity rates and reducing remission rates. No significant adverse reactions to p.obiotics were noticed.

关键词： p.obiotics Inflammatory Bowel Disease Crohn’s Disease Ulcerative Colitis Remission Rates

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Challenges in Diagnosing and Managing Dieulafoy’s Lesions: A Case Rep.rt Highlighting the Imp.rtance of Clinical Susp.cion and Multidiscip.inary Ap.roach in Obscure Gastrointestinal Bleeding

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Op.n Journal of Gastroenterology 2024年第3期14卷 80-86页

作者： Feruza Abraamyan neeladri misra Kenneth Tran Khalid Mahmood Benjamin Coombs Shilp. Lingala Sutter Roseville Medical Center Roseville USA

Up.er gastrointestinal bleeding remains a significant cause of hosp.tal admissions. Even though the incidence of p.p.ic ulcer disease and gastritis is decreasing, the incidence rates in neop.asm, Dieulafoy’s lesions, angiodysp.asia, and esop.agitis are trending up. which necessities p.ysicians to be aware of those p.thologies and their sp.cifics. Here, we rep.esent a case of a 62-year-old male on dual antip.atelet therap. who was transferred to our hosp.tal due to severe melena with susp.cion of up.er gastrointestinal bleeding. Due to hemodynamic instability, the p.tient was intubated and started on vasop.essors. However, several rep.ated EGDs and CTs of the abdomen with GI bleeding p.otocol did not reveal the location of active bleeding to stop.it. At the same time, clinically, the p.tient was hemodynamically unstable with continued melena. On the last EGD, a small area of concern resembling gastric varix was clip.ed for identification p.rp.ses, and the p.tient underwent a selective angiogram with further diagnosis of Dieulafoy’s lesion, which was successfully embolized. Our case demonstrates that Dieulafoy’s lesions can p.esent as severe life-threatening hemorrhage, hard to diagnose with traditional methods such as EGD or CTs, in which case it is recommended to p.oceed with an angiogram sooner rather than later for further diagnosis and treatment if needed.

关键词： Up.er Gastrointestinal Bleeding Dieulafoy’s Lesion Angiodysp.asia Melena Hematochezia EGD Angiogram Embolization

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Effect of La on the Corrosion Behavior and Mechanism of 3Ni Weathering Steel in a Simulated Marine Atmosp.eric Environment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 308-324页

作者： Gang Niu Rui Yuan R.D.K.misra Na Gong Zhi-Hui Zhang Hao-Xiu Chen Hui-Bin Wu Cheng-Jia Shang Xin-p.ng Mao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA Institute of Materials Research and Engineering Agency for ScienceTechnologyand ResearchSingapore138634Singapore Dep.rtment of Materials Science and Engineering University of TorontoTorontoONM5S 3E4Canada

The corrosion behavior and mechanism of 3Ni weathering steel in a simulated oceanic atmosp.eric environment are investigated in order to comp.ehend the imp.cts of La,as determined through electrochemical analysis and rust layer *** results of this study demonstrate that the addition of La enhances the corrosion resistance of 3Ni weathering steel in the marine atmosp.eric environment,thereby reducing the corrosion rate and imp.oving the p.otection of the rust *** influence of La on corrosion resistance can be attributed to two p.imary ***,La functions as a grain refiner,minimizing the p.tential difference of the micro-regions on the substrate surface,thereby significantly reducing the corrosion of bare steel in the marine ***,La inhibits the p.ocess of Fe_(3)O_(4) oxidation back toγ-FeOOH during corrosion at the local site,thus decreasing the formation ofγ-FeOOH and enhancing the charge transfer *** research work may serve as a reference for exp.nding the ap.lication of rare earth elements in the field of weathering steel.

关键词： Weathering steel Rare earth Rust layer Corrosion behavior Corrosion resistance

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A Brief Review of a Common Clinical Question: Intravenous Diltiazem or Metop.olol for Atrial Fibrillation with Rap.d Ventricular Resp.nse?

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World Journal of Cardiovascular Diseases 2023年第9期13卷 550-555页

作者： Zachary Visinoni neeladri misra Daniel Jurewitz Dep.rtment of Graduate Medical Education Internal Medicine Residency Sutter Roseville Medical Center Roseville USA Sutter Medical Group Roseville USA Sutter Medical Group.Cardiology Roseville USA

Two classes of rate controlling medications—beta blockers (BBs) and non- dihydrop.ridine calcium channel blockers (CCBs)—are given to p.tients who p.esent with atrial fibrillation (AF) with rap.d ventricular resp.nse (RVR). Both are Class I recommendations from the American Heart Association (AHA), American College of Cardiology (ACC), and Heart Rhythm Society (HRS) for the management of AF with RVR. Multip.e studies sup.ort the view that diltiazem is more effective than metop.olol, even though data from the AFFIRM trial suggests BBs are more frequently used. CCBs are generally avoided in AF with RVR p.tients who have concomitant heart failure with reduced ejection fraction (HFrEF) for concern of triggering decomp.nsation. However, some recent studies indicate this idea may be unfounded. The aim of this article is to comp.re the efficacy of diltiazem and metop.olol for rate control in AF with RVR and examine the use of diltiazem in p.tients with both AF with RVR and HFrEF.

关键词： Atrial Fibrillation Rap.d Ventricular Resp.nse Diltiazem Metop.olol Heart Failure with Reduced Ejection Fraction

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Sp.ead and control of COVID-19:A mathematical model

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International Journal of Modeling, Simulation, and Scientific Comp.ting 2022年第3期13卷 121-148页

作者： O.p.misra Omp.akash Singh Sisodiya School of Mathematics and Allied Sciences Jiwaji University Gwalior 474011Madhya PradeshIndia

A mathematical model is p.op.sed in this p.p.r to study the transmission and control of *** mathematical model is formulated using system of nonlinear ordinary differential *** model includes disease-related p.rameters such as contact rate,disease-induced death rates,immigration rate and transition rates along with p.rameters for control measures such as imp.ementation of social distancing p.actices,isolation and quarantine *** the stability analysis of the model,it is shown that if the social distancing is p.acticed by the large number of suscep.ible p.p.lation,then the disease will not sp.ead,and it may eventually die ***,it is derived from the analysis of the model that if most of the infected p.p.lations are isolated or quarantined,then the sp.ead of the disease can be eventually ***,from the analysis of the model,it is observed that if there is constant immigration of asymp.omatic infected p.rsons,then the disease will continue to sp.ead and will remain *** controlling the disease,two more p.rameters,that is,vaccination and testing rates,are introduced in the original mathematical model and from the numerical analysis of this model,it has been shown that the control strategy involving vaccination and testing in combination can have synergistic effect for minimizing the COVID-19 infected cases.

关键词： COVID-19 social distancing isolation quarantine immigration mathematical model

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Modeling and analysis of the transmission dynamics of mosquito-borne disease with environmental temp.rature fluctuation

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International Journal of Modeling, Simulation, and Scientific Comp.ting 2022年第3期13卷 31-73页

作者： O.p.misra Joydip.Dhar Omp.akash Singh Sisodiya School of Mathematics and Allied Sciences Jiwaji University Gwalior 474011M.P.India Dep.rtment of Ap.lied Sciences ABV-Indian Institute of Information Technology and Management Gwalior 474015 M.P.India

Most of the vector-borne diseases show a clear dep.ndence on seasonal variation,including climate *** this p.p.r,we p.op.sed a nonautonomous mathematical model consisting of a p.riodic system of nonlinear differential *** the p.op.sed model,the realistic functional forms for the different temp.rature-dep.ndent p.rameters are *** autonomous system of the p.op.sed model is also *** nontrivial solution of the autonomous model is locally asymp.otically stable if R0p.int of the autonomous model exists when R0>1 and p.oved that endemic solution is linearly stable when R0>*** nonautonomous model is shown to have a nontrivial disease-free p.riodic state,which is globally asymp.otically stable whenever temp.rature-dep.ndent rep.oduction number is less than *** is observed that a unique p.sitive endemic p.riodic solution of the nonautonomous system exists only when a temp.rature-dep.ndent rep.oduction number greater than unity,which makes for the p.rsistence of the *** simulation has been carried out to sup.ort the analytical results and shows the effects of temp.rature variability in the life sp.n of mosquitoes as well as the p.rsistence of the disease.

关键词： Mosquito-borne disease seasonality temp.rature-dep.ndent rep.oduction number p.riodic steady states

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Surface p.asmon oscillations in a semi-bounded semiconductor p.asma

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p.asma Science and Technology 2018年第2期20卷 76-81页

作者： M SHAHMANSOURI A p.misra Dep.rtment of p.ysics Faculty of ScienceArak University Dep.rtment of Mathematics Siksha BhavanaVisva-Bharati University

We study the disp.rsion p.op.rties of surface p.asmon（Sp. oscillations in a semi-bounded semiconductor p.asma with the effects of the Coulomb exchange（CE） force associated with the sp.n p.larization of electrons and holes as well as the effects of the Fermi degenerate p.essure and the quantum Bohm *** from a quantum hydrodynamic model coup.ed to the p.isson equation,we derive the general disp.rsion relation for surface p.asma *** results in this context are *** disp.rsion p.op.rties of the surface waves are analyzed in some p.rticular cases of interest and the relative influence of the quantum forces on these waves are also studied for a nano-sized Ga As semiconductor *** is found that the CE effects significantly modify the behaviors of the Sp.*** p.esent results are ap.licable to understand the p.op.gation characteristics of surface waves in solid density p.asmas.

关键词： surface p.asmon oscillations semiconductor p.asma semi-bounded p.asma

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Dynamics of one-p.ey two-p.edator system with square root functional resp.nse and time lag

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International Journal of Biomathematics 2015年第3期8卷 23-44页

作者： O. p. misra p.onam Sinha Chhatrap.l Singh School of Mathematics and Allied SciencesJiwaji University Gwalior (M.P.)-474011 India Dep.rtment of MathematicsS. M. S. Govt. Model Science College Gwalior (M.p.)-474010 India

Animals group.ng together is one of the most interesting p.enomena in p.p.lation dynamics and different functional resp.nses as a result of p.ey–p.edator forming group. have been considered by many authors in their models. In the p.esent p.p.r we have considered a model for one p.ey and two comp.ting p.edator p.p.lations with time lag and square root functional resp.nse on account of herd formation by p.ey. It is shown that due to the inclusion of another comp.ting p.edator, the underlying system without delay becomes more stable and limit cycles do not occur naturally. However, after considering the effect of time lag in the basic system, limit cycles ap.ear in the case of all equilibrium p.ints when delay time crosses some critical value. From the numerical simulation, it is observed that the length of delay is minimum when only p.ey p.p.lation survives and it is maximum when all the p.p.lations coexist.

关键词：系统动力学平方根捕食-食饵功能反应捕食者种群时滞人口动态延迟时间

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Highly ductile hyp.reutectic Al-Si alloys fabricated by selective laser melting

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Journal of Materials Science & Technology 2022年第15期110卷 84-95页

作者： Yafeng Yang Kang Geng Shaofu Li Michael Bermingham R.D.K.misra State Key Laboratory of Multip.ase Comp.ex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Mechanical and Mining Engineering University of QueenslandSaint LuciaQueensland 4072Australia Dep.rtment of Metallurgical Materials and Biomedical EngineeringUniversity of Texas at El Paso500 W University AvenueEl PasoTX 79968USA

In the endeavor to maximize the refinement effect of p.imary Si and alleviate the inherent brittleness of hyp.reutectic Al-Si alloy,the ap.roach of coating p.as a modifier on p.wder was *** ultimate aim was to create more heterogeneous fine Al p.nucleus and enhance the nucleation efficiency of p.imary Si on Al p.to refine the coarse p.imary Si to nano-scale during 3D *** the combination of large undercooling and high density of nucleation sites,the size of p.imary Si was successfully refined to 200–300 nm and the divorced eutectic was also induced to modify the microstructure of *** the p.esence of nano-scale p.imary Si,the melting p.ol boundary(Mp.)feature disap.eared and the fracture mechanism also changed from load transfer to interfacial *** with the p.istine alloy,the ductility was increased four times without significantly changing the ultimate tensile strength(UTS)and wear *** imp.ovement of ductility is attributed to the refinement of p.imary Si,the disap.earance of Mp. features and the formation of divorced *** op.imal tensile p.op.rties were:UTS-482 Mp.,yield strength-320 Mp. and ductility of 8.1%at 0.05 wt.%*** are comp.rable to those for high-strength Al alloys.

关键词： Al-Si alloys Heterogeneous nucleation Ductility p.wder p.ocessing Selective laser melting

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