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Upper Gastrointestinal Endoscopic Outcomes in Patients with Gastrointestinal Symptoms: Retrospective Analysis at a Tertiary Care Hospital

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Open Journal of Gastroenterology 2019年第8期9卷 141-157页

作者： Iftikhar Haider Naqvi Abu Talib Muqadus Tabraze Omer Mustafa Siddiqui Maheen Fatima Hussaini Neha Saleem Paryani Rida Effendi Samrah lnam Siddiqui Syeda Zuhaa Hassan Maham Munawar Zaiya Waseem Ameer Ahmed Khan Zafir Zohab Hussain Khan S. Zain Naeem Rizvi Sofia Fatima Farooqui misbah munaf Hasan Obaid Faryal Khan Dow University of Health Sciences Department of Medicine Karachi Pakistan

Background: Endoscopic procedures are frequently performed to rule out any disease process which eventuates with either a positive or negative outcome. Association of patient demographics, clinical features with endoscopic outcomes are of paramount importance for better understanding and practice of endoscopy. Objectives: This study aimed to determine the frequency of positive endoscopic findings in patients with gastrointestinal symptoms compared to those with negative findings. As a secondary objective, the association between relevant demographics, symptoms, laboratory investigations and procedural outcomes of the participants and positive endoscopic findings were also assessed. Methods: A retrospective analysis of all the patients who underwent esophagogastroduodenoscopy from January 2017 to December 2017 was conducted. A total of 1066 endoscopy records were retrieved and using a convenience sampling technique, relevant data were manually entered to the questionnaires. Records with incomplete or inconsistent data were disregarded as per the exclusion criteria, resulting in 1011 patient records ultimately utilized for the study. All data were entered and analyzed using IBM SPSS 23.0. Results: The study comprised a total of 1011 patients where 52.2% were females and 47.8% males while the mean age of patients was 42.16 ± 15.45. Positive endoscopic findings were observed in 88.1%, where the most common finding was gastritis (49.1%). Approximately 14.5% had positive investigation findings for HBsAg and 23.1% were seropositive for anti-HCV antibody. P-values statistically significant were for age (p = 0.044), hematemesis (p = 0.002), betel quid addiction (p = 0.044), anti-HCV antibody (p = 0.043), HCV-RNA (p = 0.041) and “H. pylori” antigen (p = 0.032). Conclusion: Both genders were almost equally included where most patients presented between the 3rd and 5th decades of life. A high incidence of gastritis was noted. Positive endoscopic findings were associated with be

关键词： Esophagogastroduodenoscopy Endoscopy Gastritis Esophageal Varices

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Prevalence and clinicopathological characteristics of appendiceal carcinoids in Sharjah(United Arab Emirates)

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World Journal of Gastrointestinal Oncology 2014年第7期6卷 253-256页

作者： Khurshid Anwar munaf Desai Noura Al-Bloushi Farheen Alam Farhan Sachal Cyprian Clinical Science Department College of Medi-cine University of Sharjah Emirates of Sharjah 27272 United Arab Emirates Department of Pathology College of Medicine Alfaisal University Riyadh 11533 Kingdom of Saudi Arabia Specialist Histopathologist Al-Qasmi Hospital Sharjah Emirates of Sharjah 3500 United Arab Emirates Health Science College University of Shar-jah Emirates of Sharjah 27272 United Arab Emirates College of Medicine University of Sharjah Emirates of Sharjah 27272 United Arab Emirates

AIM:To determine the incidence and clinico-patho-logical profile of appendiceal carcinoids in a cohort of patients undergoing emergency appendicectomies for clinically suspected acute appendicitis in Sharjah,Unit-ed Arab Emirates(UAE).METHODS:The study included the retrospective data of 964 patients operated for clinically suspected acute appendicitis,and the resected specimens were received at Al-Qasmi Hospital(Sharjah)from January 2010 to December *** data of the patients who were histologically reported to have carcinoid tumors of the appendix were extensively evaluated for the patient’s demographics,indication for surgery,surgical pro-cedure,tumor localization in the appendix,diameter of the lesion,concomitant appendicitis,immunohisto-chemistry studies and clinical ***:Out of the 964 patients included in the study,9(0.93%)were found to have appendiceal *** mean age reported was 28.7 years with a male to female ratio of 2:*** tumors were located near the tip of the appendix with a mean diameter of 3.3 mm,while the remaining one was near the proximal end of the *** the cases were associated with concomitant suppurative *** seven report-ed cases,tumors were confined to the muscular layer while in one case each there was an extension to the serosa and mesoappendix,*** tumors were found to be positive for chromogranin A,synaptophysin and neuron-specific enolase on immunohistochemistry but negative for *** of the patients developed recurrence or any reportable complications in the short follow-up period(12-26 mo)that was ar-ranged as a six-monthly re-evaluation by abdominal ***:Our study found a higher incidence of appendiceal carcinoids in patients undergoing emer-gency appendectomy for acute appendicitis in Sharjah,UAE compared to two previous studies from the Persian Gulf ***,tumors were found to be more commonly in young males,which is in con

关键词： Appendix Carcinoid Prevalence Sharjah United Arab Emirates

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Separation of Inorganic Anions Using Methacrylate-Based Monolithic Column Modified with Trimethylamine in Ion Chromatography Capillary System

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American Journal of Analytical Chemistry 2013年第9期4卷 451-456页

作者： Fitri Mairizki Athika Rahmah Hilma Radhia Putri Rahmiana Zein Lee Wah Lim Toyohide Takeuchi Edison munaf Department of Chemistry Faculty of Engineering Gifu University Gifu Japan Department of Chemistry Faculty of Mathematics and Natural Sciences Andalas Universiy Padang Indonesia

Methacrylate-based monolithic column was prepared in fused-silica capillary (80 ′ 0.32 mm i.d.) by in situ polymerizetion reaction using glycidyl methacrylate as monomer;ethylene dimethacrylate as crosslinker;1-propanol, 1,4-butanediol, and water as porogenic solvents. The monolith matrix was modified with trimethylamine to create strong anion exchanger via ring opening reaction of epoxy groups. The morphology of the monolithic column was studied by using Scanning Electron Microscope (SEM). This column had good mechanical stability and permeability. The effects of various mobile phases for separation of inorganic anions were investigated. Iodate, bromate, nitrite, bromide, and nitrate were separated within 11 min using100 mMpotassium chloride as mobile phase and detected at 210 nm. This method showed good precision of retention time, acceptable linearity and good sensitivity. Under the optimum condition, the RSD of the retention time was in the range of 1.09%-1.75% (n = 6). The calibration curve showed linear relationships between the peak area and the concentration. The limits of detection (LOD) and the limits of quantitation (LOQ) were between 0.08-0.18 mM and 0.26-0.61 mM, respectively. This method was applied to the determination of inorganic anions in tap water and ground water samples.

关键词： Methacrylate-Based Monolithic Column Trimethylamine Ion Chromatography Capillary System Inorganic Anions Water Sample

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Dose-dependent relationship between serum metformin levels and glycemic control, insulin resistance and leptin levels in females newly diagnosed with type 2 diabetes mellitus

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Journal of Diabetes Mellitus 2012年第2期2卷 179-185页

作者： Kadhim Ali Kadhim Dowser Khalil Ismael Ban Hoshi Khalaf Khalid Ibrahim Hussein munaf Hashim Zalzala Saad Abdulrahman Hussain Department of Pharmacology and Therapeutics College of Pharmacy Al-Mustansriya University Baghdad Iraq Departments of Pharmacology and Toxicology College of Pharmacy University of Baghdad Baghdad Iraq Specialized Center for Endocrinology and Diabetes Baghdad Iraq

Despite the extensive clinical experience with the use of metformin worldwide, no formal dose-ranging study has been conducted because the current dosing strategy of metformin was determined empirically, rather than by an understanding of its dose-response relationship in patients with type 2 diabetes. The present study was designed to evaluate the correlation between serum metformin levels and glycemic control, insulin resistance and leptin levels in females newly diagnosed with type 2 diabetes. Sixty type 2 diabetic females were recruited for the study and were allocated into 3 groups;each receiving metformin 1000, 1500 and 2000 mg/day respectively for 3 months. Blood samples withdrawn from each patient at zero time and after 3 months is used to evaluate serum levels of HbA1c, glucose, leptin and insulin, in addition, the measurement of serum level of metformin in blood after 3 months by HPLC. The results demonstrated that all the treated groups with different doses of metformin showed significant improve in all parameters;the use of increased metformin doses was only correlated with plasma leptin levels in the highest dose. In conclusion, serum metformin levels are not good predictors for correlating improvement in clinical and biochemical parameters with increasing the dose in newly diagnosed non-insulin resistant females with type 2 diabetes.

关键词： Type2 Diabetes Mellitus Leptin BMI Serum Metformin Glycemic Control

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二合一芯片

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电气时代 2014年第5期 42-44页

作者： munaf Rahimo Liutauras Storasta Chiara Corvasce Arnost Kopta

由于整合开关器件与反并联二极管这一概念具有难以攻克的技术挑战，因此近年来这一技术仅被用于低功率组件（如IGBT和MOSFET）以及特殊应用。另外，IGCT等大面积双极型器件已经采用了单片集成技术，但其中的IGCT和二：极管需要完全分离... 详细信息

由于整合开关器件与反并联二极管这一概念具有难以攻克的技术挑战，因此近年来这一技术仅被用于低功率组件（如IGBT和MOSFET）以及特殊应用。另外，IGCT等大面积双极型器件已经采用了单片集成技术，但其中的IGCT和二：极管需要完全分离的硅区。

关键词：二合一单片集成技术芯片开关器件 IGCT IGBT 功率组件二极管

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Dogs: Active Role Model for Cancer Studies—A Review

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Journal of Cancer Therapy 2013年第5期4卷 989-995页

作者： Sana munaf Hawai M. Al-Zayer Mohammed M. Ali Yuanjie Niu A. Alawad M. Aljofan A. Aljarbou S. Altuwaijri College of Applied Medical Science Qassim University Qassim Saudi Arabia College of Pharmacy Qassim University Qassim Saudi Arabia King Abdulaziz City of Science and Technology Riyadh Saudi Arabia Saad Research and Development Center Clinical Research Laboratory SAAD Specialist Hospital Al Khobar Saudi Arabia Tianjin Institute of Urological Surgery Tianjin Medical Univer- sity Tianjin China

Many studies have been done and many results have been established for studying cancers in human and the ways of treating it. However, one thing that remains relevant is the study model that is used to diagnose, cure or conclude treatment methods for human cancers. The scientists have tried some ways to link the data and tried to analyze the malicious disease in various animal models in order to solve the problem for humans. Out of all the models, scientists have preferred dogs as the most suitable model and conducted studies on them. Our article will review the reason for preferences given to dog as a study model and what the previous studies have tried to conclude by considering the dreaded disease in dogs. Our article has focused on most of the recent observations and tried to elucidate the reasons/preferences for studying cancer disease in dogs (scientific name;Canis Lupus familiaris). We will also talk about the idea of comparative oncology programs that many centers adapt in order to study the disease called cancer.

关键词： Cancer Models Dogs Comparative Oncology

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论小地震的MW与ML之间的关系

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世界地震译丛 2017年第3期48卷 248-256页

作者： Irene munafò L.Malagnini L.Chiaraluce 杨国栋（译）曾文浩（译）朱玉萍（校）不详甘肃省地震局中国地震局地球物理研究所

估计小地震的矩震级(M_W)是具有挑战性的任务。一个可行的测量办法是计算其地方震级(M_L),再把地方震级转换成具有物理基础的矩震级M_W。不幸的是,正确地进行这样的转换并不容易;而且,虽然很多研究表明小地震的M_L与M_W之间的等值是错误... 详细信息

估计小地震的矩震级(M_W)是具有挑战性的任务。一个可行的测量办法是计算其地方震级(M_L),再把地方震级转换成具有物理基础的矩震级M_W。不幸的是,正确地进行这样的转换并不容易;而且,虽然很多研究表明小地震的M_L与M_W之间的等值是错误的,但不管地震大小,人们时常还是认为这两个参数是严格等值的。我们使用随机振动理论表明,在M_W4以下,小地震的M_L正比于它的地震矩的对数,下列关系式成立:M_(W_(SMALL))=2/3M_(L_(SMALL))+C′我们在台伯河上游流域(意大利亚平宁山脉北部)由0≤M_L≤3.8事件构成的具有M_L和M_W精确估计值的高质量数据集上检验了我们的发现。

关键词：小地震随机振动理论亚平宁山脉矩震级物理基础上游流域估计值挑战性

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为耐用和可靠而设计的4．5kV压接式封装IGBT

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电力电子 2004年第6期2卷 -页

作者： S.埃克尔 M.雷西莫 E.齐普拉柯夫 D.施内德 U.施拉普巴赫 E.卡洛尔梁苏军 ABB公司半导体分部北京国安电气总公司

介绍了额定电压达4500V、额定电流达2000A的新型压接式封装IGBT(PPI)。在这种新器件的开发期间,特别强调系统制造商易于使用的可选用性。为了便于把压接式封装的IGBT紧固在长的骨架上,其机械设计是精心优化的。即使在骨架上的紧固会发... 详细信息

介绍了额定电压达4500V、额定电流达2000A的新型压接式封装IGBT(PPI)。在这种新器件的开发期间,特别强调系统制造商易于使用的可选用性。为了便于把压接式封装的IGBT紧固在长的骨架上,其机械设计是精心优化的。即使在骨架上的紧固会发生某些不均匀现象,这种压接式封装的IGBT由于其独特的设计,对每个芯片都用单独的压针压紧,因而它们都会发挥其完善的功能。进而,材料的选择也得到优化,以保证在野外也能达到极高的可靠性。在功率循环次数及在故障情况下运行之间的折中平衡点亦已被推向新的限界。这里的IGBT和二极管二者的芯片都是基于SPT(软穿通)技术。先进的IGBT平面元胞设计同二极管精密的寿命控制工程相结合,这样的芯片就具备了崭新的安全工作区。这就大大便利了系统设计,使原先使用的夹具或减振器成为过时。

关键词： IGBT 压接式封装压接式封装IGBT 功率循环短路失效模式模块化率安全工作区

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