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Robotic total meso-rectal excision for rectal cancer: A systematic review following the publication of the ROLARR trial

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World Journal of Gastrointestinal Oncology 2018年第11期10卷 449-464页

作者： katie Jones Mohamed G Qassem Parv Sains mirza k baig Muhammad S Sajid Department of General and Laparoscopic Colorectal Surgery Brighton and Sussex University Hospitals NHS Trust the Royal Sussex County Hospital Brighton Lecturer of General Surgery Ain Shams Faculty of Medicine Department of General and Laparoscopic Colorectal Surgery Western Sussex Hospitals NHS Foundation Trust Worthing Hospital

AIM To compare outcomes in patients undergoing rectal resection by robotic total meso-rectal excision(RTME) vs laparoscopic total meso-rectal excision(LTME).METHODS Standard medical electronic databases such as Pub-Med, MEDLINE, EMBASE and Scopus were searched to find relevant articles. The data retrieved from all types of included published comparative trials in pati-ents undergoing RTME vs LTME was analysed using the principles of meta-analysis. The operative, post-operative and oncological outcomes were evaluated to assess the effectiveness of both techniques of TME. The summated outcome of continuous variables was expressed as standardized mean difference(SMD) and dichotomous data was presented in odds ratio(OR).RESULTS One RCT(ROLARR trial) and 27 other comparative studies reporting the non-oncological and oncological outcomes following RTME vs LTME were included in this review. In the random effects model analysis using the statistical software Review Manager 5.3, the RTME was associated with longer operation time(SMD, 0.46; 95%CI: 0.25, 0.67; z = 4.33; P = 0.0001), early passage of first flatus(P = 0.002), lower risk of conversion(P = 0.00001) and shorter hospitalization(P = 0.01). The statistical equivalence was seen between RTME and LTME for non-oncological variables like blo-od loss, morbidity, mortality and re-operation risk. The oncological variables such as recurrence(P = 0.96), number of harvested nodes(P = 0.49) and positive circumferential resection margin risk(P = 0.53) were also comparable in both groups. The length of distal resection margins was similar in both groups. CONCLUSION RTME is feasible and oncologically safe but failed to demonstrate any superiority over LTME for many sur-gical outcomes except early passage of flatus, lower risk of conversion and shorter hospitalization.

关键词： Diverticular disease Colorectal resections Multi-incision laparoscopic surgery Colorectal cancer Single incision laparoscopic surgery

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Specimen retrieval approaches in patients undergoing laparoscopic colorectal resections:a literature-based review of published studies

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Gastroenterology Report 2014年第4期2卷 251-261页

作者： Muhammad S.Sajid Muhammad I.Bhatti Parv Sains mirza k.baig Department of General&Laparoscopic Colorectal Surgery Worthing HospitalWorthingUK Department of General Surgery Queen Elizabeth HospitalKings Lynn NHS Foundation TrustKings LynnUK

Objective:To review the published studies reporting various specimen retrieval incisions being used by colorectal surgeons in patients undergoing laparoscopic colorectal resections(LCR).Methods:Standard medical electronic databases were searched to find relevant articles and a summary conclusion was ***:There were 43 studies reporting various approaches used for the purpose of specimen retrieval in 2388 patients undergoing *** most common approaches were periumbilical midline incision(1260 reported case in the literature),transverse incision(583 reported cases in the literature)in the right-or left iliac fossa,depending on the side of colonic resection,and Pfannensteil incision(293 reported cases in the literature).Periumbilical midline incision was associated with the higher risk of developing incisional hernia(odds ratio 53.72;95%confidence interval 7.48–386.04;Z=3.96;P=0.0001).In terms of surgical site infection(SSI),there was no difference between the three common approaches to specimen *** and transvaginal approaches were associated with higher risk of ***:Midline,transverse and Pfannensteil incisions were the most commonly used approaches for specimen retrieval following *** incision was associated with higher risk of incisional *** of SSI was similar in all three common *** transanal and transvaginal approaches pose a higher risk of *** conclusions are based on the combined outcome of published case series,case reports and comparative ***,controlled trials with longer follow-up are required before recommending the routine use of any approach for specimen retrieval in patients undergoing LCR.

关键词： colorectal cancer laparoscopic colorectal surgery umbilical incision transverse incision anal retrieval vaginal retrieval

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Limited segmental rectal resection in the treatment of deeply infiltrating rectal endometriosis:10 years’experience from a tertiary referral unit

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Gastroenterology Report 2014年第4期2卷 288-294页

作者： James English Muhammad S.Sajid Jenney Lo Guy Hudelist mirza k.baig William A.Miles Department of Obstetrics and Gynaecology Brighton and Sussex University Hospitals NHS Trust177 Preston Road BrightonBN1 AGUK Department of General Endoscopic&Laparoscopic Colorectal SurgeryWestern Sussex Hospitals NHS Foundation TrustWorthing HospitalWorthingWest SussexBN112DHUK Department of Obstetrics and Gynaecology Western Sussex Hospitals NHS TrustWorthing HospitalWorthingWest SussexBN112DHUK Department of Obstetrics and Gynaecology Wilhelminen HospitalViennaAustria

*** management of symptomatic rectal endometriosis is a challenging condition that may necessitate limited stripping or limited segmental anterior rectal resection(LSARR)depending upon the extent and severity of the *** report the efficacy of LSARR in terms of pain,quality of life and short-and long-term complications—in particular,those pertaining to bowel *** case notes of all patients undergoing LSARR were *** analysed variables included surgical complications,overall symptomatic improvement rate,dysmenorrhoea,dyspareunia,and *** pain was measured using a visual analogue *** of life was measured using the EQ-5D *** symptoms were assessed using the Memorial Sloan kettering Cancer Centre(MSkCC)***-four women who underwent LSARR by both open and laparoscopic approaches were included in this ***-nine(93.2%)women reported improvement in pain and the same percentage would recommend the similar procedure to a friend with the same *** 42%of women who wished to conceive had at least one *** higher frequency of defecation was a problem in the early post-operative period but this settled in later stages without influencing the quality of life ***-operative complications were recorded in 14.9%of *** for rectal endometriosis is associated with a high degree of symptomatic *** relief achieved following LSARR does not appear to degrade with *** anticipated,some rectal symptoms persist in few patients after long-term follow-up but LSARR is nonetheless still associated with a very high degree of patient satisfaction.

关键词： rectal endometriosis limited segmental anterior rectal resection long-term outcomes quality of life

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Development of biomedical hydrogels for rheumatoid arthritis treatment

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 35-48页

作者： mirza Muhammad Faran Ashraf baig Lee kiWong Abdul Wasy Zia Hongkai Wu Department of Chemistry Hong Kong University of Science and TechnologyHong Kong 999077China Institute of Mechanical Process and Energy Engineering(IMPEE)School of Engineering and Physical SciencesHeriot-Watt UniversityEdinburghUnited Kingdom

Rheumatoid Arthritis(RA)is an autoimmune disorder that hinders the normal functioning of bones and joints and reduces the quality of human *** year,millions of people are diagnosed with RA worldwide,particularly among elderly individuals and ***,there is a global need to develop new biomaterials,medicines and therapeutic methods for treating *** will improve the Healthcare Access and Quality Index and also relieve administrative and financial burdens on healthcare service providers at a global *** are soft and cross-linked polymeric materials that can store a chunk of fluids,drugs and biomolecules for hydration and therapeutic *** are biocompatible and exhibit excellent mechanical properties,such as providing elastic cushions to articulating joints by mimicking the natural synovial ***,hydrogels create a natural biological environment within the synovial cavity to reduce autoimmune reactions and *** also lubricate the articulating joint surfaces to prevent degradation of synovial surfaces of bones and cartilage,thus exhibiting high potential for treating *** work reviews the progress in injectable and implantable hydrogels,synthesis methods,types of drugs,advantages and ***,it discusses the role of hydrogels in targeted drug delivery,mechanistic behaviour and tribological performance for RA treatment.

关键词： Rheumatoid arthritis Orthopeadic joints Hydrogel Therapeutics Mechanical properties Medicine

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Exploring Bioinspired AI for Advanced Cell Labeling:Advancements and Applications in Biomedical Research

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第3期2卷 66-71页

作者： mirza Abdul Aleem baig Center for Biomedical Engineering School of Information Science and Technology University of Science and Technology of China

Context:Bioinspired Artificial Intelligence(Bio-AI)has emerged as a transformative tool in biomedical research,addressing challenges in cell labeling essential for understanding cellular behavior and *** cell labeling methods often struggle with accuracy,scalability,and adaptability in complex ***:This paper theoretically explores the integration of Bio-AI models into cell labeling *** aims to assess how these models C encompassing neural networks,swarm intelligence,evolutionary algorithms,and self-organizing maps C can enhance cell identification and ***:The paper examines various Bio-AI models that mimic biological processes such as neural functioning,swarm behavior,and evolutionary *** also evaluates the application of multimodal AI systems that combine imaging data with molecular and genetic *** addition,the potential of dynamic cell labeling,inspired by neural plasticity,is ***:The integration of Bio-AI models has demonstrated significant improvements in accuracy,adaptability,and scalability for cell *** labeling systems minimize human error and enhance *** advancements in multimodal AI systems have shown promise in combining imaging with genetic and molecular data,providing more comprehensive insights into cellular *** labeling models inspired by neural plasticity offer enhanced tracking of cellular transitions over ***:Bio-AI holds transformative potential in biomedical research via enabling real-time,dynamic labeling,essential for tracking cellular changes over time in processes like cancer progression,stem cell differentiation,and immune *** continued evolution of these AI-driven approaches is expected to accelerate breakthroughs in understanding diseases,tissue engineering,and regenerative medicine.

关键词： Bioinspired Artificial Intelligence Biomedical Research Cell Labeling Bio-AI Models

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Bridging the Gap:Integration of Artificial Intelligence with Organ-on-Chip(AI-OoC)

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第1期2卷 17-23页

作者： mirza Abdul Aleem baig Center for Biomedical Engineering School of Electronic Engineering and Information ScienceUniversity of Science and Technology of China(USTC)HefeiAnhuiP.R.China

.Organ-on-Chip(OoC)has emerged as a revolutionary approach to emulate human organ function-ality in vitro,offering unparalleled insights into physiological processes and disease *** integration of artiﬁcial intelligence(AI)with OoC platforms presents a transformative synergy,combining the precision of microscale organ replication with the analytical prowess of intelligent algorithms,is emerging as a transforma-tive force in harnessing the full potential of *** perspective investigates the multifaceted implications of integrating AI with OoC,examining its impact on biomedical research,acknowledging the synergistic po-tential that arises from combining the precision of microscale organ replication with the analytical capabilities of intelligent algorithms,and fostering a future where the intricate workings of the technology and biology.

关键词： Organ-on-Chip(OoC) Artiﬁcial Intelligence(AI) Biomedical Research Technology&Biology.

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Navigating Biomedical Ethical Challenges of Artificial Intelligence in Healthcare

IJLAI Transactions on Science and Engineering

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IJLAI Transactions on Science and Engineering 2024年第2期2卷 29-35页

作者： mirza Abdul Aleem baig Center for Biomedical Engineering School of Electronic Engineering and Information Science University of Science and Technology of China(USTC) HefeiAnhuiP.R.China

Biomedical ethics,commonly known as bioethics,constitutes a dynamic and interdisciplinary field that confronts the intricate ethical challenges and moral quandaries inherent at the convergence of medicine,healthcare,and the life *** foundation lies in the core principles of respect for autonomy,beneficence,non-maleficence,and justice,which collectively establish a robust framework for guiding ethical decisionmaking in the realm of clinical practice,research endeavors,and the formulation of healthcare *** principle of autonomy underscores the importance of respecting individuals’rights to make informed decisions about their own healthcare,while beneficence and non-maleficence emphasize the ethical obligation to promote well-being and prevent ***,in the context of biomedical ethics,demands the equitable distribution of resources and fair treatment for all *** ethics serves as an indispensable compass for healthcare professionals,researchers,policymakers,and society at large,providing ethical guidance to navigate the intricate landscape of advancements in medicine and the life sciences.

关键词： Biomedical ethics Autonomy underscores Non-maleficence

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Non-thermal plasma enhanced catalytic conversion of methane into value added chemicals and fuels

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Journal of Energy Chemistry 2024年第10期97卷 265-301,I0006页

作者： Shanza baig Baharak Sajjadi Mewbourne School of Petroleum and Geological Engineering University of OklahomaNormanOK 73019USA

Plasma catalysis has recently gained increased attention for its application in gas conversion,notably in processes like the dry reforming of methane aimed at transforming them into valuable chemicals and *** this field is still in its early developmental stages,there is a crucial necessity to explore the synergistic mechanism between plasma and *** optimization of catalysts is imperative to improve their selectivity and conversion rates for desired products in a plasma ***,delving into microscale investigations of plasma characteristics,such as electron temperature and the density of energetic species,is essential to enhance the stability and activity of *** review examines recent advancements in various methane conversion techniques,encompassing Dry Reforming of Methane,Steam Methane Reforming,Pa rtial Oxidation of Metha ne,and Methane Decomposition utilizing non-thermal dielectric barrier discharge(DBD)*** aim is to gain a deeper understanding of plasma-catalyst interactions and to refine catalyst selection strategies for maximizing the production of desired products such as syngas,oxygenates,or higher *** review delves into the catalytic mechanisms that delineate the synergistic effects between DBD plasma and catalyst in each technology,shedding light on the role of diverse catalytic properties in activating methane molecules-a pivotal step in hybrid plasma-catalytic *** approaches employed by researchers in exploring suitable catalysts and optimal reaction conditions to bolster CH_(4) conversion rates and selectivity using DBD plasma are ***,the review identifies gaps in the realm of plasma catalysis,underscoring the necessity for further research to fully understand the underlying principles of plasma and catalyst which are not trivial to uncover.

关键词： Non-thermal plasma DBD Catalyst Methane

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Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis karmakar Manaswini Dash Swagat kumar Tripathy Priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta kumar Mohapatra mirza J.baig kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

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FlowBreakdown of Hybrid Nanofluid on a Rigid Surface with Power Law Fluid as Lubricated Layers

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1485-1499页

作者： mirza Naveed Jahangeer baig NadeemSalamat Sohail Nadeem NaeemUllah Mohamed Bechir Ben Hamida Hassan Ali Ghazwani Sayed M.Eldin A.S.Al-Shafay Instituite of Mathematics Khwaja Fareed University of Engineering and Information TechnologyRahim yar Khan64200Pakistan Department of Mathematics Quaid-I-Azam UniversityIslamabad44000Pakistan Department of Mathematics Wenzhou UniversityWenzhou325035China College of Engineering Department of Mechanical EngineeringImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11564Saudi Arabia Research Laboratory of Ionized Backgrounds and Reagents Studies(EMIR) Preparatory Institute for Engineering Studies of Monastir(IPEIM)University of MonastirMonastir5060Tunisia Higher School of Sciences and Technology of Hammam Sousse Department of PhysicsJazan82511Kingdom of Saudia Arabia Department of Mechanical Engineering Faculty of engineeringJazan UniversityP.O.Box 45124JazanKingdom of Saudia Arabia Center of Research Faculty of EngineeringFuture University in EgyptNew Cairo11835Egypt Department of Mechanical Engineering College of EngineeringPrince Sattam bin Abdulaziz UniversityAlkharj16436Saudi Arabia

Thiswork investigates an oblique stagnation point flowof hybrid nanofluid over a rigid surface with power lawfluidas lubricated layers. Copper (Cu) and Silver (Ag) solid particles are used as hybrid particles acting in water H2O asa base fluid. The mathematical formulation of flow configuration is presented in terms of differential systemthat isnonlinear in nature. The thermal aspects of the flow field are also investigated by assuming the surface is a heatedsurface with a constant temperature T. Numerical solutions to the governing mathematical model are calculatedby the Rk45 algorithm. The results based on the numerical solution against various flow and thermal controllingparameters are presented in terms of line graphs. The specific results depict that the heat flux increases over thelubricated-indexed parameter.

关键词： Oblique stagnation point flow hybrid nanofluid lubricated layer magnetohydrodynamics

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